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List of works by Thomas A Milne

A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling

scientific article (publication date: 6 July 2006)

A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program

scientific article published on 25 November 2021

Addendum: Precise tuning of gene expression levels in mammalian cells.

scientific article

BET inhibition disrupts transcription but retains enhancer-promoter contact

scientific article published on 11 January 2021

Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia

scientific article

Chromatin immunoprecipitation (ChIP) for analysis of histone modifications and chromatin-associated proteins.

scientific article

DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation

scientific article published on 26 June 2019

Dangerous liaisons: cooperation between Pbx3, Meis1 and Hoxa9 in leukemia

scientific article published on July 2015

Decoupling tRNA promoter and processing activities enables specific Pol-II Cas9 guide RNA expression

scientific article published on 02 April 2019

Dimerization of MLL fusion proteins immortalizes hematopoietic cells

scientific article published in September 2003

Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs

scientific article published on 05 August 2019

Enhancer of Polycomb is a suppressor of position-effect variegation in Drosophila melanogaster.

scientific article

Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors

scientific article published in February 2018

Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes

scientific article

H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells

scientific article published on 02 April 2020

Hepcidin is regulated by promoter-associated histone acetylation and HDAC3.

scientific article published on September 2017

Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization

scientific article

In situ functional dissection of RNA cis-regulatory elements by multiplex CRISPR-Cas9 genome engineering

scientific article published on 13 December 2017

Instructive Role of MLL-Fusion Proteins Revealed by a Model of t(4;11) Pro-B Acute Lymphoblastic Leukemia.

scientific article published in November 2016

Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia

scientific article published on 29 October 2012

Interaction of MLL amino terminal sequences with menin is required for transformation

scientific article published on 01 August 2007

Intragenic enhancers act as alternative promoters

scientific article

LEDGF: a leukemia-specific target

scientific article

Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration

scientific article

Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications

scientific article published in December 2005

MLL associates specifically with a subset of transcriptionally active target genes

scientific article

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia.

scientific article published on January 2017

MLL-AF4 binds directly to a BCL-2 specific enhancer and modulates H3K27 acetylation

scientific article

MLL-AF9 Expression in Hematopoietic Stem Cells Drives a Highly Invasive AML Expressing EMT-Related Genes Linked to Poor Outcome.

scientific article published on 23 June 2016

MLL5 expression as a biomarker for DNA hypermethylation and sensitivity to epigenetic therapy

scientific article published in September 2014

Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus

scientific article

Metabolic gatekeeper function of B-lymphoid transcription factors

scientific article published on 13 February 2017

Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis

scientific article published on 10 September 2012

Mouse models of MLL leukemia: recapitulating the human disease

scientific article published on 8 February 2017

Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis

scientific article

Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF

scientific article

Precise tuning of gene expression levels in mammalian cells

article

Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression

scientific article

RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells

scientific article

RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction

scientific article published on 24 January 2013

Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia

scientific article published on 08 August 2019

Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions

scientific article

Regulation of MLL1 H3K4 methyltransferase activity by its core components

scientific article (publication date: August 2006)

Regulation of hippocampal H3 histone methylation by acute and chronic stress.

scientific article

Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia

scientific article

Taking LSD 1 to a new high.

scientific article

Tantalus, a novel ASX-interacting protein with tissue-specific functions.

scientific article published in June 2001

The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes

scientific article

The Additional sex combs gene of Drosophila is required for activation and repression of homeotic loci, and interacts specifically with Polycomb and super sex combs

scientific article published in June 1999

The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia.

scientific article published on 24 April 2018

WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development

scientific article (publication date: 17 June 2005)

Why are so many MLL lysine methyltransferases required for normal mammalian development?

scientific article published on 16 May 2019

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