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List of works by Jeroen E Guikema

A mutated B cell chronic lymphocytic leukemia subset that recognizes and responds to fungi.

scientific article published on 7 January 2013

A novel chronic lymphocytic leukemia subset expressing mutated IGHV3-7-encoded rheumatoid factor B-cell receptors that are functionally proficient

scientific article published on 20 August 2012

AKT signaling restrains tumor suppressive functions of FOXO transcription factors and GSK3 kinase in multiple myeloma

scientific article published on 01 September 2020

APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination

APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination.

scientific article

ATM increases activation-induced cytidine deaminase activity at downstream S regions during class-switch recombination.

scientific article

Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins.

scientific article published on 27 December 2016

Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig Loci in activated B cells

scientific article published on January 2011

Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair

scientific article published in November 2007

Apurinic/apyrimidinic endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge.

scientific article

Apurinic/apyrimidinic endonuclease 2 regulates the expansion of germinal centers by protecting against activation-induced cytidine deaminase-independent DNA damage in B cells.

scientific article

Autologous stem cell transplantation in multiple myeloma after VAD and EDAP courses: a high incidence of oligoclonal serum Igs post transplantation

scientific article published on 01 April 2000

B-Lymphoblastic Lymphomas Evolving from Follicular Lymphomas Co-Express Surrogate Light Chains and Mutated Gamma Heavy Chains.

scientific article published on 14 October 2016

CD27 is heterogeneously expressed in multiple myeloma: low CD27 expression in patients with high-risk disease

scientific article published in April 2003

CD27-triggering on primary plasma cell leukaemia cells has anti-apoptotic effects involving mitogen activated protein kinases.

scientific article

Chronic lymphocytic leukemia development is accelerated in mice with deficiency of the pro-apoptotic regulator NOXA.

scientific article published on 13 June 2016

Chronic lymphocytic leukemia disease progression is accelerated by APRIL-TACI interaction in the TCL1 transgenic mouse model.

scientific article

Complex biallelic IGH rearrangements in IgM-expressing Z-138 cell line: Involvement of downstream immunoglobulin class switch recombination.

scientific article

Computational Model Reveals Limited Correlation between Germinal Center B-Cell Subclone Abundancy and Affinity: Implications for Repertoire Sequencing

scientific article published on 06 March 2017

Consensus strategy to quantitate malignant cells in myeloma patients is validated in a multicenter study. Belgium-Dutch Hematology-Oncology Group

scientific article published on 01 July 2000

De novo gene mutations in normal human memory B cells

article

Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay.

scientific article

Exploiting the pro-apoptotic function of NOXA as a therapeutic modality in cancer.

scientific article published on 3 July 2017

Expression of activation-induced cytidine deaminase is confined to B-cell non-Hodgkin's lymphomas of germinal-center phenotype

scientific article published in July 2003

H2AX is not affected in mantle cell lymphoma with 11q23 deletion

scientific article published on 01 April 2006

Heterogeneity in the multiple myeloma tumor clone.

scientific article published in May 2004

Identification of a novel stereotypic IGHV4-59/IGHJ5-encoded B-cell receptor subset expressed by various B-cell lymphomas with high affinity rheumatoid factor activity.

scientific article published on 8 February 2016

In vitro induction of antibody secretion of primary B-cell chronic lymphocytic leukaemia cells

scientific article published on 10 September 2014

MYC in diffuse large B-cell lymphoma: always the bad guy?

scientific article published on 18 June 2015

Mechanism and regulation of class switch recombination

scientific article

Mobilized human CD34+ hematopoietic stem cells enhance tumor growth in a nonobese diabetic/severe combined immunodeficient mouse model of human non-Hodgkin's lymphoma

scientific article published on 01 October 2001

Multiple myeloma related cells in patients undergoing autologous peripheral blood stem cell transplantation

scientific article published in March 1999

Myeloma clonotypic B cells are hampered in their ability to undergo B-cell differentiation in vitro

scientific article published on 01 October 2002

NF-κB and AKT signaling prevent DNA damage in transformed pre-B cells by suppressing RAG1/2 expression and activity

scientific article

Quantitative RT-PCR analysis of activation-induced cytidine deaminase expression in tissue samples from mantle cell lymphoma and B-cell chronic lymphocytic leukemia patients

scientific article published in April 2005

Reassessment of the role of Mut S homolog 5 in Ig class switch recombination shows lack of involvement in cis- and trans-switching.

scientific article published on December 2008

Stereotypic rheumatoid factors that are frequently expressed in mucosa-associated lymphoid tissue-type lymphomas are rare in the labial salivary glands of patients with Sjögren's syndrome.

scientific article published in April 2015

Structure and consequences of IGH switch breakpoints in Burkitt lymphoma

scientific article published in January 2008

The Complex Interplay between DNA Injury and Repair in Enzymatically Induced Mutagenesis and DNA Damage in B Lymphocytes.

scientific article published on 30 August 2017

The DNA Damage Response Regulates RAG1/2 Expression in Pre-B Cells through ATM-FOXO1 Signaling

scientific article

The NEDD8-activating enzyme inhibitor MLN4924 induces DNA damage in Ph+ leukemia and sensitizes for ABL kinase inhibitors

scientific article published on 26 July 2019

The role of Apex2 in class-switch recombination of immunoglobulin genes

article

ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma.

scientific article published on 23 March 2017

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