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Authors whose works are in public domain in at least one jurisdiction

List of works by Ricky W Johnstone

A Comprehensive Protocol Resource for Performing Pooled shRNA and CRISPR Screens

scientific article published in January 2018

A central role for Bid in granzyme B-induced apoptosis

scientific article published in December 2004

A chemical probe toolbox for dissecting the cancer epigenome

scientific article published on February 2017

A community-based model of rapid autopsy in end-stage cancer patients

scientific article published on 12 September 2016

A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance.

scientific article

A focus on the preclinical development and clinical status of the histone deacetylase inhibitor, romidepsin (depsipeptide, Istodax(®)).

scientific article

A functional genomics screen identifies PCAF and ADA3 as regulators of human granzyme B-mediated apoptosis and Bid cleavage.

scientific article published on 24 January 2014

A genome scale RNAi screen identifies GLI1 as a novel gene regulating vorinostat sensitivity.

scientific article published on 12 February 2016

A high rate of durable responses with romidepsin, bortezomib, and dexamethasone in relapsed or refractory multiple myeloma

scientific article

A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway

scientific article

A novel CDK9 inhibitor increases the efficacy of venetoclax (ABT-199) in multiple models of hematologic malignancies

scientific article published on 11 December 2019

A novel c-Jun-dependent signal transduction pathway necessary for the transcriptional activation of interferon gamma response genes

scientific article published on 14 November 2006

A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1

scientific article

A pharmacogenomic approach validates AG-221 as an effective and on-target therapy in IDH2 mutant AML

scientific article published on 10 March 2017

A role for P-glycoprotein in regulating cell growth and survival

A role for multiple chimeric antigen receptor-expressing leukocytes in antigen-specific responses to cancer

scientific article published on 02 May 2016

AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer

scientific article

AKT signalling is required for ribosomal RNA synthesis and progression of Eμ-Myc B-cell lymphoma in vivo

scientific article published on 13 February 2013

AML: Deacetylases

Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy

scientific article (publication date: October 2014)

An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice

scientific article published on 3 January 2012

An intact immune system is required for the anticancer activities of histone deacetylase inhibitors

scientific article published on 24 October 2013

Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma

scholarly article

Antagonism of IAPs Enhances CAR T-cell Efficacy

scientific article published on 16 January 2019

Antibodies targeted to TRAIL receptor-2 and ErbB-2 synergize in vivo and induce an antitumor immune response

scholarly article

Anticancer activities of histone deacetylase inhibitors

scientific article (publication date: September 2006)

Antigen-driven EGR2 expression is required for exhausted CD8<sup>+</sup> T cell stability and maintenance

scientific article published on 13 May 2021

Antitumor activities and on-target toxicities mediated by a TRAIL receptor agonist following cotreatment with panobinostat

article

Apoptosis: a link between cancer genetics and chemotherapy

scientific article

Asymmetric cell division of T cells upon antigen presentation uses multiple conserved mechanisms

scientific article published on 07 June 2010

BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members

scientific article published on 12 July 2016

BET inhibitor resistance emerges from leukaemia stem cells

scientific article published on 14 September 2015

BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1

scientific article

Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis

scientific article published on 22 March 2019

Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2.

scientific article

Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity.

scientific article

CD271 Expression on Patient Melanoma Cells Is Unstable and Unlinked to Tumorigenicity

scientific article published on 20 June 2016

CD46 (MCP) confers protection from lysis by xenogeneic antibodies

scientific article published on 01 February 1993

CDK13 cooperates with CDK12 to control global RNA polymerase II processivity

scientific article published on 29 April 2020

CDK9 inhibition by dinaciclib potently suppresses Mcl-1 to induce durable apoptotic responses in aggressive MYC-driven B-cell lymphoma in vivo.

scientific article published on 12 January 2014

Cell death research, on an island girt by sea.

scientific article published on 16 March 2012

Characterisation of the novel apoptotic and therapeutic activities of the histone deacetylase inhibitor romidepsin

scientific article published in May 2008

Ciao 1 Is a Novel WD40 Protein That Interacts with the Tumor Suppressor Protein WT1 ⬇️

scientific article published on May 1, 1998

Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma

scientific article

Cloning and characterisation of Ifi206: a new murine HIN-200 family member

scientific article

Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma

scientific article

Combination anti-CD137 and anti-CD40 antibody therapy in murine myc-driven hematological cancers.

scientific article published on 2 June 2014

Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonist

scholarly article

Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas

scientific article published on 12 February 2013

Combined targeting of JAK2 and Bcl-2/Bcl-xL to cure mutant JAK2-driven malignancies and overcome acquired resistance to JAK2 inhibitors

scientific article

Combining the differentiating effect of panobinostat with the apoptotic effect of arsenic trioxide leads to significant survival benefit in a model of t(8;21) acute myeloid leukemia

scientific article

Commentary on: Biomarkers Provide Clues to Early Events in the Pathogenesis of Breast Implant-Associated Anaplastic Large Cell Lymphoma

scientific article published on 19 April 2016

Comparison of in vitro cell binding characteristics of four monoclonal antibodies and their individual tumor localization properties in mice.

scientific article published on July 1990

Constitutive IFNα/β signaling maintains expression of signaling intermediaries for efficient cytokine responses

scientific article published on 18 May 2016

Constitutive type I interferon modulates homeostatic balance through tonic signaling

scientific article

Coordinate functions of multiple complement regulating molecules, CD46, CD55, and CD59

scientific article published on 01 June 1994

DOCK8 Drives Src-Dependent NK Cell Effector Function

scientific article published on 9 August 2017

Deamidation of Bcl-XL

scientific article published on 01 October 2002

Deciphering the molecular and biologic processes that mediate histone deacetylase inhibitor-induced thrombocytopenia

scientific article

Deciphering the molecular events necessary for synergistic tumor cell apoptosis mediated by the histone deacetylase inhibitor vorinostat and the BH3 mimetic ABT-737.

scientific article published on 11 March 2011

Defining the target specificity of ABT-737 and synergistic antitumor activities in combination with histone deacetylase inhibitors

scientific article

Different membrane cofactor protein (CD46) isoforms protect transfected cells against antibody and complement mediated lysis

scientific article published on 01 January 1993

Differential induction of apoptosis and senescence by the DNA methyltransferase inhibitors 5-azacytidine and 5-aza-2'-deoxycytidine in solid tumor cells

scientific article published on 7 August 2013

Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors

scientific article

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

scientific article published in Nature Communications

Dissecting the apoptotic mechanisms of chemotherapeutic drugs and lymphocytes to design effective anticancer therapies

Distinct and overlapping mechanisms of resistance to azacytidine and guadecitabine in acute myeloid leukemia

scientific article published on 13 July 2020

Down-regulation of a pro-apoptotic pathway regulated by PCAF/ADA3 in early stage gastric cancer

scientific article

Drug response in a genetically engineered mouse model of multiple myeloma is predictive of clinical efficacy

scientific article

Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting.

scientific article published on 13 December 2016

Durable clinical remission induced by romidepsin for chemotherapy-refractory peripheral T-cell lymphoma with central nervous system involvement

scientific article

E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis

scientific article published on 11 June 2012

Efficacy of CHK inhibitors as single agents in MYC-driven lymphoma cells ⬇️

scientific article published on August 15, 2011

Enhancing the antitumor effects of radiotherapy with combinations of immunostimulatory antibodies

scientific article published on December 2012

Enhancing the apoptotic and therapeutic effects of HDAC inhibitors

scientific article published on 08 April 2009

Epigenetic Drugs Histone Deacetylase Inhibitors

article published in 2008

Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs

scientific article published on December 2005

Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization

scientific article

Epigenetic targeting of Notch1-driven transcription using the HDACi panobinostat is a potential therapy against T-cell acute lymphoblastic leukemia

scientific article published on 15 September 2017

Epigenetic targets in hematological malignancies: combination therapies with HDACis and demethylating agents

scientific article published on October 2007

Epigenetics in cancer: targeting chromatin modifications

scientific article published on 09 June 2009

Equivalent Death of P-Glycoprotein Expressing and Nonexpressing Cells Induced by the Protein Kinase C Inhibitor Staurosporine

scientific article published on 01 September 2000

Eradication of solid tumors using histone deacetylase inhibitors combined with immune-stimulating antibodies

scientific article

Expression of IFI 16 in epithelial cells and lymphoid tissues.

scientific article published on 20 December 2002

Fas Ligand-Mediated Lysis of Self Bystander Targets by Human Papillomavirus-Specific CD8+Cytotoxic T Lymphocytes ⬇️

scientific article published on July 1, 1998

Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas

scientific article published on 2 February 2014

Filamin (280-kDa Actin-binding Protein) Is a Caspase Substrate and Is Also Cleaved Directly by the Cytotoxic T Lymphocyte Protease Granzyme B during Apoptosis

scientific article published in Journal of Biological Chemistry

From anecdote to targeted therapy: the curious case of thalidomide in multiple myeloma

scientific article published on January 2014

From cancer immunosurveillance to cancer immunotherapy

scientific article published on December 2007

Functional characterisation of alternatively spliced CD46 cytoplasmic tails

scientific article published on October 1, 1992

Functional crosstalk between type I and II interferon through the regulated expression of STAT1.

scientific article

Functional dissociation of DeltaPsim and cytochrome c release defines the contribution of mitochondria upstream of caspase activation during granzyme B-induced apoptosis

scientific article published in April 2006

Functional interdependence of BRD4 and DOT1L in MLL leukemia

scientific article published on 13 June 2016

Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies

scientific article

Genome-wide functional genomic and transcriptomic analyses for genes regulating sensitivity to vorinostat

scientific article

Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene

scientific article published on 06 March 2017

Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737

scientific article

Growth differentiating factor 15 enhances the tumor-initiating and self-renewal potential of multiple myeloma cells.

scientific article published on 17 December 2013

HDAC Inhibitor Panobinostat Engages Host Innate Immune Defenses to Promote the Tumoricidal Effects of Trastuzumab in HER2+ Tumors

scientific article

HDAC3 activity is required for initiation of leukemogenesis in acute promyelocytic leukemia

scientific article

Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma

scientific article

Histone deacetylase inhibitors are unable to synergize with ABT-737 in killing primary chronic lymphocytic leukaemia cells in vitro

scientific article published on 06 January 2012

Histone deacetylase inhibitors in cancer therapy

Histone deacetylase inhibitors in cancer therapy: is transcription the primary target?

scientific article

Histone deacetylase inhibitors in lymphoma and solid malignancies

scientific article published on March 2008

Histone deacetylase inhibitors potently repress CXCR4 chemokine receptor expression and function in acute lymphoblastic leukaemia

Histone deacetylase inhibitors reduce glycoprotein VI expression and platelet responses to collagen related peptide

scientific article published on 2 May 2013

Histone deacetylase inhibitors specifically kill nonproliferating tumour cells

scientific article published on September 2004

Histone deacetylase inhibitors: potential targets responsible for their anti-cancer effect

scientific article published on 14 December 2010

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

scientific article

Histone-deacetylase inhibitors for the treatment of cancer.

scientific article published on 14 June 2004

Histone-deacetylase inhibitors: novel drugs for the treatment of cancer

scientific article

How do tumor cells respond to HDAC inhibition?

scientific article published on 26 April 2016

Human astrocytes express membrane cofactor protein (CD46), a regulator of complement activation

scientific article published on 01 February 1992

Human immunodeficiency virus type 1 Nef binds to tumor suppressor p53 and protects cells against p53-mediated apoptosis.

scientific article

IFNgamma signaling-does it mean JAK-STAT?

scientific article published on 16 October 2008

Id2 and E Proteins Orchestrate the Initiation and Maintenance of MLL-Rearranged Acute Myeloid Leukemia

scientific article published on 30 June 2016

Id2 represses E2A-mediated activation of IL-10 expression in T cells.

scientific article published on 10 April 2014

Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors

scientific article

Identification and quantification of complement regulator CD46 on normal human tissues

scientific article published on 01 July 1993

Identification of four different CD46 (MCP) molecules with anti-peptide antibodies

scientific article published on 01 October 1991

Identification, cloning, expression, and biochemical characterization of the testis-specific RNA polymerase II elongation factor ELL3

scientific article published in October 2000

Identifying molecular targets mediating the anticancer activity of histone deacetylase inhibitors: a work in progress.

scientific article

Imprinted CDKN1C is a tumor suppressor in rhabdoid tumor and activated by restoration of SMARCB1 and histone deacetylase inhibitors

scientific article

In the Midst of Life-Cell Death: What Is It, What Is It Good for, and How to Study It.

scientific article published in December 2016

In vivo activity of combined PI3K/mTOR and MEK inhibition in a Kras(G12D);Pten deletion mouse model of ovarian cancer

scientific article

Inducible activation of IFI 16 results in suppression of telomerase activity, growth suppression and induction of cellular senescence

scientific article

Induction of autophagy does not alter the anti-tumor effects of HDAC inhibitors

scientific article published on 6 September 2012

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

scientific article

Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53

scientific journal article

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

scientific article

Inhibition of pyrimidine biosynthesis targets protein translation in acute myeloid leukemia

scientific article published in 2022

Inhibition of retinoblastoma protein degradation by interaction with the serpin plasminogen activator inhibitor 2 via a novel consensus motif

scientific article

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

scientific article published in Nature

Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

scientific article

Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia

scientific article published on 01 August 2019

Intrinsic and extrinsic apoptotic pathway signaling as determinants of histone deacetylase inhibitor antitumor activity

scientific article published on January 2012

Isotypic variants of the interferon-inducible transcriptional repressor IFI 16 arise through differential mRNA splicing

scientific article

JAK2 is dispensable for maintenance of JAK2 mutant B-cell acute lymphoblastic leukemias

Joseph F. Sambrook (1939-2019)

scientific article published on 01 October 2019

Lethal giant larvae 1 tumour suppressor activity is not conserved in models of mammalian T and B cell leukaemia

scientific article published on 27 January 2014

Letter to the Editor, "BET inhibitor JQ1 blocks inflammation and bone destruction".

scientific article

Long term, continuous exposure to panobinostat induces terminal differentiation and long term survival in the TH-MYCN neuroblastoma mouse model

scientific article published on 23 February 2016

MLL-aberrant leukemia: complete cytogenetic remission following treatment with a histone deacetylase inhibitor (HDACi)

scientific article published on 15 October 2010

Manipulation of B-cell responses with histone deacetylase inhibitors

scientific article published on 27 April 2015

Mapping of the human PAWR (par-4) gene to chromosome 12q21.

scientific article

Modulation of antitumour immune responses by intratumoural Stat1 expression

scientific article published on 20 August 2013

Molecular and biologic analysis of histone deacetylase inhibitors with diverse specificities

scientific article published on 3 October 2013

Molecular characterization of the polymorphic expression of CD46: a cell surface molecule protecting cells from complement attack

scientific article published on 01 February 1992

Multiple deficiencies underlie NK cell inactivity in lymphotoxin-alpha gene-targeted mice

article

Mutational analysis of P-glycoprotein: suppression of caspase activation in the absence of ATP-dependent drug efflux.

scientific article published on September 2004

NKT cell adjuvant-based tumor vaccine for treatment of myc oncogene-driven mouse B-cell lymphoma

scientific article published on 28 August 2012

Natural Killer Cells Suppress T Cell-Associated Tumor Immune Evasion

scientific article published on 01 September 2019

New and emerging HDAC inhibitors for cancer treatment

scientific article

Novel mechanisms of apoptosis induced by histone deacetylase inhibitors.

scientific article published in August 2003

Novel properties of the protein kinase CK2-site-regulated nuclear- localization sequence of the interferon-induced nuclear factor IFI 16

scientific article

Oncogenes in cell survival and cell death

scientific article

Overview of Histone Deacetylase Inhibitors in Haematological Malignancies

scientific article

P-glycoprotein Does Not Protect Cells against Cytolysis Induced by Pore-forming Proteins

scientific article published in Journal of Biological Chemistry

P-glycoprotein as a General Antiapoptotic Protein

P-glycoprotein inhibits caspase-8 activation but not formation of the death inducing signal complex (disc) following Fas ligation

scientific article published in November 2002

P-glycoprotein protects leukemia cells against caspase-dependent, but not caspase-independent, cell death

scientific article published on 01 February 1999

PIDDosome-independent tumor suppression by Caspase-2.

scientific article

Panobinostat (LBH589): a potent pan-deacetylase inhibitor with promising activity against hematologic and solid tumors

scientific article published on June 2009

Perforin-mediated suppression of B-cell lymphoma

scholarly article

Polymorphic expression of CD46 protein isoforms due to tissue-specific RNA splicing

scientific article published on 01 October 1993

Preclinical screening of histone deacetylase inhibitors combined with ABT-737, rhTRAIL/MD5-1 or 5-azacytidine using syngeneic Vk*MYC multiple myeloma

scientific article published on 12 September 2013

Promises and challenges of anticancer drugs that target the epigenome

scientific article published on October 2011

Radiotherapy increases the permissiveness of established mammary tumors to rejection by immunomodulatory antibodies

scientific article published on 8 May 2012

Rare T-Cell Subtypes

scientific article published on 01 January 2019

Rational combination therapies targeting survival signaling in aggressive B-cell leukemia/lymphoma

scientific article published on July 2014

Rational combinations using HDAC inhibitors

scientific article published on 09 June 2009

Regulating the TRAIL of destruction: how A20 protects glioblastomas from TRAIL-mediated death

scientific article

Response of BRAF-mutant melanoma to BRAF inhibition is mediated by a network of transcriptional regulators of glycolysis

scientific article

Response: Does Bid Play a Role in the DNA Damage Response?

article

Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence

scientific article

Scribble acts as an oncogene in Eμ-myc-driven lymphoma

scientific article published on 18 May 2015

Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity.

scientific article published on 12 January 2016

Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

scholarly article

SnapShot: Extrinsic Apoptosis Pathways

Socrates: identification of genomic rearrangements in tumour genomes by re-aligning soft clipped reads.

scientific article published on 22 January 2014

Strong associations between RFLP and protein polymorphisms for CD46

scientific article published on 01 January 1992

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

scientific article

Suberoylanilide hydroxamic acid (SAHA) overcomes multidrug resistance and induces cell death in P-glycoprotein-expressing cells

scientific article

Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors

scientific article published on 3 September 2013

Synthesis and elaboration of N-methylpyrrolidone as an acetamide fragment substitute in bromodomain inhibition

scientific article published on 28 October 2019

T-cell acute leukaemia exhibits dynamic interactions with bone marrow microenvironments

scientific article

Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition

scientific article published on 01 May 2021

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics.

scientific article published in February 2016

Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy

scientific article

Targeting the epigenetic regulation of antitumour immunity

scientific article published on 14 September 2020

Thalidomide-analogue biology: immunological, molecular and epigenetic targets in cancer therapy.

scientific article published on 14 January 2013

The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest

scientific article published on 01 April 2007

The CDK9 Inhibitor Dinaciclib Exerts Potent Apoptotic and Antitumor Effects in Preclinical Models of MLL-Rearranged Acute Myeloid Leukemia.

scientific article published in December 2015

The HIN-200 family: more than interferon-inducible genes?

scientific article

The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations

scientific article

The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

scientific article published on 17 May 2021

The Role of p202 in Regulating Hematopoietic Cell Proliferation and Differentiation

scientific article published on 01 January 2008

The SMAC mimetic, LCL-161, reduces survival in aggressive MYC-driven lymphoma while promoting susceptibility to endotoxic shock

scientific article published on 4 April 2016

The TRAIL apoptotic pathway in cancer onset, progression and therapy

scientific article published on October 2008

The anticancer effects of HDAC inhibitors require the immune system

scientific article published on January 2014

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

scientific article

The combination of histone deacetylase inhibitors with immune-stimulating antibodies has potent anti-cancer effects

scientific article published on May 2012

The curative outcome of radioimmunotherapy in a mouse breast cancer model relies on mTOR signaling

scientific article

The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis ⬇️

scientific article published on June 9, 1998

The drug vehicle and solvent N-methylpyrrolidone is an immunomodulator and antimyeloma compound

scientific article

The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species

scientific article

The histone deacetylase inhibitors LAQ824 and LBH589 do not require death receptor signaling or a functional apoptosome to mediate tumor cell death or therapeutic efficacy

scientific article

The human interferon-inducible protein, IFI 16, is a repressor of transcription

scientific article

The mTORC1 inhibitor everolimus prevents and treats Eμ-Myc lymphoma by restoring oncogene-induced senescence

scientific article published on 14 December 2012

The molecular basis of CD46 polymorphic expression and demonstration of a protective role against lysis by xenosera

scientific article published on April 1, 1992

The multidrug resistance gene mdr1a influences resistance to ectromelia virus infection by mechanisms other than conventional immunity

scientific article published in October 2004

The question begs — what is the role of P-glycoprotein in normal physiology?

scientific article published on 01 January 1998

The role of p21(waf1/cip1) and p27(Kip1) in HDACi-mediated tumor cell death and cell cycle arrest in the Eμ-myc model of B-cell lymphoma

scientific article published on 2 December 2013

Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells.

scientific article published on 18 February 2016

Tissue-specific expression of CD46 isoforms

article

Tumor immune evasion arises through loss of TNF sensitivity

scientific article published on 01 May 2018

Tumor localization by combinations of monoclonal antibodies in a new human colon carcinoma cell line (LIM1899).

scientific article published on September 1990

UV-Associated Mutations Underlie the Etiology of MCV-Negative Merkel Cell Carcinomas

scientific article published on 15 December 2015

Whole exome sequencing reveals activating JAK1 and STAT3 mutations in breast implant-associated anaplastic large cell lymphoma anaplastic large cell lymphoma

scientific article published on 19 May 2016

Wilms Tumor Suppressor WT1

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