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List of works by Joris Jth Roelofs

A rabbit model for selective portal vein embolization.

scientific article

A short course of infusion of a hydrogen sulfide-donor attenuates endotoxemia induced organ injury via stimulation of anti-inflammatory pathways, with no additional protection from prolonged infusion

scientific article

A thrombomodulin mutation that impairs active protein C generation is detrimental in severe pneumonia-derived gram-negative sepsis (melioidosis).

scientific article

A tick mannose-binding lectin inhibitor interferes with the vertebrate complement cascade to enhance transmission of the lyme disease agent

scientific article

Absence of thrombin-activatable fibrinolysis inhibitor protects against sepsis-induced liver injury in mice.

scientific article

Accuracy of abdominal ultrasound and MRI for detection of Crohn disease and ulcerative colitis in children

scientific article published on 06 June 2014

Activated protein C protects against renal ischaemia/reperfusion injury, independent of its anticoagulant properties

scientific article published on 7 April 2016

Activation of coagulation and tissue fibrin deposition in experimental influenza in ferrets

scientific article

Acute phase response impairs host defense against Pseudomonas aeruginosa pneumonia in mice

scientific article published in February 2008

Age-Dependent Changes in the Pulmonary Renin-Angiotensin System Are Associated With Severity of Lung Injury in a Model of Acute Lung Injury in Rats

scientific article

Antithrombin inhibits bronchoalveolar activation of coagulation and limits lung injury during Streptococcus pneumoniae pneumonia in rats*

scientific article published on 01 January 2008

Assessment of future remnant liver function using hepatobiliary scintigraphy in patients undergoing major liver resection

scientific article

Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection

scientific article published on 01 April 2021

CD14 impairs host defense against gram-negative sepsis caused by Burkholderia pseudomallei in mice

scientific article published on 01 November 2008

CD44 deficiency increases tubular damage but reduces renal fibrosis in obstructive nephropathy

scientific article published in March 2004

Case report of cheilitis granulomatosa and joint complaints as presentation of Crohn's disease

scientific article published on 26 March 2016

Deficiency of FHL2 attenuates airway inflammation in mice and genetic variation associates with human bronchial hyper-responsiveness

scientific article published on 28 July 2015

Effect of hepatic artery embolization on liver hypertrophy response in a rabbit liver VX2 tumor model

scientific article published in December 2013

Effect of recombinant ADAMTS-13 on microthrombosis and brain injury after experimental subarachnoid hemorrhage

scientific article published on 01 June 2014

Effect of the oral thrombin inhibitor dabigatran on allergic lung inflammation induced by repeated house dust mite administration in mice

scientific article published on 28 August 2015

Endogenous protein C has a protective role during Gram-negative pneumosepsis (melioidosis)

scientific article published on 01 February 2013

Endogenous tissue factor pathway inhibitor has a limited effect on host defence in murine pneumococcal pneumonia.

scientific article published on 2 April 2015

Endogenous tissue-type plasminogen activator impairs host defense during severe experimental Gram-negative sepsis (melioidosis)*.

scientific article

Endogenous tissue-type plasminogen activator is protective during Escherichia coli-induced abdominal sepsis in mice.

scientific article

Endogenous tissue-type plasminogen activator is protective during ascending urinary tract infection.

scientific article

Endogenous α2-antiplasmin is protective during severe gram-negative sepsis (melioidosis).

scientific article

Enterococcal surface protein transiently aggravates Enterococcus faecium-induced urinary tract infection in mice

scientific article published on 01 October 2009

Evaluation of conventional, dynamic contrast enhanced and diffusion weighted MRI for quantitative Crohn's disease assessment with histopathology of surgical specimens

scientific article published on 15 September 2013

Expression and function of S100A8/A9 (calprotectin) in human typhoid fever and the murine Salmonella model

scientific article

Expression of urokinase plasminogen activator and its receptor during acute renal allograft rejection

scientific article published in November 2003

Factor V Leiden mutation does not affect coagulopathy or outcome in lethal H1N1 influenza

scientific article published on 22 April 2010

Factor XI deficiency enhances the pulmonary allergic response to house dust mite in mice independent of factor XII.

scientific article

Factor XI regulates pathological thrombus formation on acutely ruptured atherosclerotic plaques

scientific article published on 19 June 2014

Factor XIII Val34Leu mutation accelerates the development of fibrosis in patients with chronic hepatitis B and C.

scientific article published on 5 March 2012

Feasibility and Safety of Local Treatment with Recombinant Human Tissue Factor Pathway Inhibitor in a Rat Model of Streptococcus pneumoniae Pneumonia

scientific article published on 18 May 2015

Fluoxetine administration to pregnant rats increases anxiety-related behavior in the offspring.

scientific article published on 14 April 2011

General, but not myeloid or type II lung epithelial cell, myeloid differentiation factor 88 deficiency abrogates house dust mite induced allergic lung inflammation.

scientific article published on 14 September 2016

Genetic deletion of dectin-1 does not affect the course of murine experimental colitis

scientific article

Giant haemangioma of the liver: diagnosis and treatment

scientific article

Granzyme A impairs host defense during Streptococcus pneumoniae pneumonia.

scientific article published on 24 June 2016

High Levels of S100A8/A9 Proteins Aggravate Ventilator-Induced Lung Injury via TLR4 Signaling ⬇️

scientific article published on July 18, 2013

Hydrogen sulfide donor NaHS reduces organ injury in a rat model of pneumococcal pneumosepsis, associated with improved bio-energetic status

scientific article

Impact of endogenous protein C on pulmonary coagulation and injury during lethal H1N1 influenza in mice

scientific article published on 17 February 2011

Impact of the factor V Leiden mutation on the outcome of pneumococcal pneumonia: a controlled laboratory study

scientific article

Induced hypothermia is protective in a rat model of pneumococcal pneumonia associated with increased adenosine triphosphate availability and turnover*.

scientific article published in March 2012

Inflammation patterns induced by different Burkholderia species in mice

scientific article (publication date: 2008)

Intestinal colonization with Enterococcus faecium does not influence pulmonary defense against Pseudomonas aeruginosa in mice

scientific article

Intragraft Blood Dendritic Cell Antigen-1-Positive Myeloid Dendritic Cells Increase during BK Polyomavirus-Associated Nephropathy

scientific article published on 23 December 2015

Intragraft tubular vimentin and CD44 expression correlate with long-term renal allograft function and interstitial fibrosis and tubular atrophy

scientific article published on 01 September 2010

Limited role for ASC and NLRP3 during in vivo Salmonella Typhimurium infection.

scientific article

Lipopolysaccharide inhibits Th2 lung inflammation induced by house dust mite allergens in mice

scientific article

Liver regeneration after portal vein embolization using absorbable and permanent embolization materials in a rabbit model.

scientific article published on February 2012

Management of giant liver hemangiomas: an update ⬇️

scientific article published on March 1, 2013

Mast cell-deficient kit mice develop house dust mite-induced lung inflammation despite impaired eosinophil recruitment.

scientific article published on 18 October 2013

Matrix metalloproteinase-9 deficiency impairs host defense against abdominal sepsis

scientific article published in March 2006

Mechanical Ventilation and the Titer of Antibodies as Risk Factors for the Development of Transfusion-Related Lung Injury ⬇️

scientific article published on June 4, 2012

Mechanical ventilation aggravates transfusion-related acute lung injury induced by MHC class I antibodies

scientific article published in March 2010

Mechanical ventilation aggravates transfusion-related acute lung injury induced by MHC-I class antibodies

scientific article published on 11 March 2010

Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy mice

scientific article published on 19 January 2009

Mechanical ventilation with heliox in an animal model of acute respiratory distress syndrome

scientific article published on 6 February 2014

Methylprednisolone fails to attenuate lung injury in a mouse model of transfusion related acute lung injury

scientific article published on 27 August 2013

Mice lacking the lectin-like domain of thrombomodulin are protected against melioidosis

scientific article published on March 2014

Mild hypothermia reduces ventilator-induced lung injury, irrespective of reducing respiratory rate

scientific article published on 10 November 2011

MyD88 dependent signaling contributes to protective host defense against Burkholderia pseudomallei

scientific article

Nebulized C1-Esterase Inhibitor does not Reduce Pulmonary Complement Activation in Rats with Severe Streptococcus Pneumoniae Pneumonia.

scientific article published on 28 September 2016

Nebulized anticoagulants limit coagulopathy but not inflammation in pseudomonas aeruginosa-induced pneumonia in rats

scientific article published on 01 October 2011

Nebulized anticoagulants limit pulmonary coagulopathy, but not inflammation, in a model of experimental lung injury

scientific article published on 01 April 2010

Nebulized fibrinolytic agents improve pulmonary fibrinolysis but not inflammation in rat models of direct and indirect acute lung injury

scientific article

Neutrophil extracellular traps in the host defense against sepsis induced by Burkholderia pseudomallei (melioidosis)

scientific article

Nuclear Receptor Nur77 Attenuates Airway Inflammation in Mice by Suppressing NF-κB Activity in Lung Epithelial Cells

scientific article published on 13 July 2015

Oestrogens promote tumorigenesis in a mouse model for colitis-associated cancer.

scientific article published on 13 February 2013

Overexpression of activated protein C hampers bacterial dissemination during pneumococcal pneumonia.

scientific article

Overexpression of activated protein C is detrimental during severe experimental gram-negative sepsis (melioidosis).

scientific article published in October 2013

Overexpression of the endothelial protein C receptor is detrimental during pneumonia-derived gram-negative sepsis (Melioidosis).

scientific article

Peritoneal macrophages are important for the early containment of Enterococcus faecium peritonitis in mice

scientific article published in February 2009

Plasma-derived human C1-esterase inhibitor does not prevent mechanical ventilation-induced pulmonary complement activation in a rat model of Streptococcus pneumoniae pneumonia

scientific article published in November 2014

Plasminogen activator inhibitor type 1 is protective during severe Gram-negative pneumonia

scientific article

Plasminogen activator inhibitor type I contributes to protective immunity during experimental Gram-negative sepsis (melioidosis)

scientific article published on 01 October 2011

Plasminogen activator inhibitor-1 regulates neutrophil influx during acute pyelonephritis.

scientific article

Plasminogen activator inhibitor-type I gene deficient mice show reduced influx of neutrophils in ventilator-induced lung injury

scientific article

Platelet and endothelial cell P-selectin are required for host defense against Klebsiella pneumoniae-induced pneumosepsis.

scientific article published on 23 April 2015

Portal vein embolization induces more liver regeneration than portal vein ligation in a standardized rabbit model ⬇️

scientific article published on March 1, 2011

Pre-transplant plasma and cellular levels of CD44 correlate with acute renal allograft rejection

scientific article published on 01 October 2005

Pre-treatment with allopurinol or uricase attenuates barrier dysfunction but not inflammation during murine ventilator-induced lung injury ⬇️

scientific article published on November 30, 2012

Precursor T-lymphoblastic lymphoma presenting as primary renal lymphoma with acute renal failure

scientific article published on 22 July 2011

Preferential protection of Borrelia burgdorferi sensu stricto by a Salp15 homologue in Ixodes ricinus saliva.

scientific article

Protease activated receptor 4 limits bacterial growth and lung pathology during late stage Streptococcus pneumoniae induced pneumonia in mice

scientific article published on 20 June 2013

Protease-activated receptor 2 suppresses lymphangiogenesis and subsequent lymph node metastasis in a murine pancreatic cancer model

scientific article published on 12 September 2014

Protease-activated receptor-1 impairs host defense in murine pneumococcal pneumonia: a controlled laboratory study ⬇️

scientific article published on December 27, 2012

Protease-activated receptor-2 deficient mice have reduced house dust mite-evoked allergic lung inflammation

scientific article published on 18 September 2013

Protection against renal ischemia reperfusion injury by CD44 disruption

scientific article

R-roscovitine Reduces Lung Inflammation Induced by Lipoteichoic Acid and Streptococcus pneumoniae ⬇️

scientific article published on September 25, 2012

Recombinant activated protein C attenuates coagulopathy and inflammation when administered early in murine pneumococcal pneumonia

scientific article published on 08 September 2011

Recombinant human activated protein C inhibits local and systemic activation of coagulation without influencing inflammation during Pseudomonas aeruginosa pneumonia in rats

scientific article published on 01 May 2007

Recombinant human soluble tumor necrosis factor-alpha receptor fusion protein partly attenuates ventilator-induced lung injury

scientific article published on 01 March 2009

Recombinant human tissue factor pathway inhibitor exerts anticoagulant, anti-inflammatory and antimicrobial effects in murine pneumococcal pneumonia

scientific article published on 01 January 2011

Relative Tissue Factor Deficiency Attenuates Ventilator-Induced Coagulopathy but Does Not Protect against Ventilator-Induced Lung Injury in Mice.

scientific article

Release of extracellular DNA influences renal ischemia reperfusion injury by platelet activation and formation of neutrophil extracellular traps

scientific article published on 27 September 2016

Renal and urinary levels of endothelial protein C receptor correlate with acute renal allograft rejection

scientific article

Renal endothelial protein C receptor expression and shedding during diabetic nephropathy

scientific article published on 16 March 2016

Renal expression of CD44 correlates with acute renal allograft rejection

scientific article published on 26 July 2006

Reply from the authors

scientific article published in November 2012

Retrospective comparison of magnetic resonance imaging features and histopathology in Crohn's disease patients

scientific article published on 04 February 2011

Short-term effects of combined hepatic vein embolization and portal vein embolization for the induction of liver regeneration in a rabbit model

scientific article published on 24 May 2012

Supernatant of stored platelets causes lung inflammation and coagulopathy in a novel in vivo transfusion model

scientific article published on 17 May 2010

Suspended animation inducer hydrogen sulfide is protective in an in vivo model of ventilator-induced lung injury

scientific article

The Acute‐Phase Response and Serum Amyloid A Inhibit the Inflammatory Response toAcinetobacter baumanniiPneumonia

scientific article published on 07 December 2005

The effect of C1-inhibitor in a murine model of transfusion-related acute lung injury

scientific article published on 27 December 2013

The endothelial protein C receptor and activated protein C play a limited role in host defense during experimental tuberculosis.

scientific article

The endothelial protein C receptor impairs the antibacterial response in murine pneumococcal pneumonia and sepsis

scientific article published on 09 January 2014

The extent of ventilator-induced lung injury in mice partly depends on duration of mechanical ventilation.

scientific article published on 17 April 2013

The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia.

scientific article published on 28 October 2015

The importance of testing anti-IL-17 antibodies from different suppliers

scientific article published on 07 December 2011

The lectin like domain of thrombomodulin is involved in the defence against pyelonephritis.

scientific article published on 10 November 2015

The lectin-like domain of thrombomodulin hampers host defence in pneumococcal pneumonia

scientific article published on 30 August 2012

The prognostic significance of glomerular infiltrating leukocytes during acute renal allograft rejection

scientific article published on 20 October 2015

The receptor for advanced glycation end products in ventilator-induced lung injury

scientific article published on 2 August 2014

The role of plasminogen activator inhibitor type 1 in the inflammatory response to local tissue injury

scientific article published on 01 May 2005

The role of platelet MyD88 in host response during gram-negative sepsis.

scientific article

The role of thrombin-activatable fibrinolysis inhibitor in diabetic wound healing.

scientific article published on 9 September 2010

The thrombomodulin lectin-like domain does not change host responses to tuberculosis

scientific article published on 17 October 2013

The urokinase plasminogen activator receptor is crucially involved in host defense during acute pyelonephritis.

scientific article

The urokinase receptor (uPAR) facilitates clearance of Borrelia burgdorferi

scientific article

Therapeutic recombinant murine activated protein C attenuates pulmonary coagulopathy and improves survival in murine pneumococcal pneumonia

scientific article published on 6 October 2010

Thrombin receptor deficiency leads to a high bone mass phenotype by decreasing the RANKL/OPG ratio

scientific article published on 18 November 2014

Thrombocytopenia impairs host defense during murine Streptococcus pneumoniae pneumonia

scientific article

Tissue factor-dependent chemokine production aggravates experimental colitis.

scientific article

Tissue-Type Plasminogen Activator Modulates Inflammatory Responses and Renal Function in Ischemia Reperfusion Injury

article

Toll-like receptor-4 coordinates the innate immune response of the kidney to renal ischemia/reperfusion injury

scientific article

Transgenic tissue-type plasminogen activator expression improves host defense during Klebsiella pneumonia

scientific article published on 9 January 2008

Traumatic brain injury in rats induces lung injury and systemic immune suppression

scientific article

Unique Renal Manifestation of Type I Cryoglobulinemia, With Massive Crystalloid Deposits in Glomerular Histiocytes, Podocytes, and Endothelial Cells

scientific article published on 21 January 2016

Urokinase receptor is necessary for bacterial defense against pneumonia-derived septic melioidosis by facilitating phagocytosis

scientific article published on 08 February 2010

Urokinase-type plasminogen activator receptor plays a role in neutrophil migration during lipopolysaccharide-induced peritoneal inflammation but not during Escherichia coli-induced peritonitis

scientific article published on 05 January 2006

Ventilator-induced lung injury is mediated by the NLRP3 inflammasome

scientific article published in May 2012

miR-511-3p, embedded in the macrophage mannose receptor gene, contributes to intestinal inflammation.

scientific article published on 4 November 2015

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