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List of works by Qiang Shen

A novel STAT3 inhibitor, HJC0152, exerts potent antitumor activity in glioblastoma

scientific article published on 01 April 2019

AP-1 blockade in breast cancer cells causes cell cycle arrest by suppressing G1 cyclin expression and reducing cyclin-dependent kinase activity.

scientific article

Activation of STAT3 and Bcl-2 and reduction of reactive oxygen species (ROS) promote radioresistance in breast cancer and overcome of radioresistance with niclosamide

scientific article published on 31 May 2018

Calcium-sensing stromal interaction molecule 2 upregulates nuclear factor of activated T cells 1 and transforming growth factor-β signaling to promote breast cancer metastasis

scientific article published on 29 August 2019

Cancer drug delivery in the nano era: An overview and perspectives (Review)

scientific article published on 14 June 2017

Chlorpyrifos exposure in common carp (Cyprinus carpio L.) leads to oxidative stress and immune responses.

scientific article published on 22 June 2017

Combination chemotherapy of valproic acid (VPA) and gemcitabine regulates STAT3/Bmi1 pathway to differentially potentiate the motility of pancreatic cancer cells.

scientific article

Comparable Responses in Male and Female Mice to Cerulein-Induced Chronic Pancreatic Injury and Recovery

scientific article published on 28 September 2018

Dendritic cells loaded with pancreatic Cancer Stem Cells (CSCs) lysates induce antitumor immune killing effect in vitro

scientific article published on 18 December 2014

Discovery and development of natural product oridonin-inspired anticancer agents

scientific article

Discovery of O-Alkylamino-Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents ⬇️

scientific article published on January 15, 2013

Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3).

scientific article

Downregulation of ACE2/Ang-(1-7)/Mas axis promotes breast cancer metastasis by enhancing store-operated calcium entry

scientific article published on 7 April 2016

Effect of cadmium on oxidative stress and immune function of common carp (Cyprinus carpio L.) by transcriptome analysis.

scientific article published on 23 September 2017

Effect of epidermal growth factor receptor inhibitor on development of estrogen receptor-negative mammary tumors.

scientific article published on December 2003

Efficacy and Safety of Nedaplatin in Advanced Breast Cancer Therapy

scientific article published on 8 April 2016

Fragment-based drug design and identification of HJC0123, a novel orally bioavailable STAT3 inhibitor for cancer therapy.

scientific article published on 26 January 2013

Gemcitabine treatment promotes pancreatic cancer stemness through the Nox/ROS/NF-κB/STAT3 signaling cascade.

scientific article published on 26 August 2016

HJC0152 suppresses human non-small-cell lung cancer by inhibiting STAT3 and modulating metabolism

scientific article published on 05 February 2020

High glucose promotes pancreatic cancer cells to escape from immune surveillance via AMPK-Bmi1-GATA2-MICA/B pathway

scientific article published on 14 May 2019

Humanized NOD-SCID IL2rg–/– mice as a preclinical model for cancer research and its potential use for individualized cancer therapies.

scientific article published on March 2014

Knockdown of lncRNA H19 restores chemo-sensitivity in paclitaxel-resistant triple-negative breast cancer through triggering apoptosis and regulating Akt signaling pathway

scientific article published in November 2018

Macranthoidin B Modulates Key Metabolic Pathways to Enhance ROS Generation and Induce Cytotoxicity and Apoptosis in Colorectal Cancer.

scientific article published on 18 April 2018

Mechanistic Evaluation and Translational Signature of Gemcitabine-induced Chemoresistance by Quantitative Phosphoproteomics Analysis with iTRAQ Labeling Mass Spectrometry

scientific article published on 10 October 2017

MiR-519d-3p suppresses breast cancer cell growth and motility via targeting LIM domain kinase 1.

scientific article published on 29 November 2017

Mitochondrial Ca²⁺ uniporter is critical for store-operated Ca²⁺ entry-dependent breast cancer cell migration.

scientific article

Mitochondrial calcium uniporter as a target of microRNA-340 and promoter of metastasis via enhancing the Warburg effect.

scientific article published on 31 July 2017

Molecular cloning of a cDNA encoding the neuropeptides APGWamide and cerebral peptide 1: Localization of APGWamide-like immunoreactivity in the central nervous system and male reproductive organs ofAplysia ⬇️

scientific article published on October 13, 1997

Novel nitrogen-enriched oridonin analogues with thiazole-fused A-ring: protecting group-free synthesis, enhanced anticancer profile, and improved aqueous solubility

scientific article published on 19 June 2013

Oridonin ring A-based diverse constructions of enone functionality: identification of novel dienone analogues effective for highly aggressive breast cancer by inducing apoptosis.

scientific article published on 31 October 2013

Oxidative stress upregulates PDCD4 expression in patients with gastric cancer via miR-21.

scientific article published in January 2014

Peiminine inhibits colorectal cancer cell proliferation by inducing apoptosis and autophagy and modulating key metabolic pathways

scientific article

Polydatin down-regulates the phosphorylation level of Creb and induces apoptosis in human breast cancer cell

scientific article

Qigesan inhibits migration and invasion of esophageal cancer cells via inducing connexin expression and enhancing gap junction function

scientific article published on 23 June 2016

ROS/KRAS/AMPK Signaling Contributes to Gemcitabine-Induced Stem-like Cell Properties in Pancreatic Cancer

scientific article published on 09 August 2019

Regio- and Stereospecific Synthesis of Oridonin D-Ring Aziridinated Analogues for the Treatment of Triple-Negative Breast Cancer via Mediated Irreversible Covalent Warheads.

scientific article published on 12 March 2018

Rexinoid-induced expression of IGFBP-6 requires RARbeta-dependent permissive cooperation of retinoid receptors and AP-1

scientific article published on 28 October 2008

Small molecule inhibitors targeting activator protein 1 (AP-1).

scientific article

Structure-activity relationship studies on Bax activator SMBA1 for the treatment of ER-positive and triple-negative breast cancer

scientific article published on 08 June 2019

Suppression of the Growth and Invasion of Human Head and Neck Squamous Cell Carcinomas via Regulating STAT3 Signaling and the miR-21/β-catenin Axis with HJC0152.

scientific article published on 30 January 2017

Targeting STAT3/miR-21 axis inhibits epithelial-mesenchymal transition via regulating CDK5 in head and neck squamous cell carcinoma

scientific article

Targeting the NRF-2/RHOA/ROCK signaling pathway with a novel aziridonin, YD0514, to suppress breast cancer progression and lung metastasis.

scientific article published on 23 March 2018

Targeting the activator protein 1 transcription factor for the prevention of estrogen receptor-negative mammary tumors

scientific article published on 31 March 2008

The AP-1 transcription factor regulates breast cancer cell growth via cyclins and E2F factors.

scientific article

The AP-1 transcription factor regulates postnatal mammary gland development

scientific article published in July 2006

The microRNA miR-181c enhances chemosensitivity and reduces chemoresistance in breast cancer cells via down-regulating osteopontin

scientific article published on 08 December 2018

The microRNAs miR-200b-3p and miR-429-5p target the LIMK1/CFL1 pathway to inhibit growth and motility of breast cancer cells.

scientific article published on 12 July 2017

The rexinoid bexarotene represses cyclin D1 transcription by inducing the DEC2 transcriptional repressor.

scientific article

Therapeutic Potential of Oridonin and Its Analogs: From Anticancer and Antiinflammation to Neuroprotection

scientific article published on 22 February 2018

Traditional Chinese medicine targeting apoptotic mechanisms for esophageal cancer therapy

scientific article

Transgenic mouse models for the prevention of breast cancer.

scientific article

Up-regulation of glycolysis promotes the stemness and EMT phenotypes in gemcitabine-resistant pancreatic cancer cells

scientific article published on 28 February 2017

Value of folate receptor-positive circulating tumour cells in the clinical management of indeterminate lung nodules: A non-invasive biomarker for predicting malignancy and tumour invasiveness

scientific article published on 12 March 2019

cFos is critical for MCF-7 breast cancer cell growth.

scientific article published on September 2005

ent-Kaurane-based regio- and stereoselective inverse electron demand hetero-Diels-Alder reactions: synthesis of dihydropyran-fused diterpenoids

scientific article

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