List of works - Jed N Lampe

Active-site residues move independently from the rest of the protein in a 200 ns molecular dynamics simulation of cytochrome P450 CYP119 ⬇️

scientific article published on February 26, 2011

Advances in the Understanding of Protein-Protein Interactions in Drug Metabolizing Enzymes through the Use of Biophysical Techniques

scientific article

Analysis of cytochrome P450 CYP119 ligand-dependent conformational dynamics by two-dimensional NMR and X-ray crystallography

scientific article

Aqueous synthesis of a small-molecule lanthanide chelator amenable to copper-free click chemistry

scientific article published on 27 March 2019

Common drugs inhibit human organic cation transporter 1 (OCT1)-mediated neurotransmitter uptake

scientific article

Cysteine 98 in CYP3A4 contributes to conformational integrity required for P450 interaction with CYP reductase.

scientific article published on 22 August 2006

Cytochrome P450 Enzyme Metabolites in Lead Discovery and Development.

scientific article

Digging Deeper into CYP3A Testosterone Metabolism: Kinetic, Regioselectivity, and Stereoselectivity Differences between CYP3A4/5 and CYP3A7.

scientific article

Ligand-dependent modulation of hOCT1 transport reveals discrete ligand binding sites within the substrate translocation channel

scientific article published on 20 August 2018

Ligand-induced conformational heterogeneity of cytochrome P450 CYP119 identified by 2D NMR spectroscopy with the unnatural amino acid (13)C-p-methoxyphenylalanine.

scientific article published on December 2008

Longitudinal study of insulin-like growth factor, insulin-like growth factor binding protein-3, and their polymorphisms: risk of neoplastic progression in Barrett's esophagus

scientific article published on 01 November 2007

Mouse strain-dependent caspase activation during acetaminophen hepatotoxicity does not result in apoptosis or modulation of inflammation.

scientific article published on 14 October 2011

Neonatal cytochrome P450 CYP3A7: A comprehensive review of its role in development, disease, and xenobiotic metabolism

scientific article published on 22 August 2019

Role of Cysteine Residues in Heme Binding to Human Heme Oxygenase-2 Elucidated by Two-dimensional NMR Spectroscopy ⬇️

scientific article published on August 24, 2012

Role of protein-protein interactions in cytochrome P450-mediated drug metabolism and toxicity

scientific article

Spectral resolution of a second binding site for Nile Red on cytochrome P4503A4.

scientific article

The role of hepatocyte nuclear factor 4-alpha in perfluorooctanoic acid- and perfluorooctanesulfonic acid-induced hepatocellular dysfunction

scientific article published on 3 May 2016

Time-resolved fluorescence studies of heterotropic ligand binding to cytochrome P450 3A4

scientific article published on 01 October 2006

Two-dimensional NMR and all-atom molecular dynamics of cytochrome P450 CYP119 reveal hidden conformational substates

scientific article

List of works by Jed N Lampe

Active-site residues move independently from the rest of the protein in a 200 ns molecular dynamics simulation of cytochrome P450 CYP119 ⬇️

Advances in the Understanding of Protein-Protein Interactions in Drug Metabolizing Enzymes through the Use of Biophysical Techniques

Analysis of cytochrome P450 CYP119 ligand-dependent conformational dynamics by two-dimensional NMR and X-ray crystallography

Aqueous synthesis of a small-molecule lanthanide chelator amenable to copper-free click chemistry

Common drugs inhibit human organic cation transporter 1 (OCT1)-mediated neurotransmitter uptake

Cysteine 98 in CYP3A4 contributes to conformational integrity required for P450 interaction with CYP reductase.

Cytochrome P450 Enzyme Metabolites in Lead Discovery and Development.

Digging Deeper into CYP3A Testosterone Metabolism: Kinetic, Regioselectivity, and Stereoselectivity Differences between CYP3A4/5 and CYP3A7.

Ligand-dependent modulation of hOCT1 transport reveals discrete ligand binding sites within the substrate translocation channel

Ligand-induced conformational heterogeneity of cytochrome P450 CYP119 identified by 2D NMR spectroscopy with the unnatural amino acid (13)C-p-methoxyphenylalanine.

Longitudinal study of insulin-like growth factor, insulin-like growth factor binding protein-3, and their polymorphisms: risk of neoplastic progression in Barrett's esophagus

Mouse strain-dependent caspase activation during acetaminophen hepatotoxicity does not result in apoptosis or modulation of inflammation.

Neonatal cytochrome P450 CYP3A7: A comprehensive review of its role in development, disease, and xenobiotic metabolism

Role of Cysteine Residues in Heme Binding to Human Heme Oxygenase-2 Elucidated by Two-dimensional NMR Spectroscopy ⬇️

Role of protein-protein interactions in cytochrome P450-mediated drug metabolism and toxicity

Spectral resolution of a second binding site for Nile Red on cytochrome P4503A4.

The role of hepatocyte nuclear factor 4-alpha in perfluorooctanoic acid- and perfluorooctanesulfonic acid-induced hepatocellular dysfunction

Time-resolved fluorescence studies of heterotropic ligand binding to cytochrome P450 3A4

Two-dimensional NMR and all-atom molecular dynamics of cytochrome P450 CYP119 reveal hidden conformational substates