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List of works by Philippe E Van den Steen

"Reverse degradomics", monitoring of proteolytic trimming by multi-CE and confocal detection of fluorescent substrates and reaction products

scientific article published in July 2009

11β-hydroxysteroid dehydrogenase type 1 has no effect on survival during experimental malaria but affects parasitemia in a parasite strain-specific manner.

scientific article published on 23 October 2017

4 1 integrin and 190-kDa CD44v constitute a cell surface docking complex for gelatinase B/MMP-9 in chronic leukemic but not in normal B cells

scientific article published on 07 March 2008

A catalytically inactive gelatinase B/MMP-9 mutant impairs homing of chronic lymphocytic leukemia cells by altering migration regulatory pathways.

scientific article published on 25 October 2017

A monoclonal antibody inhibits gelatinase B/MMP-9 by selective binding to part of the catalytic domain and not to the fibronectin or zinc binding domains

scientific article published on 26 October 2006

A novel rationale for inhibition of gelatinase B in multiple sclerosis: MMP-9 destroys alpha B-crystallin and generates a promiscuous T cell epitope.

scientific article published on August 2003

Adrenal hormones mediate disease tolerance in malaria

scientific article published in Nature Communications

Ajuga remota Benth.: from ethnopharmacology to phytomedical perspective in the treatment of malaria.

scientific article published on 19 October 2011

Altered Lipid Composition of Surfactant and Lung Tissue in Murine Experimental Malaria-Associated Acute Respiratory Distress Syndrome

scientific article

Astemizole analogues with reduced hERG inhibition as potent antimalarial compounds.

scientific article published on 7 October 2017

Beta-hematin interaction with the hemopexin domain of gelatinase B/MMP-9 provokes autocatalytic processing of the propeptide, thereby priming activation by MMP-3.

scientific article published on February 2008

Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): the next decade

scientific article

CXCR3 determines strain susceptibility to murine cerebral malaria by mediating T lymphocyte migration toward IFN-gamma-induced chemokines

scientific article published in April 2008

CXCR3 ligands in disease and therapy.

scientific article

Carboxyterminal cleavage of the chemokines MIG and IP-10 by gelatinase B and neutrophil collagenase

scientific article published on 01 October 2003

Circular trimers of gelatinase B/matrix metalloproteinase-9 constitute a distinct population of functional enzyme molecules differentially regulated by tissue inhibitor of metalloproteinases-1.

scientific article

Cleavage of denatured natural collagen type II by neutrophil gelatinase B reveals enzyme specificity, post-translational modifications in the substrate, and the formation of remnant epitopes in rheumatoid arthritis

scientific article published in March 2002

Contribution of the Ly49E natural killer receptor in the immune response to Plasmodium berghei infection and control of hepatic parasite development

scientific article published on 30 January 2014

Critical Roles of Endogenous Glucocorticoids for Disease Tolerance in Malaria

scientific article published on 09 October 2019

Deficiency of gelatinase B/MMP-9 aggravates lpr-induced lymphoproliferation and lupus-like systemic autoimmune disease

scientific article published on 03 March 2011

Differential induction of malaria liver pathology in mice infected with Plasmodium chabaudi AS or Plasmodium berghei NK65.

scientific article

Direct visualization of protease action on collagen triple helical structure

scientific article

Endothelial Response to Glucocorticoids in Inflammatory Diseases

scientific article

Enzymatic degradation of adhesive-dentin interfaces produced by mild self-etch adhesives

scientific article published on October 2010

Enzymatic processing by MMP-2 and MMP-9 of wild-type and mutated mouse β-dystroglycan.

scientific article

Etiology of lactic acidosis in malaria

scientific article published on 07 January 2021

Experimental malaria-associated acute respiratory distress syndrome is dependent on the parasite-host combination and coincides with normocyte invasion

scientific article published on 5 March 2018

Expression of angiogenic and fibrogenic factors in proliferative vitreoretinal disorders

scientific article published on 01 February 2007

Gelatin degradation assay reveals MMP-9 inhibitors and function of O-glycosylated domain

scientific article

Gelatinase B is diabetogenic in acute and chronic pancreatitis by cleaving insulin.

scientific article published on 5 March 2003

Gelatinase B/MMP-9 and neutrophil collagenase/MMP-8 process the chemokines human GCP-2/CXCL6, ENA-78/CXCL5 and mouse GCP-2/LIX and modulate their physiological activities.

scientific article

Gelatinase B/matrix metalloproteinase-9 cleaves interferon-beta and is a target for immunotherapy

scientific article published in June 2003

Gelatinase B: a tuner and amplifier of immune functions.

scientific article

Generation of glycosylated remnant epitopes from human collagen type II by gelatinase B.

scientific article

Glycosylation of natural human neutrophil gelatinase B and neutrophil gelatinase B-associated lipocalin.

scientific article

Hemozoin induces hepatic inflammation in mice and is differentially associated with liver pathology depending on the Plasmodium strain

scientific article

Hemozoin induces lung inflammation and correlates with malaria-associated acute respiratory distress syndrome.

scientific article

Immunopathology and Dexamethasone Therapy in a New Model for Malaria-associated Acute Respiratory Distress Syndrome

article

Improved methods for haemozoin quantification in tissues yield organ-and parasite-specific information in malaria-infected mice.

scientific article published on 14 May 2012

Increased gelatinase B/matrix metalloproteinase 9 (MMP-9) activity in a murine model of acute coxsackievirus B4-induced pancreatitis

article

Inhibition of enzymatic degradation of adhesive-dentin interfaces

scientific article published on 27 October 2009

Inhibition of lethal endotoxin shock with an L-pyridylalanine containing metalloproteinase inhibitor selected by high-throughput screening of a new peptide library

scientific article published in September 2006

Inhibition of neutrophil collagenase/MMP-8 and gelatinase B/MMP-9 and protection against endotoxin shock.

scientific article

Inhibitors of gelatinase B/matrix metalloproteinase-9 activity comparison of a peptidomimetic and polyhistidine with single-chain derivatives of a neutralizing monoclonal antibody

scientific article published in March 2004

Insights into the structure and domain flexibility of full-length pro-matrix metalloproteinase-9/gelatinase B.

scientific article

Insufficiently defined genetic background confounds phenotypes in transgenic studies as exemplified by malaria infection in Tlr9 knockout mice

scientific article (publication date: 2011)

Limitations of neutrophil depletion by anti-Ly6G antibodies in two heterogenic immunological models

scientific article published on 18 June 2019

MMP-9 affects gene expression in chronic lymphocytic leukemia revealing CD99 as an MMP-9 target and a novel partner in malignant cell migration/arrest

scientific article published on 13 February 2019

MalarImDB: an open-access literature-based malaria immunology database

scientific article

Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases.

scientific article published on June 2007

Matrix metalloproteinase-9 induces a pro-angiogenic profile in chronic lymphocytic leukemia cells

scientific article published on 01 October 2019

Matrix metalloproteinases as therapeutic targets in protozoan parasitic infections.

scientific article

Matrix metalloproteinases, tissue inhibitors of MMPs and TACE in experimental cerebral malaria

scientific article published on 24 July 2006

Matrix remodelling enzymes, the protease cascade and glycosylation ⬇️

scientific article published on October 3, 2001

Meprins process matrix metalloproteinase-9 (MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3

scientific article

Natural haemozoin induces expression and release of human monocyte tissue inhibitor of metalloproteinase-1.

scientific article

Natural haemozoin modulates matrix metalloproteinases and induces morphological changes in human microvascular endothelium

scientific article published on 27 June 2011

Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor (FGF-2)/FGFR-2 pathway.

scientific article

O-Glycan Analysis of Natural Human Neutrophil Gelatinase B Using a Combination of Normal Phase- HPLC and Online Tandem Mass Spectrometry: Implications for the Domain Organization of the Enzyme†

article

Oligosaccharides of recombinant mouse gelatinase B variants

scientific article published on 01 November 1998

Overexpression of progelatinase B/proMMP-9 affects migration regulatory pathways and impairs chronic lymphocytic leukemia cell homing to bone marrow and spleen

scientific article

Pathogenesis of malaria-associated acute respiratory distress syndrome.

scientific article published on 03 June 2013

Pathogenic CD8+ T Cells Cause Increased Levels of VEGF-A in Experimental Malaria-Associated Acute Respiratory Distress Syndrome, but Therapeutic VEGFR Inhibition Is Not Effective

scientific article published on 20 September 2017

Plasmodium berghei NK65 in Combination with IFN-γ Induces Endothelial Glucocorticoid Resistance via Sustained Activation of p38 and JNK.

scientific article published on 28 September 2017

Release of endothelial activation markers in lungs of patients with malaria-associated acute respiratory distress syndrome

scientific article published on 03 December 2019

Remnant epitopes, autoimmunity and glycosylation.

scientific article

Replication of Plasmodium in reticulocytes can occur without hemozoin formation, resulting in chloroquine resistance

scientific article

Simulation of evolution-selected propeptide by high-throughput selection of a peptidomimetic inhibitor on a capillary DNA sequencer platform.

scientific article published in April 2005

Structural Characterization of the Catalytic Active Site in the Latent and Active Natural Gelatinase B from Human Neutrophils

scientific article published in Journal of Biological Chemistry

Targeting neutrophil collagenase/matrix metalloproteinase-8 and gelatinase B/matrix metalloproteinase-9 with a peptidomimetic inhibitor protects against endotoxin shock

scientific article published on 01 August 2005

The biochemical, biological, and pathological kaleidoscope of cell surface substrates processed by matrix metalloproteinases.

scientific article published on May 2007

The collagen binding domain of gelatinase A modulates degradation of collagen IV by gelatinase B.

scientific article

The hemopexin and O-glycosylated domains tune gelatinase B/MMP-9 bioavailability via inhibition and binding to cargo receptors

scientific article

The immunological balance between host and parasite in malaria

scientific article

Zymography methods for visualizing hydrolytic enzymes.

scientific article

von Willebrand factor in experimental malaria-associated acute respiratory distress syndrome

scientific article published on 12 June 2019

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