List of works - Colin J Suckling

2,2,2-Trifluoro-N-(isoquinolin-5-ylmethyl)acetamide ⬇️

scientific article published on December 12, 2009

3-Acetoxycyclohex-4-ene-1,2-dicarboxylic anhydride

scientific article published on 01 June 2000

6-Acetyl-7,7-dimethyl-5,6,7,8-tetrahydropterin is an activator of nitric oxide synthases

scientific article published on 30 January 2008

A Powerful Palladium-Catalyzed Multicomponent Process for the Preparation of Oxazolines and Benzoxazoles

scientific article published on 02 November 2011

A detailed binding free energy study of 2 : 1 ligand–DNA complex formation by experiment and simulation

scientific article published on 22 September 2009

A divergent synthesis of minor groove binders with tail group variation

scientific article

A modelling study of a non-concerted hydrolytic cycloaddition reaction by the catalytic antibody H11.

scientific article published on 27 December 2005

A new synthesis of alkene-containing minor-groove binders and essential hydrogen bonding in binding to DNA and in antibacterial activity

scientific article published on 12 March 2009

A prototype solid phase synthesis of pteridines and related heterocyclic compounds

scientific article published in June 2003

Amide isosteres in structure-activity studies of antibacterial minor groove binders

scientific article published on 30 August 2011

An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics

scientific article published on 29 March 2016

Antimicrobial lexitropsins containing amide, amidine, and alkene linking groups

scientific article published on 26 October 2007

Asymmetric Rhodium-Catalysed Addition of Arylboronic Acids to Acyclic Unsaturated Esters Containing a Basic γ-Amino Group

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives

scientific article published on 15 January 2016

Communication between the Zinc and Tetrahydrobiopterin Binding Sites in Nitric Oxide Synthase

scientific article

Crystal structure of N,N-dimethyl-2-[(4-methyl-benz-yl)sulfon-yl]ethanamine

scientific article published on 6 June 2015

DNA binding of a short lexitropsin

scientific article published in March 2004

DNA sequence recognition by an isopropyl substituted thiazole polyamide

scientific article published on 24 June 2004

Designing anti-inflammatory drugs from parasitic worms: a synthetic small molecule analogue of the Acanthocheilonema viteae product ES-62 prevents development of collagen-induced arthritis.

scientific article

Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity

scientific article published on April 2004

Diversity oriented syntheses of fused pyrimidines designed as potential antifolates

scientific article published on 6 March 2009

Drug-like analogues of the parasitic worm-derived immunomodulator ES-62 are therapeutic in the MRL/Lpr model of systemic lupus erythematosus

scientific article

From Multiply Active Natural Product To Candidate Drug? Antibacterial (And Other) Minor Groove Binders for DNA ⬇️

scientific article published on May 1, 2012

In Silico Footprinting of Ligands Binding to the Minor Groove of DNA

scientific article published on 01 November 2005

In situ detection of pterins by SERS.

scientific article published on 20 May 2009

M4 agonists/5HT7 antagonists with potential as antischizophrenic drugs: serominic compounds

scientific article published on 2 February 2007

Manganese dioxide mediated one-pot synthesis of methyl 9H-pyrido[3,4-b]indole-1-carboxylate: Concise synthesis of alangiobussinine

scientific article

Mechanistic Exploration of the Palladium-catalyzed Process for the Synthesis of Benzoxazoles and Benzothiazoles

scientific article published on 25 January 2013

Minor groove binders 1998 – 2004

Minor groove binders as anti-infective agents.

scientific article

On the Specificity of Reactions Catalysed by the Antibody H11

article

Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome ⬇️

scientific article published on 11 May 2015

Ranking ligand affinity for the DNA minor groove by experiment and simulation

scientific article

Recognition of the DNA minor groove by thiazotropsin analogues

scientific article

Selective anti-malarial minor groove binders

scientific article published on 13 May 2016

Short lexitropsin that recognizes the DNA minor groove at 5'-ACTAGT-3': understanding the role of isopropyl-thiazole

scientific article published in September 2004

Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties

scientific article

Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening

scientific article

Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1

scientific article

Structure-Based Design of Pteridine Reductase Inhibitors Targeting African Sleeping Sickness and the Leishmaniases

scientific article

Syntheses of highly functionalised 6-substituted pteridines

scientific article published in February 2003

Synthesis and antimicrobial activity of some netropsin analogues

scientific article published on 6 October 2004

Tetrahydrobiopterin analogues with NO-dependent pulmonary vasodilator properties

scientific article published on 13 October 2010

The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits

scientific article

The amazingly patient tutor: students' interactions with an online carbohydrate chemistry course

The diversity-oriented synthesis of pteridines - achievements and potential for development

scientific article published on 26 February 2013

The synthesis of 7-deazaguanines as potential inhibitors of guanosine triphosphate cyclohydrolase I

Thiazotropsin aggregation and its relationship to molecular recognition in the DNA minor groove

scientific article published on 25 April 2013

List of works by Colin J Suckling

2,2,2-Trifluoro-N-(isoquinolin-5-ylmethyl)acetamide ⬇️

3-Acetoxycyclohex-4-ene-1,2-dicarboxylic anhydride

6-Acetyl-7,7-dimethyl-5,6,7,8-tetrahydropterin is an activator of nitric oxide synthases

A Powerful Palladium-Catalyzed Multicomponent Process for the Preparation of Oxazolines and Benzoxazoles

A detailed binding free energy study of 2 : 1 ligand–DNA complex formation by experiment and simulation

A divergent synthesis of minor groove binders with tail group variation

A modelling study of a non-concerted hydrolytic cycloaddition reaction by the catalytic antibody H11.

A new synthesis of alkene-containing minor-groove binders and essential hydrogen bonding in binding to DNA and in antibacterial activity

A prototype solid phase synthesis of pteridines and related heterocyclic compounds

Amide isosteres in structure-activity studies of antibacterial minor groove binders

An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics

Antimicrobial lexitropsins containing amide, amidine, and alkene linking groups

Asymmetric Rhodium-Catalysed Addition of Arylboronic Acids to Acyclic Unsaturated Esters Containing a Basic γ-Amino Group

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives

Communication between the Zinc and Tetrahydrobiopterin Binding Sites in Nitric Oxide Synthase

Crystal structure of N,N-dimethyl-2-[(4-methyl-benz-yl)sulfon-yl]ethanamine

DNA binding of a short lexitropsin

DNA sequence recognition by an isopropyl substituted thiazole polyamide

Designing anti-inflammatory drugs from parasitic worms: a synthetic small molecule analogue of the Acanthocheilonema viteae product ES-62 prevents development of collagen-induced arthritis.

Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity

Diversity oriented syntheses of fused pyrimidines designed as potential antifolates

Drug-like analogues of the parasitic worm-derived immunomodulator ES-62 are therapeutic in the MRL/Lpr model of systemic lupus erythematosus

From Multiply Active Natural Product To Candidate Drug? Antibacterial (And Other) Minor Groove Binders for DNA ⬇️

In Silico Footprinting of Ligands Binding to the Minor Groove of DNA

In situ detection of pterins by SERS.

M4 agonists/5HT7 antagonists with potential as antischizophrenic drugs: serominic compounds

Manganese dioxide mediated one-pot synthesis of methyl 9H-pyrido[3,4-b]indole-1-carboxylate: Concise synthesis of alangiobussinine

Mechanistic Exploration of the Palladium-catalyzed Process for the Synthesis of Benzoxazoles and Benzothiazoles

Minor groove binders 1998 – 2004

Minor groove binders as anti-infective agents.

On the Specificity of Reactions Catalysed by the Antibody H11

Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome ⬇️

Ranking ligand affinity for the DNA minor groove by experiment and simulation

Recognition of the DNA minor groove by thiazotropsin analogues

Selective anti-malarial minor groove binders

Short lexitropsin that recognizes the DNA minor groove at 5'-ACTAGT-3': understanding the role of isopropyl-thiazole

Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties

Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening

Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1

Structure-Based Design of Pteridine Reductase Inhibitors Targeting African Sleeping Sickness and the Leishmaniases

Syntheses of highly functionalised 6-substituted pteridines

Synthesis and antimicrobial activity of some netropsin analogues

Tetrahydrobiopterin analogues with NO-dependent pulmonary vasodilator properties

The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits

The amazingly patient tutor: students' interactions with an online carbohydrate chemistry course

The diversity-oriented synthesis of pteridines - achievements and potential for development

The synthesis of 7-deazaguanines as potential inhibitors of guanosine triphosphate cyclohydrolase I

Thiazotropsin aggregation and its relationship to molecular recognition in the DNA minor groove

Unexpected Dealkylation During Nucleophilic Substitution: Synthesis of 2-N,N-Dialkylamino Benzoxazoles and Benzothiazoles