List of works - Li Wu

-Methyladenosine-binding proteins suppress HIV-1 infectivity and viral production

scientific article published in Journal of Biological Chemistry

A Cyclin-binding Motif in Human SAMHD1 Is Required for Its HIV-1 Restriction, dNTPase Activity, Tetramer Formation, and Efficient Phosphorylation

scientific article published on 10 January 2018

A Putative Cyclin-binding Motif in Human SAMHD1 Contributes to Protein Phosphorylation, Localization, and Stability

scientific article published on 4 November 2016

A Single Amino Acid in the Reverse Transcriptase Domain of Hepatitis B Virus Affects Virus Replication Efficiency ⬇️

scientific article published on December 1, 2001

A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection

scientific article

A new class of multimerization selective inhibitors of HIV-1 integrase

scientific article

Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages

scientific article published on July 2009

BET proteins promote efficient murine leukemia virus integration at transcription start sites

scientific article published on July 2013

Biology of HIV mucosal transmission

scientific article published on September 2008

Cellular and Biochemical Mechanisms of the Retroviral Restriction Factor SAMHD1.

scientific article published on July 2013

Cellular and viral mechanisms of HIV-1 transmission mediated by dendritic cells

scientific article

Co-evolution of primate SAMHD1 and lentivirus Vpx leads to the loss of the vpx gene in HIV-1 ancestor

scientific article

Comparing the immunogenicity of hepatitis B virus S gene variants by DNA immunization

scientific article published in January 2001

Correction: N6-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression

scientific article published on 13 September 2017

Dendritic-cell interactions with HIV: infection and viral dissemination

scientific article

Differential effects of Vpr on single-cycle and spreading HIV-1 infections in CD4+ T-cells and dendritic cells

scientific article

Downregulation of SAMHD1 expression correlates with promoter DNA methylation in Sézary syndrome patients.

scientific article

Exogenous expression of SAMHD1 inhibits proliferation and induces apoptosis in cutaneous T-cell lymphoma-derived HuT78 cells.

scientific article published on 08 December 2016

From APOBEC to ZAP: Diverse mechanisms used by cellular restriction factors to inhibit virus infections

scientific article published on 02 October 2018

Functional evaluation of DC-SIGN monoclonal antibodies reveals DC-SIGN interactions with ICAM-3 do not promote human immunodeficiency virus type 1 transmission

scientific article

Genome modification of CXCR4 by Staphylococcus aureus Cas9 renders cells resistance to HIV-1 infection

scientific article published on 15 November 2017

HIV Evades Immune Surveillance by Methylation of Viral RNA

article

HIV-1 Exploits a Dynamic Multi-aminoacyl-tRNA Synthetase Complex To Enhance Viral Replication

scientific article published on 16 August 2017

HIV-1 Nef enhances dendritic cell-mediated viral transmission to CD4+ T cells and promotes T-cell activation

scientific article

HIV-1 Nef-associated Factor 1 Enhances Viral Production by Interacting with CRM1 to Promote Nuclear Export of Unspliced HIV-1 gag mRNA.

scientific article published on 5 January 2016

HIV-1 envelope proteins up-regulate N 6-methyladenosine levels of cellular RNA independently of viral replication

scientific article published on 07 January 2019

HIV-1 inhibition in cells with CXCR4 mutant genome created by CRISPR-Cas9 and piggyBac recombinant technologies.

scientific article

HIV-1 transmission by dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) is regulated by determinants in the carbohydrate recognition domain that are absent in liver/lymph node-SIGN (L-SIGN)

scientific article

Histamine enhances HIV-1-induced modulation of dendritic cells to skew naïve T cell differentiation toward regulatory T cells

scientific article

Human Genetic Determinants of Viral Diseases

scientific article published on 30 August 2017

Human immunodeficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses

scientific article

Identification of cellular proteins interacting with the retroviral restriction factor SAMHD1

scientific article

Impaired dNTPase activity of SAMHD1 by phosphomimetic mutation of Thr-592

scientific article

Inhibition of HIV type 1 replication by human T lymphotropic virus types 1 and 2 Tax proteins in vitro

scientific article

MicroRNA-181 contributes to downregulation of SAMHD1 expression in CD4+ T-cells derived from Sèzary syndrome patients

scientific article

Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors ⬇️

scientific article published on March 21, 2012

N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression

scientific article

Naf1 Regulates HIV-1 Latency by Suppressing Viral Promoter-Driven Gene Expression in Primary CD4+ T Cells.

scientific article published on 19 October 2016

Penicillium marneffei-stimulated dendritic cells enhance HIV-1 trans-infection and promote viral infection by activating primary CD4+ T cells

scientific article

Phosphorylation of mouse SAMHD1 regulates its restriction of human immunodeficiency virus type 1 infection, but not murine leukemia virus infection.

scientific article

Polymorphisms of the SAMHD1 Gene Are Not Associated with the Infection and Natural Control of HIV Type 1 in Europeans and African-Americans ⬇️

scientific article published on June 1, 2012

Promoter Methylation Regulates SAMHD1 Gene Expression in Human CD4+ T Cells ⬇️

scientific article published on February 20, 2013

RNA sequencing and transcriptomal analysis of human monocyte to macrophage differentiation ⬇️

scientific article published on February 28, 2013

Raji B cells, misidentified as THP-1 cells, stimulate DC-SIGN-mediated HIV transmission

scientific article published on January 2004

Recruitment of HIV and its receptors to dendritic cell-T cell junctions

scientific article published in May 2003

Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications

scientific article

Role of DC-SIGN in the activation of dendritic cells by HPV-16 L1 virus-like particle vaccine

scientific article

SAMHD1 Impairs HIV-1 Gene Expression and Negatively Modulates Reactivation of Viral Latency in CD4+ T-cells.

scientific article published on 23 May 2018

SAMHD1 Suppression of Antiviral Immune Responses

article

SAMHD1 inhibits epithelial cell transformation in vitro and affects leukemia development in xenograft mice

scientific article published on 04 December 2018

SAMHD1 knockout mice: modeling retrovirus restriction in vivo.

scientific article

SAMHD1 modulates in vitro proliferation of acute myeloid leukemia-derived THP-1 cells through the PI3K-Akt-p27 axis

scholarly article by Karthik M Kodigepalli published in January 2018

SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons

scientific article published on 11 December 2012

SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathways

scientific article published on 2 April 2018

SAMHD1-mediated HIV-1 restriction in cells does not involve ribonuclease activity

scientific article

SAMHD1: a new contributor to HIV-1 restriction in resting CD4+ T-cells.

scientific article published on 23 October 2012

SAMHD1: a new insight into HIV-1 restriction in myeloid cells ⬇️

scientific article published on 08 July 2011

TRAF6 and TAK1 contribute to SAMHD1-mediated negative regulation of NF-κB signaling

scientific article published on 11 November 2020

TRIM5 acts as more than a retroviral restriction factor ⬇️

scientific article published on July 1, 2011

The Dynamic Interplay between HIV-1, SAMHD1, and the Innate Antiviral Response

scientific article published on 10 November 2017

The Polar Region of the HIV-1 Envelope Protein Determines Viral Fusion and Infectivity by Stabilizing the gp120-gp41 Association

scientific article published on 21 March 2019

The SAM domain of mouse SAMHD1 is critical for its activation and regulation

scientific article published on 29 January 2018

The dNTPase activity of SAMHD1 is important for its suppression of innate immune responses in differentiated monocytic cells

scientific article published on 30 December 2019

Trans-dominant cellular inhibition of DC-SIGN-mediated HIV-1 transmission

scientific article

Wild type mumps viruses circulating in China establish a new genotype

scientific article published in January 1998

Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation ⬇️

scientific article published on August 29, 2011

List of works by Li Wu

-Methyladenosine-binding proteins suppress HIV-1 infectivity and viral production

A Cyclin-binding Motif in Human SAMHD1 Is Required for Its HIV-1 Restriction, dNTPase Activity, Tetramer Formation, and Efficient Phosphorylation

A Putative Cyclin-binding Motif in Human SAMHD1 Contributes to Protein Phosphorylation, Localization, and Stability

A Single Amino Acid in the Reverse Transcriptase Domain of Hepatitis B Virus Affects Virus Replication Efficiency ⬇️

A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection

A new class of multimerization selective inhibitors of HIV-1 integrase

Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages

BET proteins promote efficient murine leukemia virus integration at transcription start sites

Biology of HIV mucosal transmission

Cellular and Biochemical Mechanisms of the Retroviral Restriction Factor SAMHD1.

Cellular and viral mechanisms of HIV-1 transmission mediated by dendritic cells

Co-evolution of primate SAMHD1 and lentivirus Vpx leads to the loss of the vpx gene in HIV-1 ancestor

Comparing the immunogenicity of hepatitis B virus S gene variants by DNA immunization

Correction: N6-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression

Dendritic-cell interactions with HIV: infection and viral dissemination

Differential effects of Vpr on single-cycle and spreading HIV-1 infections in CD4+ T-cells and dendritic cells

Downregulation of SAMHD1 expression correlates with promoter DNA methylation in Sézary syndrome patients.

Exogenous expression of SAMHD1 inhibits proliferation and induces apoptosis in cutaneous T-cell lymphoma-derived HuT78 cells.

From APOBEC to ZAP: Diverse mechanisms used by cellular restriction factors to inhibit virus infections

Functional evaluation of DC-SIGN monoclonal antibodies reveals DC-SIGN interactions with ICAM-3 do not promote human immunodeficiency virus type 1 transmission

Genome modification of CXCR4 by Staphylococcus aureus Cas9 renders cells resistance to HIV-1 infection

HIV Evades Immune Surveillance by Methylation of Viral RNA

HIV-1 Exploits a Dynamic Multi-aminoacyl-tRNA Synthetase Complex To Enhance Viral Replication

HIV-1 Nef enhances dendritic cell-mediated viral transmission to CD4+ T cells and promotes T-cell activation

HIV-1 Nef-associated Factor 1 Enhances Viral Production by Interacting with CRM1 to Promote Nuclear Export of Unspliced HIV-1 gag mRNA.

HIV-1 envelope proteins up-regulate N 6-methyladenosine levels of cellular RNA independently of viral replication

HIV-1 inhibition in cells with CXCR4 mutant genome created by CRISPR-Cas9 and piggyBac recombinant technologies.

HIV-1 transmission by dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) is regulated by determinants in the carbohydrate recognition domain that are absent in liver/lymph node-SIGN (L-SIGN)

Histamine enhances HIV-1-induced modulation of dendritic cells to skew naïve T cell differentiation toward regulatory T cells

Human Genetic Determinants of Viral Diseases

Human immunodeficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses

Identification of cellular proteins interacting with the retroviral restriction factor SAMHD1

Impaired dNTPase activity of SAMHD1 by phosphomimetic mutation of Thr-592

Inhibition of HIV type 1 replication by human T lymphotropic virus types 1 and 2 Tax proteins in vitro

MicroRNA-181 contributes to downregulation of SAMHD1 expression in CD4+ T-cells derived from Sèzary syndrome patients

Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors ⬇️

N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression

Naf1 Regulates HIV-1 Latency by Suppressing Viral Promoter-Driven Gene Expression in Primary CD4+ T Cells.

Penicillium marneffei-stimulated dendritic cells enhance HIV-1 trans-infection and promote viral infection by activating primary CD4+ T cells

Phosphorylation of mouse SAMHD1 regulates its restriction of human immunodeficiency virus type 1 infection, but not murine leukemia virus infection.

Polymorphisms of the SAMHD1 Gene Are Not Associated with the Infection and Natural Control of HIV Type 1 in Europeans and African-Americans ⬇️

Promoter Methylation Regulates SAMHD1 Gene Expression in Human CD4+ T Cells ⬇️

RNA sequencing and transcriptomal analysis of human monocyte to macrophage differentiation ⬇️

Raji B cells, misidentified as THP-1 cells, stimulate DC-SIGN-mediated HIV transmission

Recruitment of HIV and its receptors to dendritic cell-T cell junctions

Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications

Role of DC-SIGN in the activation of dendritic cells by HPV-16 L1 virus-like particle vaccine

SAMHD1 Impairs HIV-1 Gene Expression and Negatively Modulates Reactivation of Viral Latency in CD4+ T-cells.

SAMHD1 Suppression of Antiviral Immune Responses

SAMHD1 inhibits epithelial cell transformation in vitro and affects leukemia development in xenograft mice

SAMHD1 knockout mice: modeling retrovirus restriction in vivo.

SAMHD1 modulates in vitro proliferation of acute myeloid leukemia-derived THP-1 cells through the PI3K-Akt-p27 axis

SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons

SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathways

SAMHD1-mediated HIV-1 restriction in cells does not involve ribonuclease activity

SAMHD1: a new contributor to HIV-1 restriction in resting CD4+ T-cells.

SAMHD1: a new insight into HIV-1 restriction in myeloid cells ⬇️

TRAF6 and TAK1 contribute to SAMHD1-mediated negative regulation of NF-κB signaling

TRIM5 acts as more than a retroviral restriction factor ⬇️

The Dynamic Interplay between HIV-1, SAMHD1, and the Innate Antiviral Response

The Polar Region of the HIV-1 Envelope Protein Determines Viral Fusion and Infectivity by Stabilizing the gp120-gp41 Association

The SAM domain of mouse SAMHD1 is critical for its activation and regulation

The dNTPase activity of SAMHD1 is important for its suppression of innate immune responses in differentiated monocytic cells

Trans-dominant cellular inhibition of DC-SIGN-mediated HIV-1 transmission

Wild type mumps viruses circulating in China establish a new genotype

Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation ⬇️