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List of works by Jean Sévigny

17β-Estradiol upregulates ecto-5'-nucleotidase (CD73) in hippocampal synaptosomes of female rats through action mediated by estrogen receptor-α and -β.

scientific article published on 14 March 2016

17β-Estradiol-Induced Synaptic Rearrangements Are Accompanied by Altered Ectonucleotidase Activities in Male Rat Hippocampal Synaptosomes

scientific article published on 15 December 2016

2-Alkoxy-3-(sulfonylarylaminomethylene)-chroman-4-ones as potent and selective inhibitors of ectonucleotidases.

scientific article published on 3 March 2016

2-Hexylthio-β,γ-CH2-ATP is an effective and selective NTPDase2 inhibitor

scientific article published on 14 July 2014

2-MeS-beta,gamma-CCl2-ATP is a potent agent for reducing intraocular pressure

scientific article published on April 2010

2-Substituted 7-trifluoromethyl-thiadiazolopyrimidones as alkaline phosphatase inhibitors. Synthesis, structure activity relationship and molecular docking study.

scientific article

4-Aminopyridine based amide derivatives as dual inhibitors of tissue non-specific alkaline phosphatase and ecto-5'-nucleotidase with potential anticancer activity

scientific article published on 21 November 2017

8-BuS-ATP derivatives as specific NTPDase1 inhibitors.

scientific article

A Simple and Efficient Genetic Immunization Protocol for the Production of Highly Specific Polyclonal and Monoclonal Antibodies against the Native Form of Mammalian Proteins

scientific article published on 25 September 2020

A domino reaction of 3-chlorochromones with aminoheterocycles. Synthesis of pyrazolopyridines and benzofuropyridines and their optical and ecto-5'-nucleotidase inhibitory effects.

scientific article

A highly sensitive CE-UV method with dynamic coating of silica-fused capillaries for monitoring of nucleotide pyrophosphatase/phosphodiesterase reactions

scientific article

A highly sensitive capillary electrophoresis method using p-nitrophenyl 5′-thymidine monophosphate as a substrate for the monitoring of nucleotide pyrophosphatase/phosphodiesterase activities

article

Adenosine A2A receptor and ecto-5'-nucleotidase/CD73 are upregulated in hippocampal astrocytes of human patients with mesial temporal lobe epilepsy (MTLE).

scientific article published on 20 September 2016

Altered lipid and salt taste responsivity in ghrelin and GOAT null mice

scientific article

Assignment of ecto-nucleoside triphosphate diphosphohydrolase-1/cd39 expression to microglia and vasculature of the brain

scientific article published in December 2000

Association of the ecto-ATPase NTPDase2 with glial cells of the peripheral nervous system

scientific article

Blue blocker glasses impede the capacity of bright light to suppress melatonin production

scientific article published in August 2006

CD39 as a caveolar-associated ectonucleotidase.

scientific article

CD39 is the dominant Langerhans cell-associated ecto-NTPDase: modulatory roles in inflammation and immune responsiveness

scientific article

CD39/vascular ATP diphosphohydrolase modulates xenograft survival

scientific article published on 01 August 2000

CD73 Downregulation Decreases In Vitro and In Vivo Glioblastoma Growth

scientific article published on 16 August 2018

Ca2+ responses in enteric glia are mediated by connexin-43 hemichannels and modulate colonic transit in mice

scientific article

Changes in expression and activity levels of ecto-5'-nucleotidase/CD73 along the mouse female estrous cycle

scientific article published on 6 February 2010

Characterization of ecto-nucleotidases in human oviducts with an improved approach simultaneously identifying protein expression and in situ enzyme activity.

scientific article published on 22 December 2017

Characterization of soluble CD39 (SolCD39/NTPDase1) from PiggyBac nonviral system as a tool to control the nucleotides level

scientific article published on 11 June 2019

Characterization of the Endometrial MSC Marker Ectonucleoside Triphosphate Diphosphohydrolase-2 (NTPDase2/CD39L1) in Low- and High-Grade Endometrial Carcinomas: Loss of Stromal Expression in the Invasive Phenotypes

scientific article published on 22 April 2021

Chemoselective synthesis and biological evaluation of arylated 2-(Trifluoromethyl) quinolines as nucleotide pyrophosphatase (NPPs) inhibitors.

scientific article published on 13 July 2017

Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-3

scientific journal article

Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-8

scientific journal article

Coexpression of ecto-5'-nucleotidase/CD73 with specific NTPDases differentially regulates adenosine formation in the rat liver.

scientific article published on December 2011

Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8.

scientific article

Comparative hydrolysis of extracellular adenine nucleotides and adenosine in synaptic membranes from porcine brain cortex, hippocampus, cerebellum and medulla oblongata

scientific article published in December 2004

Concomitant activation of P2Y(2) and P2Y(6) receptors on monocytes is required for TLR1/2-induced neutrophil migration by regulating IL-8 secretion.

scientific article published on October 2009

Cystic fibrosis remodels the regulation of purinergic signaling by NTPDase1 (CD39) and NTPDase3

scientific article

Demonstration and immunolocalization of ATP diphosphohydrolase in the pig digestive system ⬇️

scientific article published on 01 September 1998

Diadenosine 5′,5′′-(Boranated)polyphosphonate Analogues as Selective Nucleotide Pyrophosphatase/Phosphodiesterase Inhibitors ⬇️

scientific article published on November 22, 2010

Diadenosine and diuridine poly(borano)phosphate analogues: synthesis, chemical and enzymatic stability, and activity at P2Y1 and P2Y2 receptors.

scientific article published on March 2006

Differential macrophage activation alters the expression profile of NTPDase and ecto-5'-nucleotidase

scientific article

Disordered cellular migration and angiogenesis in cd39-null mice

scientific article published in December 2001

Distinct roles of ecto-nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) in liver regeneration and fibrosis.

scientific article published on 13 November 2017

Distinctive Inhibition of Alkaline Phosphatase Isozymes by thiazol-2-ylidene-Benzamide Derivatives: Functional insights into their Anticancer Role.

scientific article published on 24 January 2018

Distribution of ecto-nucleotidases in mouse sensory circuits suggests roles for nucleoside triphosphate diphosphohydrolase-3 in nociception and mechanoreception.

scientific article

Distribution of ectonucleoside triphosphate diphosphohydrolases 1 and 2 in rat cochlea

scientific article published in August 2002

Distribution, cloning, and characterization of porcine nucleoside triphosphate diphosphohydrolase-1.

scientific article published in July 2000

Down-regulation of NTPDase2 and ADP-sensitive P2 Purinoceptors Correlate with Severity of Symptoms during Experimental Autoimmune Encephalomyelitis.

scientific article published on 30 October 2017

Ecto-5'-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions

scientific article published on July 2013

Ecto-5'-nucleotidase/CD73 contributes to the radiosensitivity of T24 human bladder cancer cell line.

scientific article published on 5 January 2018

Ecto-nucleotidases distribution in human cyclic and postmenopausic endometrium

scientific article published on 6 December 2012

Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic β Cells for In Vitro and In Vivo Analysis

scientific article published on 15 November 2018

Ectonucleotidase Inhibitory and Redox Activity of Imidazole-Based Organic Salts and Ionic Liquids

scientific article published on 23 October 2018

Ectonucleotidase NTPDase2 Is Selectively Down-Regulated in Biliary Cirrhosis

Ectonucleotidases in the digestive system: focus on NTPDase3 localization.

scientific article

Ectonucleotidases in the kidney.

scientific article published on 31 March 2009

Endothelial P2Y2 receptor regulates LPS-induced neutrophil transendothelial migration in vitro

scientific article published on 21 December 2009

Epitope mapping in cell surface proteins by site-directed masking: defining the structural elements of NTPDase3 inhibition by a monoclonal antibody.

scientific article

Establishment and characterization of rat portal myofibroblast cell lines

scientific article published on 30 March 2015

Exploration of carboxy pyrazole derivatives: Synthesis, alkaline phosphatase, nucleotide pyrophosphatase/phosphodiesterase and nucleoside triphosphate diphosphohydrolase inhibition studies with potential anticancer profile

scientific article published on 07 July 2018

Expression of Ecto-ATPase NTPDase2 in Human Dental Pulp ⬇️

scientific article published on December 14, 2011

Expression of NTPDase1 and NTPDase2 in murine kidney: relevance to regulation of P2 receptor signaling

scientific article published on 04 January 2005

Expression of the ecto-ATPase NTPDase2 in the germinal zones of the developing and adult rat brain

scientific article published in April 2003

Extracellular ATP Selectively Upregulates Ecto-Nucleoside Triphosphate Diphosphohydrolase 2 and Ecto-5'-Nucleotidase by Rat Cortical Astrocytes In Vitro

scientific article published on 17 June 2015

Extracellular ATP and P2 receptors are required for IL-8 to induce neutrophil migration.

scientific article published on 19 March 2009

Extracellular ectonucleotidases are differentially regulated in murine tissues and human polymorphonuclear leukocytes during sepsis and inflammation

scientific article published on 04 October 2021

Extracellular nucleosides and nucleotides regulate liver functions via a complex system of membrane proteins.

scientific article published on 17 January 2011

Extracellular nucleotide signaling in adult neural stem cells: synergism with growth factor-mediated cellular proliferation.

scientific article

Feed-forward inhibition of CD73 and upregulation of adenosine deaminase contribute to the loss of adenosine neuromodulation in postinflammatory ileitis

scientific article

Fluorescence polarization immunoassays for monitoring nucleoside triphosphate diphosphohydrolase (NTPDase) activity.

scientific article

Functional expression of the ecto-ATPase NTPDase2 and of nucleotide receptors by neuronal progenitor cells in the adult murine hippocampus

scientific article published in June 2005

Generation and Characterization of Specific Antibodies to the Murine and Human Ectonucleotidase NTPDase8.

scientific article published on 08 March 2017

Generation and characterization of polyclonal and monoclonal antibodies to human NTPDase2 including a blocking antibody.

scientific article published on 13 April 2017

Ghrelin is produced in taste cells and ghrelin receptor null mice show reduced taste responsivity to salty (NaCl) and sour (citric acid) tastants

scientific article

High expression and activity of ecto-5'-nucleotidase/CD73 in the male murine reproductive tract

scientific article published on 11 May 2010

Highly Selective and Potent Ectonucleotide Pyrophosphatase-1 (NPP1) Inhibitors Based on Uridine 5'-Pα,α-Dithiophosphate Analogues.

scientific article published on 22 April 2018

Highly potent and selective ectonucleoside triphosphate diphosphohydrolases (ENTPDase1, 2, 3 and 8) inhibitors having 2-substituted-7-trifluoromethyl-thiadiazolopyrimidones scaffold

scientific article published on 13 June 2019

Highly potent and selective ectonucleotide pyrophosphatase/phosphodiesterase I inhibitors based on an adenosine 5'-(α or γ)-thio-(α,β- or β,γ)-methylenetriphosphate scaffold.

scientific article

Histamine induces ATP release from human subcutaneous fibroblasts, via pannexin-1 hemichannels, leading to Ca2+ mobilization and cell proliferation

scientific article published on 05 August 2013

Homocysteine modifies extracellular ATP availability in macrophages

scientific article published on 19 September 2013

Hydrolysis of P2-purinoceptor agonists by a purified ectonucleotidase from the bovine aorta, the ATP-diphosphohydrolase

scientific article published on 01 June 1996

IL-6 downregulates transcription of NTPDase2 via specific promoter elements

scientific journal article

Identification and characterization of CD39/vascular ATP diphosphohydrolase

scientific article

Identification and characterization of a novel hepatic canalicular ATP diphosphohydrolase

scientific article published in February 2000

Identification and immunolocalization of two isoforms of ATP-diphosphohydrolase (ATPDase) in the pig immune system

scientific article published on 01 October 1999

Identification of adenine-N9-(methoxy)ethyl-β-bisphosphonate as NPP1 inhibitor attenuates NPPase activity in human osteoarthritic chondrocytes

scientific article published on 25 April 2019

Identification of hydrolytically stable and selective P2Y(1) receptor agonists.

scientific article

Identification of novel chromone based sulfonamides as highly potent and selective inhibitors of alkaline phosphatases

scientific article published on 19 June 2013

Identification of small molecule sulfonic acids as ecto-5'-Nucleotidase inhibitors

scientific article published on 01 November 2012

Identification of sulfonic acids as efficient ecto-5'-nucleotidase inhibitors.

scientific article published on 28 October 2013

Identification of the ectonucleotidases expressed in mouse, rat, and human Langerhans islets: potential role of NTPDase3 in insulin secretion.

scientific article published on 3 August 2010

Identification, characterization, and immunolocalization of a nucleoside triphosphate diphosphohydrolase in pig liver

scientific article published on 01 May 2000

Immunocytochemical localization of NTPDases1 and 2 in the neural retina of mouse and zebrafish

scientific article

Immunolocalization of ectonucleotidases along the rat nephron

scientific article published on 27 September 2005

Impact of ectoenzymes on p2 and p1 receptor signaling.

scientific article

Impact of ectonucleotidases in autonomic nervous functions.

scientific article published on 11 May 2015

Induction of NTPDase1/CD39 by Reactive Microglia and Macrophages Is Associated With the Functional State During EAE

scientific article published on 26 April 2019

Inhibition of vascular ectonucleotidase activities by the pro-drugs ticlopidine and clopidogrel favours platelet aggregation.

scientific article published on November 2010

Investigation of new quinoline derivatives as promising inhibitors of NTPDases: Synthesis, SAR analysis and molecular docking studies

scientific article published on 12 March 2019

Involvement of purinergic system in the release of cytokines by macrophages exposed to glioma-conditioned medium.

scientific article

Localization of nucleoside triphosphate diphosphohydrolase-1 (NTPDase1) and NTPDase2 in pancreas and salivary gland

scientific article published on 01 July 2004

Localization of plasma membrane bound NTPDases in the murine reproductive tract.

scientific article published on 6 January 2009

Longitudinal analysis of calorie restriction on rat taste bud morphology and expression of sweet taste modulators

scientific article published on 28 September 2013

Loss of vascular expression of nucleoside triphosphate diphosphohydrolase-1/CD39 in hypertension.

scientific article published on 13 December 2017

Methotrexate up-regulates ecto-5'-nucleotidase/CD73 and reduces the frequency of T lymphocytes in the glioblastoma microenvironment.

scientific article published on 24 February 2016

NTPDase1 (CD39) controls nucleotide-dependent vasoconstriction in mouse.

scientific article published on January 2010

NTPDase1 controls IL-8 production by human neutrophils

scientific article published on 13 June 2011

NTPDase1 governs P2X7-dependent functions in murine macrophages

scientific article

NTPDase3 and ecto-5'-nucleotidase/CD73 are differentially expressed during mouse bladder cancer progression

scientific article

New one-pot synthesis of N-fused isoquinoline derivatives by palladium-catalyzed C-H arylation: potent inhibitors of nucleotide pyrophosphatase-1 and -3

scientific article published on 18 November 2016

Noise exposure induces up-regulation of ecto-nucleoside triphosphate diphosphohydrolases 1 and 2 in rat cochlea

scientific journal article

Nonhydrolyzable ATP analogues as selective inhibitors of human NPP1: a combined computational/experimental study

scientific article published on 22 October 2013

Nucleoside triphosphate diphosphohydrolase-1 ectonucleotidase is required for normal vas deferens contraction and male fertility through maintaining P2X1 receptor function

scientific article

Nucleoside triphosphate diphosphohydrolase-2 (NTPDase2/CD39L1) is the dominant ectonucleotidase expressed by rat astrocytes

scientific journal article

Nucleoside triphosphate diphosphohydrolase-2 is the ecto-ATPase of type I cells in taste buds

scientific article

Nucleoside triphosphate diphosphohydrolases role in the pathophysiology of cognitive impairment induced by seizure in early age.

scientific article published on 16 February 2011

Nucleoside-(5'→P) methylenebisphosphonodithioate analogues: synthesis and chemical properties

scientific article

Opposing Effects of Adenosine and Inosine in Human Subcutaneous Fibroblasts May Be Regulated by Third Party ADA Cell Providers

scientific article published on 07 March 2020

Overexpression of NTPDase2 in gliomas promotes systemic inflammation and pulmonary injury

scientific article

P21(Waf1/Cip1) in endothelial cell survival

scientific article published in March 2004

P2Y2 receptor transcription is increased by NF-kappa B and stimulates cyclooxygenase-2 expression and PGE2 released by intestinal epithelial cells.

scientific article published on 4 September 2009

P2Y6 Receptors Regulate CXCL10 Expression and Secretion in Mouse Intestinal Epithelial Cells.

scientific article

Palladium-catalyzed synthesis and nucleotide pyrophosphatase inhibition of benzo[4,5]furo[3,2-b]indoles

scientific article published on 22 November 2019

Palmitoylation targets CD39/endothelial ATP diphosphohydrolase to caveolae.

scientific article

Physical exercise prevents alterations in purinergic system and oxidative status in lipopolysaccharide-induced sepsis in rats

scientific article published on 19 September 2018

Physical exercise prevents memory impairment in an animal model of hypertension through modulation of CD39 and CD73 activities and A2A receptor expression

scientific article published on 01 January 2019

Polyoxometalates--potent and selective ecto-nucleotidase inhibitors

scientific article

Portal fibroblasts regulate the proliferation of bile duct epithelia via expression of NTPDase2.

scientific article

Probing the high potency of pyrazolyl pyrimidinetriones and thioxopyrimidinediones as selective and efficient non-nucleotide inhibitors of recombinant human ectonucleotidases

scientific article published on 02 April 2019

Purification of the blood vessel ATP diphosphohydrolase, identification and localisation by immunological techniques

scholarly article by Jean Sévigny et al published February 1997 in BBA - General Subjects

Purification, characterization, and localization of two ATP diphosphohydrolase isoforms in bovine heart ⬇️

scientific article published on August 1, 1997

Purine-metabolizing ectoenzymes control IL-8 production in human colon HT-29 cells.

scientific article

Purinergic Signalling in Immune System Regulation in Health and Disease.

scientific article

Rat submandibular glands secrete nanovesicles with NTPDase and 5'-nucleotidase activities

scientific article

Reduced striatal ecto-nucleotidase activity in schizophrenia patients supports the "adenosine hypothesis".

scientific article published on 16 June 2013

Regional and sex-related differences in modulating effects of female sex steroids on ecto-5'-nucleotidase expression in the rat cerebral cortex and hippocampus

scientific article published on 10 June 2016

Role of ecto-NTPDases on UDP-sensitive P2Y(6) receptor activation during osteogenic differentiation of primary bone marrow stromal cells from postmenopausal women

scientific article published in June 2012

Schiff bases of tryptamine as potent inhibitors of nucleoside triphosphate diphosphohydrolases (NTPDases): Structure-activity relationship

scientific article published on 30 October 2018

Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide.

scientific article

Stimulation of the P2Y1 receptor up-regulates nucleoside-triphosphate diphosphohydrolase-1 in human retinal pigment epithelial cells.

scientific article published on 12 July 2007

Structural elements and limited proteolysis of CD39 influence ATP diphosphohydrolase activity

scientific article published on 01 February 1999

Synthesis of novel (E)-1-(2-(2-(4(dimethylamino) benzylidene) hydrazinyl)-4-methylthiazol-5-yl)ethanone derivatives as ecto-5′-nucleotidase inhibitors

scientific article published on 12 September 2018

Synthesis, biological evaluation, and docking studies of new raloxifene sulfonate or sulfamate derivatives as inhibitors of nucleotide pyrophosphatase/phosphodiesterase

scientific article published on 25 July 2019

Synthesis, biological evaluation, and molecular docking study of sulfonate derivatives as nucleotide pyrophosphatase/phosphodiesterase (NPP) inhibitors

scientific article published on 26 April 2019

Synthesis, characterization and biological evaluation of novel chalcone sulfonamide hybrids as potent intestinal alkaline phosphatase inhibitors.

scientific article published on 5 January 2017

Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation

scientific article published in September 1999

Targeted disruption of cd73/ecto-5'-nucleotidase alters thromboregulation and augments vascular inflammatory response

scientific article

Targeting platelet aggregation: CD39 gene transfer augments nucleoside triphosphate diphosphohydrolase activity in injured rabbit arteries

article

The ecto-nucleoside triphosphate diphosphohydrolase NTPDase2/CD39L1 is expressed in a novel functional compartment within the liver

scientific journal article

The ectonucleoside triphosphate diphosphohydrolase-2 (NTPDase2) in human endometrium: a novel marker of basal stroma and mesenchymal stem cells

scientific article published on 23 May 2019

The expression of NTPDase1 and -2 of Leishmania infantum chagasi in bacterial and mammalian cells: Comparative expression, refolding and nucleotidase characterization.

scientific article published on 14 November 2016

Ticlopidine in its prodrug form is a selective inhibitor of human NTPDase1

scientific article

Trafficking and intracellular ATPase activity of human ecto-nucleotidase NTPDase3 and the effect of ER-targeted NTPDase3 on protein folding.

scientific article published on 12 August 2008

Transforming growth factor-beta and substrate stiffness regulate portal fibroblast activation in culture

scientific article published on 01 October 2007

Tricyclic coumarin sulphonate derivatives with alkaline phosphatase inhibitory effects: in vitro and docking studies.

scientific article published in December 2018

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