List of works - Michael Gotthardt

A proteome map of murine heart and skeletal muscle

scientific article

Adaptations in titin's spring elements in normal and cardiomyopathic hearts.

scientific article published in January 2003

Altered contractility of skeletal muscle in mice deficient in titin's M-band region

scientific article

Axial tubule junctions control rapid calcium signaling in atria

scientific article

CAR-diology--a virus receptor in the healthy and diseased heart

scientific article published on 03 June 2009

Calcium sensitivity and myofilament lattice structure in titin N2B KO mice

scientific article published on 14 December 2012

Calcium sensitivity and the Frank-Starling mechanism of the heart are increased in titin N2B region-deficient mice

scientific article

Cardiac deletion of the Coxsackievirus-adenovirus receptor abolishes Coxsackievirus B3 infection and prevents myocarditis in vivo

scientific article

Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region

scientific article published on 29 January 2007

Cellular signalling by lipoprotein receptors

scientific article

Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure

scientific article

Consequences of epidermal growth factor receptor (ErbB1) loss for vascular smooth muscle cells from mice with targeted deletion of ErbB1.

scientific article published on 21 April 2011

Coxsackie and adenovirus receptor is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemia

scientific article

Deconstructing sarcomeric structure-function relations in titin-BioID knock-in mice

scientific article published on 19 June 2020

Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome

scientific article published on 26 March 2021

Deleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac Phenotypes

scientific article published on 01 April 2019

Deletion of the titin N2B region accelerates myofibrillar force development but does not alter relaxation kinetics

scientific article

Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling.

scientific article

Enhancement of the endothelial NO synthase attenuates experimental diastolic heart failure

scientific article

Excision of titin's cardiac PEVK spring element abolishes PKCalpha-induced increases in myocardial stiffness

scientific article

Expanding the map of protein-RNA interaction sites via cell fusion followed by PAR-CLIP.

scientific article

Functional genomics of chicken, mouse, and human titin supports splice diversity as an important mechanism for regulating biomechanics of striated muscle

scholarly article by Henk Granzier et al published August 2007 in American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants

scientific article

Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling

scientific journal article

Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease

scientific article

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction

scientific article

Interspecies differences in virus uptake versus cardiac function of the coxsackievirus and adenovirus receptor

scientific article published on 16 April 2014

LRP and PDGF signaling: a pathway to atherosclerosis

scientific article published on February 2004

LRP: role in vascular wall integrity and protection from atherosclerosis

scientific article

Loss of epidermal growth factor receptor in vascular smooth muscle cells and cardiomyocytes causes arterial hypotension and cardiac hypertrophy

scientific article published on 17 December 2012

M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere

scientific journal article

Mechanics on myocardium deficient in the N2B region of titin: the cardiac-unique spring element improves efficiency of the cardiac cycle

scientific article

Moderate inappropriately high aldosterone/NaCl constellation in mice: cardiovascular effects and the role of cardiovascular epidermal growth factor receptor

scientific article

Molecular basis of titin exon exclusion by RBM20 and the novel titin splice regulator PTB4.

scientific article published on 6 March 2018

Muscle atrophy in Titin M-line deficient mice

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

scientific article

Normal blood pressure and plasma renin activity in mice lacking the renin-binding protein, a cellular renin inhibitor

scientific journal article

Platelet-derived growth factor mediates tyrosine phosphorylation of the cytoplasmic domain of the low Density lipoprotein receptor-related protein in caveolae

scientific journal article

Podocyte-Specific Deletion of Murine CXADR Does Not Impair Podocyte Development, Function or Stress Response

scientific article (publication date: 2015)

RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing

scientific article

RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing

scientific article

Recessive TTN truncating mutations define novel forms of core myopathy with heart disease

scientific article published on 08 October 2013

Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy

scientific article published on 26 November 2016

Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2

scientific article

Role of smooth muscle cGMP/cGKI signaling in murine vascular restenosis

scientific article published on 17 April 2008

Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury

scientific article published on 14 October 2007

SLM2 Is A Novel Cardiac Splicing Factor Involved in Heart Failure due to Dilated Cardiomyopathy

scientific article published in 2022

Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure

scientific article

Sustained somatic gene inactivation by viral transfer of Cre recombinase.

scientific article published in November 1996

Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy

scientific journal article

The Src homology and collagen A (ShcA) adaptor protein is required for the spatial organization of the costamere/Z-disk network during heart development

scientific article published on 8 December 2014

The cell adhesion protein CAR is a negative regulator of synaptic transmission

article

The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system

scientific article

The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2

scientific journal article

The tight junction protein CAR regulates cardiac conduction and cell-cell communication

scientific article published on 15 September 2008

Titin based viscosity in ventricular physiology: an integrative investigation of PEVK-actin interactions

scientific article

Titin visualization in real time reveals an unexpected level of mobility within and between sarcomeres

scientific article

Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction

scientific article

Upregulation of hepatic LDL transport by n-3 fatty acids in LDL receptor knockout mice.

scientific article published in May 2002

Visualization of β-adrenergic receptor dynamics and differential localization in cardiomyocytes

scientific article published in 2021

List of works by Michael Gotthardt

A proteome map of murine heart and skeletal muscle

Adaptations in titin's spring elements in normal and cardiomyopathic hearts.

Altered contractility of skeletal muscle in mice deficient in titin's M-band region

Axial tubule junctions control rapid calcium signaling in atria

CAR-diology--a virus receptor in the healthy and diseased heart

Calcium sensitivity and myofilament lattice structure in titin N2B KO mice

Calcium sensitivity and the Frank-Starling mechanism of the heart are increased in titin N2B region-deficient mice

Cardiac deletion of the Coxsackievirus-adenovirus receptor abolishes Coxsackievirus B3 infection and prevents myocarditis in vivo

Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region

Cellular signalling by lipoprotein receptors

Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure

Consequences of epidermal growth factor receptor (ErbB1) loss for vascular smooth muscle cells from mice with targeted deletion of ErbB1.

Coxsackie and adenovirus receptor is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemia

Deconstructing sarcomeric structure-function relations in titin-BioID knock-in mice

Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome

Deleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac Phenotypes

Deletion of the titin N2B region accelerates myofibrillar force development but does not alter relaxation kinetics

Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling.

Enhancement of the endothelial NO synthase attenuates experimental diastolic heart failure

Excision of titin's cardiac PEVK spring element abolishes PKCalpha-induced increases in myocardial stiffness

Expanding the map of protein-RNA interaction sites via cell fusion followed by PAR-CLIP.

Functional genomics of chicken, mouse, and human titin supports splice diversity as an important mechanism for regulating biomechanics of striated muscle

Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants

Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling

Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction

Interspecies differences in virus uptake versus cardiac function of the coxsackievirus and adenovirus receptor

LRP and PDGF signaling: a pathway to atherosclerosis

LRP: role in vascular wall integrity and protection from atherosclerosis

Loss of epidermal growth factor receptor in vascular smooth muscle cells and cardiomyocytes causes arterial hypotension and cardiac hypertrophy

M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere

Mechanics on myocardium deficient in the N2B region of titin: the cardiac-unique spring element improves efficiency of the cardiac cycle

Moderate inappropriately high aldosterone/NaCl constellation in mice: cardiovascular effects and the role of cardiovascular epidermal growth factor receptor

Molecular basis of titin exon exclusion by RBM20 and the novel titin splice regulator PTB4.

Muscle atrophy in Titin M-line deficient mice

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

Normal blood pressure and plasma renin activity in mice lacking the renin-binding protein, a cellular renin inhibitor

Platelet-derived growth factor mediates tyrosine phosphorylation of the cytoplasmic domain of the low Density lipoprotein receptor-related protein in caveolae

Podocyte-Specific Deletion of Murine CXADR Does Not Impair Podocyte Development, Function or Stress Response

RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing

RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing

Recessive TTN truncating mutations define novel forms of core myopathy with heart disease

Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy

Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2

Role of smooth muscle cGMP/cGKI signaling in murine vascular restenosis

Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury

SLM2 Is A Novel Cardiac Splicing Factor Involved in Heart Failure due to Dilated Cardiomyopathy

Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure

Sustained somatic gene inactivation by viral transfer of Cre recombinase.

Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy

The Src homology and collagen A (ShcA) adaptor protein is required for the spatial organization of the costamere/Z-disk network during heart development

The cell adhesion protein CAR is a negative regulator of synaptic transmission

The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system

The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2

The tight junction protein CAR regulates cardiac conduction and cell-cell communication

Titin based viscosity in ventricular physiology: an integrative investigation of PEVK-actin interactions

Titin visualization in real time reveals an unexpected level of mobility within and between sarcomeres

Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction

Upregulation of hepatic LDL transport by n-3 fatty acids in LDL receptor knockout mice.

Visualization of β-adrenergic receptor dynamics and differential localization in cardiomyocytes