List of works - Jamie Vandenberg

'Shooting gallery' for membrane proteins provides new insights into complexities of their function and structural dynamics.

scientific article published on January 2015

A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm.

scientific article published on 13 July 2015

A Universal and Robust Integrated Platform for the Scalable Production of Human Cardiomyocytes From Pluripotent Stem Cells

scientific article

A transgenic zebrafish model of a human cardiac sodium channel mutation exhibits bradycardia, conduction-system abnormalities and early death

scientific article

An 'alternans' way to quantify arrhythmogenic substrates

scientific article published on 01 May 2016

An improved curvilinear gradient method for parameter optimization in complex biological models.

scientific article

Application of progress curve analysis to in situ enzyme kinetics using 1H NMR spectroscopy

scientific article published in May 1986

C-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels

scientific article

Ca2+ buffering in the heart: Ca2+ binding to and activation of cardiac myofibrils.

scientific article published on March 2000

Can many subunits make light work of ion channel inactivation?

scientific article published on 01 October 2014

Cardiac expression of the cystic fibrosis transmembrane conductance regulator involves novel exon 1 usage to produce a unique amino-terminal protein

scientific article published on 30 January 2004

Cell swelling has differential effects on the rapid and slow components of delayed rectifier potassium current in guinea pig cardiac myocytes

scientific article published on December 1995

Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century.

scientific article published on 09 April 2016

Cortisol influences the ontogeny of both alpha- and beta-subunits of the cardiac sodium channel in fetal sheep.

scientific article published in March 2004

Developmental regulation of the gradient of cftr expression in the rabbit heart.

scientific article published in June 2000

Differential Response to Risperidone in Schizophrenia Patients by KCNH2 Genotype and Drug Metabolizer Status

scientific article

Domain reorientation and rotation of an intracellular assembly regulate conduction in Kir potassium channels

scientific article

Drug binding to the inactivated state is necessary but not sufficient for high-affinity binding to human ether-à-go-go-related gene channels

scientific article published on 13 August 2008

Effect of S5P alpha-helix charge mutants on inactivation of hERG K+ channels

scientific article published on 23 March 2006

Effects of premature stimulation on HERG K(+) channels

scientific article published on 01 December 2001

Electrogram prolongation and nifedipine-suppressible ventricular arrhythmias in mice following targeted disruption of KCNE1

scientific journal article

Enkephalin degradation by human erythrocytes and hemolysates studied using 1H NMR spectroscopy.

scientific article

Epistatic effects of potassium channel variation on cardiac repolarization and atrial fibrillation risk

scientific article

Estimation of systolic and diastolic free intracellular Ca2+ by titration of Ca2+ buffering in the ferret heart.

scientific article published on March 2000

Experimentally Validated Pharmacoinformatics Approach to Predict hERG Inhibition Potential of New Chemical Entities

scholarly article by Saba Munawar et al published 2018 in Frontiers in Pharmacology

Extracellular acidosis modulates drug block of Kv4.3 currents by flecainide and quinidine

scientific article published in June 2003

Extracellular osmotic pressure modulates sodium-calcium exchange in isolated guinea-pig ventricular myocytes

scientific article published on 01 October 1995

From kinetics to imaging: an NMR odyssey--a festschrift symposium in honour of Philip William Kuchel

scientific article published in January 2013

Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis

scientific article published on 27 December 2013

Getting to the heart of hERG K(+) channel gating.

scientific article published on June 2015

Heritability of ECG Biomarkers in the Netherlands Twin Registry Measured from Holter ECGs

scientific article published on 29 April 2016

Hodgkin and Huxley and the basis for electrical signalling: a remarkable legacy still going strong

scientific article published in June 2012

Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels.

scientific article published on September 2013

In Vitro and In Silico Risk Assessment in Acquired Long QT Syndrome: The Devil Is in the Details

scientific article published on 16 November 2017

In silico assessment of kinetics and state dependent binding properties of drugs causing acquired LQTS.

scientific article

Inherited cardiac arrhythmia syndromes: what have they taught us about arrhythmias and anti-arrhythmic therapy?

scientific article published on 01 December 2004

Ion channelopathies: what have they taught us about arrhythmias and anti-arrythmic therapy

scientific article published on 01 July 2005

Ion channels--a plethora of pharmaceutical targets

scientific article published on 01 November 2000

Is medroxyprogesterone safe in women with long QT syndrome?

scientific article published on 6 March 2012

Kinetics of drug interaction with the Kv11.1 potassium channel

scientific article

Lentiviral vectors for delivery of genes into neonatal and adult ventricular cardiac myocytes in vitro and in vivo.

scientific article published on September 2002

Loss of the normal epicardial to endocardial gradient of cftr mRNA expression in the hypertrophied rabbit left ventricle

scientific article published on 01 November 2000

Mapping the sequence of conformational changes underlying selectivity filter gating in the K(v)11.1 potassium channel

scientific article published on 19 December 2010

Measuring kinetics and potency of hERG block for CiPA.

scientific article published on 10 February 2017

Mechanism of block of the hERG K+ channel by the scorpion toxin CnErg1

scientific article published on 16 March 2007

Molecular basis of slow activation of the human ether-a-go-go related gene potassium channel

scientific article published on 4 June 2004

Molecular dynamics and continuum electrostatics studies of inactivation in the HERG potassium channel.

scientific article published on February 2007

Multiple interactions between cytoplasmic domains regulate slow deactivation of Kv11.1 channels.

scientific article

Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2.

scientific article published on 25 September 2014

Mutant MiRP1 subunits modulate HERG K+ channel gating: a mechanism for pro-arrhythmia in long QT syndrome type 6.

scientific article published on 18 June 2003

Never at rest: insights into the conformational dynamics of ion channels from cryo-electron microscopy

scientific article

Not all hERG pore domain mutations have a severe phenotype: G584S has an inactivation gating defect with mild phenotype compared to G572S, which has a dominant negative trafficking defect and a severe phenotype

scientific article

Oxidative stress fine-tunes the dance of hERG K+ channels

scientific article published on August 2010

Pharmacological activation of IKr in models of long QT Type 2 risks overcorrection of repolarization

scientific article published on 13 September 2019

Post-transcriptional regulation of the cystic fibrosis gene in cardiac development and hypertrophy

scientific article published in June 2004

Potassium channels in the heart: structure, function and regulation.

scientific article published on 13 November 2016

Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics

scientific article published on 3 November 2016

Proteins, membranes and cells: the structure-function nexus-ASB 2008

scientific article published on 01 December 2009

Protocol-Dependent Differences in IC50 Values Measured in Human Ether-Á-Go-Go-Related Gene Assays Occur in a Predictable Way and Can Be Used to Quantify State Preference of Drug Binding

scientific article published on 15 February 2019

Quantifying the origins of population variability in cardiac electrical activity through sensitivity analysis of the electrocardiogram.

scientific article

R222Q SCN5A mutation is associated with reversible ventricular ectopy and dilated cardiomyopathy

scientific article

Recent advances in understanding and prevention of sudden cardiac death

scientific article published on 31 August 2017

Rescue of protein expression defects may not be enough to abolish the pro-arrhythmic phenotype of long QT type 2 mutations

scientific article published on 9 March 2016

Role of the cytoplasmic N-terminal Cap and Per-Arnt-Sim (PAS) domain in trafficking and stabilization of Kv11.1 channels.

scientific article

Sensitivity limits for voltage control of P2Y receptor-evoked Ca2+ mobilization in the rat megakaryocyte

scientific article published on 28 November 2003

Sinus node dysfunction following targeted disruption of the murine cardiac sodium channel gene Scn5a

scientific journal article

Sinusoidal Voltage Protocols For Rapid Characterisation Of Ion Channel Kinetics

Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics.

scientific article published on 24 March 2018

Stretch-sensitive KCNQ1 mutation A link between genetic and environmental factors in the pathogenesis of atrial fibrillation?

scientific article published on 22 January 2007

Structure of the HERG K+ channel S5P extracellular linker: role of an amphipathic alpha-helix in C-type inactivation

scientific article published on 5 August 2003

Structure of the pore-helix of the hERG K(+) channel

scientific article

Substrate specificity of platypus venom L-to-D-peptide isomerase

scientific article published on 24 December 2007

T-wave morphology can distinguish healthy controls from LQTS patients.

scientific article

TECRL: connecting sequence to consequence for a new sudden cardiac death gene.

scientific article

Temperature Effects on Kinetics of KV11.1 Drug Block Have Important Consequences for In Silico Proarrhythmic Risk Prediction

scientific article

Temperature dependence of human ether-a-go-go-related gene K+ currents.

scientific article published in February 2006

The M1P1 loop of TASK3 K2P channels apposes the selectivity filter and influences channel function.

scientific article published on 16 April 2008

The N–Terminal Tail of hERG Contains an Amphipathic α–Helix That Regulates Channel Deactivation

scientific article

The S1 helix critically regulates the finely tuned gating of Kv11.1 channels

scientific article

The S4–S5 Linker Acts as a Signal Integrator for hERG K+ Channel Activation and Deactivation Gating

scientific article

The Temperature Dependence of Kinetics Associated with Drug Block of hERG Channels Is Compound-Specific and an Important Factor for Proarrhythmic Risk Prediction

scientific article published on 04 May 2018

The assimilation of tri- and tetrapeptides by human erythrocytes.

scientific article published in July 1985

The effect of Mg2+ on cardiac muscle function: Is CaATP the substrate for priming myofibril cross-bridge formation and Ca2+ reuptake by the sarcoplasmic reticulum?

scientific article

The pore domain outer helix contributes to both activation and inactivation of the HERG K+ channel.

scientific article

The schizophrenia-associated Kv11.1-3.1 isoform results in reduced current accumulation during repetitive brief depolarizations.

scientific article

The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size.

scientific article

Towards a Structural View of Drug Binding to hERG K(+) Channels

scientific article

Trafficking defects in PAS domain mutant Kv11.1 channels: roles of reduced domain stability and altered domain-domain interactions.

scientific article published in August 2013

Tryptophan scanning mutagenesis of the HERG K+ channel: the S4 domain is loosely packed and likely to be lipid exposed

scientific article published on 15 September 2005

Tyrosine Residues from the S4-S5 Linker of Kv11.1 Channels Are Critical for Slow Deactivation

scientific article published on 17 June 2016

List of works by Jamie Vandenberg

'Shooting gallery' for membrane proteins provides new insights into complexities of their function and structural dynamics.

A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm.

A Universal and Robust Integrated Platform for the Scalable Production of Human Cardiomyocytes From Pluripotent Stem Cells

A transgenic zebrafish model of a human cardiac sodium channel mutation exhibits bradycardia, conduction-system abnormalities and early death

An 'alternans' way to quantify arrhythmogenic substrates

An improved curvilinear gradient method for parameter optimization in complex biological models.

Application of progress curve analysis to in situ enzyme kinetics using 1H NMR spectroscopy

C-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels

Ca2+ buffering in the heart: Ca2+ binding to and activation of cardiac myofibrils.

Can many subunits make light work of ion channel inactivation?

Cardiac expression of the cystic fibrosis transmembrane conductance regulator involves novel exon 1 usage to produce a unique amino-terminal protein

Cell swelling has differential effects on the rapid and slow components of delayed rectifier potassium current in guinea pig cardiac myocytes

Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century.

Cortisol influences the ontogeny of both alpha- and beta-subunits of the cardiac sodium channel in fetal sheep.

Developmental regulation of the gradient of cftr expression in the rabbit heart.

Differential Response to Risperidone in Schizophrenia Patients by KCNH2 Genotype and Drug Metabolizer Status

Domain reorientation and rotation of an intracellular assembly regulate conduction in Kir potassium channels

Drug binding to the inactivated state is necessary but not sufficient for high-affinity binding to human ether-à-go-go-related gene channels

Effect of S5P alpha-helix charge mutants on inactivation of hERG K+ channels

Effects of premature stimulation on HERG K(+) channels

Electrogram prolongation and nifedipine-suppressible ventricular arrhythmias in mice following targeted disruption of KCNE1

Enkephalin degradation by human erythrocytes and hemolysates studied using 1H NMR spectroscopy.

Epistatic effects of potassium channel variation on cardiac repolarization and atrial fibrillation risk

Estimation of systolic and diastolic free intracellular Ca2+ by titration of Ca2+ buffering in the ferret heart.

Experimentally Validated Pharmacoinformatics Approach to Predict hERG Inhibition Potential of New Chemical Entities

Extracellular acidosis modulates drug block of Kv4.3 currents by flecainide and quinidine

Extracellular osmotic pressure modulates sodium-calcium exchange in isolated guinea-pig ventricular myocytes

From kinetics to imaging: an NMR odyssey--a festschrift symposium in honour of Philip William Kuchel

Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis

Getting to the heart of hERG K(+) channel gating.

Heritability of ECG Biomarkers in the Netherlands Twin Registry Measured from Holter ECGs

Hodgkin and Huxley and the basis for electrical signalling: a remarkable legacy still going strong

Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels.

In Vitro and In Silico Risk Assessment in Acquired Long QT Syndrome: The Devil Is in the Details

In silico assessment of kinetics and state dependent binding properties of drugs causing acquired LQTS.

Inherited cardiac arrhythmia syndromes: what have they taught us about arrhythmias and anti-arrhythmic therapy?

Ion channelopathies: what have they taught us about arrhythmias and anti-arrythmic therapy

Ion channels--a plethora of pharmaceutical targets

Is medroxyprogesterone safe in women with long QT syndrome?

Kinetics of drug interaction with the Kv11.1 potassium channel

Lentiviral vectors for delivery of genes into neonatal and adult ventricular cardiac myocytes in vitro and in vivo.

Loss of the normal epicardial to endocardial gradient of cftr mRNA expression in the hypertrophied rabbit left ventricle

Mapping the sequence of conformational changes underlying selectivity filter gating in the K(v)11.1 potassium channel

Measuring kinetics and potency of hERG block for CiPA.

Mechanism of block of the hERG K+ channel by the scorpion toxin CnErg1

Molecular basis of slow activation of the human ether-a-go-go related gene potassium channel

Molecular dynamics and continuum electrostatics studies of inactivation in the HERG potassium channel.

Multiple interactions between cytoplasmic domains regulate slow deactivation of Kv11.1 channels.

Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2.

Mutant MiRP1 subunits modulate HERG K+ channel gating: a mechanism for pro-arrhythmia in long QT syndrome type 6.

Never at rest: insights into the conformational dynamics of ion channels from cryo-electron microscopy

Not all hERG pore domain mutations have a severe phenotype: G584S has an inactivation gating defect with mild phenotype compared to G572S, which has a dominant negative trafficking defect and a severe phenotype

Oxidative stress fine-tunes the dance of hERG K+ channels

Pharmacological activation of IKr in models of long QT Type 2 risks overcorrection of repolarization

Post-transcriptional regulation of the cystic fibrosis gene in cardiac development and hypertrophy

Potassium channels in the heart: structure, function and regulation.

Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics

Proteins, membranes and cells: the structure-function nexus-ASB 2008

Protocol-Dependent Differences in IC50 Values Measured in Human Ether-Á-Go-Go-Related Gene Assays Occur in a Predictable Way and Can Be Used to Quantify State Preference of Drug Binding

Quantifying the origins of population variability in cardiac electrical activity through sensitivity analysis of the electrocardiogram.

R222Q SCN5A mutation is associated with reversible ventricular ectopy and dilated cardiomyopathy

Recent advances in understanding and prevention of sudden cardiac death

Rescue of protein expression defects may not be enough to abolish the pro-arrhythmic phenotype of long QT type 2 mutations

Role of the cytoplasmic N-terminal Cap and Per-Arnt-Sim (PAS) domain in trafficking and stabilization of Kv11.1 channels.

Sensitivity limits for voltage control of P2Y receptor-evoked Ca2+ mobilization in the rat megakaryocyte

Sinus node dysfunction following targeted disruption of the murine cardiac sodium channel gene Scn5a

Sinusoidal Voltage Protocols For Rapid Characterisation Of Ion Channel Kinetics

Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics.

Stretch-sensitive KCNQ1 mutation A link between genetic and environmental factors in the pathogenesis of atrial fibrillation?

Structure of the HERG K+ channel S5P extracellular linker: role of an amphipathic alpha-helix in C-type inactivation

Structure of the pore-helix of the hERG K(+) channel

Substrate specificity of platypus venom L-to-D-peptide isomerase

T-wave morphology can distinguish healthy controls from LQTS patients.

TECRL: connecting sequence to consequence for a new sudden cardiac death gene.

Temperature Effects on Kinetics of KV11.1 Drug Block Have Important Consequences for In Silico Proarrhythmic Risk Prediction

Temperature dependence of human ether-a-go-go-related gene K+ currents.

The M1P1 loop of TASK3 K2P channels apposes the selectivity filter and influences channel function.

The N–Terminal Tail of hERG Contains an Amphipathic α–Helix That Regulates Channel Deactivation

The S1 helix critically regulates the finely tuned gating of Kv11.1 channels