List of works - Rainer Heuchel

3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing

scientific article published on 27 February 2013

A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity.

scientific article published on 28 July 2004

A gain-of-function mutation in the PDGFR-beta alters the kinetics of injury response in liver and skin

scientific article published on September 2008

Age-dependent and differential effects of Smad7ΔEx1 on neural progenitor cell proliferation and on neurogenesis

scientific article

An activating mutation in the PDGF receptor-beta causes abnormal morphology in the mouse placenta

scientific article published on 01 January 2007

CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice

scientific article

Deficiency of Smad7 enhances cardiac remodeling induced by angiotensin II infusion in a mouse model of hypertension

scientific article

Deletion of exon I of SMAD7 in mice results in altered B cell responses.

scientific article published on June 2006

Desmoplasia and chemoresistance in pancreatic cancer

2014 scientific article

Disruption of Smad7 promotes ANG II-mediated renal inflammation and fibrosis via Sp1-TGF-β/Smad3-NF.κB-dependent mechanisms in mice.

scientific article

Disruption of the Smad7 gene enhances CCI4-dependent liver damage and fibrogenesis in mice

scientific article published on 4 February 2008

Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice

scientific article published on 18 December 2008

Efficient TGF-beta induction of the Smad7 gene requires cooperation between AP-1, Sp1, and Smad proteins on the mouse Smad7 promoter

scientific article published on September 2000

Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1.

scientific article

Endoscopic papillectomy and KRAS expression in the treatment of adenoma in the major duodenal papilla.

scientific article published on 14 May 2015

Expression and function of the gene encoding the voltage-dependent calcium channel beta3-subunit in the mouse placenta.

scientific article published on 5 July 2006

Fluorescence labeled microbubbles for multimodal imaging.

scientific article published on 14 July 2015

Hypoxic pulmonary hypertension in mice with constitutively active platelet-derived growth factor receptor-β.

scientific article

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

scientific article

Inhibitory role of Smad7 in hepatocarcinogenesis in mice and in vitro.

scientific article

Multiple phenotypes in adult mice following inactivation of the Coxsackievirus and Adenovirus Receptor (Car) gene

scientific article

Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy.

scientific article published in November 2011

Pdx1-Cre-driven conditional gene depletion suggests PAK4 as dispensable for mouse pancreas development

scientific article

Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3' kinase signaling

scientific article published on September 1999

Platelet-derived growth factor receptor-beta constitutive activity promotes angiogenesis in vivo and in vitro.

scientific article

Platelet-derived growth factor receptor-beta promotes early endothelial cell differentiation

scientific article published on 11 May 2006

Platelet-derived growth factor receptor-beta, carrying the activating mutation D849N, accelerates the establishment of B16 melanoma

scientific article

Real-time assessment of tissue hypoxia in vivo with combined photoacoustics and high-frequency ultrasound.

scientific article

Smad7 regulates terminal maturation of chondrocytes in the growth plate

scientific article

Smad7 regulates the adult neural stem/progenitor cell pool in a transforming growth factor beta- and bone morphogenetic protein-independent manner

scientific article

The nucleotides responsible for the direct physical contact between the chromatin insulator protein CTCF and the H19 imprinting control region manifest parent of origin-specific long-distance insulation and methylation-free domains

scientific article

The protective role of Smad7 in diabetic kidney disease: mechanism and therapeutic potential

scientific article

Therapy with Cell Encapsulation for Substitution of Organ Function and Tumor Treatment

Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation

scientific article published on 01 January 2003

Variant Profiling of Candidate Genes in Pancreatic Ductal Adenocarcinoma

scientific article published on 16 September 2015

List of works by Rainer Heuchel

3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing

A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity.

A gain-of-function mutation in the PDGFR-beta alters the kinetics of injury response in liver and skin

Age-dependent and differential effects of Smad7ΔEx1 on neural progenitor cell proliferation and on neurogenesis

An activating mutation in the PDGF receptor-beta causes abnormal morphology in the mouse placenta

CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice

Deficiency of Smad7 enhances cardiac remodeling induced by angiotensin II infusion in a mouse model of hypertension

Deletion of exon I of SMAD7 in mice results in altered B cell responses.

Desmoplasia and chemoresistance in pancreatic cancer

Disruption of Smad7 promotes ANG II-mediated renal inflammation and fibrosis via Sp1-TGF-β/Smad3-NF.κB-dependent mechanisms in mice.

Disruption of the Smad7 gene enhances CCI4-dependent liver damage and fibrogenesis in mice

Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice

Efficient TGF-beta induction of the Smad7 gene requires cooperation between AP-1, Sp1, and Smad proteins on the mouse Smad7 promoter

Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1.

Endoscopic papillectomy and KRAS expression in the treatment of adenoma in the major duodenal papilla.

Expression and function of the gene encoding the voltage-dependent calcium channel beta3-subunit in the mouse placenta.

Fluorescence labeled microbubbles for multimodal imaging.

Hypoxic pulmonary hypertension in mice with constitutively active platelet-derived growth factor receptor-β.

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

Inhibitory role of Smad7 in hepatocarcinogenesis in mice and in vitro.

Multiple phenotypes in adult mice following inactivation of the Coxsackievirus and Adenovirus Receptor (Car) gene

Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy.

Pdx1-Cre-driven conditional gene depletion suggests PAK4 as dispensable for mouse pancreas development

Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3' kinase signaling

Platelet-derived growth factor receptor-beta constitutive activity promotes angiogenesis in vivo and in vitro.

Platelet-derived growth factor receptor-beta promotes early endothelial cell differentiation

Platelet-derived growth factor receptor-beta, carrying the activating mutation D849N, accelerates the establishment of B16 melanoma

Real-time assessment of tissue hypoxia in vivo with combined photoacoustics and high-frequency ultrasound.

Smad7 regulates terminal maturation of chondrocytes in the growth plate

Smad7 regulates the adult neural stem/progenitor cell pool in a transforming growth factor beta- and bone morphogenetic protein-independent manner

The nucleotides responsible for the direct physical contact between the chromatin insulator protein CTCF and the H19 imprinting control region manifest parent of origin-specific long-distance insulation and methylation-free domains

The protective role of Smad7 in diabetic kidney disease: mechanism and therapeutic potential

Therapy with Cell Encapsulation for Substitution of Organ Function and Tumor Treatment

Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation

Variant Profiling of Candidate Genes in Pancreatic Ductal Adenocarcinoma