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List of works by Simo Saarakkala

2-D finite difference time domain model of ultrasound reflection from normal and osteoarthritic human articular cartilage surface.

scientific article

3D Morphometric analysis of calcified cartilage properties using micro-computed tomography

scientific article published on 01 October 2018

3D histopathological grading of osteochondral tissue using contrast-enhanced micro-computed tomography

scientific article published on 9 June 2017

Ability of ultrasound backscattering to predict mechanical properties of bovine trabecular bone

scientific article published in July 2004

Ability of ultrasound imaging to detect erosions in a bone phantom model

scientific article published on 19 July 2010

Adaptive segmentation of knee radiographs for selecting the optimal ROI in texture analysis

scientific article published on 20 March 2020

Age-related changes in organization and content of the collagen matrix in rabbit cortical bone

scientific article published on 22 August 2011

Alterations in structural macromolecules and chondrocyte deformations in lapine retropatellar cartilage 9 weeks after anterior cruciate ligament transection.

scientific article

An Automatic Regularization Method: An Application for 3-D X-Ray Micro-CT Reconstruction Using Sparse Data

scientific article published on 16 August 2018

Anterior cruciate ligament transection alters the n-3/n-6 fatty acid balance in the lapine infrapatellar fat pad

scientific article published on 18 March 2019

Anterior cruciate ligament transection of rabbits alters composition, structure and biomechanics of articular cartilage and chondrocyte deformation 2 weeks post-surgery in a site-specific manner

scientific article published on 23 October 2019

Application of a semi-automatic cartilage segmentation method for biomechanical modeling of the knee joint

scientific article

Application of second derivative spectroscopy for increasing molecular specificity of fourier transform infrared spectroscopic imaging of articular cartilage

scientific article published in May 2012

Arthroscopic Ultrasound Assessment of Articular Cartilage in the Human Knee Joint: A Potential Diagnostic Method.

scientific article

Arthroscopic Ultrasound Technique for Simultaneous Quantitative Assessment of Articular Cartilage and Subchondral Bone: An In Vitro and In Vivo Feasibility Study

scientific article published in August 2013

Assessment of meniscus with adiabatic T1ρ and T2ρ relaxation time in asymptomatic subjects and patients with mild osteoarthritis: a feasibility study.

scientific article published on 18 December 2017

Assessment of myocardial perfusion with MRI using a modified dual bolus method

scientific article published on 27 February 2014

Assessment of risk of femoral neck fracture with radiographic texture parameters: a retrospective study.

scientific article published on 9 March 2014

Association between quantitative MRI and ICRS arthroscopic grading of articular cartilage

scientific article published on 11 September 2014

Association between radiography-based subchondral bone structure and MRI-based cartilage composition in postmenopausal women with mild osteoarthritis.

scientific article

Association between subchondral bone structure and osteoarthritis histopathological grade.

scientific article

Associations between MRI-defined structural pathology and generalized and localized knee pain - the Oulu Knee Osteoarthritis study

scientific article

Atlas-based knee osteophyte assessment with ultrasonography and radiography: relationship to arthroscopic degeneration of articular cartilage.

scientific article published in September 2015

Automated analysis of rabbit knee calcified cartilage morphology using micro-computed tomography and deep learning

scientific article published on 29 March 2021

Automatic Grading of Individual Knee Osteoarthritis Features in Plain Radiographs Using Deep Convolutional Neural Networks

scientific article published on 10 November 2020

Automatic Knee Osteoarthritis Diagnosis from Plain Radiographs: A Deep Learning-Based Approach

scientific article

Automating three-dimensional osteoarthritis histopathological grading of human osteochondral tissue using machine learning on contrast-enhanced micro-computed tomography

scientific article published on 10 May 2020

Biomechanical properties of knee articular cartilage

scientific article published in 2003

Bone Density and Texture from Minimally Post-Processed Knee Radiographs in Subjects with Knee Osteoarthritis

scientific article published on 14 February 2019

Bone healing in rabbit calvarial critical-sized defects filled with stem cells and growth factors combined with granular or solid scaffolds.

scientific article published on 19 January 2016

Cationic Contrast Agent Diffusion Differs Between Cartilage and Meniscus

scientific article published on 29 April 2016

Cell-tissue interactions in osteoarthritic human hip joint articular cartilage

scientific article

Characterization of Center Frequency and Bandwidth of Broadband Ultrasound Reflected by the Articular Cartilage to Subchondral Bone Interface

scientific article published in January 2011

Clinical Contrast-enhanced Computed Tomography with Semiautomatic Segmentation Provides Feasible Input for Computational Models of the Knee Joint

scientific article published on 01 October 2019

Clinimetrics of Ultrasound Pathologies in Osteoarthritis: SystematicLiterature Review and Meta-analysis ⬇️

scientific article published on 6 February 2018

Cluster analysis of infrared spectra can differentiate intact and repaired articular cartilage

scientific article

Cluster analysis of infrared spectra of rabbit cortical bone samples during maturation and growth

scientific article

Clustering of infrared spectra reveals histological zones in intact articular cartilage

scientific article published in February 2012

Collagen XIII-derived ectodomain regulates bone angiogenesis and intracortical remodeling

scientific article published on 17 June 2019

Combination of optical coherence tomography and near infrared spectroscopy enhances determination of articular cartilage composition and structure

scientific article published on 6 September 2017

Comparison between infrared and Raman spectroscopic analysis of maturing rabbit cortical bone

scientific article published in June 2011

Comparison of Diagnostic Performance of Semi-Quantitative Knee Ultrasound and Knee Radiography with MRI: Oulu Knee Osteoarthritis Study

scientific article

Comparison of bone texture between normal individuals and patients with Kashin-Beck disease from plain radiographs in knee

scientific article published in Scientific Reports

Comparison of different material models of articular cartilage in 3D computational modeling of the knee: Data from the Osteoarthritis Initiative (OAI).

scientific article

Comparison of nonlinear mechanical properties of bovine articular cartilage and meniscus.

scientific article published on 19 October 2013

Comparison of ultrasound and optical coherence tomography techniques for evaluation of integrity of spontaneously repaired horse cartilage

scientific article published on 01 April 2012

Composition, structure and tensile biomechanical properties of equine articular cartilage during growth and maturation

scientific article published on 27 July 2018

Comprehensive optimization process of paranasal sinus radiography.

scientific article published on April 2009

Contrast-Enhanced Computed Tomography Enables Quantitative Evaluation of Tissue Properties at Intrajoint Regions in Cadaveric Knee Cartilage

scientific article published in September 2016

Correlation of Subchondral Bone Density and Structure from Plain Radiographs with Micro Computed Tomography Ex Vivo

scientific article

Correlations of low-field NMR and variable-field NMR parameters with osteoarthritis in human articular cartilage under load

scientific article published on 24 May 2017

Corrigendum to "In Vivo Quantitative Ultrasound Image Analysis of Femoral Subchondral Bone in Knee Osteoarthritis".

scientific article

Corrigendum to "Multimodality scoring of chondral injuries in the equine fetlock joint ex vivo" [Osteoarthritis Cartilage 25 (5) (2017 May) 790-798].

scientific article published on 26 May 2017

DeepKnee: Towards open source fully-automatic Kellgren-Lawrence grading

scientific article published in 2019

Delivering Agents Locally into Articular Cartilage by Intense MHz Ultrasound

scientific article

Dependence of light attenuation and backscattering on collagen concentration and chondrocyte density in agarose scaffolds

scientific article published on 13 October 2014

Depth-wise progression of osteoarthritis in human articular cartilage: investigation of composition, structure and biomechanics

scientific article published on 29 August 2009

Design and development of poly-L/D-lactide copolymer and barium titanate nanoparticle 3D composite scaffolds using breath figure method for tissue engineering applications

scientific article published on 13 December 2020

Detecting hip osteoarthritis on clinical CT: a deep learning application based on 2-D summation images derived from CT

scientific article published on 02 September 2021

Detection of experimental cartilage damage with acoustic emissions technique: An in vitro equine study

scientific article published on 06 June 2019

Determining collagen distribution in articular cartilage using contrast-enhanced micro-computed tomography

scientific article published on 20 May 2015

Development of osteoarthritis in patients with degenerative meniscal tears treated with exercise therapy or surgery: a randomized controlled trial

scientific article published on 14 March 2020

Diagnostic performance of knee ultrasonography for detecting degenerative changes of articular cartilage

scientific article published in May 2012

Differences in tibial subchondral bone structure evaluated using plain radiographs between knees with and without cartilage damage or bone marrow lesions - the Oulu Knee Osteoarthritis study

scientific article published on 24 April 2017

Discrimination of Low-Energy Acetabular Fractures from Controls Using Computed Tomography-Based Bone Characteristics

scientific article published on 09 July 2020

Dual energy x-ray laser measurement of calcaneal bone mineral density.

scientific article

Early arthritis induces disturbances at bone nanostructural level reflected in decreased tissue hardness in an animal model of arthritis

scientific article published on 9 January 2018

Effect of celastrol on bone structure and mechanics in arthritic rats

scientific article published on 14 September 2017

Effect of centrifugal force on the development of articular neocartilage with bovine primary chondrocytes

article

Effects of Articular Cartilage Constituents on Phosphotungstic Acid Enhanced Micro-Computed Tomography

scientific article

Effects of Estrogen Level, Dietary Loading, and Aging on Types I, II, and X Collagen Expression and Structure of Rat Mandibular Condylar Cartilage

scientific article published on 01 September 2020

Effects of Ultrasound Beam Angle and Surface Roughness on the Quantitative Ultrasound Parameters of Articular Cartilage

scientific article published in August 2009

Effects of optical beam angle on quantitative optical coherence tomography (OCT) in normal and surface degenerated bovine articular cartilage

scientific article published on 30 December 2010

Effects of tofacitinib in early arthritis-induced bone loss in an adjuvant-induced arthritis rat model

scientific article published on 01 February 2019

Effects of tofacitinib in early arthritis-induced bone loss in an adjuvant-induced arthritis rat model

scientific article published on 01 August 2018

Effects of ultrasound frequency, temporal sampling frequency, and spatial sampling step on the quantitative ultrasound parameters of articular cartilage

scientific article published in July 2009

Elastic, Viscoelastic and Fibril-Reinforced Poroelastic Material Properties of Healthy and Osteoarthritic Human Tibial Cartilage

scientific article published on 28 January 2019

Electrical and dielectric properties of bovine trabecular bone relationships with mechanical properties and mineral density

scientific article published on March 21, 2003

Electromechanical properties of human osteoarthritic and asymptomatic articular cartilage are sensitive and early detectors of degeneration.

scientific article published on 8 December 2017

Elevated adiabatic T1ρ and T2ρ in articular cartilage are associated with cartilage and bone lesions in early osteoarthritis: A preliminary study

scientific article published on 24 January 2017

Erratum: Comparison of Diagnostic Performance of Semi-Quantitative Knee Ultrasound and Knee Radiography with MRI: Oulu Knee Osteoarthritis Study.

scientific article published on 16 September 2016

Estimation of the Effect of Body Weight on the Development of Osteoarthritis Based on Cumulative Stresses in Cartilage: Data from the Osteoarthritis Initiative.

scientific article published on 26 December 2017

Experimental and numerical validation for the novel configuration of an arthroscopic indentation instrument

scientific article published on 20 May 2003

Fourier transform infrared spectroscopic imaging and multivariate regression for prediction of proteoglycan content of articular cartilage

scientific article

Histochemical quantification of collagen content in articular cartilage

scientific article published on 07 November 2019

Hypotonic challenge modulates cell volumes differently in the superficial zone of intact articular cartilage and cartilage explant

scientific article

Imaging of Osteoarthritic Human Articular Cartilage using Fourier Transform Infrared Microspectroscopy Combined with Multivariate and Univariate Analysis

scientific article

Imaging of subchondral bone by optical coherence tomography upon optical clearing of articular cartilage

scientific article published on 22 June 2015

In vivo quantitative ultrasound image analysis of femoral subchondral bone in knee osteoarthritis

scientific article published on 27 May 2013

In-Vitro Comparison of Time-Domain, Frequency-Domain and Wavelet Ultrasound Parameters in Diagnostics of Cartilage Degeneration

scientific article published in January 2008

Infrared microspectroscopic determination of collagen cross-links in articular cartilage.

scientific article published in March 2017

Infrared spectroscopic analysis of human and bovine articular cartilage proteoglycans using carbohydrate peak or its second derivative

scientific article published in September 2013

Infrared spectroscopy indicates altered bone turnover and remodeling activity in renal osteodystrophy

scientific article published in June 2010

Infrared spectroscopy reveals both qualitative and quantitative differences in equine subchondral bone during maturation.

scientific article published in November 2010

In vitro method for 3D morphometry of human articular cartilage chondrons based on micro-computed tomography

scientific article published on 23 May 2018

In vivo comparison of delayed gadolinium-enhanced MRI of cartilage and delayed quantitative CT arthrography in imaging of articular cartilage.

scientific article published on 26 December 2012

Iterative and discrete reconstruction in the evaluation of the rabbit model of osteoarthritis

scientific article published in Scientific Reports

Laser-ultrasonic delivery of agents into articular cartilage.

scientific article

Local Binary Patterns to Evaluate Trabecular Bone Structure from Micro-CT Data: Application to Studies of Human Osteoarthritis

scientific article published in 2015

Localization of sentinel nodes in breast cancer: novel method and device to help pen marking of active nodes during gamma camera imaging

scientific article published on 16 March 2005

Localized delivery of compounds into articular cartilage by using high-intensity focused ultrasound

scientific article published on 04 November 2019

Low-Field NMR Relaxation Times Distributions and Their Magnetic Field Dependence as a Possible Biomarker in Cartilage

scientific article published on 13 June 2017

Machine Learning Classification of Articular Cartilage Integrity Using Near Infrared Spectroscopy

scientific article published on 09 March 2020

Magnetic resonance imaging (MRI)-defined cartilage degeneration and joint pain are associated with poor physical function in knee osteoarthritis – the Oulu Knee Osteoarthritis study

scientific article published on 08 July 2017

Mechano-acoustic determination of Young's modulus of articular cartilage

scientific article published in 2004

Mechano-acoustic diagnosis of cartilage degeneration and repair

scientific article published in 2003

Method for Segmentation of Knee Articular Cartilages Based on Contrast-Enhanced CT Images

scientific article published on 21 August 2018

Micro-CT Analysis of Bone Healing in Rabbit Calvarial Critical-Sized Defects with Solid Bioactive Glass, Tricalcium Phosphate Granules or Autogenous Bone

scientific article published on April 2016

Micro-Scale Distribution of CA4+ in Ex vivo Human Articular Cartilage Detected with Contrast-Enhanced Micro-Computed Tomography Imaging

scientific article published on 31 August 2017

Mineralization of dental tissues and caries lesions detailed with Raman microspectroscopic imaging

scientific article published on 09 December 2020

Minimally invasive ultrasound method for intra-articular diagnostics of cartilage degeneration.

scientific article published on 26 June 2009

Multimodal Machine Learning-based Knee Osteoarthritis Progression Prediction from Plain Radiographs and Clinical Data

scientific article published on 27 December 2019

Multimodality scoring of chondral injuries in the equine fetlock joint ex vivo.

scientific article

Multiparametric MR imaging reveals early cartilage degeneration at 2 and 8 weeks after ACL transection in a rabbit model

scientific article published on 04 March 2020

Multiparametric MRI assessment of human articular cartilage degeneration: Correlation with quantitative histology and mechanical properties.

scientific article

Nanotechnological Strategies for Osteoarthritis Diagnosis, Monitoring, Clinical Management, and Regenerative Medicine: Recent Advances and Future Opportunities

scientific article published on 04 April 2020

Near Infrared Spectroscopy Enables Differentiation of Mechanically and Enzymatically Induced Cartilage Injuries

scientific article published on 16 April 2020

Novel mechano-acoustic technique and instrument for diagnosis of cartilage degeneration

scientific article published on 22 May 2002

Optical coherence tomography enables accurate measurement of equine cartilage thickness for determination of speed of sound.

scientific article

Optical spectral imaging of degeneration of articular cartilage.

scientific article published in July 2010

Optical spectral reflectance of human articular cartilage - relationships with tissue structure, composition and mechanical properties

scientific article

Optimal variable selection for Fourier transform infrared spectroscopic analysis of articular cartilage composition

scientific article published in February 2014

Orientation anisotropy of quantitative MRI relaxation parameters in ordered tissue

scientific article

Osteoarthritis Year In Review 2018: Imaging

article

Power Doppler ultrasonography and synovitis: correlating ultrasound imaging with histopathological findings and evaluating the performance of ultrasound equipments

scientific article published on 17 May 2006

Prediction of compressive stiffness of articular cartilage using Fourier transform infrared spectroscopy

scientific article published on 26 March 2013

Proteoglycan and collagen sensitive MRI evaluation of normal and degenerated articular cartilage.

scientific article published in May 2004

Quantification of Stiffness Change in Degenerated Articular Cartilage Using Optical Coherence Tomography-Based Air-Jet Indentation

scientific article published on 18 May 2011

Quantification of differences in bone texture from plain radiographs in knees with and without osteoarthritis

scientific article published on October 2014

Quantification of the optical surface reflection and surface roughness of articular cartilage using optical coherence tomography

scientific article published on 28 October 2009

Quantifying Complex Micro-Topography of Degenerated Articular Cartilage Surface by Contrast-Enhanced Micro-Computed Tomography and Parametric Analyses

scientific article published on 05 March 2019

Quantifying Subresolution 3D Morphology of Bone with Clinical Computed Tomography

scientific article published on 03 October 2019

Quantitative Analysis of Musculoskeletal Ultrasound: Techniques and Clinical Applications.

scientific article published on 30 April 2017

Quantitative Information From Ultrasound Evaluation of Articular Cartilage Should Be Interpreted With Care

scientific article published in October 2007

Quantitative analysis of spatial proteoglycan content in articular cartilage with Fourier transform infrared imaging spectroscopy: Critical evaluation of analysis methods and specificity of the parameters

scientific article

Quantitative assessment of articular cartilage using high-frequency ultrasound: research findings and diagnostic prospects.

scientific article published on January 2009

Quantitative assessment of articular cartilage with morphologic, acoustic and mechanical properties obtained using high-frequency ultrasound.

scientific article published in March 2010

Quantitative evaluation of spontaneously and surgically repaired rabbit articular cartilage using intra-articular ultrasound method in situ.

scientific article published in May 2010

Quantitative susceptibility mapping of articular cartilage: Ex vivo findings at multiple orientations and following different degradation treatments

scientific article published on 24 April 2018

Quantitative ultrasound imaging detects degenerative changes in articular cartilage surface and subchondral bone.

scientific article published on 3 October 2006

Quantitative ultrasound imaging of spontaneous repair of porcine cartilage

scientific article published in March 2006

Raccoon dog model shows preservation of bone during prolonged catabolism and reduced physical activity.

scientific article

Raman microspectroscopic analysis of the tissue-specific composition of the human osteochondral junction in osteoarthritis: A pilot study

scientific article published on 17 February 2020

Rapid CT-based Estimation of Articular Cartilage Biomechanics in the Knee Joint Without Cartilage Segmentation

scientific article published on 11 November 2020

Recent advances in understanding the phenotypes of osteoarthritis

scientific article published on 12 December 2019

Reversible Data Hiding in FTIR Microspectroscopy Images with Tamper Indication and Payload Error Correction

scientific article published on 13 November 2017

Semixup: In-and Out-of-Manifold Regularization for Deep Semi-Supervised Knee Osteoarthritis Severity Grading from Plain Radiographs

scientific article published on 17 August 2020

Simulation of Subject-Specific Progression of Knee Osteoarthritis and Comparison to Experimental Follow-up Data: Data from the Osteoarthritis Initiative

scientific article

Site-specific glycosaminoglycan content is better maintained in the pericellular matrix than the extracellular matrix in early post-traumatic osteoarthritis.

scientific article published on 25 April 2018

Site-specific ultrasound reflection properties and superficial collagen content of bovine knee articular cartilage

scientific article published on 28 June 2005

Specificity of Fourier Transform Infrared (FTIR) Microspectroscopy to Estimate Depth-Wise Proteoglycan Content in Normal and Osteoarthritic Human Articular Cartilage

scientific article

Speed of sound in normal and degenerated bovine articular cartilage

scientific article published in March 2003

Standard radiography: untapped potential in the assessment of osteoporotic fracture risk.

scientific article

State of the Art: Imaging of Osteoarthritis-Revisited 2020

scientific article published on 19 May 2020

Structural and Compositional Changes in Peri- and Extracellular Matrix of Osteoarthritic Cartilage Modulate Chondrocyte Morphology

scientific article published on 18 May 2011

Structural risk factors for low-energy acetabular fractures

scientific article published on 05 July 2019

Structure-Function Relationships of Healthy and Osteoarthritic Human Tibial Cartilage: Experimental and Numerical Investigation

scientific article published on 09 July 2020

Structure-function relationships of human meniscus.

scientific article

Structure-symptom relationship with wide-area ultrasound scanning of knee osteoarthritis.

scientific article

Subchondral bone histology and grading in osteoarthritis

scientific article

The bright ultra-short echo time SWIFT MRI signal at the osteochondral junction is not located in the calcified cartilage

scientific article published on 16 June 2020

The effect of body configuration on the strain magnitude and distribution within the acetabulum during sideways falls: A finite element approach

scientific article published on 01 December 2020

The effect of collagen degradation on chondrocyte volume and morphology in bovine articular cartilage following a hypotonic challenge.

scientific article

Three-dimensional microstructure of human meniscus posterior horn in health and osteoarthritis

scientific article published on 10 July 2019

Trabecular and subchondral bone development of the talus and distal tibia from foal to adult in the warmblood horse

scientific article published on 27 February 2018

Trabecular homogeneity index derived from plain radiograph to evaluate bone quality.

scientific article

Ultrasonic quantitation of superficial degradation of articular cartilage.

scientific article published in June 2004

Ultrasonography of the late-stage knee osteoarthritis prior to total knee arthroplasty: comparison of the ultrasonographic, radiographic and intra-operative findings

scientific article published in Scientific Reports

Ultrasound arthroscopy of human knee cartilage and subchondral bone in vivo.

scientific article published on 9 July 2014

Ultrasound attenuation in normal and spontaneously degenerated articular cartilage

scientific article published in April 2004

Ultrasound evaluation of mechanical injury of bovine knee articular cartilage under arthroscopic control.

scientific article published in January 2011

Ultrasound indentation of bovine knee articular cartilage in situ.

scientific article published on September 2003

Ultrasound indentation of normal and spontaneously degenerated bovine articular cartilage

scientific article published on 01 September 2003

Undersulfated chondroitin sulfate does not increase in osteoarthritic cartilage

scientific article published in December 2004

Use of air-steroid-saline mixture as contrast medium in greyscale ultrasound imaging: experimental study and practical applications in rheumatology

scientific article published on 01 May 2005

Variable angle gray level co-occurrence matrix analysis of T2 relaxation time maps reveals degenerative changes of cartilage in knee osteoarthritis: Oulu knee osteoarthritis study

scientific article

Verification of palpation-guided intra-articular injections using glucocorticoid-air-saline mixture and ultrasound imaging (GAS-graphy)

scientific article published on 01 May 2006

Volumetric Assessment of Bone Microstructures by a 3D Local Binary Patterns –Based Method: Bone Changes with Osteoarthritis

scientific article published on 13 June 2017

WS2 and MoS2 thin film gas sensors with high response to NH3 in air at low temperature

scientific article published on 27 June 2019

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