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List of works by Shimon Efrat

A qualitative difference in the interleukin 2 (IL-2) requirement of helper and cytotoxic T lymphocytes

scientific article published in October 1984

Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele

scientific journal article

Adenovirus E3 MHC inhibitory genes but not TNF/Fas apoptotic inhibitory genes expressed in beta cells prevent autoimmune diabetes

scientific article

Adenovirus early region 3 antiapoptotic 10.4K, 14.5K, and 14.7K genes decrease the incidence of autoimmune diabetes in NOD mice

article

Adenovirus early region 3(E3) immunomodulatory genes decrease the incidence of autoimmune diabetes in NOD mice.

scientific article

Baculovirus p35 increases pancreatic beta-cell resistance to apoptosis

scientific article

Beta-Cell Dedifferentiation in Type 2 Diabetes: Concise Review

scientific article published on 31 July 2019

Beta-cell expansion for therapeutic compensation of insulin resistance in type 2 diabetes

scientific article published on 01 January 2003

Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene

scientific article

Beta-cell replacement for insulin-dependent diabetes mellitus

scientific article published on 11 October 2007

Cell replacement therapy for type 1 diabetes

scientific article

Cell therapy approaches for the treatment of diabetes.

scientific article

Cell-based therapy for insulin-dependent diabetes mellitus ⬇️

scientific article published on February 1, 1998

Cell-specific Expression and Regulation of a Glucokinase Gene Locus Transgene

scientific article published in Journal of Biological Chemistry

Clonal insulinoma cell line that stably maintains correct glucose responsiveness.

scientific article published on December 1994

Control of biologically active interleukin 2 messenger RNA formation in induced human lymphocytes.

scientific article

Coordinate expression of the endogenous p53 gene in beta cells of transgenic mice expressing hybrid insulin-SV40 T antigen genes

scientific article published on September 1987

Development of engineered pancreatic beta-cell lines for cell therapy of diabetes.

scientific article

Development of human insulin-producing cells for cell therapy of diabetes

scientific article published on December 1, 2011

Differentiation of human liver-derived, insulin-producing cells toward the beta-cell phenotype

scientific article published in September 2005

Divalent Metal Transporter 1 Regulates Iron-Mediated ROS and Pancreatic β Cell Fate in Response to Cytokines

article

Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells

scientific article published in July 2011

Epithelial-mesenchymal transition in cells expanded in vitro from lineage-traced adult human pancreatic beta cells

scientific article

Evidence for threshold effects in transformation of pancreatic beta cells by SV40 T antigen in transgenic mice

scientific article published on 01 January 1989

Ex-vivo Expansion of Adult Human Pancreatic Beta-Cells

scientific article published on 10 August 2008

Expansion and redifferentiation of adult human pancreatic islet cells

scientific article published on 19 January 2006

Expression of adenoviral E3 transgenes in beta cells prevents autoimmune diabetes

scientific article published on September 1997

Functional analysis of a conditionally transformed pancreatic beta-cell line ⬇️

scientific article published on September 1, 1998

Generation of insulin-producing cells from human bone marrow mesenchymal stem cells by genetic manipulation

scientific article published on 05 July 2007

Generation of surrogate beta cells from tissue stem cells

scientific article published in August 2004

Genetically engineered pancreatic beta-cell lines for cell therapy of diabetes.

scientific article

Glucagon gene regulatory region directs oncoprotein expression to neurons and pancreatic alpha cells

scientific article published on 01 September 1988

Glucose induces insulin gene transcription in a murine pancreatic beta-cell line ⬇️

scientific article published on June 15, 1991

Glucose transporter isotypes switch in T-antigen-transformed pancreatic beta cells growing in culture and in mice

scientific article published on January 1992

Growth factor-dependent proliferation of the pancreatic beta-cell line betaTC-tet: an assay for beta-cell mitogenic factors

scientific article

HES-1 is involved in adaptation of adult human beta-cells to proliferation in vitro

scientific article published on 3 July 2008

In Vitro Proliferation of Cells Derived From Adult Human  -Cells Revealed By Cell-Lineage Tracing

scientific article (publication date: 3 March 2008)

In situ glucose uptake and glucokinase activity of pancreatic islets in diabetic and obese rodents

scientific article

In vitro expansion and redifferentiation of adult human islet cells

In vitro expansion of human beta cells

scientific article published on 29 April 2008

Inducible and reversible beta-cell autoimmunity and hyperplasia in transgenic mice expressing a conditional oncogene

scientific article published on 01 October 2001

Inhibition of ZEB1 expression induces redifferentiation of adult human β cells expanded in vitro

scientific article

Inhibition of islet amyloid polypeptide fibril formation: a potential role for heteroaromatic interactions

scientific article

Insulin-producing cells from tissue stem/progenitor cells: are autologous cells preferable to allogeneic?

scientific article published on 10 May 2005

Insulin-producing cells generated from dedifferentiated human pancreatic beta cells expanded in vitro

scientific article

Kinetics of induction and molecular size of mRNAs encoding human interleukin-2 and gamma-interferon

scientific article published in May 1982

Making sense of glucose sensing ⬇️

scientific article published on November 1, 1997

Making β cells from adult tissues

scientific article published on 25 April 2012

Mechanisms of adult human β-cell in vitro dedifferentiation and redifferentiation

scientific article published on September 2016

MiR-375 promotes redifferentiation of adult human β cells expanded in vitro

scientific article published on 13 April 2015

Preventing type 1 diabetes mellitus: the promise of gene therapy

scientific article

Prospects for gene therapy of insulin-dependent diabetes mellitus

scientific article published in December 1998

Prospects for treatment of type 2 diabetes by expansion of the beta-cell mass.

scientific article published on February 2001

Prospects of Stem Cell Therapy in Diabetes - Introduction to the RDS Special Issue ⬇️

scientific article published on August 10, 2010

Recent progress in generation of human surrogate β cells

scientific article published on August 2013

Redifferentiation of adult human β cells expanded in vitro by inhibition of the WNT pathway

scientific article

Redifferentiation of expanded human islet β cells by inhibition of ARX.

scientific article published on 09 February 2016

Redifferentiation of expanded human pancreatic β-cell-derived cells by inhibition of the NOTCH pathway

scientific article

Regulation of Human Interleukin-2 and Interferon-Gamma Gene Expression by Suppressor T Lymphocytes ⬇️

scientific article published on May 1, 1991

Regulation of insulin secretion from beta-cell lines derived from transgenic mice insulinomas resembles that of normal beta-cells

scientific article published on 01 June 1990

Regulation of insulin secretion: insights from engineered beta-cell lines

scientific article published on April 2004

Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells

scientific article

Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion

scientific journal article

Sexual dimorphism of pancreatic beta-cell degeneration in transgenic mice expressing an insulin-ras hybrid gene

scientific article published on 01 February 1991

Superinduction of human interleukin-2 messenger RNA by inhibitors of translation

scientific article published on 01 September 1984

TGFβ Pathway Inhibition Redifferentiates Human Pancreatic Islet β Cells Expanded In Vitro

scientific article published on 29 September 2015

The NOTCH pathway in β-cell growth and differentiation

scientific article published on January 2014

The pancreatic beta-cell glucose sensor.

scientific article published on December 1994

Time-sensitive reversal of hyperplasia in transgenic mice expressing SV40 T antigen

scientific article

Transplantation of β cells from transgenic mice into nude athymic diabetic rats restores glucose regulation ⬇️

scientific article published on December 1, 1991

[Val12] HRAS downregulates GLUT2 in beta cells of transgenic mice without affecting glucose homeostasis

scientific article

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