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List of works by Rudi Fasan

Aldehyde and Ketone Synthesis by P450-Catalyzed Oxidative Deamination of Alkyl Azides

scientific article published on 26 July 2016

Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis.

scientific article published on 08 August 2017

Biocatalytic Strategy for Highly Diastereo- and Enantioselective Synthesis of 2,3-Dihydrobenzofuran-Based Tricyclic Scaffolds

scientific article published on 24 June 2019

Biocatalytic Synthesis of Allylic and Allenyl Sulfides through a Myoglobin-Catalyzed Doyle-Kirmse Reaction.

scientific article published on 20 September 2016

Bioinspired strategy for the ribosomal synthesis of thioether-bridged macrocyclic peptides in bacteria

scientific article published on August 2014

C-H Amination via Nitrene Transfer Catalyzed by Mononuclear Non-Heme Iron-Dependent Enzymes

scientific article published on 18 March 2020

Chemo-enzymatic fluorination of unactivated organic compounds

scientific article

Chemoenzymatic synthesis and antileukemic activity of novel C9- and C14-functionalized parthenolide analogs.

scientific article published on 16 June 2016

Chemoselective Cyclopropanation over Carbene Y-H Insertion Catalyzed by an Engineered Carbene Transferase

scientific article published on 06 July 2018

Comprehensive Structure-Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C-H Functionalization

scientific article published on 28 April 2021

Controlled oxidation of remote sp3 C-H bonds in artemisinin via P450 catalysts with fine-tuned regio- and stereoselectivity

scientific article

Correction: Myoglobin-catalyzed intermolecular carbene N-H insertion with arylamine substrates

scientific article published on 01 January 2015

Cyclopropanations via Heme Carbenes: Basic Mechanism and Effects of Carbene Substituent, Protein Axial Ligand, and Porphyrin Substitution.

scientific article published on 22 December 2017

Design and Evolution of a Macrocyclic Peptide Inhibitor of the Sonic Hedgehog/Patched Interaction

scientific article published on 31 July 2017

Design, synthesis, and diversification of ribosomally derived peptide macrocycles

scientific article published on 12 July 2013

Designer macrocyclic organo-peptide hybrids inhibit the interaction between p53 and HDM2/X by accommodating a functional α-helix

scientific article published on 7 April 2014

Discovery of potent parthenolide-based antileukemic agents enabled by late-stage P450-mediated C-H functionalization

scientific article

Diverse organo-peptide macrocycles via a fast and catalyst-free oxime/intein-mediated dual ligation

scientific article published on 07 September 2011

Effect of proximal ligand substitutions on the carbene and nitrene transferase activity of myoglobin

scientific article published on 11 March 2019

Efficient conversion of primary azides to aldehydes catalyzed by active site variants of myoglobin

scientific article published on 28 September 2015

Emerging strategies to access peptide macrocycles from genetically encoded polypeptides

scientific article published on 29 March 2013

Engineered alkane-hydroxylating cytochrome P450(BM3) exhibiting nativelike catalytic properties

scientific article

Enhancing the efficiency and regioselectivity of P450 oxidation catalysts by unnatural amino acid mutagenesis.

scientific article

Enzymatic C(sp(3))-H Amination: P450-Catalyzed Conversion of Carbonazidates into Oxazolidinones

scientific article published on 29 January 2015

Enzymatic catalysis: New functional twists for P450s

scientific article published on 01 June 2017

Enzyme stabilization via computationally guided protein stapling

scientific article published on 6 November 2017

Evolutionary history of a specialized p450 propane monooxygenase

scientific article (publication date: 28 November 2008)

Expanded toolbox for directing the biosynthesis of macrocyclic peptides in bacterial cells

scientific article published on 27 May 2020

Exploiting and engineering hemoproteins for abiological carbene and nitrene transfer reactions

scientific article

Gram-Scale Synthesis of Chiral Cyclopropane-Containing Drugs and Drug Precursors with Engineered Myoglobin Catalysts Featuring Complementary Stereoselectivity.

scientific article published on 25 November 2016

Highly Diastereo- and Enantioselective Synthesis of Trifluoromethyl-Substituted Cyclopropanes via Myoglobin-Catalyzed Transfer of Trifluoromethylcarbene

scientific article published on 2 April 2017

Highly Stereoselective Synthesis of Fused Cyclopropane-γ-Lactams via Biocatalytic Iron-Catalyzed Intramolecular Cyclopropanation

scientific article published on 14 January 2020

Highly diastereo- and enantioselective synthesis of nitrile-substituted cyclopropanes via myoglobin-mediated carbene transfer catalysis

scientific article published on 05 November 2018

Highly diastereoselective and enantioselective olefin cyclopropanation using engineered myoglobin-based catalysts

scientific article published on 23 December 2014

Improved product-per-glucose yields in P450-dependent propane biotransformations using engineered Escherichia coli

scientific article published on 10 November 2010

Intermolecular carbene S-H insertion catalysed by engineered myoglobin-based catalysts†.

scientific article published on April 2015

Intramolecular C(sp(3))H amination of arylsulfonyl azides with engineered and artificial myoglobin-based catalysts.

scientific article

Macrocyclization of organo-peptide hybrids through a dual bio-orthogonal ligation: insights from structure-reactivity studies.

scientific article

Mechanistic Investigation of Biocatalytic Heme Carbenoid Si-H Insertions

scientific article published on 08 May 2019

Metal Substitution Modulates the Reactivity and Extends the Reaction Scope of Myoglobin Carbene Transfer Catalysts

scientific article published on 12 April 2017

Modular assembly of macrocyclic organo-peptide hybrids using synthetic and genetically encoded precursors.

scientific article

Myoglobin-Catalyzed C-H Functionalization of Unprotected Indoles

scientific article published on 06 July 2018

Myoglobin-Catalyzed Olefination of Aldehydes

scientific article published on 14 January 2016

Myoglobin-catalyzed intermolecular carbene N-H insertion with arylamine substrates

scientific article

Natural, engineered, and artificial biocatalysts for organic synthesis

scientific article

Organic solvent stability and long-term storage of myoglobin-based carbene transfer biocatalysts

scientific article published on 15 June 2020

Origin of high stereocontrol in olefin cyclopropanation catalyzed by an engineered carbene transferase

scientific article published on 28 December 2018

P450 fingerprinting method for rapid discovery of terpene hydroxylating P450 catalysts with diversified regioselectivity

scientific article published on 22 February 2011

P450-catalyzed intramolecular sp(3) C-H amination with arylsulfonyl azide substrates.

scientific article published on January 2014

Protein ligand design: from phage display to synthetic protein epitope mimetics in human antibody Fc-binding peptidomimetics

scientific article published in March 2006

Ribosomal Synthesis of Macrocyclic Peptides in Vitro and in Vivo Mediated by Genetically Encoded Aminothiol Unnatural Amino Acids

scientific article published on May 2015

Ribosomal Synthesis of Natural-Product-Like Bicyclic Peptides in Escherichia coli

scientific article

Ribosomal Synthesis of Thioether-Bridged Bicyclic Peptides.

scientific article

Selective Functionalization of Aliphatic Amines via Myoglobin-catalyzed Carbene N-H Insertion

scientific article published on 11 July 2019

Side-chain-to-tail cyclization of ribosomally derived peptides promoted by aryl and alkyl amino-functionalized unnatural amino acids

scientific article published on 11 April 2016

Stabilization of the Reductase Domain in the Catalytically Self-Sufficient Cytochrome P450BM3 via Consensus-Guided Mutagenesis.

scientific article published on 24 December 2017

Stereodivergent Intramolecular Cyclopropanation Enabled by Engineered Carbene Transferases

scientific article published on 29 May 2019

Stereoselective Cyclopropanation of Electron-Deficient Olefins with a Cofactor Redesigned Carbene Transferase Featuring Radical Reactivity

scientific article published on 05 September 2019

Stereoselective olefin cyclopropanation under aerobic conditions with an artificial enzyme incorporating an iron-chlorin e6 cofactor

scientific article published on 9 October 2017

Structure of Sonic Hedgehog protein in complex with zinc(II) and magnesium(II) reveals ion-coordination plasticity relevant to peptide drug design

scientific article published on 30 October 2019

Structure-activity studies in a family of beta-hairpin protein epitope mimetic inhibitors of the p53-HDM2 protein-protein interaction

scientific article published on 01 March 2006

Synthesis of bicyclic organo-peptide hybrids via oxime/intein-mediated macrocyclization followed by disulfide bond formation

scientific article published in February 2014

Synthesis of macrocyclic organo-peptide hybrids from ribosomal polypeptide precursors via CuAAC-/hydrazide-mediated cyclization

scientific article

Transcriptional coactivator PGC-1α contains a novel CBP80-binding motif that orchestrates efficient target gene expression.

scientific article published on 13 April 2018

Tuning Enzyme Thermostability via Computationally Guided Covalent Stapling and Structural Basis of Enhanced Stabilization

scientific article published on 25 May 2022

Tuning P450 Enzymes as Oxidation Catalysts

article

Two-Tier Screening Platform for Directed Evolution of Aminoacyl-tRNA Synthetases with Enhanced Stop Codon Suppression Efficiency

scientific article published on 6 April 2017

Using a beta-hairpin to mimic an alpha-helix: cyclic peptidomimetic inhibitors of the p53-HDM2 protein-protein interaction

scientific article

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