List of works - Aran F Labrijn

A novel human antibody against human immunodeficiency virus type 1 gp120 is V1, V2, and V3 loop dependent and helps delimit the epitope of the broadly neutralizing antibody immunoglobulin G1 b12.

scientific article

Antigen selection from an HIV-1 immune antibody library displayed on yeast yields many novel antibodies compared to selection from the same library displayed on phage.

scientific article

Bispecific antibodies: a mechanistic review of the pipeline

scientific article published on 01 August 2019

Broadly cross-reactive HIV-1-neutralizing human monoclonal Fab selected for binding to gp120-CD4-CCR5 complexes

scientific article

Controlled Fab-arm exchange for the generation of stable bispecific IgG1.

scientific article published on 25 September 2014

Crystal structure of the broadly cross-reactive HIV-1-neutralizing Fab X5 and fine mapping of its epitope

scientific article

Cysteine-SILAC Mass Spectrometry Enabling the Identification and Quantitation of Scrambled Interchain Disulfide Bonds: Preservation of Native Heavy-Light Chain Pairing in Bispecific IgGs Generated by Controlled Fab-arm Exchange.

scientific article published on 18 September 2017

Efficient Generation of Bispecific Murine Antibodies for Pre-Clinical Investigations in Syngeneic Rodent Models

scientific article

Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange.

scientific article published on 11 March 2013

Fab-arm exchange: what's in a name?

scientific article published on 6 September 2012

Fc-Fc interactions of human IgG4 require dissociation of heavy chains and are formed predominantly by the intra-chain hinge isomer

scientific article

Hinge-deleted IgG4 blocker therapy for acetylcholine receptor myasthenia gravis in rhesus monkeys

scientific article

Hitting Ebola, to the power of two.

scientific article published on October 2016

In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation

scientific article

Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen

scientific article published on 15 June 2016

Mutation of Y407 in the CH3 domain dramatically alters glycosylation and structure of human IgG

scientific article published on 13 February 2013

Opening the door to innovation

scientific article

Production of stable bispecific IgG1 by controlled Fab-arm exchange: scalability from bench to large-scale manufacturing by application of standard approaches.

scientific article published on 22 August 2013

Quantitative Analysis of the Interaction Strength and Dynamics of Human IgG4 Half Molecules by Native Mass Spectrometry

article

Species-Specific Determinants in the IgG CH3 Domain Enable Fab-Arm Exchange by Affecting the Noncovalent CH3-CH3 Interaction Strength

article

Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo

scientific article

When binding is enough: nonactivating antibody formats.

scientific article published on 09 July 2008

List of works by Aran F Labrijn

A novel human antibody against human immunodeficiency virus type 1 gp120 is V1, V2, and V3 loop dependent and helps delimit the epitope of the broadly neutralizing antibody immunoglobulin G1 b12.

Antigen selection from an HIV-1 immune antibody library displayed on yeast yields many novel antibodies compared to selection from the same library displayed on phage.

Bispecific antibodies: a mechanistic review of the pipeline

Broadly cross-reactive HIV-1-neutralizing human monoclonal Fab selected for binding to gp120-CD4-CCR5 complexes

Controlled Fab-arm exchange for the generation of stable bispecific IgG1.

Crystal structure of the broadly cross-reactive HIV-1-neutralizing Fab X5 and fine mapping of its epitope

Cysteine-SILAC Mass Spectrometry Enabling the Identification and Quantitation of Scrambled Interchain Disulfide Bonds: Preservation of Native Heavy-Light Chain Pairing in Bispecific IgGs Generated by Controlled Fab-arm Exchange.

Efficient Generation of Bispecific Murine Antibodies for Pre-Clinical Investigations in Syngeneic Rodent Models

Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange.

Fab-arm exchange: what's in a name?

Fc-Fc interactions of human IgG4 require dissociation of heavy chains and are formed predominantly by the intra-chain hinge isomer

Hinge-deleted IgG4 blocker therapy for acetylcholine receptor myasthenia gravis in rhesus monkeys

Hitting Ebola, to the power of two.

In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation

Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen

Mutation of Y407 in the CH3 domain dramatically alters glycosylation and structure of human IgG

Opening the door to innovation

Production of stable bispecific IgG1 by controlled Fab-arm exchange: scalability from bench to large-scale manufacturing by application of standard approaches.

Quantitative Analysis of the Interaction Strength and Dynamics of Human IgG4 Half Molecules by Native Mass Spectrometry

Species-Specific Determinants in the IgG CH3 Domain Enable Fab-Arm Exchange by Affecting the Noncovalent CH3-CH3 Interaction Strength

Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo

When binding is enough: nonactivating antibody formats.