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List of works by Helen Fletcher

A New Vaccine for Tuberculosis: The Challenges of Development and Deployment

scientific article published on 05 May 2009

A Phase I study evaluating the safety and immunogenicity of MVA85A, a candidate TB vaccine, in HIV-infected adults

scientific article (publication date: 2011)

A comparison of IFNgamma detection methods used in tuberculosis vaccine trials

scientific article published on 17 September 2008

A helicopter perspective on TB biomarkers: pathway and process based analysis of gene expression data provides new insight into TB pathogenesis

scientific article

A molecular assay for sensitive detection of pathogen-specific T-cells

scientific article

A new tool for tuberculosis vaccine screening: Ex vivo Mycobacterial Growth Inhibition Assay indicates BCG-mediated protection in a murine model of tuberculosis

scientific article

Adaption of the ex vivo mycobacterial growth inhibition assay for use with murine lung cells

scientific article published on 24 February 2020

Association of Human Antibodies to Arabinomannan With Enhanced Mycobacterial Opsonophagocytosis and Intracellular Growth Reduction

scientific article published on 07 April 2016

Big Data in Vaccinology: Introduction and section summaries

scientific article published in May 2015

Boosting BCG vaccination with MVA85A down-regulates the immunoregulatory cytokine TGF-beta1.

scientific article published on 03 August 2008

Boosting BCG with MVA85A: the first candidate subunit vaccine for tuberculosis in clinical trials

scientific article

Boosting BCG with recombinant modified vaccinia ankara expressing antigen 85A: different boosting intervals and implications for efficacy trials

scientific article

Cholera toxin enhances vaccine-induced protection against Mycobacterium tuberculosis challenge in mice

scientific article

Comparing human T cell and NK cell responses in viral-based malaria vaccine trials

scientific article

Comparing the safety and immunogenicity of a candidate TB vaccine MVA85A administered by intramuscular and intradermal delivery

scientific article

Correlates of immune protection from tuberculosis

scientific article published on May 2007

Corrigendum to “MIG (CXCL9) is a more sensitive measure than IFN-γ of vaccine induced T-cell responses in volunteers receiving investigated malaria vaccines” [J. Immunol. Methods 340 (2009) 33–41].

scientific article published in May 2011

Corrigendum: T-cell activation is an immune correlate of risk in BCG vaccinated infants

scientific article published on 6 May 2016

Differences in monocyte: lymphocyte ratio and Tuberculosis disease progression in genetically distinct populations of macaques

scientific article published on 04 March 2019

Distinct Transcriptional and Anti-Mycobacterial Profiles of Peripheral Blood Monocytes Dependent on the Ratio of Monocytes: Lymphocytes

scientific article published on 24 September 2015

Early clinical trials with a new tuberculosis vaccine, MVA85A, in tuberculosis-endemic countries: issues in study design

scientific article

Effect of vaccine dose on the safety and immunogenicity of a candidate TB vaccine, MVA85A, in BCG vaccinated UK adults

scientific article (publication date: 17 August 2012)

Evaluation of a human BCG challenge model to assess antimycobacterial immunity induced by BCG and a candidate tuberculosis vaccine, MVA85A, alone and in combination

scientific article

Evaluation of the prognostic value of IFN-gamma release assay and tuberculin skin test in household contacts of infectious tuberculosis cases in Senegal

scientific article

Gene expression and cytokine profile correlate with mycobacterial growth in a human BCG challenge model

scientific article

High monocyte to lymphocyte ratio is associated with impaired protection after subcutaneous administration of BCG in a mouse model of tuberculosis

scientific article published on 08 March 2018

Historical BCG vaccination combined with drug treatment enhances inhibition of mycobacterial growth ex vivo in human peripheral blood cells

scientific article published on 19 March 2019

Human biomarkers: can they help us to develop a new tuberculosis vaccine?

scientific article published on 20 May 2016

Identification of Pneumocystis carinii DNA by polymerase chain reaction in necropsy lung samples from children dying of respiratory tract illnesses

scientific article published in March 2002

Identification of Pneumocystis carinii DNA in oropharyngeal mouth washes from AIDS children dying of respiratory illnesses

scientific article published in April 2002

Immunological outcomes of new tuberculosis vaccine trials: WHO panel recommendations

scientific article

Increased expression of mRNA encoding interleukin (IL)-4 and its splice variant IL-4delta2 in cells from contacts of Mycobacterium tuberculosis, in the absence of in vitro stimulation.

scientific article

Individual-level factors associated with variation in mycobacterial-specific immune response: Gender and previous BCG vaccination status

scientific article

Inflammatory and myeloid-associated gene expression before and one day after infant vaccination with MVA85A correlates with induction of a T cell response

scientific article

Inhibition of mycobacterial growth in vitro following primary but not secondary vaccination with Mycobacterium bovis BCG.

scientific article published on 28 August 2013

Intracellular Cytokine Staining and Flow Cytometry: Considerations for Application in Clinical Trials of Novel Tuberculosis Vaccines

scientific article published on 14 September 2015

Investigating the induction of vaccine-induced Th17 and regulatory T cells in healthy, Mycobacterium bovis BCG-immunized adults vaccinated with a new tuberculosis vaccine, MVA85A

scientific article published on 19 May 2010

Investments in tuberculosis research - what are the gaps?

scientific article published on 25 August 2016

MIG (CXCL9) is a more sensitive measure than IFN-gamma of vaccine induced T-cell responses in volunteers receiving investigated malaria vaccines

scientific article published on 24 October 2008

MIG and the regulatory cytokines IL-10 and TGF-β1 correlate with malaria vaccine immunogenicity and efficacy

scientific article

Molecular analysis of Mycobacterium tuberculosis DNA from a family of 18th century Hungarians

scientific article published in January 2003

Mycobacterial growth inhibition in murine splenocytes as a surrogate for protection against Mycobacterium tuberculosis (M. tb).

scientific article

Peripheral blood monocyte-to-lymphocyte ratio at study enrollment predicts efficacy of the RTS,S malaria vaccine: analysis of pooled phase II clinical trial data

scientific article

Perspectives on Advances in Tuberculosis Diagnostics, Drugs, and Vaccines

scientific article

Polyfunctional CD4 T-cells correlate with in vitro mycobacterial growth inhibition following Mycobacterium bovis BCG-vaccination of infants

scientific article

Potent CD8+ T-cell immunogenicity in humans of a novel heterosubtypic influenza A vaccine, MVA-NP+M1.

scientific article

Process of assay selection and optimization for the study of case and control samples from a phase IIb efficacy trial of a candidate tuberculosis vaccine, MVA85A

scientific article

Profiling the host immune response to tuberculosis vaccines

scientific article published on August 2015

Profiling the host response to malaria vaccination and malaria challenge

scientific article

Progress and challenges in TB vaccine development

scientific article published on 16 February 2018

Quantitative PCR evaluation of cellular immune responses in Kenyan children vaccinated with a candidate malaria vaccine

scientific article published on 23 December 2009

Ratio of monocytes to lymphocytes in peripheral blood identifies adults at risk of incident tuberculosis among HIV-infected adults initiating antiretroviral therapy

scientific article published on 16 September 2013

Recognition of stage-specific mycobacterial antigens differentiates between acute and latent infections with Mycobacterium tuberculosis

scientific article

Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans

scientific article

Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin

scientific article published in Nature Communications

Roles for Treg expansion and HMGB1 signaling through the TLR1-2-6 axis in determining the magnitude of the antigen-specific immune response to MVA85A.

scientific article published on 03 July 2013

Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in healthy adults in South Africa

scientific article

Safety and immunogenicity of boosting BCG vaccinated subjects with BCG: comparison with boosting with a new TB vaccine, MVA85A

scientific article

Safety and immunogenicity of the candidate tuberculosis vaccine MVA85A in West Africa

scientific article

Sensitivity of IFN-gamma release assay to detect latent tuberculosis infection is retained in HIV-infected patients but dependent on HIV/AIDS progression

scientific article

Serum indoleamine 2,3-dioxygenase activity is associated with reduced immunogenicity following vaccination with MVA85A

scientific article

Single nucleotide polymorphisms in the Toll-like receptor 3 and CD44 genes are associated with persistence of vaccine-induced immunity to the serogroup C meningococcal conjugate vaccine

scientific article published on 28 December 2011

Sleeping Beauty and the Story of the Bacille Calmette-Guérin Vaccine

scientific article published on 30 August 2016

Social determinants and BCG efficacy: a call for a socio-biological approach to TB prevention.

scientific article published on 23 February 2018

Systematic tracking of altered haematopoiesis during sporozoite-mediated malaria development reveals multiple response points

scientific article

T-Cell Responses Are Associated with Survival in Acute Melioidosis Patients

scientific article published on 23 October 2015

T-cell activation is an immune correlate of risk in BCG vaccinated infants

scientific article published on 12 April 2016

TB vaccine development and the End TB Strategy: importance and current status.

scientific article

TRANSVAC workshop on standardisation and harmonisation of analytical platforms for HIV, TB and malaria vaccines: 'how can big data help?'.

scientific article

Th1/Th17 cell induction and corresponding reduction in ATP consumption following vaccination with the novel Mycobacterium tuberculosis vaccine MVA85A

scientific article (publication date: 2011)

The <i>in vitro</i> direct mycobacterial growth inhibition assay (MGIA) for the early evaluation of TB vaccine candidates and assessment of protective immunity: a protocol for non-human primate cells

publication published on 30 March 2021

The association between the ratio of monocytes: lymphocytes and risk of tuberculosis among HIV-infected postpartum women

scientific article

The convergent epidemiology of tuberculosis and human cytomegalovirus infection

scientific article

The prospective evaluation of a nested polymerase chain reaction assay for the early detection of Aspergillus infection in patients with leukaemia or undergoing allograft treatment

scientific article published on 01 December 2002

The ratio of monocytes to lymphocytes in peripheral blood correlates with increased susceptibility to clinical malaria in Kenyan children

scientific article

Transcriptional changes induced by candidate malaria vaccines and correlation with protection against malaria in a human challenge model

scientific article

Transcriptional profiling of mycobacterial antigen-induced responses in infants vaccinated with BCG at birth

scientific article

Tuberculosis vaccines: current status and future prospects

scientific article

Upregulation of TGF-beta, FOXP3, and CD4+CD25+ regulatory T cells correlates with more rapid parasite growth in human malaria infection

scientific article published on September 2005

VALIDATE: Exploiting the synergy between complex intracellular pathogens to expedite vaccine research and development for tuberculosis, leishmaniasis, melioidosis and leprosy.

scientific article

Widespread occurrence of Mycobacterium tuberculosis DNA from 18th-19th century Hungarians

scientific article

World TB Day 2018: The Challenge of Drug Resistant Tuberculosis

scientific article

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