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List of works by W David Wilson

A New Generation of Minor-Groove-Binding-Heterocyclic Diamidines That Recognize G·C Base Pairs in an AT Sequence Context

scientific article published on 07 March 2019

A modular design for minor groove binding and recognition of mixed base pair sequences of DNA.

scientific article

A novel approach using electrospray ionization mass spectrometry to study competitive binding of small molecules with mixed DNA sequences.

scientific article

A short DNA sequence confers strong bleomycin binding to hairpin DNAs

scientific article

AzaHx, a novel fluorescent, DNA minor groove and G·C recognition element: Synthesis and DNA binding properties of a p-anisyl-4-aza-benzimidazole-pyrrole-imidazole (azaHx-PI) polyamide.

scientific article published on 19 June 2015

Binding to the DNA Minor Groove by Heterocyclic Dications: From AT‐Specific Monomers to GC Recognition with Dimers ⬇️

scientific article published on December 1, 2012

Bound Compound, Interfacial Water, and Phenyl Ring Rotation Dynamics of a Compound in the DNA Minor Groove

scientific article published on 09 August 2018

Compound Shape Effects in Minor Groove Binding Affinity and Specificity for Mixed Sequence DNA

article

Correlation of local effects of DNA sequence and position of β-alanine inserts with polyamide-DNA complex binding affinities and kinetics.

scientific article published on 28 November 2012

DNA Binding Polyamides and the Importance of DNA Recognition in their use as Gene-Specific and Antiviral Agents

scientific article published on February 2014

DNA-Binding Properties of New Fluorescent AzaHx Amides: Methoxypyridylazabenzimidazolepyrroleimidazole/pyrrole

scientific article published on 15 August 2018

Design and synthesis of heterocyclic cations for specific DNA recognition: from AT-rich to mixed-base-pair DNA sequences

scientific article published on 21 January 2014

Design, synthesis, and DNA binding characteristics of a group of orthogonally positioned diamino, N-formamido, pyrrole- and imidazole-containing polyamides

scientific article

Different thermodynamic signatures for DNA minor groove binding with changes in salt concentration and temperature

scientific article published on October 2013

Discovery of new G-quadruplex binding chemotypes

scientific article published on January 2014

Dynamic self-assembly of DNA minor groove-binding ligand DB921 into nanotubes triggered by an alkali halide.

scientific article

Extending the σ-Hole Motif for Sequence-Specific Recognition of the DNA Minor Groove

scientific article published on 15 April 2020

First Structure of a Designed Minor Groove Binding Heterocyclic Cation that Specifically Recognizes Mixed DNA Base Pair Sequences.

scientific article

Green fluorescent diamidines as diagnostic probes for trypanosomes

scientific article published on 23 December 2013

Heterocyclic Diamidine DNA Ligands as HOXA9 Transcription Factor Inhibitors: Design, Molecular Evaluation, and Cellular Consequences in a HOXA9-Dependant Leukemia Cell Model

scientific article published on 01 February 2019

Hx-amides: DNA sequence recognition by the fluorescent Hx (p-anisylbenzimidazole)•pyrrole and Hx•imidazole pairings.

scientific article

Imino proton NMR guides the reprogramming of A•T specific minor groove binders for mixed base pair recognition.

scientific article published on 29 April 2016

Lithium Hexamethyldisilazane Transformation of Transiently Protected 4-Aza/Benzimidazole Nitriles to Amidines and their Dimethyl Sulfoxide Mediated Imidazole Ring Formation

scientific article published on 8 September 2016

May the Best Molecule Win: Competition ESI Mass Spectrometry

scientific article

Mechanistic heterogeneity in site recognition by the structurally homologous DNA-binding domains of the ETS family transcription factors Ets-1 and PU.1.

scientific article

Mixed up minor groove binders: Convincing A·T specific compounds to recognize a G·C base pair

scientific article

Modulation of DNA-polyamide interaction by β-alanine substitutions: a study of positional effects on binding affinity, kinetics and thermodynamics.

scientific article published on October 2014

Modulation of topoisomerase IIα expression and chemosensitivity through targeted inhibition of NF-Y:DNA binding by a diamino p-anisyl-benzimidazole (Hx) polyamide

scientific article published on 14 October 2016

Molecular Basis for Sequence-Dependent Induced DNA Bending

scientific article

Novel amidines and analogues as promising agents against intracellular parasites: a systematic review

scientific article

Probing the electrostatics and pharmacological modulation of sequence-specific binding by the DNA-binding domain of the ETS family transcription factor PU.1: a binding affinity and kinetics investigation

scientific article published on 14 February 2013

Quantitative Investigation of Protein-Nucleic Acid Interactions by Biosensor Surface Plasmon Resonance.

scientific article

Resolution of mixed site DNA complexes with dimer-forming minor-groove binders by using electrospray ionization mass spectrometry: compound structure and DNA sequence effects

scientific article published on 20 February 2015

Second Generation G-Quadruplex Stabilizing Trimethine Cyanines

scientific article published on 26 September 2019

Selective G-quadruplex DNA recognition by a new class of designed cyanines

scientific article published on 4 November 2013

Small-molecule Binding to the DNA Minor Groove Is Mediated by a Conserved Water Cluster ⬇️

scientific article published on January 16, 2013

Strand invasion of DNA quadruplexes by PNA: comparison of homologous and complementary hybridization.

scientific article published on 19 July 2013

Structure-based design of flavone derivatives as c-myc oncogene down-regulators

scientific article published on 02 November 2012

Structure-dependent binding of arylimidamides to the DNA minor groove

scientific article published on 9 December 2013

Structure-dependent inhibition of the ETS-family transcription factor PU.1 by novel heterocyclic diamidines

scientific article published on 23 October 2013

Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues

scientific article published on 13 August 2013

Synthesis, DNA binding and antitrypanosomal activity of benzimidazole analogues of DAPI.

scientific article published on 3 November 2016

Systematic synthetic and biophysical development of mixed sequence DNA binding agents.

scientific article

The Thiophene "Sigma-Hole" as a Concept for Preorganized, Specific Recognition of G⋅C Base Pairs in the DNA Minor Groove

scientific article published on 14 September 2016

The unusual monomer recognition of guanine-containing mixed sequence DNA by a dithiophene heterocyclic diamidine

scientific article published on 13 February 2014

Understanding mixed sequence DNA recognition by novel designed compounds: the kinetic and thermodynamic behavior of azabenzimidazole diamidines

scientific article

Unexpected DNA Affinity and Sequence Selectivity through Core Rigidity in Guanidinium-Based Minor Groove Binders

scientific article published on 11 September 2014

YM155 inhibits topoisomerase function

scientific article published on 13 October 2016

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