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List of works by John D. Imig

11,12,20-Trihydroxy-eicosa-8(Z)-enoic acid: a selective inhibitor of 11,12-EET-induced relaxations of bovine coronary and rat mesenteric arteries ⬇️

scientific article published on February 3, 2012

12-Hydroxyeicosatetraenoic acid participates in angiotensin II afferent arteriolar vasoconstriction by activating L-type calcium channels

scientific article published in September 2003

14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) surrogates: carboxylate modifications

scientific article

20-HETE or EETs: which arachidonic acid metabolite regulates proximal tubule transporters and contributes to pressure natriuresis?

scientific article

20-hydroxyeicosatetraenoic acid and angiotensin: a positive feedback system to cause hypertension

scientific article published on 13 September 2010

ACE Inhibition and Bradykinin-Mediated Renal Vascular Responses: EDHF Involvement

scientific article

Adaptations of the renal microcirculation to hypertension.

scientific article

Adenosine2A receptors and epoxyeicosatrienoic acids: a recipe for salt and blood pressure regulation

scientific article published on 12 October 2009

Administration of a substituted adamantyl urea inhibitor of soluble epoxide hydrolase protects the kidney from damage in hypertensive Goto-Kakizaki rats.

scientific article published on January 2009

Afferent arteriolar dilation to 11, 12-EET analogs involves PP2A activity and Ca2+-activated K+ Channels.

scientific article published on February 2008

Afferent arteriolar reactivity to angiotensin II is enhanced during the early phase of angiotensin II hypertension

scientific article

Age-related alterations in NOS and oxidative stress in mesenteric arteries from male and female rats

scientific article

Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension

scientific article

Ang II accumulation in rat renal endosomes during Ang II-induced hypertension: role of AT(1) receptor

scientific article published in January 2002

Angiotensin II hypertension is attenuated in interleukin-6 knockout mice

scientific article published on 11 November 2005

Anti-inflammatory effects of ω-3 polyunsaturated fatty acids and soluble epoxide hydrolase inhibitors in angiotensin-II-dependent hypertension.

scientific article published on September 2013

Antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats is mediated by suppression of the intrarenal renin-angiotensin system.

scientific article published on April 2013

Antihypertensive and renoprotective actions of soluble epoxide hydrolase inhibition in ANG II-dependent malignant hypertension are abolished by pretreatment with L-NAME.

scientific article published on February 2013

Antihypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting.

scientific article published in September 2007

Azilsartan decreases renal and cardiovascular injury in the spontaneously hypertensive obese rat

scientific article published on 01 August 2014

Azilsartan improves glycemic status and reduces kidney damage in zucker diabetic fatty rats

scientific article published on 05 March 2014

Calcium Mobilization Contributes to Pressure-Mediated Afferent Arteriolar Vasoconstriction ⬇️

scientific article published on 01 January 1998

Calcium and chloride channel activation by angiotensin II-AT1 receptors in preglomerular vascular smooth muscle cells

scientific article published on 7 June 2005

Captopril attenuates hypertension and renal injury induced by the vascular endothelial growth factor inhibitor sorafenib.

scientific article published on May 2012

Cardiovascular therapeutic aspects of soluble epoxide hydrolase inhibitors.

scientific article published on January 2006

Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension

scientific article

Chemokine receptor 2b inhibition provides renal protection in angiotensin II - salt hypertension.

scientific article published on 15 October 2007

Combined inhibition of 20-hydroxyeicosatetraenoic acid formation and of epoxyeicosatrienoic acids degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats.

scientific article

Correction to 14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) Surrogates: Carboxylate Modifications

scholarly article published in Journal of Medicinal Chemistry

Cytochrome P450 eicosanoids and cerebral vascular function ⬇️

scientific article published on March 1, 2011

Cytochrome P450 epoxygenases provide a novel mechanism for penile erection

scientific article

Decreased epoxygenase and increased epoxide hydrolase expression in the mesenteric artery of obese Zucker rats

scientific article published on 2 September 2004

Decreased renal cytochrome P450 2C enzymes and impaired vasodilation are associated with angiotensin salt-sensitive hypertension.

scientific article published on 16 December 2002

Deletion of soluble epoxide hydrolase gene improves renal endothelial function and reduces renal inflammation and injury in streptozotocin-induced type 1 diabetes.

scientific article published on 10 August 2011

Development of epoxyeicosatrienoic acid analogs with in vivo anti-hypertensive actions

scientific article

Different mechanisms of acute versus long-term antihypertensive effects of soluble epoxide hydrolase inhibition: studies in Cyp1a1-Ren-2 transgenic rats.

scientific article published on December 2014

Downregulation of renal CYP-derived eicosanoid synthesis in rats with diet-induced hypertension

scientific article published on 25 August 2003

ETA and ETB receptors differentially modulate afferent and efferent arteriolar responses to endothelin

scientific article published in December 2005

Early diabetes mellitus stimulates proximal tubule renin mRNA expression in the rat

scientific article published on 01 December 2000

Effects of chronic cytochrome P-450 inhibition on the course of hypertension and end-organ damage in Ren-2 transgenic rats

scientific article published on 02 June 2007

Eicosanoids and renal damage in cardiometabolic syndrome.

scientific article

Eicosanoids and renal vascular function in diseases.

scientific article published on July 2006

Elevated Aminopeptidase P Attenuates Cerebral Arterial Responses to Bradykinin in Fawn-Hooded Hypertensive Rats

scientific article published on 18 December 2015

Elevated arterial pressure impairs autoregulation independently of AT(1) receptor activation

scientific article

Endothelial dysfunction and the development of renal injury in spontaneously hypertensive rats fed a high-fat diet

scientific article

Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice.

scientific article

Endothelin antagonism prevents early EGFR transactivation but not increased matrix metalloproteinase activity in diabetes

scientific article published on 20 October 2005

Enhanced renal microvascular reactivity to angiotensin II in hypertension is ameliorated by the sulfonimide analog of 11,12-epoxyeicosatrienoic acid

scientific article

Epigenetic Soluble Epoxide Hydrolase Regulation Causes Endothelial Dysfunction

scientific article published on 26 October 2018

Epoxide hydrolase and epoxygenase metabolites as therapeutic targets for renal diseases

scientific article

Epoxides and Soluble Epoxide Hydrolase in Cardiovascular Physiology ⬇️

scientific article published on January 1, 2012

Epoxyeicosatrienoic acid analog attenuates angiotensin II hypertension and kidney injury

scientific article

Epoxyeicosatrienoic acid analogue lowers blood pressure through vasodilation and sodium channel inhibition.

scientific article

Epoxyeicosatrienoic acids, 20-hydroxyeicosatetraenoic acid, and renal microvascular function

scientific article

Epoxyeicosatrienoic acids, hypertension, and kidney injury

scientific article

Epoxygenase metabolites contribute to nitric oxide-independent afferent arteriolar vasodilation in response to bradykinin

scientific article published in May 2001

Fructose stimulates Na/H exchange activity and sensitizes the proximal tubule to angiotensin II.

scientific article

Glomerular expression of kidney injury molecule-1 and podocytopenia in diabetic glomerulopathy.

scientific article

Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy.

scientific article

IL6 suppression provides renal protection independent of blood pressure in a murine model of salt-sensitive hypertension

scientific article published on 15 June 2007

Immune and inflammatory role in renal disease.

scientific article published on April 2013

Impaired Ca2+ signaling attenuates P2X receptor-mediated vasoconstriction of afferent arterioles in angiotensin II hypertension

scientific article published on 22 August 2005

Increased RhoA/Rho-kinase signaling mediates spontaneous tone in aorta from angiotensin II-induced hypertensive rats

scientific article published on 28 March 2006

Increased blood pressure in mice lacking cytochrome P450 2J5

scientific journal article

Increased renal proximal convoluted tubule transport contributes to hypertension in Cyp4a14 knockout mice

scientific article

Increased renal vascular reactivity to ANG II after unilateral nephrectomy in the rat involves 20-HETE

scientific article published on 04 May 2006

Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension.

scientific article

Inhibition of soluble epoxide hydrolase improves the impaired pressure–natriuresis relationship and attenuates the development of hypertension and hypertension-associated end-organ damage in Cyp1a1-Ren-2 transgenic rats ⬇️

scientific article published on August 1, 2011

Inhibition of soluble epoxide hydrolase is renoprotective in 5/6 nephrectomized Ren-2 transgenic hypertensive rats

scientific article (publication date: March 2014)

Inhibition of soluble epoxide hydrolase prevents renal interstitial fibrosis and inflammation.

scientific article

Intrarenal cytochrome P-450 metabolites of arachidonic acid in the regulation of the nonclipped kidney function in two-kidney, one-clip Goldblatt hypertensive rats.

scientific article

L-type calcium channels in the renal microcirculatory response to endothelin

scientific article published on 16 November 2004

Normalization of the ovarian cancer microenvironment by SPARC.

scientific article

Novel nitric oxide synthase--dependent mechanism of vasorelaxation in small arteries from hypertensive rats

scientific article published on 19 February 2007

Novel orally active epoxyeicosatrienoic acid (EET) analogs attenuate cisplatin nephrotoxicity.

scientific article published on 19 April 2013

Obesity induced renal oxidative stress contributes to renal injury in salt-sensitive hypertension.

scientific article published on 18 January 2009

Obesity is the major contributor to vascular dysfunction and inflammation in high-fat diet hypertensive rats

scientific article

Obesity, insulin resistance, and renal function.

scientific article published on June 2007

Orally active epoxyeicosatrienoic acid analog attenuates kidney injury in hypertensive Dahl salt-sensitive rat.

scientific article published on 26 August 2013

Orally active epoxyeicosatrienoic acid analog does not exhibit antihypertensive and reno- or cardioprotective actions in two-kidney, one-clip Goldblatt hypertensive rats.

scientific article published on 21 August 2015

P2X receptor-stimulated calcium responses in preglomerular vascular smooth muscle cells involves 20-hydroxyeicosatetraenoic acid

scientific article published on 17 August 2004

PPAR-alpha activator fenofibrate increases renal CYP-derived eicosanoid synthesis and improves endothelial dilator function in obese Zucker rats

scientific article published on 24 February 2006

Peroxisome proliferator-activated receptor-alpha activation reduces salt-dependent hypertension during chronic endothelin B receptor blockade

scientific journal article

Pharmacological inhibition of soluble epoxide hydrolase prevents renal interstitial fibrogenesis in obstructive nephropathy.

scientific article

Postglomerular vasoconstriction to angiotensin II and norepinephrine depends on intracellular calcium release

scientific article published on 01 June 2000

Protein phosphatase 2A and Ca2+-activated K+ channels contribute to 11,12-epoxyeicosatrienoic acid analog mediated mesenteric arterial relaxation

scientific article published on 07 November 2006

Renal AT1 receptor protein expression during the early stage of diabetes mellitus.

scientific article

Renal autoregulation in P2X1 knockout mice.

scientific article published in August 2004

Renal mechanisms contributing to the antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats with inducible hypertension

scientific article published on 01 January 2011

Renal uptake of circulating angiotensin II in Val5-angiotensin II infused rats is mediated by AT1 receptor

scientific article published in May 1998

Reply to "Letter to the editor: 'Concern regarding quantification of urinary nephrin by commercially available ELISA'"

scientific article published on 01 August 2015

Rofecoxib decreases renal injury in obese Zucker rats

scientific article

Role of cytochrome P-450 metabolites in the regulation of renal function and blood pressure in 2-kidney 1-clip hypertensive rats

scientific article

Roles of the cytochrome P450 arachidonic acid monooxygenases in the control of systemic blood pressure and experimental hypertension.

scientific article published on 27 June 2007

Salt-sensitive hypertension after exposure to angiotensin is associated with inability to upregulate renal epoxygenases

scientific article published on 04 August 2003

Simvastatin and tempol protect against endothelial dysfunction and renal injury in a model of obesity and hypertension.

scientific article

Soluble Epoxide Hydrolase Inhibition Exhibits Antihypertensive Actions Independently of Nitric Oxide in Mice with Renovascular Hypertension ⬇️

scientific article published on August 29, 2012

Soluble epoxide hydrolase contamination of specific catalase preparations inhibits epoxyeicosatrienoic acid vasodilation of rat renal arterioles.

scientific article

Soluble epoxide hydrolase deficiency alters pancreatic islet size and improves glucose homeostasis in a model of insulin resistance ⬇️

scientific article published on May 12, 2011

Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension

scientific journal article

Soluble epoxide inhibition is protective against cerebral ischemia via vascular and neural protection.

scientific article published on 12 May 2009

Substituted adamantyl-urea inhibitors of the soluble epoxide hydrolase dilate mesenteric resistance vessels

scientific article published on 13 June 2006

TNF-alpha inhibition reduces renal injury in DOCA-salt hypertensive rats

scientific article

Telmisartan provides better renal protection than valsartan in a rat model of metabolic syndrome.

scientific article published on 17 March 2011

The Bradykinin B2 receptor is required for full expression of renal COX-2 and renin

scientific article published in August 2003

The Cyp2c44 epoxygenase regulates epithelial sodium channel activity and the blood pressure responses to increased dietary salt.

scientific article published on 24 December 2013

The Roles of Intrarenal 20-Hydroxyeicosatetraenoic and Epoxyeicosatrienoic Acids in the Regulation of Renal Function in Hypertensive Ren-2 Transgenic Rats

scientific article published on 30 August 2007

Thioredoxin-interacting protein is required for endothelial NLRP3 inflammasome activation and cell death in a rat model of high-fat diet

scientific article published on 8 November 2013

Tumor necrosis factor alpha blockade increases renal Cyp2c23 expression and slows the progression of renal damage in salt-sensitive hypertension

scientific article published on 16 January 2006

Tumour necrosis factor-α contributes to improved cardiac ischaemic tolerance in rats adapted to chronic continuous hypoxia

scientific article published on 28 March 2015

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