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List of works by René P. Zahedi

"Watching the Detectives" report of the general assembly of the EU project DETECTIVE Brussels, 24-25 November 2015.

scientific article published on 29 April 2016

A Unique Morphological Phenotype in Chemoresistant Triple-Negative Breast Cancer Reveals Metabolic Reprogramming and PLIN4 Expression as a Molecular Vulnerability

scientific article published on 19 September 2019

A complex standard for protein identification, designed by evolution.

scientific article published on 13 September 2012

Alterations of the platelet proteome in type I Glanzmann thrombasthenia caused by different homozygous delG frameshift mutations in ITGA2B.

scientific article published on 12 January 2017

Amyloid-β peptide induces mitochondrial dysfunction by inhibition of preprotein maturation.

scientific article

An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development.

scientific article

An improved workflow for quantitative N-terminal charge-based fractional diagonal chromatography (ChaFRADIC) to study proteolytic events in Arabidopsis thaliana

scientific article

Analysis of Post-translational Modifications

Analysis of the membrane proteome of canine pancreatic rough microsomes identifies a novel Hsp40, termed ERj7.

scientific article

Assembly of nuclear pore complexes mediated by major vault protein.

scientific article published on 24 February 2009

Bottom-up proteomics suggests an association between differential expression of mitochondrial proteins and chronic fatigue syndrome

scientific article

Catch me if you can: mass spectrometry-based phosphoproteomics and quantification strategies.

scientific article published on 11 January 2011

Cellular Signature of SIL1 Depletion: Disease Pathogenesis due to Alterations in Protein Composition Beyond the ER Machinery

scientific article

Combined Quantification of the Global Proteome, Phosphoproteome, and Proteolytic Cleavage to Characterize Altered Platelet Functions in the Human Scott Syndrome.

scientific article

Comparative proteomic analysis of biofilm and planktonic cells of Neisseria meningitidis.

scientific article published on 17 November 2010

Comprehensive mutational analysis reveals p6Gag phosphorylation to be dispensable for HIV-1 morphogenesis and replication

scientific article published on 31 October 2012

Current strategies and findings in clinically relevant post-translational modification-specific proteomics

scientific article

Cytomegalovirus downregulates IRE1 to repress the unfolded protein response

scientific article

D-score: a search engine independent MD-score.

scientific article published on 15 February 2013

Detecting post-translational modification signatures as potential biomarkers in clinical mass spectrometry

scientific article published on 01 June 2018

Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors.

scientific article published on June 2017

Dual function of Sdh3 in the respiratory chain and TIM22 protein translocase of the mitochondrial inner membrane

scientific article

Effective assignment of α2,3/α2,6 sialic acid isomers in LC-MS/MS based glycoproteomics.

scientific article

EnhancedN-Glycosylation Site Analysis of Sialoglycopeptides by Strong Cation Exchange Prefractionation Applied to Platelet Plasma Membranes

article

Enrichment of Cross-Linked Peptides Using Charge-Based Fractional Diagonal Chromatography (ChaFRADIC).

scientific article

Fast, Efficient, and Quality-Controlled Phosphopeptide Enrichment from Minute Sample Amounts Using Titanium Dioxide

scientific article published on 01 January 2014

Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability

scientific article

High spatial and temporal resolution cell manipulation techniques in microchannels

scientific article published on 18 February 2016

Highly sensitive phosphoproteomics by tailoring solid-phase extraction to electrostatic repulsion-hydrophilic interaction chromatography

scientific article published on 13 January 2015

Homologous desensitization of guanylyl cyclase A, the receptor for atrial natriuretic peptide, is associated with a complex phosphorylation pattern

scientific article published on 26 April 2010

How iMALDI can improve clinical diagnostics

scientific article published on 01 May 2018

Hypoxia-induced p38 MAPK activation reduces Mcl-1 expression and facilitates sensitivity towards BH3 mimetics in chronic lymphocytic leukemia

scientific article published on 7 November 2014

INPP5K and SIL1 associated pathologies with overlapping clinical phenotypes converge through dysregulation of PHGDH

scientific article published on 31 March 2021

Identification of cleavage sites and substrate proteins for two mitochondrial intermediate peptidases in Arabidopsis thaliana

scientific article published on March 2015

Impact of digestion conditions on phosphoproteomics.

scientific article published on 7 May 2014

Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S

scientific article published on 04 October 2019

Insight into the Inhibition of Drug-Resistant Mutants of the Receptor Tyrosine Kinase EGFR

scientific article

Integral Quantification Accuracy Estimation for Reporter Ion-based Quantitative Proteomics (iQuARI)

scientific article published on 30 August 2012

Integration of polycarbonate membranes in microfluidic free-flow electrophoresis

scientific article published on 30 October 2017

Intermembrane space proteome of yeast mitochondria

scientific article

Joining forces: studying multiple post-translational modifications to understand dynamic disease mechanisms

scientific article published on 12 September 2016

Landscape of submitochondrial protein distribution.

scientific article published on 18 August 2017

Mass spectrometry-based protein analysis to unravel the tissue pathophysiology in Duchenne muscular dystrophy

scientific article published on 20 June 2017

Multi-OMICS: a critical technical perspective on integrative lipidomics approaches.

scientific article published on 10 February 2017

Multidimensional electrostatic repulsion-hydrophilic interaction chromatography (ERLIC) for quantitative analysis of the proteome and phosphoproteome in clinical and biomedical research

scientific article published on 22 January 2015

Mutations in INPP5K, Encoding a Phosphoinositide 5-Phosphatase, Cause Congenital Muscular Dystrophy with Cataracts and Mild Cognitive Impairment

scientific article published on 8 February 2017

Myopathy in Marinesco-Sjögren syndrome links endoplasmic reticulum chaperone dysfunction to nuclear envelope pathology

scientific article published on 21 December 2013

Novel highly sensitive, specific, and straightforward strategy for comprehensive N-terminal proteomics reveals unknown substrates of the mitochondrial peptidase Icp55.

scientific article published on 21 August 2013

Nuclear envelopes from amphibian oocytes--from morphology to protein inventory

scientific article

PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis

scientific article

PKA-RII subunit phosphorylation precedes activation by cAMP and regulates activity termination.

scientific article published on 3 April 2018

Peptide identification quality control

scientific article published on 18 April 2011

PeptideShaker enables reanalysis of MS-derived proteomics data sets.

scientific article published in January 2015

Phosphoproteome analysis of the platelet plasma membrane

scientific article published in January 2011

Phosphoproteome of resting human platelets

scientific article

Phosphoproteomics Profiling of Tobacco Mature Pollen and Pollen Activated in vitro

scientific article published on 20 January 2016

Phosphoproteomics of human platelets: A quest for novel activation pathways

scientific article

Phosphoproteomics--more than meets the eye.

scientific article

Phosphorylation of CalDAG-GEFI by protein kinase A prevents Rap1b activation.

scientific article published in August 2013

Platelet membrane proteomics: a novel repository for functional research

scientific article published on 12 May 2009

Positive regulation of A-RAF by phosphorylation of isoform-specific hinge segment and identification of novel phosphorylation sites

scientific article published on 28 July 2008

Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase

scientific article

Protease Specificity Profiling in a Pipet Tip Using "Charge-Synchronized" Proteome-Derived Peptide Libraries.

scientific article published on 17 April 2018

Protein carbamylation: In vivo modification or in vitro artefact?

scientific article published on 01 March 2013

Protein lipid modifications--More than just a greasy ballast

scientific article published on 18 December 2015

Proteome Profiling and Ultrastructural Characterization of the Human RCMH Cell Line: Myoblastic Properties and Suitability for Myopathological Studies

scientific article published on 19 January 2016

Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins

scientific article

Proteomic and metabolomic analyses of mitochondrial complex I-deficient mouse model generated by spontaneous B2 short interspersed nuclear element (SINE) insertion into NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) gene

scientific journal article

Proteomics - moving from inventory to personalized medicine?

scientific article published on 01 September 2014

Quantifying Missing (Phospho)Proteome Regions with the Broad-Specificity Protease Subtilisin.

scientific article published on 14 November 2017

Quantitative Profiling for Substrates of the Mitochondrial Presequence Processing Protease Reveals a Set of Nonsubstrate Proteins Increased upon Proteotoxic Stress.

scientific article published on 8 October 2015

Raf kinases mediate the phosphorylation of eukaryotic translation elongation factor 1A and regulate its stability in eukaryotic cells.

scientific article published in March 2012

Recent advances in yeast organelle and membrane proteomics

scientific article published on October 2009

Regulation of mitochondrial protein import by cytosolic kinases.

scientific article

Response: platelet transcriptome and proteome--relation rather than correlation.

scientific article published in June 2013

Revealing phosphoproteins playing role in tobacco pollen activated in vitro

Robust Workflow for iTRAQ-Based Peptide and Protein Quantification

Shedding light on black boxes in protein identification

scientific article

Simultaneous Metabolite, Protein, Lipid Extraction (SIMPLEX): A Combinatorial Multimolecular Omics Approach for Systems Biology

scientific article published on 26 January 2016

Systematic and quantitative comparison of digest efficiency and specificity reveals the impact of trypsin quality on MS-based proteomics

scientific article published on 30 November 2011

Taking the stock of granule cargo: Platelet releasate proteomics

scientific article published on 08 December 2016

Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach

scientific article

Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition

scientific article published on 9 November 2016

The Caveolin-3 G56S sequence variant of unknown significance: Muscle biopsy findings and functional cell biological analysis

scientific article published on 14 October 2016

The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier

scientific article

The Human Platelet Membrane Proteome Reveals Several New Potential Membrane Proteins

scientific article published on 03 August 2005

The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways

scientific article

The good, the bad, the ugly: validating the mass spectrometric analysis of modified peptides

scientific article published on 7 February 2011

The mTOR and PP2A Pathways Regulate PHD2 Phosphorylation to Fine-Tune HIF1α Levels and Colorectal Cancer Cell Survival under Hypoxia.

scientific article published on February 2017

The next level of complexity: crosstalk of posttranslational modifications.

scientific article

The protein import machinery of mitochondria-a regulatory hub in metabolism, stress, and disease

scientific article published on 20 February 2014

The proteome of Saccharomyces cerevisiae mitochondria

scientific article

The proteome of baker's yeast mitochondria.

scientific article published on 14 August 2016

Time-resolved characterization of cAMP/PKA-dependent signaling reveals that platelet inhibition is a concerted process involving multiple signaling pathways.

scientific article

Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics

scientific article

Tracking Effects of SIL1 Increase: Taking a Closer Look Beyond the Consequences of Elevated Expression Level

scientific article published on 11 April 2017

Two Birds with One Stone: Parallel Quantification of Proteome and Phosphoproteome Using iTRAQ.

scientific article published on January 2016

Two-dimensional benzyldimethyl-n-hexadecylammonium chloride/SDS-PAGE for membrane proteomics.

scientific article published in September 2005

Tyr728 in the kinase domain of the murine kinase suppressor of RAS 1 regulates binding and activation of the mitogen-activated protein kinase kinase

scientific article published on 24 October 2013

Unraveling the Phosphocholination Mechanism of the Legionella pneumophila Enzyme AnkX.

scientific article published on 12 July 2016

Variable Digestion Strategies for Phosphoproteomics Analysis

scientific article published in January 2016

What can proteomics tell us about platelets?

scientific article published on March 2014

Why phosphoproteomics is still a challenge

scientific article published on 01 June 2015

iTRAQ data interpretation.

scientific article

iTRAQ protein quantification: A quality-controlled workflow

scientific article published on 16 February 2011

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