List of works - Marc R. Birtwistle

A Mechanistic Beta-Binomial Probability Model for mRNA Sequencing Data

scientific article

A mechanistic pan-cancer pathway model informed by multi-omics data interprets stochastic cell fate responses to drugs and mitogens.

scientific article published on 26 March 2018

Analysis of copy number loss of the ErbB4 receptor tyrosine kinase in glioblastoma.

scientific article published on 17 January 2018

Analytical reduction of combinatorial complexity arising from multiple protein modification sites.

scientific article

Biology using engineering tools: the negative feedback amplifier

scientific article published on July 2011

Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches

scientific article published on 27 January 2016

CNS Anticancer Drug Discovery and Development Conference White Paper.

scientific article

Cell fate decisions are specified by the dynamic ERK interactome

scientific article

Cell size assays for mass cytometry

scientific article published on 21 October 2016

Critical Role of Histone Turnover in Neuronal Transcription and Plasticity

scientific article published in July 2015

Current Proteomic Methods to Investigate the Dynamics of Histone Turnover in the Central Nervous System.

scientific article published on 16 February 2016

Dimerization-based control of cooperativity

scientific article

Drug response consistency in CCLE and CGP.

scientific article published in November 2016

ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin-β2.

scientific article

Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise ⬇️

scientific article published on August 24, 2012

Evaluating strategies to normalise biological replicates of Western blot data

scientific article

Extracellular signal-regulated kinase regulates RhoA activation and tumor cell plasticity by inhibiting guanine exchange factor H1 activity

scientific article published on 16 September 2013

Fluorescence Multiplexing with Spectral Imaging and Combinatorics

scientific article published on 30 October 2018

Four-dimensional dynamics of MAPK information processing systems.

scientific article published on July 2009

In silico model-based inference: an emerging approach for inverse problems in engineering better medicines

scientific article

Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses

scientific article

Ligand-specific c-Fos expression emerges from the spatiotemporal control of ErbB network dynamics

scientific article

Linear approaches to intramolecular Förster resonance energy transfer probe measurements for quantitative modeling

scientific article

Mammalian protein expression noise: scaling principles and the implications for knockdown experiments

scientific article published on 01 November 2012

Mechanistic Systems Modeling to Improve Understanding and Prediction of Cardiotoxicity Caused by Targeted Cancer Therapeutics.

scientific article published on 8 September 2017

Mechanistic vs. Empirical network models of drug action

scientific article published on 06 September 2013

Mitochondrial origins of fractional control in regulated cell death

scientific article published on 21 March 2019

Mitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant Transformation

scientific article

NFκB and HIF display synergistic behaviour during hypoxic inflammation.

scientific article

Network pharmacodynamic models for customized cancer therapy.

scientific article published on 24 April 2015

Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses

scientific article

Novel Somatic Mutations to PI3K Pathway Genes in Metastatic Melanoma ⬇️

scientific article published on August 17, 2012

Predicting In Vivo Efficacy from In Vitro Data: Quantitative Systems Pharmacology Modeling for an Epigenetic Modifier Drug in Cancer

scientific article published on 16 January 2020

Raf family kinases: old dogs have learned new tricks

scientific article

Silence on the relevant literature and errors in implementation

scientific article published in April 2015

The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier

scientific article published on 21 December 2010

Transcriptomes and shRNA suppressors in a TP53 allele-specific model of early-onset colon cancer in African Americans

scientific article

Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity

scientific article published on 23 September 2020

List of works by Marc R. Birtwistle

A Mechanistic Beta-Binomial Probability Model for mRNA Sequencing Data

A mechanistic pan-cancer pathway model informed by multi-omics data interprets stochastic cell fate responses to drugs and mitogens.

Analysis of copy number loss of the ErbB4 receptor tyrosine kinase in glioblastoma.

Analytical reduction of combinatorial complexity arising from multiple protein modification sites.

Biology using engineering tools: the negative feedback amplifier

Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches

CNS Anticancer Drug Discovery and Development Conference White Paper.

Cell fate decisions are specified by the dynamic ERK interactome

Cell size assays for mass cytometry

Critical Role of Histone Turnover in Neuronal Transcription and Plasticity

Current Proteomic Methods to Investigate the Dynamics of Histone Turnover in the Central Nervous System.

Dimerization-based control of cooperativity

Drug response consistency in CCLE and CGP.

ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin-β2.

Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise ⬇️

Evaluating strategies to normalise biological replicates of Western blot data

Extracellular signal-regulated kinase regulates RhoA activation and tumor cell plasticity by inhibiting guanine exchange factor H1 activity

Fluorescence Multiplexing with Spectral Imaging and Combinatorics

Four-dimensional dynamics of MAPK information processing systems.

In silico model-based inference: an emerging approach for inverse problems in engineering better medicines

Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses

Ligand-specific c-Fos expression emerges from the spatiotemporal control of ErbB network dynamics

Linear approaches to intramolecular Förster resonance energy transfer probe measurements for quantitative modeling

Mammalian protein expression noise: scaling principles and the implications for knockdown experiments

Mechanistic Systems Modeling to Improve Understanding and Prediction of Cardiotoxicity Caused by Targeted Cancer Therapeutics.

Mechanistic vs. Empirical network models of drug action

Mitochondrial origins of fractional control in regulated cell death

Mitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant Transformation

NFκB and HIF display synergistic behaviour during hypoxic inflammation.

Network pharmacodynamic models for customized cancer therapy.

Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses

Novel Somatic Mutations to PI3K Pathway Genes in Metastatic Melanoma ⬇️

Predicting In Vivo Efficacy from In Vitro Data: Quantitative Systems Pharmacology Modeling for an Epigenetic Modifier Drug in Cancer

Raf family kinases: old dogs have learned new tricks

Silence on the relevant literature and errors in implementation

The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier

Transcriptomes and shRNA suppressors in a TP53 allele-specific model of early-onset colon cancer in African Americans

Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity