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List of works by William I Weis

25 Years of Tension over Actin Binding to the Cadherin Cell Adhesion Complex: The Devil is in the Details

scientific article published on 7 May 2016

A Novel Mechanism for Binding of Galactose-terminated Glycans by the C-type Carbohydrate Recognition Domain in Blood Dendritic Cell Antigen 2.

scientific article published on 20 May 2015

A Small-Molecule Antagonist of the β-Catenin/TCF4 Interaction Blocks the Self-Renewal of Cancer Stem Cells and Suppresses Tumorigenesis.

scientific article published on 8 December 2015

A conserved phosphorylation switch controls the interaction between cadherin and β-catenin in vitro and in vivo

scientific article

A monoclonal antibody for G protein-coupled receptor crystallography

scientific article

A novel snare N-terminal domain revealed by the crystal structure of Sec22b

scientific article

A polarized epithelium organized by beta- and alpha-catenin predates cadherin and metazoan origins

scientific article

Activation and allosteric modulation of a muscarinic acetylcholine receptor

scientific article

Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody

scientific article

Advances in X-ray free electron laser (XFEL) diffraction data processing applied to the crystal structure of the synaptotagmin-1 / SNARE complex

scientific article

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

scientific article published on 13 July 2016

Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly.

scientific article

AlphaE-catenin regulates actin dynamics independently of cadherin-mediated cell-cell adhesion ⬇️

scientific article

An epithelial tissue in Dictyostelium challenges the traditional origin of metazoan multicellularity

scientific article (publication date: October 2012)

Applications of molecular replacement to G protein-coupled receptors

scientific article published on 18 October 2013

Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis

scientific article

Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation

scientific article published on 13 March 2005

Binding Sites for Acylated Trehalose Analogs of Glycolipid Ligands on an Extended Carbohydrate Recognition Domain of the Macrophage Receptor Mincle

scientific article published on 19 August 2016

Biochemical and Structural Characterization of β-Catenin Interactions with Nonphosphorylated and CK2-Phosphorylated Lef-1

scientific article

Biochemical and Structural Definition of the l-Afadin- and Actin-binding Sites of alpha -Catenin

scientific article

Biochemical and structural analysis of alpha-catenin in cell-cell contacts

scientific article

CD23 is a glycan-binding receptor in some mammalian species

scientific article published on 05 September 2019

Ca2+-dependent structural changes in C-type mannose-binding proteins

scientific article

Cadherin structure: a revealing zipper.

scientific article

Catenins: playing both sides of the synapse

scientific article published on 23 October 2007

Cell-surface carbohydrate recognition by animal and viral lectins.

scientific article

Characterization of the Cadherin-Catenin Complex of the Sea Anemone Nematostella vectensis and Implications for the Evolution of Metazoan Cell-Cell Adhesion

scientific article published on 28 April 2016

Common Polymorphisms in Human Langerin Change Specificity for Glycan Ligands

scientific article

Conformational changes of p97 during nucleotide hydrolysis determined by small-angle X-Ray scattering

scientific article published in February 2005

Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle

scientific article (publication date: December 2002)

Crystal structure and biophysical properties of a complex between the N-terminal SNARE region of SNAP25 and syntaxin 1a

scientific article

Crystal structure of a rigid four-spectrin-repeat fragment of the human desmoplakin plakin domain

scientific article

Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2

scientific article (publication date: 15 May 2003)

Crystal structure of the S.cerevisiae exocyst component Exo70p

scientific article published on 10 November 2005

Crystal structure of the hexamerization domain of N-ethylmaleimide-sensitive fusion protein

scientific article

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor

scientific article

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

scientific article

Crystal structure of the β2 adrenergic receptor-Gs protein complex

scientific article

Crystal structures of the M1 and M4 muscarinic acetylcholine receptors

scientific article

Danio rerio αE-catenin is a monomeric F-actin binding protein with distinct properties from Mus musculus αE-catenin

scientific article published on 20 June 2013

Data Exploration Toolkit for serial diffraction experiments

scientific article

Deconstructing the cadherin-catenin-actin complex

scientific article

Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling

scientific article

Direct ubiquitination of beta-catenin by Siah-1 and regulation by the exchange factor TBL1.

scientific article

Drugging a stem cell compartment using Wnt3a protein as a therapeutic

scientific article (publication date: 2014)

E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch

scientific article

Enabling X-ray free electron laser crystallography for challenging biological systems from a limited number of crystals

scientific article

Evolution and cell physiology. 3. Using Dictyostelium discoideum to investigate mechanisms of epithelial polarity

scientific article published on 25 September 2013

Extended neck regions stabilize tetramers of the receptors DC-SIGN and DC-SIGNR.

scientific article published on 26 October 2004

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function

scientific article

High-density grids for efficient data collection from multiple crystals

scientific article

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

scientific article

High-resolution crystal structure of human protease-activated receptor 1

scientific article

How to build a cell junction

scientific article published in Nature

ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules

scientific article

IOTA: integration optimization, triage and analysis tool for the processing of XFEL diffraction images

scientific article

Improved structures of full-length p97, an AAA ATPase: implications for mechanisms of nucleotide-dependent conformational change

scientific article

In vitro and in vivo reconstitution of the cadherin-catenin-actin complex from Caenorhabditis elegans

scientific article

Interactions of Plakoglobin and  -Catenin with Desmosomal Cadherins: BASIS OF SELECTIVE EXCLUSION OF  - AND  -CATENIN FROM DESMOSOMES

scientific article

Lattice micropatterning for cryo-electron tomography studies of cell-cell contacts

scientific article published on 11 September 2021

Lectins on a roll: the structure of E-selectin.

scientific article

Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

scientific article

Limited Dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction

scientific article published on 16 April 2020

Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography.

scientific article published on 30 September 2015

Mechanism for Recognition of an Unusual Mycobacterial Glycolipid by the Macrophage Receptor Mincle

scientific article

Mechanism of N-Acetylgalactosamine Binding to a C-type Animal Lectin Carbohydrate-recognition Domain ⬇️

scientific article published on July 31, 1998

Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure.

scientific article

Mechanism of pH-dependent N-acetylgalactosamine binding by a functional mimic of the hepatocyte asialoglycoprotein receptor

scientific article

Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation

scientific article

Molecular functions of the TLE tetramerization domain in Wnt target gene repression

scientific article

Multiple Modes of Binding Enhance the Affinity of DC-SIGN for High Mannose N-Linked Glycans Found on Viral Glycoproteins

scientific article

Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide

scientific article

Munc18a does not alter fusion rates mediated by neuronal SNAREs, synaptotagmin, and complexin

scientific article

N-Terminal T4 Lysozyme Fusion Facilitates Crystallization of a G Protein Coupled Receptor

scientific article

Orientation of bound ligands in mannose-binding proteins. Implications for multivalent ligand recognition

scientific article

Protein evolution in cell and tissue development: going beyond sequence and transcriptional analysis

scientific article published on July 2011

Protein-protein interactions in intracellular membrane fusion.

scientific article

Purification, crystallization and initial crystallographic analysis of the α-catenin homologue HMP-1 from Caenorhabditis elegans

scientific article published on 19 February 2016

Purification, crystallization and preliminary X-ray diffraction studies of the β-catenin homolog HMP-2 from Caenorhabditis elegans

scientific article

Re-solving the cadherin-catenin-actin conundrum

scientific article

Reevaluating αE-catenin monomer and homodimer functions by characterizing E-cadherin/αE-catenin chimeras

scientific article

Roles of cadherins and catenins in cell-cell adhesion and epithelial cell polarity

scientific article published on January 2013

SNARE the rod, coil the complex

scientific article published in Nature

Scavenger Receptor C-type Lectin Binds to the Leukocyte Cell Surface Glycan Lewisx by a Novel Mechanism

scientific article

Segmented Helical Structure of the Neck Region of the Glycan-Binding Receptor DC-SIGNR

scientific article

Structural Basis for Langerin Recognition of Diverse Pathogen and Mammalian Glycans through a Single Binding Site

scientific article

Structural Basis for Selective Recognition of Oligosaccharides by DC-SIGN and DC-SIGNR ⬇️

scientific article published on December 7, 2001

Structural Correlates of Antibodies Associated with Acute Reversal of Amyloid  -related Behavioral Deficits in a Mouse Model of Alzheimer Disease

scientific article

Structural Studies of Wnts and Identification of an LRP6 Binding Site

scientific article

Structural and Thermodynamic Characterization of Cadherin·β-Catenin·α-Catenin Complex Formation

scientific article

Structural and functional characterization of the α-catenin·β-catenin binding interface in Caenorhabditis elegans reveals conserved requirements for cell-cell adhesion in metazoans.

scientific article published on 25 August 2017

Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR.

scientific article

Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6

scientific article

Structural basis of lectin-carbohydrate recognition

scientific article

Structural basis of αE-catenin-F-actin catch bond behavior

scientific article published on 11 September 2020

Structural insights into G-protein-coupled receptor activation

scientific article published on 17 November 2008

Structural insights into binding specificity, efficacy and bias of a βAR partial agonist

scientific article

Structural insights into µ-opioid receptor activation

scientific article

Structure and dynamics of the M3 muscarinic acetylcholine receptor

scientific article

Structure and function of an irreversible agonist-β(2) adrenoceptor complex

scientific article

Structure and mechanism of cadherins and catenins in cell-cell contacts

scientific article published on January 2007

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

scientific article

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide

scientific article

Structure of photosystem II and substrate binding at room temperature.

scientific article

Structure of the Calcium-Dependent Lectin Domain from a Rat Mannose-Binding Protein Determined by MAD Phasing ⬇️

scientific article published on December 13, 1991

Structure of the Dimerization and β-Catenin- Binding Region of α-Catenin

scientific article published in March 2000

Structure of the Intermediate Filament-Binding Region of Desmoplakin

scientific article published on 25 January 2016

Structure of the armadillo repeat domain of plakophilin 1

scientific article

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

scientific article

Structure of the yeast polarity protein Sro7 reveals a SNARE regulatory mechanism

scientific article

Structure of the δ-opioid receptor bound to naltrindole

scientific article

Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure

scientific article

Studies on the structure of the influenza virus haemagglutinin at the pH of membrane fusion

scientific article

Studying epithelial morphogenesis in Dictyostelium

scientific article published in January 2015

Syntaxin1a variants lacking an N-peptide or bearing the LE mutation bind to Munc18a in a closed conformation

scientific article

The C-type lectin superfamily in the immune system

scientific article published in June 1998

The beta-catenin binding protein ICAT modulates androgen receptor activity

scientific article

The cytoplasmic face of cell contact sites

scientific article

The evolutionary origin of epithelial cell-cell adhesion mechanisms

scientific article

The first propeller domain of LRP6 regulates sensitivity to DKK1.

scientific article published on 28 May 2009

The linac coherent light source single particle imaging road map

scientific article published on 21 April 2015

The β-catenin destruction complex

scientific article

Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity

scientific article

Three αSNAP and 10 ATP molecules are used in SNARE complex disassembly by N-ethylmaleimide-sensitive factor (NSF)

scientific article

Three-dimensional structure of the amino-terminal domain of syntaxin 6, a SNAP-25 C homolog

scientific article

Three-dimensional structure of the armadillo repeat region of beta-catenin

scientific article

Trimeric Structure of Langerin

scientific article

Trimeric structure of a C-type mannose-binding protein

scientific article

Unraveling the mechanism of the vesicle transport ATPase NSF, the N-ethylmaleimide-sensitive factor.

scientific article

Vinculin forms a directionally asymmetric catch bond with F-actin.

scientific article

X-ray structure determination at low resolution

scientific article published on 20 January 2009

beta-catenin: molecular plasticity and drug design.

scientific article

α-catenin and IQGAP regulate myosin localization to control epithelial tube morphogenesis in Dictyostelium

scientific article published on 16 August 2012

αE-catenin actin-binding domain alters actin filament conformation and regulates binding of nucleation and disassembly factors

scientific article

αE-catenin is an autoinhibited molecule that coactivates vinculin

scientific article

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