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List of works by David M Sansom

1,25(OH)2D3 Promotes the Efficacy of CD28 Costimulation Blockade by Abatacept

scientific article

1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3.

scientific article

A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding

scientific article published on 23 November 2016

A role for RANTES in T lymphocyte proliferation

scientific article published on 01 February 1996

A transendocytosis model of CTLA-4 function predicts its suppressive behavior on regulatory T cells

scientific article published on 28 January 2015

A transendocytosis perspective on the CD28/CTLA-4 pathway

scientific article published on January 2014

Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3

scientific article

Activation of human T cells with superantigen (staphylococcal enterotoxin B) and CD28 confers resistance to apoptosis via CD95

scientific article published on 01 March 1998

Activation of phosphatidylinositol 3-kinase following Fas engagement is not required for Fas-mediated apoptosis in Jurkat T cells

scientific article published on 01 May 1997

Activation of the PI3K effector protein kinase B following ligation of CD28 or Fas

scientific article published on 01 November 1997

Antibody ligation of CD7 leads to association with phosphoinositide 3-kinase and phosphatidylinositol 3,4,5-trisphosphate formation in T lymphocytes

scientific article published on 01 February 1995

Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations

scientific article

Availability of 25-hydroxyvitamin D(3) to APCs controls the balance between regulatory and inflammatory T cell responses

scientific article

B7/BB1, the ligand for CD28, is expressed on repeatedly activated human T cells in vitro.

scientific article published on January 1993

B7/CD28 but not LFA-3/CD2 interactions can provide 'third-party' co-stimulation for human T-cell activation

scientific article published on 01 October 1993

CD28 costimulation: Walking the immunological tightrope ⬇️

scientific article published on January 1, 2013

CD28, CTLA-4 and their ligands: who does what and to whom?

scientific article

CD86 and CD80 differentially modulate the suppressive function of human regulatory T cells

scientific article published in March 2004

CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement

scientific article

CTLA-4-mediated transendocytosis of costimulatory molecules primarily targets migratory dendritic cells

scientific article published on 01 May 2019

CTLA-4: a moving target in immunotherapy.

scientific article published on 8 November 2017

CTLA4 gene polymorphism and autoimmunity

scientific article

Characterization of CTLA4 Trafficking and Implications for Its Function

article published in 2018

Co-stimulation with B7 and targeted superantigen is required for MHC class II-independent T-cell proliferation but not cytotoxicity.

scientific article published on October 1993

Comparison of the intracellular trafficking itinerary of ctla-4 orthologues

scientific article

Confusing signals: recent progress in CTLA-4 biology

scientific article published on 09 January 2015

Constitutive clathrin-mediated endocytosis of CTLA-4 persists during T cell activation

scientific article published on 19 January 2012

Correction: A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding

scientific article

Costimulation of human CD4+ T lymphocytes with B7 and lymphocyte function-associated antigen-3 results in distinct cell activation profiles.

scientific article published on September 1994

Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity

scientific article published on 01 January 2009

Cutting edge: cell-extrinsic immune regulation by CTLA-4 expressed on conventional T cells

scientific article published on 29 June 2012

Decreased proliferative capacity and increased susceptibility to activation-induced cell death in late-passage human cd4+ tcr2+ cultured T cell clones

scientific article published on 01 November 1996

Decreased sensitivity to 1,25-dihydroxyvitamin D3 in T cells from the rheumatoid joint

scientific article published on 21 October 2017

Differential expression of the costimulatory molecules B7.1 (CD80) and B7.2 (CD86) in rheumatoid synovial tissue

scientific article published on 01 January 1996

Down-regulation of CD28 via Fas (CD95): influence of CD28 on T-cell apoptosis

scientific article

Effects of antigen presentation on superantigen-induced apoptosis mediated by Fas/Fas ligand interactions in human T cells

scientific article

Evidence that a kinase distinct from protein kinase C and phosphatidylinositol 3-kinase mediates ligation-dependent serine/threonine phosphorylation of the T-lymphocyte co-stimulatory molecule CD28.

scientific article published on August 1997

Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells

scientific article

Expression and function of the autoimmune regulator (Aire) gene in non-thymic tissue ⬇️

scientific article published on March 1, 2011

Expression and secretion of parathyroid hormone-related protein by human bone-derived cells in vitro: Effects of glucocorticoids

scientific article published on 01 January 1995

Extra-renal 25-hydroxyvitamin D3-1alpha-hydroxylase in human health and disease

scientific article published on March 2007

Follicular helper T cell signature in type 1 diabetes

scientific article

Genetic variation at the CD28 locus and its impact on expansion of pro-inflammatory CD28 negative T cells in healthy individuals

scientific article

Genomic profiling of T-cell activation suggests increased sensitivity of memory T cells to CD28 costimulation

scientific article published on 23 November 2020

HLA DQ POLYMORPHISM IN RHEUMATOID ARTHRITIS

scientific article published on 01 January 1988

HLA DQα and DQβ restriction fragment length polymorphisms associated with Felty's syndrome and DR4-positive rheumatoid arthritis

scientific article published on 01 August 1987

HLA-DO-related restriction fragment length polymorphisms in rheumatoid arthritis: evidence for a link with disease expression

scientific article published on 01 October 1989

HLA-DP in rheumatoid arthritis

scientific article published on 01 February 1988

Hematopoietic stem cell transplantation for CTLA4 deficiency

article

Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis

scientific article published on 15 July 2019

Human gamma delta T cells are resistant to induction of anergy but not to induction of cell death in vitro

scientific article published in April 1995

Human naive and memory T-helper cells display distinct adhesion properties to ICAM-1, LFA-3 and B7 molecules

scientific article published in December 1993

Human vascular endothelial cells process and present autoantigen to human T cell lines.

scientific article published on March 1995

IL-2-independent activation and proliferation in human T cells induced by CD28.

scientific article

IMMUNOLOGY. Moving CTLA-4 from the trash to recycling

scientific article

Identification of a secondary zinc-binding site in staphylococcal enterotoxin C2. Implications for superantigen recognition

scientific article

Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations.

scientific article published on 3 February 2017

Immune deficiency and autoimmunity in patients with CTLA-4 (CD152) mutations.

scientific article

Inhibition of CD28-mediated T cell costimulation by the phosphoinositide 3-kinase inhibitor wortmannin

scientific article published on 01 February 1995

Inhibition of human T cell proliferation by CTLA-4 utilizes CD80 and requires CD25+ regulatory T cells

scientific article published in October 2002

Integration of CD28 and CTLA-4 function results in differential responses of T cells to CD80 and CD86.

scientific article published in June 2006

Lack of activation induced cell death in human T blasts despite CD95L up-regulation: protection from apoptosis by MEK signalling

scientific article published on 01 December 1999

Lack of costimulation by both sphingomyelinase and C2 ceramide in resting human T cells

Ligation of the T cell co-stimulatory receptor CD28 activates the serine-threonine protein kinase protein kinase B.

scientific article

Loss of CD28 expression by liver-infiltrating T cells contributes to pathogenesis of primary sclerosing cholangitis

scientific article published on 12 April 2014

Low-level hypermutation in T cell-independent germinal centers compared with high mutation rates associated with T cell-dependent germinal centers

scientific article published on February 2002

Measuring CTLA-4-Dependent Suppressive Function in Regulatory T Cells

scientific article published on 01 January 2019

Monocyte-regulated IFN-gamma production in human T cells involves CD2 signaling

scientific article published on 01 August 1993

Mutually exclusive binding of peptide and invariant chain to major histocompatibility complex class II antigens.

scientific article published on October 1994

New vector for transfer of yeast artificial chromosomes to mammalian cells

scientific article published on March 1993

Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T-cell subset.

scientific article

Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects

scientific article published on 04 May 2018

Phorbol esters modulate the coupling of the T cell costimulatory molecule CD28 to phosphatidylinositol 3-kinase

scientific article published on 01 May 1997

Positive and negative regulation of human T cell activation mediated by the CTLA-4/CD28 ligand CD80

scientific article published on 01 October 1998

Publisher Correction: Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis

scientific article published on 02 October 2019

Regulation of CTLA-4 recycling by LRBA and Rab11

scientific article published on 06 June 2021

Regulatory T cells and COPD

scientific article published on 21 October 2013

Requirements for Stimulation or Anergy Induction in Alloreactive Human T Cell Clones ⬇️

scientific article published on October 1, 1994

Restriction fragment length polymorphism in Felty's syndrome

scientific article published on 01 June 1986

Strong primary selection for the Dw4 subtype of DR4 accounts for the HLA-DQw7 association with Felty's syndrome

scientific article published on 01 September 1991

Study of an extended family with CTLA-4 deficiency suggests a CD28/CTLA-4 independent mechanism responsible for differences in disease manifestations and severity

scientific article published on 3 January 2018

Superantigen activation of CD4+ and CD8+T cells from HIV-infected subjects: role of costimulatory molecules and antigen-presenting cells (APC)

scientific article published on January 1998

The LFA-3 adhesion pathway is differently utilized by superantigen-activated human CD4+ T-cell subsets

scientific article published in August 1992

The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses ⬇️

scientific article published on November 25, 2011

The human ICAM2 gene maps to 17q23–25 ⬇️

scientific article published on October 1, 1991

The origin of HLA-DR“Br”: Exon 2 nucleotide sequence implicates possible gene conversion of DR1 by DR4-Dw10, DR5, or DRw6-Dw18

article

The phosphoinositide 3-kinase inhibitor wortmannin inhibits CD28-mediated T cell co-stimulation

scientific article published on 01 May 1995

The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology

scientific article published on August 2006

The role of endogenous peptides in the direct pathway of alloreactivity to human MHC class II molecules expressed on CHO cells.

scientific article published on December 1996

Thymus transplantation for complete DiGeorge syndrome: European experience.

scientific article

Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4

scientific article

Understanding the CD28/CTLA-4 (CD152) pathway and its implications for costimulatory blockade

scientific article published on 06 August 2014

Vedolizumab as a successful treatment of CTLA-4-associated autoimmune enterocolitis

scientific article published on 28 November 2016

Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function

scientific article published on 2 July 2015

Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS) ⬇️

scientific article

What's the difference between CD80 and CD86?

scientific article

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