List of works - Steven Molinski

Attenuation of Phosphorylation-dependent Activation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Disease-causing Mutations at the Transmission Interface

scientific article published on 21 December 2016

Biophysical Approaches Facilitate Computational Drug Discovery for ATP-Binding Cassette Proteins.

scientific article published on 19 March 2017

Comprehensive mapping of cystic fibrosis mutations to CFTR protein identifies mutation clusters and molecular docking predicts corrector binding site.

scientific article published on 23 March 2018

Computational proteome-wide screening predicts neurotoxic drug-protein interactome for the investigational analgesic BIA 10-2474.

scientific article published on 19 December 2016

Conformational defects underlie proteasomal degradation of Dent's disease-causing mutants of ClC-5

scientific article published on 01 June 2013

Correctors of the major Cystic Fibrosis mutant interact through membrane spanning domains.

scientific article published on 4 April 2018

Facilitating Structure-Function Studies of CFTR Modulator Sites with Efficiencies in Mutagenesis and Functional Screening.

scientific article published on 18 September 2015

Functional Rescue of F508del-CFTR Using Small Molecule Correctors

scientific article published on 26 September 2012

Genetic, cell biological, and clinical interrogation of the CFTR mutation c.3700 A>G (p.Ile1234Val) informs strategies for future medical intervention.

scientific article published on 20 February 2014

Giving Drugs a Second Chance: Overcoming Regulatory and Financial Hurdles in Repurposing Approved Drugs As Cancer Therapeutics

scientific article published on 14 November 2017

Identification and validation of hits from high throughput screens for CFTR modulators

scientific article

Low-fat dietary pattern and risk of cardiovascular disease: the Women's Health Initiative Randomized Controlled Dietary Modification Trial

scientific article

Mammalian multidrug-resistance proteins (MRPs).

scientific article published on September 2011

Orkambi® and amplifier co-therapy improves function from a rare CFTR mutation in gene-edited cells and patient tissue.

scientific article

Phenotypic profiling of CFTR modulators in patient-derived respiratory epithelia

scientific article

Platelet and red blood cell phagocytosis kinetics are differentially controlled by phosphatase activity within mononuclear cells

scientific article published in November 2007

Sphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity

scientific article

The Antiretroviral Agent Nelfinavir Mesylate: A Potential Therapy for Systemic Sclerosis.

scientific article

The investigational Cystic Fibrosis drug Trimethylangelicin directly modulates CFTR by stabilizing the first membrane-spanning domain.

scientific article published on 7 September 2016

The major cystic fibrosis causing mutation exhibits defective propensity for phosphorylation.

scientific article

VX-809 and related corrector compounds exhibit secondary activity stabilizing active F508del-CFTR after its partial rescue to the cell surface.

scientific article published on 10 April 2014

List of works by Steven Molinski

Attenuation of Phosphorylation-dependent Activation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Disease-causing Mutations at the Transmission Interface

Biophysical Approaches Facilitate Computational Drug Discovery for ATP-Binding Cassette Proteins.

Comprehensive mapping of cystic fibrosis mutations to CFTR protein identifies mutation clusters and molecular docking predicts corrector binding site.

Computational proteome-wide screening predicts neurotoxic drug-protein interactome for the investigational analgesic BIA 10-2474.

Conformational defects underlie proteasomal degradation of Dent's disease-causing mutants of ClC-5

Correctors of the major Cystic Fibrosis mutant interact through membrane spanning domains.

Facilitating Structure-Function Studies of CFTR Modulator Sites with Efficiencies in Mutagenesis and Functional Screening.

Functional Rescue of F508del-CFTR Using Small Molecule Correctors

Genetic, cell biological, and clinical interrogation of the CFTR mutation c.3700 A>G (p.Ile1234Val) informs strategies for future medical intervention.

Giving Drugs a Second Chance: Overcoming Regulatory and Financial Hurdles in Repurposing Approved Drugs As Cancer Therapeutics

Identification and validation of hits from high throughput screens for CFTR modulators

Low-fat dietary pattern and risk of cardiovascular disease: the Women's Health Initiative Randomized Controlled Dietary Modification Trial

Mammalian multidrug-resistance proteins (MRPs).

Orkambi® and amplifier co-therapy improves function from a rare CFTR mutation in gene-edited cells and patient tissue.

Phenotypic profiling of CFTR modulators in patient-derived respiratory epithelia

Platelet and red blood cell phagocytosis kinetics are differentially controlled by phosphatase activity within mononuclear cells

Sphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity

The Antiretroviral Agent Nelfinavir Mesylate: A Potential Therapy for Systemic Sclerosis.

The investigational Cystic Fibrosis drug Trimethylangelicin directly modulates CFTR by stabilizing the first membrane-spanning domain.

The major cystic fibrosis causing mutation exhibits defective propensity for phosphorylation.

VX-809 and related corrector compounds exhibit secondary activity stabilizing active F508del-CFTR after its partial rescue to the cell surface.