List of works - Andrei Thomas-Tikhonenko

A non-transgenic mouse model for B-cell lymphoma: in vivo infection of p53-null bone marrow progenitors by a Myc retrovirus is sufficient for tumorigenesis

scientific article

Aberrant splicing in B-cell acute lymphoblastic leukemia

scientific article published on 01 November 2018

Aberrant splicing in B-cell acute lymphoblastic leukemia

Activation of transferrin receptor 1 by c-Myc enhances cellular proliferation and tumorigenesis

scientific article published in March 2006

Aiding and ABT'ing Treatment for Glioblastoma

scientific article published on 15 May 2007

An essential role of Th1 responses and interferon gamma in infection-mediated suppression of neoplastic growth

scientific article published on November 2003

An in vivo function for the transforming Myc protein: elicitation of the angiogenic phenotype.

scientific article

B cell activator PAX5 promotes lymphomagenesis through stimulation of B cell receptor signaling

scientific article

B cell-specific loss of histone 3 lysine 9 methylation in the V(H) locus depends on Pax5

scientific journal article

B-Lymphoma cells with epigenetic silencing of Pax5 trans-differentiate into macrophages, but not other hematopoietic lineages

scientific article published on 25 October 2006

CAR T-cell therapy is effective for CD19-dim B-lymphoblastic leukemia but is impacted by prior blinatumomab therapy

scientific article published on 01 November 2019

CD19 alterations emerging after CD19-directed immunotherapy cause retention of the misfolded protein in the endoplasmic reticulum

scientific article published on 15 October 2018

CD19 is a major B cell receptor-independent activator of MYC-driven B-lymphomagenesis

scientific article

Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomas

scientific article published on 28 April 2009

Colorectal Cancer-Associated Smad4 R361 Hotspot Mutations Boost Wnt/β-Catenin Signaling through Enhanced Smad4-LEF1 Binding

scientific article published on 19 February 2021

Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy

scientific article

Correction: Transient stabilization, rather than inhibition, of MYC amplifies extrinsic apoptosis and therapeutic responses in refractory B-cell lymphoma

scientific article published on 22 November 2019

Cutting edge: systemic inhibition of angiogenesis underlies resistance to tumors during acute toxoplasmosis

scientific article

Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity.

scientific article published on October 2004

ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth

scientific article

Epigenetic histone modifications do not control Igkappa locus contraction and intranuclear localization in cells with dual B cell-macrophage potential

scientific article

Escape From ALL-CARTaz: Leukemia Immunoediting in the Age of Chimeric Antigen Receptors

scientific article published on 01 May 2019

Exons of Leukemia Suppressor Genes: Creative Assembly Required

scientific article published on 28 October 2018

Functional validation of genes implicated in lymphomagenesis: an in vivo selection assay using a Myc-induced B-cell tumor

scientific article

Heterogeneity of surface CD19 and CD22 expression in B lymphoblastic leukemia

scientific article published on 09 September 2018

IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells

scientific article published on 04 November 2020

Identifying common transcriptome signatures of cancer by interpreting deep learning models

scientific article published on 17 May 2022

Inactivation of Myc in murine two-hit B lymphomas causes dormancy with elevated levels of interleukin 10 receptor and CD20: implications for adjuvant therapies

scientific article

Infection & neoplastic growth 101: the required reading for microbial pathogens aspiring to cause cancer.

scientific article

Infection and cancer: the common vein.

scientific article

Inhibition of the single downstream target BAG1 activates the latent apoptotic potential of MYC.

scientific article published on 10 October 2011

Intratumoral delivery of an interferon gamma retrovirus-producing cells inhibits growth of a murine melanoma by a non-immune mechanism.

scientific article

Kit-activating mutations in AML: lessons from PU.1-induced murine erythroleukemia

scientific article published on 2 June 2006

Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

scientific article

MOCCASIN: a method for correcting for known and unknown confounders in RNA splicing analysis

scientific article published on 07 June 2021

MYC Hyperactivates Wnt Signaling in APC/CTNNB1-Mutated Colorectal Cancer Cells through miR-92a-Dependent Repression of DKK3

scientific article published on 30 September 2021

MYC and the art of microRNA maintenance

scientific article

Masking epistasis between MYC and TGF-β pathways in antiangiogenesis-mediated colon cancer suppression

scientific article published on 13 March 2014

Metastasis-associated protein 1 (MTA1) is an essential downstream effector of the c-MYC oncoprotein

scientific article

Myc overexpression brings out unexpected antiapoptotic effects of miR-34a ⬇️

scientific article published on February 7, 2011

Myc-transformed epithelial cells down-regulate clusterin, which inhibits their growth in vitro and carcinogenesis in vivo.

scientific article

Oncogenic BRAF regulates beta-Trcp expression and NF-kappaB activity in human melanoma cells.

scientific article published on 25 September 2006

Oscillation between B-lymphoid and myeloid lineages in Myc-induced hematopoietic tumors following spontaneous silencing/reactivation of the EBF/Pax5 pathway.

scientific article

PAX5 and B-cell neoplasms: transformation through presentation

scientific article published on 01 February 2008

Poisoning the messengers: could tumor endothelial cells acquire drug resistance?

scientific article published in May 2002

Raf inhibitor stabilizes receptor for the type I interferon but inhibits its anti-proliferative effects in human malignant melanoma cells.

scientific article

Regulation of CLU gene expression by oncogenes and epigenetic factors implications for tumorigenesis.

scientific article

Repeated loss of target surface antigen after immunotherapy in primary mediastinal large B cell lymphoma

scientific article published on 25 October 2016

Retention of CD19 intron 2 contributes to CART-19 resistance in leukemias with subclonal frameshift mutations in CD19

scientific article published on 07 October 2019

Role of GLI2 transcription factor in growth and tumorigenicity of prostate cells

scientific article published on November 2007

Shielding the messenger (RNA): microRNA-based anticancer therapies

scientific article

Targeting CD123 in blastic plasmacytoid dendritic cell neoplasm using allogeneic anti-CD123 CAR T cells

scientific article published on 28 April 2022

Targeting beta-transducin repeat-containing protein E3 ubiquitin ligase augments the effects of antitumor drugs on breast cancer cells

scientific article

Targeting of TGFβ signature and its essential component CTGF by miR-18 correlates with improved survival in glioblastoma.

scientific article published on 18 December 2012

The Myc-miR-17-92 axis amplifies B-cell receptor signaling via inhibition of ITIM proteins: a novel lymphomagenic feed-forward loop.

scientific article published on 29 October 2013

The long reach of noncoding RNAs

scientific article published on 28 June 2011

The miR-17-92 microRNA cluster regulates multiple components of the TGF-β pathway in neuroblastoma

scientific article published on December 2010

The myc-miR-17~92 axis blunts TGF{beta} signaling and production of multiple TGF{beta}-dependent antiangiogenic factors

scientific article

Transient stabilization, rather than inhibition, of MYC amplifies extrinsic apoptosis and therapeutic responses in refractory B-cell lymphoma

scientific article published on 26 March 2019

Whence thrombospondin?

scientific article published on 29 April 2004

Widespread microRNA repression by Myc contributes to tumorigenesis

scientific article

c-Myb oncoprotein is an essential target of the dleu2 tumor suppressor microRNA cluster.

scientific article

miR-17-92 cluster components analysis in Burkitt lymphoma: overexpression of miR-17 is associated with poor prognosis

scientific article published on 05 April 2016

p53 status dictates responses of B lymphomas to monotherapy with proteasome inhibitors

scientific article (publication date: June 2007)

p53-responsive miR-194 inhibits thrombospondin-1 and promotes angiogenesis in colon cancers

scientific article

List of works by Andrei Thomas-Tikhonenko

A non-transgenic mouse model for B-cell lymphoma: in vivo infection of p53-null bone marrow progenitors by a Myc retrovirus is sufficient for tumorigenesis

Aberrant splicing in B-cell acute lymphoblastic leukemia

Aberrant splicing in B-cell acute lymphoblastic leukemia

Activation of transferrin receptor 1 by c-Myc enhances cellular proliferation and tumorigenesis

Aiding and ABT'ing Treatment for Glioblastoma

An essential role of Th1 responses and interferon gamma in infection-mediated suppression of neoplastic growth

An in vivo function for the transforming Myc protein: elicitation of the angiogenic phenotype.

B cell activator PAX5 promotes lymphomagenesis through stimulation of B cell receptor signaling

B cell-specific loss of histone 3 lysine 9 methylation in the V(H) locus depends on Pax5

B-Lymphoma cells with epigenetic silencing of Pax5 trans-differentiate into macrophages, but not other hematopoietic lineages

CAR T-cell therapy is effective for CD19-dim B-lymphoblastic leukemia but is impacted by prior blinatumomab therapy

CD19 alterations emerging after CD19-directed immunotherapy cause retention of the misfolded protein in the endoplasmic reticulum

CD19 is a major B cell receptor-independent activator of MYC-driven B-lymphomagenesis

Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomas

Colorectal Cancer-Associated Smad4 R361 Hotspot Mutations Boost Wnt/β-Catenin Signaling through Enhanced Smad4-LEF1 Binding

Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy

Correction: Transient stabilization, rather than inhibition, of MYC amplifies extrinsic apoptosis and therapeutic responses in refractory B-cell lymphoma

Cutting edge: systemic inhibition of angiogenesis underlies resistance to tumors during acute toxoplasmosis

Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity.

ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth

Epigenetic histone modifications do not control Igkappa locus contraction and intranuclear localization in cells with dual B cell-macrophage potential

Escape From ALL-CARTaz: Leukemia Immunoediting in the Age of Chimeric Antigen Receptors

Exons of Leukemia Suppressor Genes: Creative Assembly Required

Functional validation of genes implicated in lymphomagenesis: an in vivo selection assay using a Myc-induced B-cell tumor

Heterogeneity of surface CD19 and CD22 expression in B lymphoblastic leukemia

IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells

Identifying common transcriptome signatures of cancer by interpreting deep learning models

Inactivation of Myc in murine two-hit B lymphomas causes dormancy with elevated levels of interleukin 10 receptor and CD20: implications for adjuvant therapies

Infection & neoplastic growth 101: the required reading for microbial pathogens aspiring to cause cancer.

Infection and cancer: the common vein.

Inhibition of the single downstream target BAG1 activates the latent apoptotic potential of MYC.

Intratumoral delivery of an interferon gamma retrovirus-producing cells inhibits growth of a murine melanoma by a non-immune mechanism.

Kit-activating mutations in AML: lessons from PU.1-induced murine erythroleukemia

Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

MOCCASIN: a method for correcting for known and unknown confounders in RNA splicing analysis

MYC Hyperactivates Wnt Signaling in <i>APC</i>/<i>CTNNB1</i>-Mutated Colorectal Cancer Cells through miR-92a-Dependent Repression of <i>DKK3</i>

MYC and the art of microRNA maintenance

Masking epistasis between MYC and TGF-β pathways in antiangiogenesis-mediated colon cancer suppression

Metastasis-associated protein 1 (MTA1) is an essential downstream effector of the c-MYC oncoprotein

Myc overexpression brings out unexpected antiapoptotic effects of miR-34a ⬇️

Myc-transformed epithelial cells down-regulate clusterin, which inhibits their growth in vitro and carcinogenesis in vivo.

Oncogenic BRAF regulates beta-Trcp expression and NF-kappaB activity in human melanoma cells.

Oscillation between B-lymphoid and myeloid lineages in Myc-induced hematopoietic tumors following spontaneous silencing/reactivation of the EBF/Pax5 pathway.

PAX5 and B-cell neoplasms: transformation through presentation

Poisoning the messengers: could tumor endothelial cells acquire drug resistance?

Raf inhibitor stabilizes receptor for the type I interferon but inhibits its anti-proliferative effects in human malignant melanoma cells.

Regulation of CLU gene expression by oncogenes and epigenetic factors implications for tumorigenesis.

Repeated loss of target surface antigen after immunotherapy in primary mediastinal large B cell lymphoma

Retention of CD19 intron 2 contributes to CART-19 resistance in leukemias with subclonal frameshift mutations in CD19

Role of GLI2 transcription factor in growth and tumorigenicity of prostate cells

Shielding the messenger (RNA): microRNA-based anticancer therapies

Targeting CD123 in blastic plasmacytoid dendritic cell neoplasm using allogeneic anti-CD123 CAR T cells

Targeting beta-transducin repeat-containing protein E3 ubiquitin ligase augments the effects of antitumor drugs on breast cancer cells

Targeting of TGFβ signature and its essential component CTGF by miR-18 correlates with improved survival in glioblastoma.

The Myc-miR-17-92 axis amplifies B-cell receptor signaling via inhibition of ITIM proteins: a novel lymphomagenic feed-forward loop.

The long reach of noncoding RNAs

The miR-17-92 microRNA cluster regulates multiple components of the TGF-β pathway in neuroblastoma

The myc-miR-17~92 axis blunts TGF{beta} signaling and production of multiple TGF{beta}-dependent antiangiogenic factors

Transient stabilization, rather than inhibition, of MYC amplifies extrinsic apoptosis and therapeutic responses in refractory B-cell lymphoma

Whence thrombospondin?

Widespread microRNA repression by Myc contributes to tumorigenesis

c-Myb oncoprotein is an essential target of the dleu2 tumor suppressor microRNA cluster.

miR-17-92 cluster components analysis in Burkitt lymphoma: overexpression of miR-17 is associated with poor prognosis

p53 status dictates responses of B lymphomas to monotherapy with proteasome inhibitors

p53-responsive miR-194 inhibits thrombospondin-1 and promotes angiogenesis in colon cancers