Search filters

List of works by Gerardo Gamba

A novel protein kinase signaling pathway essential for blood pressure regulation in humans.

scientific article published on 14 February 2008

A single nucleotide polymorphism alters the activity of the renal Na+:Cl- cotransporter and reveals a role for transmembrane segment 4 in chloride and thiazide affinity

scientific article published on 5 February 2004

AKAP79 increases the functional expression of skeletal muscle Ca2+ channels in Xenopus oocytes

scientific article published in March 2004

AT1 receptor antagonism before ischemia prevents the transition of acute kidney injury to chronic kidney disease

scientific article published on 01 February 2016

Activation of the Bumetanide-sensitive Na+,K+,2Cl− Cotransporter (NKCC2) Is Facilitated by Tamm-Horsfall Protein in a Chloride-sensitive Manner ⬇️

scientific article published on 07 July 2011

Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process

scientific article

Activity of the renal Na+-K+-2Cl- cotransporter is reduced by mutagenesis of N-glycosylation sites: role for protein surface charge in Cl- transport

scientific journal article

Adrenalectomy prevents renal ischemia-reperfusion injury

scientific article published on 5 August 2009

Aldosterone paradox: differential regulation of ion transport in distal nephron.

scientific article published on April 2011

Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway

scientific article

Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family

scientific article

Cloning and functional characterization of the Anopheles albimanus DMT1/NRAMP homolog: implications in iron metabolism in mosquitoes.

scientific article published on 2 March 2007

Cloning and functional expression of a rat kidney extracellular calcium/polyvalent cation-sensing receptor

scientific article

Deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy

scientific article published in July 2000

Disruption of the with no lysine kinase-STE20-proline alanine-rich kinase pathway reduces the hypertension induced by angiotensin II.

scientific article published on 4 September 2017

Electroneutral Na-Coupled Cotransporter Expression in the Kidney During Variations of NaCl and Water Metabolism ⬇️

scientific article published on April 1, 1998

Electroneutral cation-chloride cotransporters in the central nervous system

scientific article published in January 2004

Electroneutral chloride-coupled co-transporters.

scientific article

Exonic mutations in the SLC12A3 gene cause exon skipping and premature termination in Gitelman syndrome

scientific article

Functional properties of a truncated recombinant GIRK5 potassium channel

scientific article

Functional properties of the apical Na+-K+-2Cl- cotransporter isoforms

scientific article (publication date: 29 March 2002)

Gain-of-function missense variant in SLC12A2, encoding the bumetanide-sensitive NKCC1 cotransporter, identified in human schizophrenia

scientific article published on 27 February 2016

Geraniin is a diuretic by inhibiting the Na+:K+:2Cl- cotransporter, NKCC2.

scientific article

Heat shock protein 72 (Hsp72) specific induction and temporal stability in urine samples as a reliable biomarker of acute kidney injury (AKI)

scientific article published on 21 October 2015

Hsp72 is an early and sensitive biomarker to detect acute kidney injury.

scientific article

Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3

scientific article

Identification and functional characterization of EhClC-A, an Entamoeba histolytica ClC chloride channel located at plasma membrane

scientific article published in February 2006

Identification and functional characterization of cation-chloride cotransporters in plants.

scientific article published on 12 March 2007

Inactivation of SPAK kinase reduces body weight gain in mice fed a High-fat diet by improving energy expenditure and insulin sensitivity

scientific article published on 24 October 2017

Increased phosphorylation of the renal Na+-Cl- cotransporter in male kidney transplant recipient patients with hypertension: a prospective cohort.

scientific article published on 2 September 2015

Independent regulation of Na+ and K+ balance by the kidney.

scientific article published on 25 October 2011

Influence of WNK3 on intracellular chloride concentration and volume regulation in HEK293 cells.

scientific article

Insulin and SGK1 reduce the function of Na+/monocarboxylate transporter 1 (SMCT1/SLC5A8).

scientific article published on 3 August 2016

Intra-renal transfection of heat shock protein 90 alpha or beta (Hsp90α or Hsp90β) protects against ischemia/reperfusion injury.

scientific article published on 28 October 2013

Ion and diuretic specificity of chimeric proteins between apical Na(+)-K(+)-2Cl(-) and Na(+)-Cl(-) cotransporters

scientific article

Kidney-specific WNK1 isoform (KS-WNK1) is a potent activator of WNK4 and NCC.

scientific article

Letter to the editor: Remembering Steve Hebert (1946-2008)

scientific article published on 01 July 2018

Low calorie commercial sugar is a sensitive marker of glomerular filtration rate.

scientific article published in October 2005

Mechanisms of sodium-chloride cotransporter modulation by angiotensin II.

scientific article published on September 2012

Mineralocorticoid receptor blockade confers renoprotection in preexisting chronic cyclosporine nephrotoxicity.

scientific article

Mineralocorticoid receptor phosphorylation regulates ligand binding and renal response to volume depletion and hyperkalemia

scientific article

Mini-review: regulation of the renal NaCl cotransporter by hormones

scientific article

Modulation of NCC activity by low and high K(+) intake: insights into the signaling pathways involved.

scientific article

Molecular biology of distal nephron sodium transport mechanisms

scientific article published on 01 October 1999

Molecular cloning and characterization of the renal diuretic-sensitive electroneutral sodium-(potassium)-chloride cotransporters.

scientific article published on September 1994

Molecular evidence for a role for K(+)-Cl(-) cotransporters in the kidney.

scientific article published on 02 October 2013

Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4

scientific article

Molecular physiology and pathophysiology of electroneutral cation-chloride cotransporters.

scientific article

Molecular physiology of cation-coupled Cl? cotransport: the SLC12 family ⬇️

scientific article (publication date: February 2004)

N-Glycosylation at two sites critically alters thiazide binding and activity of the rat thiazide-sensitive Na(+):Cl(-) cotransporter.

scientific article published in February 2003

N-terminal serine dephosphorylation is required for KCC3 cotransporter full activation by cell swelling

scientific article published on 16 September 2013

NH2-terminal heterogeneity in the KCC3 K+-Cl- cotransporter

scientific article

NKCC2 surface expression in mammalian cells: down-regulation by novel interaction with aldolase B.

scientific article published on 11 September 2007

Na+:K+:ATPase mRNA Expression in the Kidney During Adaptation to Sodium Intake and Furosemide Treatment

article

New insights into the pathophysiology of cyclosporine nephrotoxicity: a role of aldosterone.

scientific article published on 11 April 2007

On the molecular mechanism of renal salt excretion modulation by extracellular potassium

scientific article published on 01 November 2016

Opposite effect of Hsp90α and Hsp90β on eNOS ability to produce nitric oxide or superoxide anion in human embryonic kidney cells.

scientific article published on 29 October 2010

Ovarian hormones and prolactin increase renal NaCl cotransporter phosphorylation.

scientific article published on 13 January 2015

Pathophysiology of functional mutations of the thiazide-sensitive Na-Cl cotransporter in Gitelman disease

scientific article

Peritoneal protein loss in patients with high peritoneal permeability: comparison between continuous ambulatory peritoneal dialysis and daytime intermittent peritoneal dialysis

scientific article published in May 2001

Phorbol ester stimulation of RasGRP1 regulates the sodium-chloride cotransporter by a PKC-independent pathway.

scholarly article

Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4.

scientific article published on 17 January 2017

Physiological role of SLC12 family members in the kidney.

scientific article published on 20 April 2016

Polymerized type I collagen reduces chronic cyclosporine nephrotoxicity

scientific article published on 5 February 2010

Potassium and Its Discontents: New Insight, New Treatments

scientific article published on 28 October 2015

Radicicol, a heat shock protein 90 inhibitor, reduces glomerular filtration rate

scientific article published on 30 July 2008

Rare mutations in SLC12A1 and SLC12A3 protect against hypertension by reducing the activity of renal salt cotransporters

scientific article published in March 2011

Re: research in areas of transport physiology

scientific article published on 19 August 2009

Recovery from ischemic acute kidney injury by spironolactone administration

scientific article published on 19 April 2012

Regulation of NKCC2 activity by SPAK truncated isoforms.

scientific article

Regulation of Renal Electrolyte Transport by WNK and SPAK-OSR1 Kinases.

scientific article published on February 2016

Regulation of the renal Na+-Cl- cotransporter by phosphorylation and ubiquitylation

scientific article

Regulation of the renal NaCl cotransporter by the WNK/SPAK pathway: lessons learned from genetically altered animals

scientific article published on 08 August 2018

Renal Na+-K+-Cl- cotransporter activity and vasopressin-induced trafficking are lipid raft-dependent.

scientific article published on 25 June 2008

Renal ischemia-reperfusion injury is prevented by the mineralocorticoid receptor blocker spironolactone

scientific article published on 20 March 2007

Renal protection by a soy diet in obese Zucker rats is associated with restoration of nitric oxide generation.

scientific article

Renocortical mRNA expression of vasoactive factors during spironolactone protective effect in chronic cyclosporine nephrotoxicity

scientific journal article

Renoprotective mechanisms of soy protein intake in the obese Zucker rat

scientific journal article

Resilience to acute kidney injury in offspring of maternal protein restriction

scientific article published on 14 October 2019

Revisiting the NaCl cotransporter regulation by with-no-lysine kinases.

scientific article published on 18 March 2015

Roles of the cation-chloride cotransporters in neurological disease.

scientific article published on September 2008

SPAK and OSR1 play essential roles in potassium homeostasis through actions on the distal convoluted tubule.

scientific article published on 29 May 2016

Similar effects of all WNK3 variants on SLC12 cotransporters ⬇️

scientific article published on May 25, 2011

Spironolactone prevents chronic kidney disease caused by ischemic acute kidney injury

scientific article

TRPV4: a new target for the hypertension-related kinases WNK1 and WNK4

scientific article published on 07 February 2006

The Calcium-Sensing Receptor Increases Activity of the Renal NCC through the WNK4-SPAK Pathway

scientific article published on 30 May 2018

The Effect of Spironolactone on Acute Kidney Injury After Cardiac Surgery: A Randomized, Placebo-Controlled Trial

scientific article

The Effect of WNK4 on the Na+-Cl- Cotransporter Is Modulated by Intracellular Chloride

scientific article published on 26 December 2014

The European Eel NCCβ Gene Encodes a Thiazide-resistant Na-Cl Cotransporter.

scientific article published on September 2016

The SLC12 family of electroneutral cation-coupled chloride cotransporters.

scientific article published on April 2013

The evolving field of salt transport regulation in the Steve Hebert Lecture

scientific article

The many roles of the calcium-sensing receptor in health and disease.

scientific article

The nanopeptide hormone vasopressin is a new player in the modulation of renal Na(+)-Cl(-) cotransporter activity.

scientific article

The regulation of Na+Cl- cotransporter by with-no-lysine kinase 4.

scientific article published on 18 June 2016

The thiazide sensitive sodium chloride co-transporter NCC is modulated by site-specific ubiquitylation

scientific article published on 11 October 2017

The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs

scientific article

Therapeutic benefit of spironolactone in experimental chronic cyclosporine A nephrotoxicity.

scientific article published in January 2003

Thiazide diuretics directly induce osteoblast differentiation and mineralized nodule formation by interacting with a sodium chloride co-transporter in bone

scientific article

Thiazide-Sensitive Cotransporter mRNA Expression Is Not Altered in Three Models of Hypertension

article

Unique chloride-sensing properties of WNK4 permit the distal nephron to modulate potassium homeostasis

scientific article

WNK kinases, renal ion transport and hypertension

scientific article

WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4.

scientific article published on 11 August 2014

WNK3 abrogates the NEDD4-2-mediated inhibition of the renal Na+-Cl- cotransporter

scientific article published on 11 June 2014

WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na+-Cl- cotransporter

scientific article

WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway

scholarly article

WNK3 is a putative chloride-sensing kinase.

scientific article published on 16 December 2011

WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis

scientific article

WNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability.

scientific article

WNK3-SPAK interaction is required for the modulation of NCC and other members of the SLC12 family.

scientific article published in March 2012

WNK4 kinase is a negative regulator of K+-Cl- cotransporters.

scientific article published on 19 December 2006

With no lysine L-WNK1 isoforms are negative regulators of the K+-Cl- cotransporters

scientific article

Paulina is supported by:

About Paulina

Help