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List of works by Helen Blackwell

2‐Aminobenzimidazole Derivatives Strongly Inhibit and Disperse Pseudomonas aeruginosa Biofilms ⬇️

scientific article published on April 5, 2012

A Comparative Analysis of Synthetic Quorum Sensing Modulators in Pseudomonas aeruginosa: New Insights into Mechanism, Active Efflux Susceptibility, Phenotypic Response, and Next-Generation Ligand Design

scientific article

A Peptoid Ribbon Secondary Structure ⬇️

scientific article published on 09 April 2013

A comparative study of non-native N-acyl l-homoserine lactone analogs in two Pseudomonas aeruginosa quorum sensing receptors that share a common native ligand yet inversely regulate virulence

scientific article published on 14 May 2018

A stoma care nurse specialist

scientific article published on 01 March 2015

Active efflux influences the potency of quorum sensing inhibitors in Pseudomonas aeruginosa.

scientific article published on 29 January 2014

Application of Ring-Closing Metathesis to the Synthesis of Rigidified Amino Acids and Peptides

article

Attenuation of quorum sensing in the pathogen Acinetobacter baumannii using non-native N-Acyl homoserine lactones

scientific article published on 14 August 2012

Attenuation of virulence in pathogenic bacteria using synthetic quorum-sensing modulators under native conditions on plant hosts

scientific article published on 6 October 2011

Bacterial Quorum Sensing Signals Self-Assemble in Aqueous Media to Form Micelles and Vesicles: An Integrated Experimental and Molecular Dynamics Study

scientific article published on 09 April 2020

Bacterial crowd control with iron

scientific article published on 01 July 2005

Characterization of structural elements in native autoinducing peptides and non-native analogues that permit the differential modulation of AgrC-type quorum sensing receptors in Staphylococcus aureus

scientific article

Chemical Control of Quorum Sensing in E. coli: Identification of Small Molecule Modulators of SdiA and Mechanistic Characterization of a Covalent Inhibitor

scientific article published on 30 October 2020

Chemical Genetics Reveals Environment-Specific Roles for Quorum Sensing Circuits in Pseudomonas aeruginosa.

scientific article

Chemical Interrogation of LuxR-type Quorum Sensing Receptors Reveals New Insights into Receptor Selectivity and the Potential for Interspecies Bacterial Signaling

scientific article

Chemical genetic approaches to plant biology

scientific article published on October 2003

Chemical methods to interrogate bacterial quorum sensing pathways ⬇️

scientific article published on October 3, 2012

Chemical modification of reactive multilayered films fabricated from poly(2-alkenyl azlactone)s: design of surfaces that prevent or promote mammalian cell adhesion and bacterial biofilm growth

scientific article published on June 2009

Chemical probes of quorum sensing: from compound development to biological discovery

scientific article

Comparative analyses of N-acylated homoserine lactones reveal unique structural features that dictate their ability to activate or inhibit quorum sensing

scientific article published on February 2008

Competition studies confirm two major barriers that can preclude the spread of resistance to quorum-sensing inhibitors in bacteria

scientific article

Conformational Switch to a β-Turn in a Staphylococcal Quorum Sensing Signal Peptide Causes a Dramatic Increase in Potency

scientific article published on 02 January 2020

Construction of Peptoids with AllTrans-Amide Backbones and Peptoid Reverse Turns via the Tactical Incorporation ofN-Aryl Side Chains Capable of Hydrogen Bonding ⬇️

scientific article published on September 17, 2010

Control of quorum sensing by a Burkholderia pseudomallei multidrug efflux pump

scientific article published on 23 March 2007

Correction to "N-Acyl l-Homocysteine Thiolactones Are Potent and Stable Synthetic Modulators of the RhlR Quorum Sensing Receptor in Pseudomonas aeruginosa"

scientific article published on 12 May 2020

Corrigendum: Active Efflux Influences the Potency of Quorum Sensing Inhibitors inPseudomonas aeruginosa

scholarly article published in ChemBioChem

Deciphering a protolanguage for bacteria-host communication.

scientific article published in August 2008

Decoding Products of Diversity Pathways from Stock Solutions Derived from Single Polymeric Macrobeads H.E.B. and L.P. contributed equally to this work. We thank the National Institute of General Medical Sciences (GM-52067) for the support of this re

Design and conformational analysis of peptoids containing N‐hydroxy amides reveals a unique sheet‐like secondary structure ⬇️

scientific article published on January 1, 2011

Design and synthesis of macrocyclic peptomers as mimics of a quorum sensing signal from Staphylococcus aureus

scientific article

Design, Synthesis, and Biochemical Characterization of Non-Native Antagonists of the Pseudomonas aeruginosa Quorum Sensing Receptor LasR with Nanomolar IC50 Values

scientific article published on 19 February 2020

Design, synthesis, and biological evaluation of abiotic, non-lactone modulators of LuxR-type quorum sensing

scientific article

Discovery of fluorescent cyanopyridine and deazalumazine dyes using small molecule macroarrays

scientific article published on 01 April 2006

Diversity-oriented synthesis of biaryl-containing medium rings using a one bead/one stock solution platform

scientific article

Efficient construction of diketopiperazine macroarrays through a cyclative-cleavage strategy and their evaluation as luminescence inhibitors in the bacterial symbiont Vibrio fischeri

scientific article

Efficient synthesis and evaluation of quorum-sensing modulators using small molecule macroarrays

scientific article

Evaluation of a focused library of N-aryl L-homoserine lactones reveals a new set of potent quorum sensing modulators

scientific article

Expanding dialogues: from natural autoinducers to non-natural analogues that modulate quorum sensing in Gram-negative bacteria

scientific article published on 02 June 2008

Expedient construction of small molecule macroarrays via sequential palladium- and copper-mediated reactions and their ex situ biological testing ⬇️

scientific article published on May 1, 2012

Expedient synthesis and design strategies for new peptoid construction

scientific article

Extraordinarily robust polyproline type I peptoid helices generated via the incorporation of α-chiral aromatic N-1-naphthylethyl side chains

scientific article

Healing the wounds

scientific article published on 01 June 2007

Helping people who self-harm

scientific article published in June 2008

Highly Efficient Synthesis of Covalently Cross-Linked Peptide Helices by Ring-Closing Metathesis

scientific article published on 01 December 1998

Highly Stable, Amide-Bridged Autoinducing Peptide Analogues that Strongly Inhibit the AgrC Quorum Sensing Receptor in Staphylococcus aureus

scientific article published on 08 June 2016

Highly potent inhibitors of quorum sensing in Staphylococcus aureus revealed through a systematic synthetic study of the group-III autoinducing peptide

scientific article published on 17 May 2013

Hitting the SPOT: small-molecule macroarrays advance combinatorial synthesis

scientific article published on 6 May 2006

Identification of Synthetic Inducers and Inhibitors of the Quorum-Sensing Regulator LasR in Pseudomonas aeruginosa by High-Throughput Screening ⬇️

scientific article published on October 8, 2010

Identification of Unanticipated and Novel N-Acyl L-Homoserine Lactones (AHLs) Using a Sensitive Non-Targeted LC-MS/MS Method

scientific article

Implant-Associated Bacterial Biofilm and Quorum Sensing in Periprosthetic Joint Infections

scientific article published on 16 April 2018

Improved Small-Molecule Macroarray Platform for the Rapid Synthesis and Discovery of Antibacterial Chalcones ⬇️

scientific article published on January 6, 2011

Interception of quorum sensing in Staphylococcus aureus: a new niche for peptidomimetics

scientific article

Interkingdom Responses to Bacterial Quorum Sensing Signals Regulate Frequency and Rate of Nodulation in Legume-Rhizobia Symbiosis

scientific article

Introduction to Bacterial Signals and Chemical Communication ⬇️

scientific article published on January 12, 2011

Isovaleryl-homoserine lactone, an unusual branched-chain quorum-sensing signal from the soybean symbiont Bradyrhizobium japonicum

scientific article

Liquid Crystal Emulsions that Intercept and Report on Bacterial Quorum Sensing

scientific article published on 02 June 2020

Local and tunable n-->pi* interactions regulate amide isomerism in the peptoid backbone

scientific article published on 03 July 2007

Mechanism of agonism and antagonism of the Pseudomonas aeruginosa quorum sensing regulator QscR with non-native ligands.

scientific article published on 13 February 2018

Microwave-Facilitated SPOT-Synthesis of Antibacterial Dipeptoids

scientific article

Microwave-accelerated SPOT-synthesis on cellulose supports

scientific article published in June 2004

Modulation of bacterial quorum sensing with synthetic ligands: systematic evaluation of N-acylated homoserine lactones in multiple species and new insights into their mechanisms of action

scientific article published on 10 October 2007

Mutational analysis of the quorum-sensing receptor LasR reveals interactions that govern activation and inhibition by nonlactone ligands

scientific article

N-Acyl Homoserine Lactone Analog Modulators of the Pseudomonas aeruginosa Rhll Quorum Sensing Signal Synthase

scientific article published on 09 October 2019

N-Acyl l-Homocysteine Thiolactones Are Potent and Stable Synthetic Modulators of the RhlR Quorum Sensing Receptor in Pseudomonas aeruginosa

scientific article published on 01 February 2019

N-Methyl and peptoid scans of an autoinducing peptide reveal new structural features required for inhibition and activation of AgrC quorum sensing receptors in Staphylococcus aureus.

scientific article

N-[1-(Pentafluorophenyl)ethyl]acetamide

scientific article published on 22 April 2006

N-phenylacetanoyl-L-homoserine lactones can strongly antagonize or superagonize quorum sensing in Vibrio fischeri

scientific article published on 04 May 2007

Nanoporous Superhydrophobic Coatings that Promote the Extended Release of Water-Labile Quorum Sensing Inhibitors and Enable Long-Term Modulation of Quorum Sensing in Staphylococcus aureus

scientific article

New and unexpected insights into the modulation of LuxR-type quorum sensing by cyclic dipeptides

scientific article

New strategies for the design of folded peptoids revealed by a survey of noncovalent interactions in model systems

scientific article

Non-native N-aroyl L-homoserine lactones are potent modulators of the quorum sensing receptor RpaR in Rhodopseudomonas palustris

scientific article

Non-native acylated homoserine lactones reveal that LuxIR quorum sensing promotes symbiont stability.

scientific article

Non-native autoinducer analogs capable of modulating the SdiA quorum sensing receptor in serovar Typhimurium

scientific article published on 17 October 2018

Nonwoven Polymer Nanofiber Coatings That Inhibit Quorum Sensing in Staphylococcus aureus: Toward New Nonbactericidal Approaches to Infection Control.

scientific article published on 24 January 2017

Omics Technologies to Understand Activation of a Biosynthetic Gene Cluster in Micromonospora sp. WMMB235: Deciphering Keyicin Biosynthesis

scientific article published on 07 June 2019

Out of the oil bath and into the oven--microwave-assisted combinatorial chemistry heats up.

scientific article

Plant responses to bacterial N-acyl L-homoserine lactones are dependent on enzymatic degradation to L-homoserine

scientific article

Potent and Selective Modulation of the RhlR Quorum Sensing Receptor by Using Non-native Ligands: An Emerging Target for Virulence Control in Pseudomonas aeruginosa

scientific article published on 10 September 2015

Potent and Selective Synthetic Modulators of a Quorum Sensing Repressor in Pseudomonas aeruginosa Identified from Second‐Generation Libraries of N‐Acylated L‐Homoserine Lactones ⬇️

scientific article published on April 11, 2011

Potent modulation of the CepR quorum sensing receptor and virulence in a Burkholderia cepacia complex member using non-native lactone ligands

scientific article published on 17 September 2019

Quorum sensing in bacterial species that use degenerate autoinducers can be tuned by using structurally identical non-native ligands.

scientific article

Quorum-sensing signals in the microbial community of the cabbage white butterfly larval midgut

scientific article (publication date: November 2008)

Rapid identification of antibacterial agents effective against Staphylococcus aureus using small-molecule macroarrays

scientific article published on 01 April 2007

Rapid synthesis of diketopiperazine macroarrays via Ugi four-component reactions on planar solid supports

scientific article

SIR1, an upstream component in auxin signaling identified by chemical genetics

scientific article

Selection of appropriate autoinducer analogs for the modulation of quorum sensing at the host-bacteria interface

scientific article published on 18 October 2018

Simplified AIP-II Peptidomimetics Are Potent Inhibitors of Staphylococcus aureus AgrC Quorum Sensing Receptors.

scientific article

Simplified Autoinducing Peptide Mimetics with Single-Nanomolar Activity Against the Staphylococcus aureus AgrC Quorum Sensing Receptor

scientific article published on 13 March 2019

Slippery Liquid-Infused Porous Surfaces that Prevent Bacterial Surface Fouling and Inhibit Virulence Phenotypes in Surrounding Planktonic Cells.

scientific article published on 07 June 2016

Slippery Liquid-Infused Porous Surfaces that Prevent Microbial Surface Fouling and Kill Non-Adherent Pathogens in Surrounding Media: A Controlled Release Approach

scientific article

Small Molecules That Modulate Quorum Sensing and Control Virulence in Pseudomonas aeruginosa ⬇️

scientific article published on October 15, 2010

Small molecule disruption of quorum sensing cross-regulation in pseudomonas aeruginosa causes major and unexpected alterations to virulence phenotypes

scientific article

Small molecule inhibitors of bacterial quorum sensing and biofilm formation

scientific article published in September 2005

Small molecule macroarray construction via Ugi four-component reactions

scientific article published on 01 September 2005

Small molecule macroarray construction via palladium-mediated carbon-carbon bond-forming reactions: highly efficient synthesis and screening of stilbene arrays

scientific article

Solid-phase and microwave-assisted syntheses of 2,5-diketopiperazines: small molecules with great potential

scientific article published on December 2007

Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop "Out" Conformation for LasR

scientific article published on 19 July 2018

Structural characterization of native autoinducing peptides and abiotic analogues reveals key features essential for activation and inhibition of an AgrC quorum sensing receptor in Staphylococcus aureus

scientific article

Structure-Based Design and Biological Evaluation of Triphenyl Scaffold-Based Hybrid Compounds as Hydrolytically Stable Modulators of a LuxR-Type Quorum Sensing Receptor

scientific article

Structure-Function Analyses of a Staphylococcus epidermidis Autoinducing Peptide Reveals Motifs Critical for AgrC-type Receptor Modulation

scientific article

Structure-Function Analyses of the N-Butanoyl l-Homoserine Lactone Quorum-Sensing Signal Define Features Critical to Activity in RhlR

scientific article published on 31 August 2018

Structure-function relationships in peptoids: recent advances toward deciphering the structural requirements for biological function

scientific article published on 11 February 2009

Surface coatings that promote rapid release of peptide-based AgrC inhibitors for attenuation of quorum sensing in Staphylococcus aureus

scientific article published on 28 June 2013

Surface-mediated release of a small-molecule modulator of bacterial biofilm formation: a non-bactericidal approach to inhibiting biofilm formation in Pseudomonas aeruginosa

scientific article

Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: Gradual release enhances activity ⬇️

scientific article published on September 9, 2010

Synthesis and application of an N-acylated l-homoserine lactone derivatized affinity matrix for the isolation of quorum sensing signal receptors ⬇️

scientific article published on April 22, 2011

Synthesis and biological evaluation of triazole-containing N-acyl homoserine lactones as quorum sensing modulators

scientific article

Synthesis and characterization of nitroaromatic peptoids: fine tuning peptoid secondary structure through monomer position and functionality

scientific article published in February 2009

Synthetic ligands that activate and inhibit a quorum-sensing regulator in Pseudomonas aeruginosa

scientific article published in May 2008

The State of the Union Is Strong: a Review of ASM's 6th Conference on Cell-Cell Communication in Bacteria

scientific article published on 25 June 2018

The role of the specialist nurse in pelvic floor dysfunction

scientific article

Thiolactone modulators of quorum sensing revealed through library design and screening ⬇️

scientific article published on August 15, 2011

Tuning peptoid secondary structure with pentafluoroaromatic functionality: a new design paradigm for the construction of discretely folded peptoid structures

scientific article published on 01 November 2006

Unraveling the contributions of hydrogen-bonding interactions to the activity of native and non-native ligands in the quorum-sensing receptor LasR.

scientific article

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