List of works - Seiji Watanabe

A copper-deficient form of mutant Cu/Zn-superoxide dismutase as an early pathological species in amyotrophic lateral sclerosis

scientific article published on 15 March 2018

ALS-linked TDP-43M337V knock-in mice exhibit splicing deregulation without neurodegeneration

scientific article published on 20 January 2020

Aggresome formation and liquid-liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 43

scientific article published on 23 October 2020

Astrocyte-derived TGF-β1 accelerates disease progression in ALS mice by interfering with the neuroprotective functions of microglia and T cells

scientific article published on 16 April 2015

Chimeric ZHHH neuroglobin acts as a cell membrane-penetrating inducer of neurite outgrowth.

scientific article published on 14 August 2017

Crucial roles of Glu60 in human neuroglobin as a guanine nucleotide dissociation inhibitor and neuroprotective agent

scientific article

Cystatin C protects neuronal cells against mutant copper-zinc superoxide dismutase-mediated toxicity

scientific article published on 30 October 2014

Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life

scientific article

Functional characterization of fish neuroglobin: zebrafish neuroglobin is highly expressed in amacrine cells after optic nerve injury and can translocate into ZF4 cells.

scientific article published on 24 February 2013

Human neuroglobin functions as an oxidative stress-responsive sensor for neuroprotection

scientific article published on 11 July 2012

Identification of residues critical for the cell-membrane-penetrating activity of zebrafish neuroglobin

scientific article published on 24 April 2010

Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis

scientific article published on 05 January 2017

Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes.

scientific article published on 22 March 2018

Intracerebroventricular administration of Cystatin C ameliorates disease in SOD1-linked amyotrophic lateral sclerosis mice

scientific article

Mahogunin ring finger 1 confers cytoprotection against mutant SOD1 aggresomes and is defective in an ALS mouse model

article

Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1-Akt signaling pathway

scientific article published on 25 July 2019

Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALS

scientific article

Module M1 of zebrafish neuroglobin acts as a structural and functional protein building block for a cell-membrane-penetrating activity

scientific article

Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons.

scientific article published on 18 February 2016

Neuroprotective function of human neuroglobin is correlated with its guanine nucleotide dissociation inhibitor activity

scientific article published on 25 February 2008

SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system

scientific article

Species-specific functional evolution of neuroglobin

scientific article published on April 1, 2011

TDP-43 accelerates age-dependent degeneration of interneurons

scientific article

Zebrafish neuroglobin is a cell-membrane-penetrating globin.

scientific article

List of works by Seiji Watanabe

A copper-deficient form of mutant Cu/Zn-superoxide dismutase as an early pathological species in amyotrophic lateral sclerosis

ALS-linked TDP-43M337V knock-in mice exhibit splicing deregulation without neurodegeneration

Aggresome formation and liquid-liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 43

Astrocyte-derived TGF-β1 accelerates disease progression in ALS mice by interfering with the neuroprotective functions of microglia and T cells

Chimeric ZHHH neuroglobin acts as a cell membrane-penetrating inducer of neurite outgrowth.

Crucial roles of Glu60 in human neuroglobin as a guanine nucleotide dissociation inhibitor and neuroprotective agent

Cystatin C protects neuronal cells against mutant copper-zinc superoxide dismutase-mediated toxicity

Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life

Functional characterization of fish neuroglobin: zebrafish neuroglobin is highly expressed in amacrine cells after optic nerve injury and can translocate into ZF4 cells.

Human neuroglobin functions as an oxidative stress-responsive sensor for neuroprotection

Identification of residues critical for the cell-membrane-penetrating activity of zebrafish neuroglobin

Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis

Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes.

Intracerebroventricular administration of Cystatin C ameliorates disease in SOD1-linked amyotrophic lateral sclerosis mice

Mahogunin ring finger 1 confers cytoprotection against mutant SOD1 aggresomes and is defective in an ALS mouse model

Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1-Akt signaling pathway

Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALS

Module M1 of zebrafish neuroglobin acts as a structural and functional protein building block for a cell-membrane-penetrating activity

Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons.

Neuroprotective function of human neuroglobin is correlated with its guanine nucleotide dissociation inhibitor activity

SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system

Species-specific functional evolution of neuroglobin

TDP-43 accelerates age-dependent degeneration of interneurons

Zebrafish neuroglobin is a cell-membrane-penetrating globin.