List of works - Nichollas E. Scott

A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling

scientific article published on 7 November 2017

A common pathway for O-linked protein-glycosylation and synthesis of capsule in Acinetobacter baumannii

scientific article published on 12 July 2013

A forward genetic screen identifies a negative regulator of rapid Ca2+-dependent cell egress (MS1) in the intracellular parasite Toxoplasma gondii.

scientific article published on 3 March 2017

A general protein O-glycosylation machinery conserved in Burkholderia species improves bacterial fitness and elicits glycan immunogenicity in humans

scientific article published on 26 July 2019

A general protein O-glycosylation system within the Burkholderia cepacia complex is involved in motility and virulence.

scientific article published on 5 March 2014

A glycoengineered antigen exploiting a conserved protein O-glycosylation pathway in the Burkholderia genus for detection of glanders infections

scientific article published on 01 December 2021

A platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using E. coli as a host

scientific article published on 21 February 2019

A promising bioconjugate vaccine against hypervirulent Klebsiella pneumoniae

scientific article published on 27 August 2019

A rapid and accurate approach for prediction of interactomes from co-elution data (PrInCE).

scientific article published on 23 October 2017

A sulfoglycolytic Entner-Doudoroff pathway in Rhizobium leguminosarum bv. trifolii SRDI565

scientific article published on 22 May 2020

Acinetobacter strains carry two functional oligosaccharyltransferases, one devoted exclusively to type IV pilin, and the other one dedicated to O-glycosylation of multiple proteins.

scientific article

Biogenesis of the Spacious Coxiella-Containing Vacuole Depends on Host Transcription Factors TFEB and TFE3

scientific article published on 20 February 2020

Burkholderia PglL enzymes are Serine preferring oligosaccharyltransferases which target conserved proteins across the Burkholderia genus

scientific article published on 07 September 2021

CDK13 cooperates with CDK12 to control global RNA polymerase II processivity

scientific article published on 29 April 2020

Cardiac Ryanodine Receptor (Ryr2)-mediated Calcium Signals Specifically Promote Glucose Oxidation via Pyruvate Dehydrogenase

scientific article published on 12 September 2016

Characterization of the Citrobacter rodentium Cpx regulon and its role in host infection

scientific article published on 11 February 2019

Characterizing Glycoproteins by Mass Spectrometry in Campylobacter jejuni.

scientific article published on January 2017

Clinical implications of glycoproteomics for Acinetobacter baumannii

scientific article published on 11 December 2014

Comparative proteomics and glycoproteomics reveal increased N-linked glycosylation and relaxed sequon specificity in Campylobacter jejuni NCTC11168 O.

scientific article published on 25 August 2014

Development and Immunogenicity of a Prototype Multivalent Group B <i>Streptococcus</i> Bioconjugate Vaccine

scientific article published on 11 October 2021

Development of a computational framework for the analysis of protein correlation profiling and spatial proteomics experiments.

scientific article published on 20 November 2014

Direct RNA sequencing and early evolution of SARS-CoV-2

scientific article (preprint)

Diversity in the protein N-glycosylation pathways within the Campylobacter genus

scientific article

Diversity within the O-linked protein glycosylation systems of acinetobacter species

scientific article

Enrichment and identification of bacterial glycopeptides by mass spectrometry

scientific article published on 01 January 2015

Expanding our understanding of the role of microbial glycoproteomes through high-throughput mass spectrometry approaches

scientific article published on 04 July 2019

Genetic Dissection of the Type VI Secretion System in Acinetobacter and Identification of a Novel Peptidoglycan Hydrolase, TagX, Required for Its Biogenesis.

scientific article published on 11 October 2016

High-Frequency Variation of Purine Biosynthesis Genes Is a Mechanism of Success in Campylobacter jejuni.

scientific article

Identification of a general O-linked protein glycosylation system in Acinetobacter baumannii and its role in virulence and biofilm formation

scientific article

Identification of membrane-associated proteins from Campylobacter jejuni strains using complementary proteomics technologies

scientific article

In vitro activity of Neisseria meningitidis PglL O-oligosaccharyltransferase with diverse synthetic lipid donors and a UDP-activated sugar

scientific article published on 4 March 2013

Interactome disassembly during apoptosis occurs independent of caspase cleavage

scientific article published on 12 January 2017

Ion Mobility–Based Enrichment-Free N-Terminomics Analysis Reveals Novel Legumain Substrates in Murine Spleen

scientific article published in 2024

Loss of O-Linked Protein Glycosylation in Burkholderia cenocepacia Impairs Biofilm Formation and Siderophore Activity and Alters Transcriptional Regulators

scientific article published on 13 November 2019

Mass spectrometric characterization of the Campylobacter jejuni adherence factor CadF reveals post-translational processing that removes immunogenicity while retaining fibronectin binding

scientific article

Mass spectrometric characterization of the surface-associated 42 kDa lipoprotein JlpA as a glycosylated antigen in strains of Campylobacter jejuni.

scientific article published in October 2009

Modern Acinetobacter baumannii clinical isolates replicate inside spacious vacuoles and egress from macrophages

scientific article published on 09 August 2021

Modification of the Campylobacter jejuni N-linked glycan by EptC protein-mediated addition of phosphoethanolamine

scientific article published on 2 July 2012

NleB2 from enteropathogenic Escherichia coli is a novel arginine-glucose transferase effector

scientific article published on 16 June 2021

Novel Host Proteins and Signaling Pathways in Enteropathogenic E. coli Pathogenesis Identified by Global Phosphoproteome Analysis

scientific article

Open database searching enables the identification and comparison of bacterial glycoproteomes without defining glycan compositions prior to searching

scientific article published on 23 June 2020

POFUT2-mediated O-glycosylation of MIC2 is dispensable for Toxoplasma gondii tachyzoites

Pathogenic Acinetobacter species have a functional type I secretion system and contact-dependent inhibition systems.

scientific article

Post-translational Mechanisms of Host Subversion by Bacterial Effectors

scientific article published on 14 November 2017

Profiling the membrane protein interactome captured in Peptidisc libraries

scientific article published on 31 July 2019

Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts.

scientific article published on 15 September 2017

Protein O-fucosyltransferase 2–mediated O-glycosylation of the adhesin MIC2 is dispensable for Toxoplasma gondii tachyzoite infection

scientific article published in Journal of Biological Chemistry

Protein O-linked glycosylation in the plant pathogen Ralstonia solanacearum

scientific article published on 3 November 2015

Proteomic identification of Coxiella burnetii effector proteins targeted to the host cell mitochondria during infection

scientific article published on 11 November 2020

Proteomics Reveals Multiple Phenotypes Associated with N-linked Glycosylation in Campylobacter jejuni

scientific article published on 07 January 2019

Proteomics of the oxidative stress response induced by hydrogen peroxide and paraquat reveals a novel AhpC-like protein in Pseudomonas aeruginosa

scientific journal article

Quantitative N-linked glycoproteomics of myocardial ischemia and reperfusion injury reveals early remodeling in the extracellular environment

scientific article

Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis

scientific article published on 04 September 2019

Salmonella Effectors SseK1 and SseK3 Target Death Domain Proteins in the TNF and TRAIL Signaling Pathways

scientific article published on 22 March 2019

Secretome of transmissible Pseudomonas aeruginosa AES-1R grown in a cystic fibrosis lung-like environment.

scientific article published on 9 October 2013

Sequence TTKF ↓ QE defines the site of proteolytic cleavage in Mhp683 protein, a novel glycosaminoglycan and cilium adhesin of Mycoplasma hyopneumoniae

scientific article published on 3 October 2011

Simultaneous glycan-peptide characterization using hydrophilic interaction chromatography and parallel fragmentation by CID, higher energy collisional dissociation, and electron transfer dissociation MS applied to the N-linked glycoproteome of Campy

scientific article published on April 2010

Site-specific glycan-peptide analysis for determination of N-glycoproteome heterogeneity

scientific article published in November 2013

Site-specific immobilization of the endosialidase reveals QSOX2 is a novel polysialylated protein

scientific article published in 2024

Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation

scientific article

Synthesis and use of 6,6,6-trifluoro-L-fucose to block core-fucosylation in hybridoma cell lines

scientific article published on 23 May 2018

The Type III Effector NleD from Enteropathogenic Escherichia coli Differentiates between Host Substrates p38 and JNK.

scientific article

The bacterial arginine glycosyltransferase effector NleB preferentially modifies Fas-associated death domain protein (FADD).

scientific article

The mycobacterial glycoside hydrolase LamH enables capsular arabinomannan release and stimulates growth

scientific article published in 2024

The role of mass spectrometry analysis in bacterial effector characterization

scientific article published on 7 August 2017

Transmission of Cricket paralysis virus via exosome-like vesicles during infection of Drosophila cells

scientific article published in Scientific Reports

Trefoil factors share a lectin activity that defines their role in mucus

scientific article published on 13 May 2020

Urinary tract colonization is enhanced by a plasmid that regulates uropathogenic Acinetobacter baumannii chromosomal genes

scientific article published on 24 June 2019

What Are We Missing by Using Hydrophilic Enrichment? Improving Bacterial Glycoproteome Coverage Using Total Proteome and FAIMS Analyses

scientific article published on 30 October 2020

List of works by Nichollas E. Scott

A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling

A common pathway for O-linked protein-glycosylation and synthesis of capsule in Acinetobacter baumannii

A forward genetic screen identifies a negative regulator of rapid Ca2+-dependent cell egress (MS1) in the intracellular parasite Toxoplasma gondii.

A general protein O-glycosylation machinery conserved in Burkholderia species improves bacterial fitness and elicits glycan immunogenicity in humans

A general protein O-glycosylation system within the Burkholderia cepacia complex is involved in motility and virulence.

A glycoengineered antigen exploiting a conserved protein O-glycosylation pathway in the Burkholderia genus for detection of glanders infections

A platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using E. coli as a host

A promising bioconjugate vaccine against hypervirulent Klebsiella pneumoniae

A rapid and accurate approach for prediction of interactomes from co-elution data (PrInCE).

A sulfoglycolytic Entner-Doudoroff pathway in Rhizobium leguminosarum bv. trifolii SRDI565

Acinetobacter strains carry two functional oligosaccharyltransferases, one devoted exclusively to type IV pilin, and the other one dedicated to O-glycosylation of multiple proteins.

Biogenesis of the Spacious Coxiella-Containing Vacuole Depends on Host Transcription Factors TFEB and TFE3

Burkholderia PglL enzymes are Serine preferring oligosaccharyltransferases which target conserved proteins across the Burkholderia genus

CDK13 cooperates with CDK12 to control global RNA polymerase II processivity

Cardiac Ryanodine Receptor (Ryr2)-mediated Calcium Signals Specifically Promote Glucose Oxidation via Pyruvate Dehydrogenase

Characterization of the Citrobacter rodentium Cpx regulon and its role in host infection

Characterizing Glycoproteins by Mass Spectrometry in Campylobacter jejuni.

Clinical implications of glycoproteomics for Acinetobacter baumannii

Comparative proteomics and glycoproteomics reveal increased N-linked glycosylation and relaxed sequon specificity in Campylobacter jejuni NCTC11168 O.

Development and Immunogenicity of a Prototype Multivalent Group B <i>Streptococcus</i> Bioconjugate Vaccine

Development of a computational framework for the analysis of protein correlation profiling and spatial proteomics experiments.

Direct RNA sequencing and early evolution of SARS-CoV-2

Diversity in the protein N-glycosylation pathways within the Campylobacter genus

Diversity within the O-linked protein glycosylation systems of acinetobacter species

Enrichment and identification of bacterial glycopeptides by mass spectrometry

Expanding our understanding of the role of microbial glycoproteomes through high-throughput mass spectrometry approaches

Genetic Dissection of the Type VI Secretion System in Acinetobacter and Identification of a Novel Peptidoglycan Hydrolase, TagX, Required for Its Biogenesis.

High-Frequency Variation of Purine Biosynthesis Genes Is a Mechanism of Success in Campylobacter jejuni.

Identification of a general O-linked protein glycosylation system in Acinetobacter baumannii and its role in virulence and biofilm formation

Identification of membrane-associated proteins from Campylobacter jejuni strains using complementary proteomics technologies

In vitro activity of Neisseria meningitidis PglL O-oligosaccharyltransferase with diverse synthetic lipid donors and a UDP-activated sugar

Interactome disassembly during apoptosis occurs independent of caspase cleavage

Ion Mobility–Based Enrichment-Free N-Terminomics Analysis Reveals Novel Legumain Substrates in Murine Spleen

Loss of O-Linked Protein Glycosylation in Burkholderia cenocepacia Impairs Biofilm Formation and Siderophore Activity and Alters Transcriptional Regulators

Mass spectrometric characterization of the Campylobacter jejuni adherence factor CadF reveals post-translational processing that removes immunogenicity while retaining fibronectin binding

Mass spectrometric characterization of the surface-associated 42 kDa lipoprotein JlpA as a glycosylated antigen in strains of Campylobacter jejuni.

Modern Acinetobacter baumannii clinical isolates replicate inside spacious vacuoles and egress from macrophages

Modification of the Campylobacter jejuni N-linked glycan by EptC protein-mediated addition of phosphoethanolamine

NleB2 from enteropathogenic Escherichia coli is a novel arginine-glucose transferase effector

Novel Host Proteins and Signaling Pathways in Enteropathogenic E. coli Pathogenesis Identified by Global Phosphoproteome Analysis

Open database searching enables the identification and comparison of bacterial glycoproteomes without defining glycan compositions prior to searching

POFUT2-mediated O-glycosylation of MIC2 is dispensable for Toxoplasma gondii tachyzoites

Pathogenic Acinetobacter species have a functional type I secretion system and contact-dependent inhibition systems.

Post-translational Mechanisms of Host Subversion by Bacterial Effectors

Profiling the membrane protein interactome captured in Peptidisc libraries

Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts.

Protein O-fucosyltransferase 2–mediated O-glycosylation of the adhesin MIC2 is dispensable for Toxoplasma gondii tachyzoite infection

Protein O-linked glycosylation in the plant pathogen Ralstonia solanacearum

Proteomic identification of Coxiella burnetii effector proteins targeted to the host cell mitochondria during infection

Proteomics Reveals Multiple Phenotypes Associated with N-linked Glycosylation in Campylobacter jejuni

Proteomics of the oxidative stress response induced by hydrogen peroxide and paraquat reveals a novel AhpC-like protein in Pseudomonas aeruginosa

Quantitative N-linked glycoproteomics of myocardial ischemia and reperfusion injury reveals early remodeling in the extracellular environment

Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis

Salmonella Effectors SseK1 and SseK3 Target Death Domain Proteins in the TNF and TRAIL Signaling Pathways

Secretome of transmissible Pseudomonas aeruginosa AES-1R grown in a cystic fibrosis lung-like environment.

Sequence TTKF ↓ QE defines the site of proteolytic cleavage in Mhp683 protein, a novel glycosaminoglycan and cilium adhesin of Mycoplasma hyopneumoniae

Simultaneous glycan-peptide characterization using hydrophilic interaction chromatography and parallel fragmentation by CID, higher energy collisional dissociation, and electron transfer dissociation MS applied to the N-linked glycoproteome of Campy

Site-specific glycan-peptide analysis for determination of N-glycoproteome heterogeneity

Site-specific immobilization of the endosialidase reveals QSOX2 is a novel polysialylated protein

Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation

Synthesis and use of 6,6,6-trifluoro-L-fucose to block core-fucosylation in hybridoma cell lines

The Type III Effector NleD from Enteropathogenic Escherichia coli Differentiates between Host Substrates p38 and JNK.

The bacterial arginine glycosyltransferase effector NleB preferentially modifies Fas-associated death domain protein (FADD).

The mycobacterial glycoside hydrolase LamH enables capsular arabinomannan release and stimulates growth

The role of mass spectrometry analysis in bacterial effector characterization

Transmission of Cricket paralysis virus via exosome-like vesicles during infection of Drosophila cells

Trefoil factors share a lectin activity that defines their role in mucus

Urinary tract colonization is enhanced by a plasmid that regulates uropathogenic Acinetobacter baumannii chromosomal genes

What Are We Missing by Using Hydrophilic Enrichment? Improving Bacterial Glycoproteome Coverage Using Total Proteome and FAIMS Analyses