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List of works by Tony Wilkinson

A Midterm Review of Lesser Toe Arthrodesis With an Intramedullary Implant.

scientific article

A bacterial virulence factor with a dual role as an adhesin and a solute-binding protein: the crystal structure at 1.5 A resolution of the PEB1a protein from the food-borne human pathogen Campylobacter jejuni

scientific article

A fluorescence-based assay for N-myristoyltransferase activity

scientific article published on 14 October 2011

A large increase in enzyme–substrate affinity by protein engineering

scientific article published in Nature

A rapid introduction to neurological biochemistry using Drosophila melanogaster

scientific article published on 8 November 2018

A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases.

scientific article

Accommodating structurally diverse peptides in proteins.

scientific article published on July 1996

Alteration of Axial Coordination by Protein Engineering in Myoglobin

scientific article published in Journal of Biological Chemistry

An ATP-binding cassette-type cysteine transporter in Campylobacter jejuni inferred from the structure of an extracytoplasmic solute receptor protein

scientific article published in July 2005

An [{Fe(mecam)}2]6− Bridge in the Crystal Structure of a Ferric Enterobactin Binding Protein

scientific article published on 01 August 2006

An evolutionary link between sporulation and prophage induction in the structure of a repressor:anti-repressor complex ⬇️

scientific article published on November 13, 1998

An oscillating Min system in Bacillus subtilis influences asymmetrical septation during sporulation.

scientific article published on 24 May 2012

Analyse von Struktur-Aktivitäts-Beziehungen bei Enzymen durch Protein-Engineering

article

Apomyoglobin as a molecular recognition surface: expression, reconstitution and crystallization of recombinant porcine myoglobin in Escherichia coli.

scientific article

Application of high-throughput technologies to a structural proteomics-type analysis of Bacillus anthracis.

scientific article published on 19 September 2006

Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens.

scientific article published on 19 September 2006

Bacillus subtilis regulatory protein GerE

scientific article published in November 1998

Bacillus subtilisdivision protein DivIVA – screen for stable oligomer state conditions

scientific article published on 26 September 2002

Changes of lipid domains in Bacillus subtilis cells with disrupted cell wall peptidoglycan.

scientific article published on 3 October 2011

Cloning, overexpression, crystallization and preliminary X-ray crystallographic analysis of a slow-processing mutant of penicillin G acylase from Kluyvera citrophila

scientific article published on 27 July 2013

Compensating Stereochemical Changes Allow Murein Tripeptide to Be Accommodated in a Conventional Peptide-binding Protein

scientific article

Condition-dependent transcriptome reveals high-level regulatory architecture in Bacillus subtilis

scientific article

Conservation of structure and mechanism in primary and secondary transporters exemplified by SiaP, a sialic acid binding virulence factor from Haemophilus influenzae

scientific article

Conserved arginine residues implicated in ATP hydrolysis, nucleotide-sensing, and inter-subunit interactions in AAA and AAA+ ATPases.

scientific article published on April 2004

Control of Initiation of DNA Replication in Bacillus subtilis and Escherichia coli.

scientific article published on 10 January 2017

Crystal and Solution Studies Reveal That the Transcriptional Regulator AcnR of Corynebacterium glutamicum Is Regulated by Citrate-Mg2+ Binding to a Non-canonical Pocket

scientific article

Crystal structure of PurE (BA0288) from Bacillus anthracis at 1.8 A resolution

scientific article published in November 2005

Crystal structure of dihydrodipicolinate synthase (BA3935) from Bacillus anthracis at 1.94 A resolution

scientific article

Crystal structure of the putative peptide-binding protein AppA from Clostridium difficile

scientific article published on 13 March 2019

Crystal structures of the GH18 domain of the bifunctional peroxiredoxin-chitinase CotE from Clostridium difficile

scientific article published on 29 May 2020

Crystallisation of the Bacillus subtilis sporulation inhibitor SinR, complexed with its antagonist, Sinl

scientific article published on 2 January 1996

Crystallization and preliminary X-ray analysis of the sporulation factor SpoIIAA in its native and phosphorylated forms

scientific article published in February 2001

Crystallization and preliminary crystallographic analysis of the DNA gyrase B protein from B. stearothermophilus

scientific article published in November 1996

Crystallization and preliminary crystallographic studies of the cofactor-binding domain of the LysR-type transcriptional regulator Cbl from Escherichia coli

scientific article

Crystallization of YloQ, a GTPase of unknown function essential for Bacillus subtilis viability

scientific article published on 23 January 2004

Crystallization of a DNA and N-acetylserine Binding Fragment (Residues 1 to 233) of Klebsiella aerogenes CysB Protein, a Member of the LysR Family

scientific article published on 01 January 1994

Crystallization of full-length CysB of Klebsiella aerogenes, a LysR-type transcriptional regulator.

scientific article

Crystallization of gankyrin, an oncoprotein that interacts with CDK4 and the S6b (rpt3) ATPase of the 19S regulator of the 26S proteasome

scientific article

Crystallization of the AAA domain of the ATP-dependent protease FtsH of Escherichia coli

scientific article published on 29 May 2002

Crystallization of the GTP-dependent transcriptional regulator CodY from Bacillus subtilis

scientific article

Crystallization of the oligopeptide-binding protein AppA from Bacillus subtilis

scientific article published on 18 December 2003

Crystallization of the periplasmic oligopeptide-binding protein of Salmonella typhimurium

scientific article published in November 1988

Crystallization of the regulatory and effector domains of the key sporulation response regulator Spo0A

scientific article published in March 1999

Crystallographic and solution studies of N-lithocholyl insulin: a new generation of prolonged-acting human insulins

scientific article

Cysteine thiolate coordination in the ferrous CO complex of an engineered cytochrome b562.

scientific article published in March 2001

Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N -Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP)

scientific article

Design and Synthesis of Inhibitors of Plasmodium falciparumN -Myristoyltransferase, A Promising Target for Antimalarial Drug Discovery

scientific article

Dimer formation and transcription activation in the sporulation response regulator Spo0A.

scientific article published in February 2002

Discovery of Novel and Ligand-Efficient Inhibitors of Plasmodium falciparum and Plasmodium vivax N -Myristoyltransferase

scientific article

Discovery of Plasmodium vivax N -Myristoyltransferase Inhibitors: Screening, Synthesis, and Structural Characterization of their Binding Mode

scientific article

Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase.

scientific article published on 19 August 2015

Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase

scientific article published on 19 August 2015

Dissecting the role of a conserved motif (the second region of homology) in the AAA family of ATPases. Site-directed mutagenesis of the ATP-dependent protease FtsH.

scientific article

Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors

scientific article

Division site recognition in Escherichia coli and Bacillus subtilis

scientific article published on 26 February 2007

Domain swapping in the sporulation response regulator Spo0A

scientific article

Engineering a ligand binding pocket into a four-helix bundle protein cytochrome b(562).

scientific article published in January 2001

Engineering of tyrosyl tRNA synthetase.

scientific article

Erratum for Hong et al., "Mucosal Antibodies to the C Terminus of Toxin A Prevent Colonization of Clostridium difficile".

scientific article

Expression and localization of SpoIISA toxin during the life cycle of Bacillus subtilis

scientific article published on 21 September 2010

Expression of soluble, active fragments of the morphogenetic protein SpoIIE from Bacillus subtilis using a library-based construct screen

scientific article

Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus.

scientific article

Functional role for a conserved aspartate in the Spo0E signature motif involved in the dephosphorylation of the Bacillus subtilis sporulation regulator Spo0A.

scientific article published on 28 November 2007

Gankyrin: a new oncoprotein and regulator of pRb and p53

scientific article published in May 2006

Genetic and biochemical analysis of the interaction of Bacillus subtilis CodY with branched-chain amino acids

scientific article published on 11 September 2009

Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism

scientific article published in March 2012

Global profiling of co- and post-translationally N-myristoylated proteomes in human cells ⬇️

scientific article

HSP90 Contributes To Entrainment of the Arabidopsis Circadian Clock via the Morning Loop

scientific article published on 18 October 2018

High-resolution temporal analysis of global promoter activity in Bacillus subtilis

scientific article published in 2012

High-resolution x-ray structures of pig metmyoglobin and two CD3 mutants: Mb(Lys45 .fwdarw. Arg) and Mb(Lys45 .fwdarw. Ser)

scientific article published on 22 September 1992

Higher-throughput approaches to crystallization and crystal structure determination

scientific article published in August 2008

Impact of CodY protein on metabolism, sporulation and virulence in Clostridioides difficile ribotype 027

scientific article published in PLoS ONE

Inversion of axial coordination in myoglobin to create a "proximal" ligand binding pocket

scientific article published in September 2003

Leishmania differentiation requires ubiquitin conjugation mediated by a UBC2-UEV1 E2 complex

scientific article published on 27 October 2020

Lessons and questions from the structure of the Spo0A activation domain: Response

scientific article published in April 2001

Lipid spirals in Bacillus subtilis and their role in cell division.

scientific article published on 22 April 2008

Mechanism of hydrogen cyanide binding to myoglobin.

scientific article published in June 1996

Morphogenic Protein RodZ Interacts with Sporulation Specific SpoIIE in Bacillus subtilis

scientific article

MpaA is a murein-tripeptide-specific zinc carboxypeptidase that functions as part of a catabolic pathway for peptidoglycan-derived peptides in γ-proteobacteria

scientific article

Mucosal Antibodies to the C Terminus of Toxin A Prevent Colonization of Clostridium difficile

scientific article published on 6 February 2017

N-Myristoyltransferase from Leishmania donovani: Structural and Functional Characterisation of a Potential Drug Target for Visceral Leishmaniasis

scientific article

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

scientific article

Novel thienopyrimidine inhibitors of Leishmania N-myristoyltransferase with on-target activity in intracellular amastigotes

scientific article published on 24 June 2020

Oligomeric structure of the Bacillus subtilis cell division protein DivIVA determined by transmission electron microscopy.

scientific article published in June 2004

Oligomerization of the Bacillus subtilis division protein DivIVA.

scientific article published in March 2002

Oxidation of residue 45 mutant forms of pig deoxymyoglobin with [Fe(CN)6]3-.

scientific article published in October 1992

Peptide Binding in OppA, the Crystal Structures of the Periplasmic Oligopeptide Binding Protein in the Unliganded Form and in Complex with Lysyllysine, ⬇️

scientific article published on August 12, 1997

Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites

scientific article

Probing the mechanism of ATP hydrolysis and substrate translocation in the AAA protease FtsH by modelling and mutagenesis

scientific article published in February 2001

Protein engineering 20 years on.

scientific article

Quaternary re-arrangement analysed by spectral enhancement: the interaction of a sporulation repressor with its antagonist

scientific article published in November 1999

Raman and CD spectroscopy of recombinant 68-kDa DNA human topoisomerase I and its complex with suicide DNA-substrate.

scientific article

Redesigning enzyme structure by site-directed mutagenesis: tyrosyl tRNA synthetase and ATP binding

scientific article published in Nature

Reduction in CD4 binding affinity associated with removal of a single glycosylation site in the external glycoprotein of HIV-2.

scientific article

Residues in the distal heme pocket of neuroglobin. Implications for the multiple ligand binding steps

scientific article

Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs

scientific article

Single-molecule optical microscopy of protein dynamics and computational analysis of images to determine cell structure development in differentiating Bacillus subtilis

scientific article published on 09 June 2020

Site-Selective C-C Modification of Proteins at Neutral pH Using Organocatalyst-Mediated Cross Aldol Ligations

Site-directed mutagenesis of the base recognition loop of ribonuclease from Bacillus intermedius (binase).

scientific article

Site-selective C-C modification of proteins at neutral pH using organocatalyst-mediated cross aldol ligations

scientific article published on 7 July 2018

Small subunits of RNA polymerase: localization, levels and implications for core enzyme composition

scientific article published on 19 August 2010

Solution of the structure of the cofactor-binding fragment of CysB: a struggle against non-isomorphism

scientific article published in February 1999

Stabilizing bound O2 in myoglobin by valine68 (E11) to asparagine substitution

scientific article

Structural Factors Governing Hemin Dissociation from Metmyoglobin†

scientific article published on 01 September 1996

Structural and biochemical characterization of a mitochondrial peroxiredoxin from Plasmodium falciparum

scientific article (publication date: August 2006)

Structural basis for the efficient phosphorylation of AZT-MP (3'-azido-3'-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinase

scientific article

Structural basis of the sulphate starvation response in E. coli: crystal structure and mutational analysis of the cofactor-binding domain of the Cbl transcriptional regulator.

scientific article

Structural characterisation of the virulence-associated protein VapG from the horse pathogen Rhodococcus equi

scientific article

Structural characterization of Spo0E-like protein-aspartic acid phosphatases that regulate sporulation in bacilli

scientific article published on 25 September 2006

Structural rearrangement accompanying ligand binding in the GAF domain of CodY from Bacillus subtilis.

scientific article

Structure and Organisation of SinR, the Master Regulator of Biofilm Formation in Bacillus subtilis

scientific article

Structure and interactions of theBacillus subtilissporulation inhibitor of DNA replication, SirA, with domain I of DnaA

scientific article

Structure and ligand binding in the putative anti-microbial peptide transporter protein, YejA

scientific article published in 2024

Structure and non-essential function of glycerol kinase in Plasmodium falciparum blood stages

scientific article

Structure determination of OppA at 2.3 A resolution using multiple-wavelength anomalous dispersion methods.

scientific article published in January 1995

Structure mediation in substrate binding and post-translational processing of penicillin acylases: Information from mutant structures of Kluyvera citrophila penicillin G acylase

scientific article

Structure of components of an intercellular channel complex in sporulating Bacillus subtilis

scientific article

Structure of purine nucleoside phosphorylase (DeoD) from Bacillus anthracis

scientific article published on 9 April 2005

Structure of the Bacillus cell fate determinant SpoIIAA in phosphorylated and unphosphorylated forms

scientific article

Structure of the Branched-chain Amino Acid and GTP-sensing Global Regulator, CodY, from Bacillus subtilis.

scientific article

Structure of the Phosphatase Domain of the Cell Fate Determinant SpoIIE from Bacillus subtilis

scientific article

Structure of the catalytic domain of the human mitochondrial Lon protease: Proposed relation of oligomer formation and activity

scientific article

Structure of the virulence-associated protein VapD from the intracellular pathogenRhodococcus equi

scientific article

Structure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors

scientific article published on October 2014

Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase

scientific article published on 11 November 2016

Structures of Plasmodium falciparum purine nucleoside phosphorylase complexed with sulfate and its natural substrate inosine

scientific article published on 16 August 2005

Structures of two superoxide dismutases from Bacillus anthracis reveal a novel active centre

scientific article published on 15 June 2005

Tension in haemoglobin revealed by Fe-His(F8) bond rupture in the fully liganded T-state

scientific article published in August 1997

Tetramerization and interdomain flexibility of the replication initiation controller YabA enables simultaneous binding to multiple partners

scientific article

The Corynebacterium glutamicum aconitase repressor: scratching around for crystals.

scientific article published on 26 August 2010

The GTPase, CpgA(YloQ), a putative translation factor, is implicated in morphogenesis in Bacillus subtilis

scientific article published on 17 February 2006

The Rhodococcus equi virulence protein VapA disrupts endolysosome function and stimulates lysosome biogenesis.

scientific article published on 19 October 2016

The Spore Coat Protein CotE Facilitates Host Colonization by Clostridium difficile

scientific article

The Structure and Interactions of SpoIISA and SpoIISB, a Toxin-Antitoxin System in Bacillus subtilis

scientific article

The Structure of Bypass of Forespore C, an Intercompartmental Signaling Factor during Sporulation inBacillus

scientific article published in Journal of Biological Chemistry

The crystal structure of YloQ, a circularly permuted GTPase essential for Bacillus subtilis viability

scientific article

The crystal structure of gankyrin, an oncoprotein found in complexes with cyclin-dependent kinase 4, a 19 S proteasomal ATPase regulator, and the tumor suppressors Rb and p53

scientific article

The crystal structure of superoxide dismutase from Plasmodium falciparum

scientific article

The crystal structure of the AAA domain of the ATP-dependent protease FtsH of Escherichia coli at 1.5 A resolution

scientific article

The crystal structures of human S100A12 in apo form and in complex with zinc: new insights into S100A12 oligomerisation

scientific article

The crystal structures of macrophage migration inhibitory factor from Plasmodium falciparum and Plasmodium berghei

scientific article

The molecular basis of thioalcohol production in human body odour

scientific article published on 27 July 2020

The response regulator Spo0A from Bacillus subtilis is efficiently phosphorylated in Escherichia coli.

scientific article

The role of water in sequence-independent ligand binding by an oligopeptide transporter protein

scientific article

The stereochemical mechanism of the cooperative effects in hemoglobin revisited

scientific article published in January 1998

The structure of CodY, a GTP- and isoleucine-responsive regulator of stationary phase and virulence in gram-positive bacteria

scientific article published on 17 February 2006

The structure of Rph, an exoribonuclease fromBacillus anthracis, at 1.7 Å resolution

scientific article

The structure of the oligopeptide-binding protein, AppA, from Bacillus subtilis in complex with a nonapeptide

scientific article published in January 2005

The substrate-binding protein in bacterial ABC transporters: dissecting roles in the evolution of substrate specificity

scientific article

The use of double mutants to detect structural changes in the active site of the tyrosyl-tRNA synthetase (Bacillus stearothermophilus)

scientific article published in October 1984

Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach ⬇️

scientific article

Where asymmetry in gene expression originates.

scientific article

dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors.

scientific article published in February 2005

pBaSysBioII: an integrative plasmid generating gfp transcriptional fusions for high-throughput analysis of gene expression in Bacillus subtilis.

scientific article published on 11 February 2010

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