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List of works by Dongsheng Duan

100-fold but not 50-fold dystrophin overexpression aggravates electrocardiographic defects in the mdx model of Duchenne muscular dystrophy.

scientific article published on 06 July 2016

A New Kid on the Playground of CRISPR DMD Therapy

scientific article published in June 2017

A marginal level of dystrophin partially ameliorates hindlimb muscle passive mechanical properties in dystrophin‐null mice ⬇️

scientific article published on December 1, 2012

A new dual-vector approach to enhance recombinant adeno-associated virus-mediated gene expression through intermolecular cis activation

scientific article published in May 2000

A single intravenous injection of adeno-associated virus serotype-9 leads to whole body skeletal muscle transduction in dogs.

scientific article published on 30 September 2008

AAV micro-dystrophin gene therapy alleviates stress-induced cardiac death but not myocardial fibrosis in >21-m-old mdx mice, an end-stage model of Duchenne muscular dystrophy cardiomyopathy.

scientific article

AAV-8 is more efficient than AAV-9 in transducing neonatal dog heart.

scientific article

AAV-microdystrophin therapy improves cardiac performance in aged female mdx mice.

scientific article

Adeno-associated virus serotype-9 mediated retinal outer plexiform layer transduction is mainly through the photoreceptors

scientific article published in January 2010

Adeno-associated virus serotype-9 microdystrophin gene therapy ameliorates electrocardiographic abnormalities in mdx mice.

scientific article

Adeno-associated virus-mediated microdystrophin expression protects young mdx muscle from contraction-induced injury.

scientific article published on February 2005

Adenovirus-mediated delivery of catalase to retinal pigment epithelial cells protects neighboring photoreceptors from photo-oxidative stress

scientific article published on October 2004

Adenovirus-mediated gene transfer to adult mouse cardiomyocytes is selectively influenced by culture medium

scientific article published in September 2003

Age-matched comparison reveals early electrocardiography and echocardiography changes in dystrophin-deficient dogs ⬇️

scientific article published on 13 May 2011

An improved method for studying mouse diaphragm function

scientific article published on 19 December 2019

Animal models of Duchenne muscular dystrophy: from basic mechanisms to gene therapy

scientific article

Automatic quantification of microscopic heart damage in a mouse model of Duchenne muscular dystrophy using optical polarization tractography.

scientific article

C-terminal-truncated microdystrophin recruits dystrobrevin and syntrophin to the dystrophin-associated glycoprotein complex and reduces muscular dystrophy in symptomatic utrophin/dystrophin double-knockout mice

scientific article published on 23 March 2006

CRISPR-Cas9 cleavage efficiency correlates strongly with target-sgRNA folding stability: from physical mechanism to off-target assessment

scientific article published on 10 March 2017

Cardiac expression of a mini-dystrophin that normalizes skeletal muscle force only partially restores heart function in aged Mdx mice.

scientific article published on 09 December 2008

Catalase overexpression does not impair extensor digitorum longus muscle function in normal mice.

scientific article published on December 2007

Challenges and opportunities in dystrophin-deficient cardiomyopathy gene therapy.

scientific article published on October 2006

Characterization of 65 epitope-specific dystrophin monoclonal antibodies in canine and murine models of duchenne muscular dystrophy by immunostaining and western blot

scientific article

Contemporary cardiac issues in Duchenne muscular dystrophy. Working Group of the National Heart, Lung, and Blood Institute in collaboration with Parent Project Muscular Dystrophy

scientific article

Design of trans-splicing adeno-associated viral vectors for Duchenne muscular dystrophy gene therapy

scientific article

Double strand interaction is the predominant pathway for intermolecular recombination of adeno-associated viral genomes

scientific article published on 01 August 2003

Dual AAV therapy ameliorates exercise-induced muscle injury and functional ischemia in murine models of Duchenne muscular dystrophy ⬇️

scientific article published on May 15, 2013

Duchenne muscular dystrophy gene therapy in the canine model.

scientific article published on 24 February 2015

Dystrophin Gene Replacement and Gene Repair Therapy for Duchenne Muscular Dystrophy in 2016: An Interview

scientific article published on March 2016

Dystrophin contains multiple independent membrane-binding domains.

scientific article published on 4 July 2016

Dystrophin deficiency compromises force production of the extensor carpi ulnaris muscle in the canine model of Duchenne muscular dystrophy

scientific article published on 4 September 2012

Dystrophin knockdown mice suggest that early, transient dystrophin expression might be enough to prevent later pathology

scientific article published on 24 September 2008

Dystrophins carrying spectrin-like repeats 16 and 17 anchor nNOS to the sarcolemma and enhance exercise performance in a mouse model of muscular dystrophy.

scientific article published on 23 February 2009

Early loss of ambulation is not a representative clinical feature in Duchenne muscular dystrophy dogs: remarks on the article of Barthélémy et al.

scientific article published in March 2015

Ectopic catalase expression in mitochondria by adeno-associated virus enhances exercise performance in mice.

scientific article

Efficient Whole-body Transduction with Trans-splicing Adeno-associated Viral Vectors

scientific article published on 01 June 2007

Efficient whole-body transduction with trans-splicing adeno-associated viral vectors

scientific article published on 30 January 2007

Endosomal processing limits gene transfer to polarized airway epithelia by adeno-associated virus.

scientific article

Enhancement of muscle gene delivery with pseudotyped adeno-associated virus type 5 correlates with myoblast differentiation.

scientific article published on August 2001

Evaluation of muscle function of the extensor digitorum longus muscle ex vivo and tibialis anterior muscle in situ in mice.

scientific article published on 9 February 2013

Exclusive skeletal muscle correction does not modulate dystrophic heart disease in the aged mdx model of Duchenne cardiomyopathy ⬇️

scientific article published on March 3, 2013

Expanding AAV packaging capacity with trans-splicing or overlapping vectors: a quantitative comparison

scientific article

Expanding adeno-associated viral vector capacity: a tale of two vectors.

scientific article published on January 2007

Full-length dystrophin reconstitution with adeno-associated viral vectors

scientific article

Gender differences in contractile and passive properties of mdx extensor digitorum longus muscle.

scientific article published in February 2012

Gender influences cardiac function in the mdx model of Duchenne cardiomyopathy.

scientific article

Gene delivery to the heart: an updated review on vectors and methods ⬇️

scientific article published on 01 October 2011

Genomic removal of a therapeutic mini-dystrophin gene from adult mice elicits a Duchenne muscular dystrophy-like phenotype

scientific article published on 22 April 2016

Genotyping mdx, mdx3cv, and mdx4cv mice by primer competition polymerase chain reaction

scientific article

Heart structural remodeling in a mouse model of Duchenne cardiomyopathy revealed using optical polarization tractography [Invited].

scientific article

High resolution imaging of the fibrous microstructure in bovine common carotid artery using optical polarization tractography

scientific article published on 11 December 2015

Histology validation of mapping depth-resolved cardiac fiber orientation in fresh mouse heart using optical polarization tractography

scientific article published on 29 July 2014

Humoral immunity to AAV-6, 8, and 9 in normal and dystrophic dogs

scientific article published on 11 January 2012

In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy.

scientific article published on 31 December 2015

Incorporation of adeno-associated virus in a calcium phosphate coprecipitate improves gene transfer to airway epithelia in vitro and in vivo.

scientific article

Lef1 Transcription Factor Expression Defines Airway Progenitor Cell Targets for In Utero Gene Therapy of Submucosal Gland in Cystic Fibrosis ⬇️

scientific article published on June 1, 1998

Manipulation of mtDNA heteroplasmy in all striated muscles of newborn mice by AAV9-mediated delivery of a mitochondria-targeted restriction endonuclease.

scientific article

Mapping 3D fiber orientation in tissue using dual-angle optical polarization tractography

scientific article published on September 2016

Marginal level dystrophin expression improves clinical outcome in a strain of dystrophin/utrophin double knockout mice

scientific article (publication date: 2010)

Microdystrophin ameliorates muscular dystrophy in the canine model of duchenne muscular dystrophy

scientific article published on 15 January 2013

Microdystrophin gene therapy of cardiomyopathy restores dystrophin-glycoprotein complex and improves sarcolemma integrity in the mdx mouse heart.

scientific article published on 02 September 2003

Mitochondria-Targeted Antiaging Gene Therapy with Adeno-associated Viral Vectors ⬇️

scientific article published on January 1, 2013

Modular flexibility of dystrophin: implications for gene therapy of Duchenne muscular dystrophy

scientific article

Monitoring Murine Skeletal Muscle Function for Muscle Gene Therapy ⬇️

scientific article published on January 1, 2011

Nanotherapy for Duchenne muscular dystrophy

scientific article published on 11 April 2017

Night Activity Reduction is a Signature Physiological Biomarker for Duchenne Muscular Dystrophy Dogs

scientific article

Nitric oxide-dependent attenuation of noradrenaline-induced vasoconstriction is impaired in the canine model of Duchenne muscular dystrophy

scientific article published on 20 September 2018

Nitrosative stress elicited by nNOSµ delocalization inhibits muscle force in dystrophin-null mice

scientific article

Non-invasive evaluation of muscle disease in the canine model of Duchenne muscular dystrophy by electrical impedance myography

scientific article

Nondestructive imaging of fiber structure in articular cartilage using optical polarization tractography

scientific article published in November 2016

Novel Mini–Dystrophin Gene Dual Adeno-Associated Virus Vectors Restore Neuronal Nitric Oxide Synthase Expression at the Sarcolemma ⬇️

scientific article published on October 24, 2011

Optical polarization tractography revealed significant fiber disarray in skeletal muscles of a mouse model for Duchenne muscular dystrophy

scientific article published on 7 January 2015

Partial restoration of cardiac function with ΔPDZ nNOS in aged mdx model of Duchenne cardiomyopathy

scientific article

Perspective on Adeno-Associated Virus Capsid Modification for Duchenne Muscular Dystrophy Gene Therapy

scientific article

Perspectives on best practices for gene therapy programs

scientific article

Phenotyping cardiac gene therapy in mice

scientific article

Polarity influences the efficiency of recombinant adenoassociated virus infection in differentiated airway epithelia.

scientific article

Prevention of dystrophin-deficient cardiomyopathy in twenty-one-month-old carrier mice by mosaic dystrophin expression or complementary dystrophin/utrophin expression

scientific article

Progress in gene therapy of dystrophic heart disease ⬇️

scientific article published on February 9, 2012

Prospect of gene therapy for cardiomyopathy in hereditary muscular dystrophy

scientific article published on 17 December 2015

Quantitative Phenotyping of Duchenne Muscular Dystrophy Dogs by Comprehensive Gait Analysis and Overnight Activity Monitoring ⬇️

scientific article published on March 27, 2013

Recombinant AAV-mediated gene delivery using dual vector heterodimerization.

scientific article published on January 2002

Recombinant adeno-associated viral vector production and purification.

scientific article published in January 2012

Reducing sarcolipin expression mitigates Duchenne muscular dystrophy and associated cardiomyopathy in mice

scientific article published on 20 October 2017

SERCA2a gene transfer improves electrocardiographic performance in aged mdx mice ⬇️

scientific article published on August 11, 2011

Safe and bodywide muscle transduction in young adult Duchenne muscular dystrophy dogs with adeno-associated virus.

scientific article

Sarcolemmal nNOS anchoring reveals a qualitative difference between dystrophin and utrophin.

scientific article

Standard Operating Procedures (SOPs) for Evaluating the Heart in Preclinical Studies of Duchenne Muscular Dystrophy

scientific article

Structural analysis of adeno-associated virus transduction circular intermediates.

scientific article published in August 1999

Sub-physiological sarcoglycan expression contributes to compensatory muscle protection in mdx mice

scientific article published on 08 January 2009

Synthetic intron improves transduction efficiency of trans-splicing adeno-associated viral vectors.

scientific article published on October 2006

Systemic AAV-9 transduction in mice is influenced by animal age but not by the route of administration

scientific article published on 27 September 2007

Systemic delivery of adeno-associated viral vectors

scientific article

Systemic gene transfer reveals distinctive muscle transduction profile of tyrosine mutant AAV-1, -6, and -9 in neonatal dogs.

scientific article

The FVB Background Does Not Dramatically Alter the Dystrophic Phenotype of Mdx Mice

scientific article

The evolution of heart gene delivery vectors

scientific article published on October 2011

The passive mechanical properties of the extensor digitorum longus muscle are compromised in 2- to 20-mo-old mdx mice

scientific article

Truncated dystrophins reduce muscle stiffness in the extensor digitorum longus muscle of mdx mice.

scientific article published on 6 December 2012

Two independent molecular pathways for recombinant adeno-associated virus genome conversion occur after UV-C and E4orf6 augmentation of transduction

scientific article published in March 1999

Unified energetics analysis unravels SpCas9 cleavage activity for optimal gRNA design

scientific article published on 15 April 2019

Uniform low-level dystrophin expression in the heart partially preserved cardiac function in an aged mouse model of Duchenne cardiomyopathy

scientific article

Whole Body Skeletal Muscle Transduction in Neonatal Dogs with AAV-9 ⬇️

scientific article published on January 1, 2011

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