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List of works by Gregory J. Kato

A GCH1 haplotype confers sex-specific susceptibility to pain crises and altered endothelial function in adults with sickle cell anemia

scientific article

A fluorescence method to detect and quantitate sterol esterification by lecithin:cholesterol acyltransferase

scientific article published on 12 July 2013

A network model to predict the risk of death in sickle cell disease

scientific article

A novel molecular signature for elevated tricuspid regurgitation velocity in sickle cell disease

scientific article

A retrospective review of acupuncture use for the treatment of pain in sickle cell disease patients: descriptive analysis from a single institution

scientific article

A systematic comparison and evaluation of high density exon arrays and RNA-seq technology used to unravel the peripheral blood transcriptome of sickle cell disease

scientific article

Abnormal pulmonary function and associated risk factors in children and adolescents with sickle cell anemia

scientific article

Abstract Animations for the Communication and Assessment of Pain in Adults: Cross-Sectional Feasibility Study

scientific article published on 03 August 2018

Activation domains of L-Myc and c-Myc determine their transforming potencies in rat embryo cells ⬇️

scientific article published on July 1, 1992

Amplified expression profiling of platelet transcriptome reveals changes in arginine metabolic pathways in patients with sickle cell disease

scientific article

An official American Thoracic Society clinical practice guideline: diagnosis, risk stratification, and management of pulmonary hypertension of sickle cell disease

scientific article published on March 2014

Anakinra, What Is Thy Bidding in Pulmonary Hypertension?

scientific article published on 01 February 2019

Ancestry of African Americans with sickle cell disease

scientific article

Anemia, age, desaturation, and impaired neurocognition in sickle cell anemia ⬇️

scientific article published on September 4, 2012

Angiogenic and inflammatory markers of cardiopulmonary changes in children and adolescents with sickle cell disease

scientific article

Anti-haemolytic effect of senicapoc and decrease in NT-proBNP in adults with sickle cell anaemia

scientific article published on 8 June 2011

Apolipoprotein A-I and serum amyloid A plasma levels are biomarkers of acute painful episodes in patients with sickle cell disease

scientific article

Association of G6PD with lower haemoglobin concentration but not increased haemolysis in patients with sickle cell anaemia

scientific article

Atorvastatin reduces serum cholesterol and triglycerides with limited improvement in vascular function in adults with sickle cell anemia

scientific article

CYB5R3c .350C>G and G6PD A Alleles Modify Severity of Anemia in Malaria and Sickle Cell Disease

scientific article published on 22 July 2020

Cardiac expression of HMOX1 and PGF in sickle cell mice and haem-treated wild type mice dominates organ expression profiles via Nrf2 (Nfe2l2)

scientific article published on 06 August 2019

Cellular normoxic biophysical markers of hydroxyurea treatment in sickle cell disease

scientific article

Cerebrovascular disease associated with sickle cell pulmonary hypertension

scientific article

Characterizing non-linear dependencies among pairs of clinical variables and imaging data

scientific article

Chronic hyper-hemolysis in sickle cell anemia: association of vascular complications and mortality with less frequent vasoocclusive pain

scientific article

Circulating blood endothelial nitric oxide synthase contributes to the regulation of systemic blood pressure and nitrite homeostasis

scientific article published on 23 May 2013

Circulating endothelial progenitor cells in adults with sickle cell disease

scientific article published on April 2013

Clinical correlates of acute pulmonary events in children and adolescents with sickle cell disease

scientific article published on 03 May 2013

Comment on "The influence of hydroxyurea on oxidative stress in sickle cell anemia" ⬇️

scientific article published on January 1, 2012

Computed tomography correlates with cardiopulmonary hemodynamics in pulmonary hypertension in adults with sickle cell disease

scientific article

Computer-assisted diagnostic tool to quantify the pulmonary veins in sickle cell associated pulmonary hypertension

Corticosteroids and increased risk of readmission after acute chest syndrome in children with sickle cell disease

scientific article published on May 2008

Critical Reviews: How we treat sickle cell patients with leg ulcers

scientific article published on 07 August 2015

DNA binding by the Myc oncoproteins

scientific article published on January 1, 1992

Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes

scientific article

Defective nitric oxide metabolism in sickle cell disease

scientific article

Diastolic dysfunction in sickle cell

scientific article published on 01 July 2010

Diastolic dysfunction is an independent risk factor for death in patients with sickle cell disease

scientific article

Diet-induced weight loss in overweight or obese women and changes in high-density lipoprotein levels and function

scientific article

Discrimination between related DNA sites by a single amino acid residue of Myc-related basic-helix-loop-helix proteins ⬇️

scientific article published on January 15, 1992

Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease

scientific article

Echocardiographic markers of elevated pulmonary pressure and left ventricular diastolic dysfunction are associated with exercise intolerance in adults and adolescents with homozygous sickle cell anemia in the United States and United Kingdom

scientific article

Effect of extended-release niacin on serum lipids and on endothelial function in adults with sickle cell anemia and low high-density lipoprotein cholesterol levels

scientific article

Effects of a single sickling event on the mechanical fragility of sickle cell trait erythrocytes

scientific article published on January 2010

Elevated pulse pressure is associated with hemolysis, proteinuria and chronic kidney disease in sickle cell disease

scientific article

Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression

scientific article

Elevated tricuspid regurgitant jet velocity in children and adolescents with sickle cell disease: association with hemolysis and hemoglobin oxygen desaturation

scientific article published on 11 February 2009

Elevated tricuspid regurgitation velocity and decline in exercise capacity over 22 months of follow up in children and adolescents with sickle cell anemia

scientific article

Endogenous nitric oxide synthase inhibitors in sickle cell disease: abnormal levels and correlations with pulmonary hypertension, desaturation, haemolysis, organ dysfunction and death

scientific article

Endothelin receptor antagonists for pulmonary hypertension in adult patients with sickle cell disease

scientific article published on 22 September 2009

Evolution of novel small-molecule therapeutics targeting sickle cell vasculopathy

scientific article

Expression of regulatory platelet microRNAs in patients with sickle cell disease

scientific article

Extensive ex vivo expansion of functional human erythroid precursors established from umbilical cord blood cells by defined factors

scientific article published on 03 September 2013

Fetal haemoglobin response to hydroxycarbamide treatment and sar1a promoter polymorphisms in sickle cell anaemia

scientific article published on 3 March 2008

Framing the research agenda for sickle cell trait: building on the current understanding of clinical events and their potential implications

scientific article

Genetic determinants of haemolysis in sickle cell anaemia

scientific article

Gout and sickle cell disease: not all pain is sickle cell pain

scientific article

Haem augments and iron chelation decreases toll-like receptor 4 mediated inflammation in monocytes from sickle cell patients

scientific article published on 26 April 2017

Haptoglobin halts hemoglobin's havoc

scientific article published on 20 July 2009

Hematologic, biochemical, and cardiopulmonary effects of L-arginine supplementation or phosphodiesterase 5 inhibition in patients with sickle cell disease who are on hydroxyurea therapy

scientific article published on 10 February 2008

Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Krüppel-like factor

scientific article

Hemodynamic predictors of mortality in adults with sickle cell disease

scientific article published on April 2013

Hemolysis-associated hypercoagulability in sickle cell disease: the plot (and blood) thickens!

scientific article published on January 2008

Hemolysis-associated pulmonary hypertension in thalassemia

scientific article

High levels of placenta growth factor in sickle cell disease promote pulmonary hypertension

scientific article

High-density lipoprotein cholesterol efflux, nitration of apolipoprotein A-I, and endothelial function in obese women

scientific article published on 19 November 2011

Homozygous factor-V mutation as a genetic cause of perinatal thrombosis and cerebral palsy

scientific article published on 01 November 1999

Hospitalization for pain in patients with sickle cell disease treated with sildenafil for elevated TRV and low exercise capacity

scientific article

Hydroxyurea-induced expression of glutathione peroxidase 1 in red blood cells of individuals with sickle cell anemia

scientific article

Identification and characterization of the novel centrosome-associated protein CCCAP

scientific journal article

Identifying adolescent and young adult patients with sickle cell disease at highest risk of death

scientific article published on 27 October 2020

Images in clinical medicine. Tumor pseudosyncytiae

scientific article published on 01 April 2003

Imaging flow cytometry documents incomplete resistance of human sickle F-cells to ex vivo hypoxia-induced sickling

scientific article published on July 2014

Imaging flow cytometry for automated detection of hypoxia-induced erythrocyte shape change in sickle cell disease

scientific article

Imaging flow cytometry for morphologic and phenotypic characterization of rare circulating endothelial cells

scientific article

Improvement in hemolysis and pulmonary arterial systolic pressure in adult patients with sickle cell disease during treatment with hydroxyurea

scientific article published on August 2009

Increased pulmonary pressures and myocardial wall stress in children with severe malaria

scientific article published on September 2010

Infrared imaging of nitric oxide-mediated blood flow in human sickle cell disease

scientific article

Infusion of hemolyzed red blood cells within peripheral blood stem cell grafts in patients with and without sickle cell disease

scientific article

Inhibition of PDE4 phosphodiesterase activity induces growth suppression, apoptosis, glucocorticoid sensitivity, p53, and p21(WAF1/CIP1) proteins in human acute lymphoblastic leukemia cells

scientific article published on May 2002

Iron restriction in sickle cell anemia: Time for controlled clinical studies

scientific article published on 16 September 2015

Kinetics of sickle cell biorheology and implications for painful vasoocclusive crisis.

scientific article

Laboratory and echocardiography markers in sickle cell patients with leg ulcers ⬇️

scientific article published on 31 May 2011

Lactate dehydrogenase and hemolysis in sickle cell disease

scientific article published on August 2013

Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease

scientific article published on 15 November 2005

Leg ulcers in sickle cell disease: current patterns and practices

scientific article published on 19 April 2013

Levels of soluble endothelium-derived adhesion molecules in patients with sickle cell disease are associated with pulmonary hypertension, organ dysfunction, and mortality

scientific article

Lipid levels in sickle-cell disease associated with haemolytic severity, vascular dysfunction and pulmonary hypertension

scientific article published on 8 March 2010

Liver stiffness increases acutely during sickle cell vaso-occlusive crisis

scientific article published on August 2013

Low-dose methotrexate therapy for hepatoblastoma

scientific article published on 01 January 1991

Lung vaso-occlusion in sickle cell disease mediated by arteriolar neutrophil-platelet microemboli

scientific article

Management of patients with sickle cell disease

Markers of severe vaso-occlusive painful episode frequency in children and adolescents with sickle cell anemia

scientific article published on 3 September 2011

Max: functional domains and interaction with c-Myc ⬇️

scientific article published on January 1, 1992

Mechanisms of hemolysis-associated platelet activation.

scientific article published on December 2013

Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African Americans

scientific article published on August 2012

Mortality in adults with sickle cell disease and pulmonary hypertension

scientific article

Mutations and polymorphisms in hemoglobin genes and the risk of pulmonary hypertension and death in sickle cell disease

scientific article

N-terminal pro-brain natriuretic peptide levels and risk of death in sickle cell disease

scientific article published in July 2006

NT-pro brain natriuretic peptide levels and the risk of death in the cooperative study of sickle cell disease

scientific article published on 21 June 2011

NT-proBNP as a marker of cardiopulmonary status in sickle cell anaemia in Africa

scientific article

Near-infrared spectra absorbance of blood from sickle cell patients and normal individuals

scientific article published on February 2009

New developments in anti-sickling agents: can drugs directly prevent the polymerization of sickle haemoglobin in vivo?

scientific article published on 8 September 2016

New insights into sickle cell disease: mechanisms and investigational therapies

scientific article published on May 2016

Nitric oxide and arginine dysregulation: a novel pathway to pulmonary hypertension in hemolytic disorders

scientific article published on November 2008

Nitric oxide for inhalation in the acute treatment of sickle cell pain crisis: a randomized controlled trial

scientific article

No NO means yes to sickle red cell adhesion

scientific article published in March 2014

Non-invasive indicators of pulmonary hypertension from pulmonary veins quantification in sickle cell disease

Oscillatory haematopoiesis in adults with sickle cell disease treated with hydroxycarbamide

scientific article

Plasma thrombospondin-1 is increased during acute sickle cell vaso-occlusive events and associated with acute chest syndrome, hydroxyurea therapy, and lower hemolytic rates

scientific article published on 8 February 2012

Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension, and nitric oxide scavenging by cell-free hemoglobin

scientific article

Pleiotropic effects of intravascular haemolysis on vascular homeostasis

scientific article published on December 2009

Predictors of osteoclast activity in patients with sickle cell disease

scientific article

Prevalence and risk factors for pulmonary artery systolic hypertension among sickle cell disease patients in Nigeria

scientific article

Priapism in Sickle-Cell Disease: A Hematologist’s Perspective ⬇️

scientific article published on May 6, 2011

Prospective echocardiography assessment of pulmonary hypertension and its potential etiologies in children with sickle cell disease

scientific article

Prospective evaluation of haemoglobin oxygen saturation at rest and after exercise in paediatric sickle cell disease patients

scientific article published on 19 August 2009

Proteomic identification of altered apolipoprotein patterns in pulmonary hypertension and vasculopathy of sickle cell disease

scientific article

Pulmonary artery pressure and iron deficiency in patients with upregulation of hypoxia sensing due to homozygous VHL(R200W) mutation (Chuvash polycythemia).

scientific article published on 11 October 2011

Pulmonary hypertension and NO in sickle cell

scientific article published on August 2010

Pulmonary hypertension in children and adolescents with sickle cell disease

scientific article published on 7 August 2007

Pulmonary hypertension in sickle cell disease: relevance to children

scientific article

RV dysfunction by MRI is associated with elevated transpulmonary gradient and poor prognosis in patients with sickle cell associated pulmonary hypertension

scientific article published on 30 January 2013

Rapid vs. delayed infrared responses after ischemia reveal recruitment of different vascular beds

scientific article

Reconstruction of Thermographic Signals to Map Perforator Vessels in Humans

scientific article published on January 2012

Reduced sensitivity of the ferroportin Q248H mutant to physiological concentrations of hepcidin

scientific article published on 12 October 2012

Relationship of erythropoietin, fetal hemoglobin, and hydroxyurea treatment to tricuspid regurgitation velocity in children with sickle cell disease

scientific article published on September 2009

Relative systemic hypertension in patients with sickle cell disease is associated with risk of pulmonary hypertension and renal insufficiency

scientific article

Reply: Practice guideline for pulmonary hypertension in sickle cell: direct evidence needed before universal adoption

scientific article published in July 2014

Risk factors for death in 632 patients with sickle cell disease in the United States and United Kingdom

scientific article

Segmentation and quantification of pulmonary artery for noninvasive CT assessment of sickle cell secondary pulmonary hypertension

scientific article

Serum albumin is independently associated with higher mortality in adult sickle cell patients: Results of three independent cohorts

scientific article published on 10 August 2020

Severe painful vaso-occlusive crises and mortality in a contemporary adult sickle cell anemia cohort study

scientific article

Severe pulmonary hypertension in an adolescent with sickle cell disease

scientific article

Severity of pulmonary hypertension during vaso-occlusive pain crisis and exercise in patients with sickle cell disease

scientific article

Sickle Cell Imaging Flow Cytometry Assay (SIFCA).

scientific article published in January 2016

Sickle cell disease and nitric oxide: a paradigm shift?

scientific article published on 17 February 2006

Sickle cell disease and pulmonary hypertension in Africa: a global perspective and review of epidemiology, pathophysiology, and management

scientific article published on January 2008

Sickle cell vasculopathy: vascular phenotype on fire!

scientific article published on 03 August 2018

Sickle cells and sickle trait in thrombosis.

scientific article published in June 2019

Sickle particulars of microparticles

scientific article published on 01 July 2020

Sickle related events following cardiac catheterisation: risk implication for other invasive procedures

article

Sildenafil therapy in patients with sickle cell disease and pulmonary hypertension

scientific article

Skeletal and myocardial microvascular blood flow in hydroxycarbamide-treated patients with sickle cell disease.

scientific article

Sleep disturbance, depression and pain in adults with sickle cell disease

scientific article

Sodium nitrite promotes regional blood flow in patients with sickle cell disease: a phase I/II study

scientific article published on 11 July 2008

Strategic plan for pediatric respiratory diseases research: an NHLBI working group report

scientific article

Strategic plan for pediatric respiratory diseases research: an NHLBI working group report

scientific article published on 01 January 2009

Successful treatment of life-threatening acute chest syndrome of sickle cell disease with venovenous extracorporeal membrane oxygenation.

scientific article published on September 1997

TRV: A physiological biomarker in sickle cell disease ⬇️

scientific article published on December 16, 2011

The mUBC9 murine ubiquitin conjugating enzyme interacts with the E2A transcription factors

scientific article published in November 1997

The proteome of sickle cell disease: insights from exploratory proteomic profiling

scientific article

The relationship between the severity of hemolysis, clinical manifestations and risk of death in 415 patients with sickle cell anemia in the US and Europe

scientific article published on 14 September 2012

Therapeutic strategies to alter the oxygen affinity of sickle hemoglobin

scientific article

Thrombospondin-1 gene polymorphism is associated with estimated pulmonary artery pressure in patients with sickle cell anemia.

scientific article

Thrombospondin-1 inhibits ADAMTS13 activity in sickle cell disease

scientific article published on November 2013

Topical sodium nitrite for chronic leg ulcers in patients with sickle cell anaemia: a phase 1 dose-finding safety and tolerability trial

scientific article published on December 2014

Tricuspid Regurgitation Velocity and Other Biomarkers of Mortality in Children, Adolescents and Young Adults with Sickle Cell Disease in the United States: the PUSH Study

scientific article published on 03 April 2020

Understanding the erythrocyte storage lesion

scientific article

Validation of a composite vascular high-risk profile for adult patients with sickle cell disease

scientific article published on 17 September 2019

Vasculopathy in sickle cell disease: Biology, pathophysiology, genetics, translational medicine, and new research directions

scientific article

Vasculopathy, inflammation, and blood flow in leg ulcers of patients with sickle cell anemia

scientific article

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