List of works - Manlio Ferrarini

A lymphoproliferative disorder of the large granular lymphocytes with natural killer activity.

scientific article published on January 1983

A phase II trial with cisplatin-paclitaxel cytotoxic treatment and concurrent external and endocavitary radiation therapy in locally advanced or recurrent cervical cancer

scientific article published on 26 January 2006

A prognostic model based on combining estrogen receptor expression and Ki-67 value after neoadjuvant chemotherapy predicts clinical outcome in locally advanced breast cancer: extension and analysis of a previously reported cohort of patients

scientific article published on 26 July 2013

A progression-risk score to predict treatment-free survival for early stage chronic lymphocytic leukemia patients.

scientific article published on 9 December 2015

A role for natural killer cells in survival: functions of large granular lymphocytes, including regulation of cell proliferation

scientific article published on 01 December 1983

A seven-gene expression panel distinguishing clonal expansions of pre-leukemic and chronic lymphocytic leukemia B cells from normal B lymphocytes.

scientific article published on 30 August 2015

Accelerated chemotherapy with or without GM-CSF for small cell lung cancer: a non-randomised pilot study

scientific article published in January 1990

Accreditation for excellence of cancer research institutes: recommendations from the Italian Network of Comprehensive Cancer Centers

scientific article

Alliance Against Cancer, the network of Italian cancer centers bridging research and care

scientific article

An Increased Number of Individuals with Clinically Recognized Monoclonal B-Cell Lymphocytosis Characterizes a Recent Database of Chronic Lymphocytic Leukemia Rai Stage 0

scientific article published on 19 January 2012

Analysis of Epstein-Barr virus (EBV) type and variant in spontaneous lymphoblastoid cells and Hu-SCID mouse tumours.

scientific article published on December 1996

Association between gene and miRNA expression profiles and stereotyped subset #4 B-cell receptor in chronic lymphocytic leukemia

scientific article published on 10 April 2015

B cell chronic lymphocytic leukaemia/small lymphocytic lymphoma: role of ZAP70 determination on bone marrow biopsy specimens

scientific article

B cells and their fate in health and disease.

scientific article

B lymphocytes in humans express ZAP-70 when activated in vivo.

scientific article published in March 2006

Baff serum level predicts time to first treatment in early chronic lymphocytic leukemia

scientific article

Biological and clinical relevance of quantitative global methylation of repetitive DNA sequences in chronic lymphocytic leukemia

scientific article published on February 2011

CASE 1. Complete remission to corticosteroids in an octreotide-refractory thymoma

scientific article published in March 2005

CD38 and chronic lymphocytic leukemia: a decade later ⬇️

scientific article published on July 15, 2011

CD5+ B cells with the features of subepithelial B cells found in human tonsils

scientific article published on 01 August 2007

Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities

scientific article

Chromosome 2p gain in monoclonal B-cell lymphocytosis and in early stage chronic lymphocytic leukemia.

scientific article published on 9 October 2012

Chronic lymphocytic leukemia

scientific article (publication date: 24 February 2005)

Chronic lymphocytic leukemia B cells can undergo somatic hypermutation and intraclonal immunoglobulin V(H)DJ(H) gene diversification.

scientific article

Chronic lymphocytic leukemia nurse-like cells express hepatocyte growth factor receptor (c-MET) and indoleamine 2,3-dioxygenase and display features of immunosuppressive type 2 skewed macrophages

scientific article

Clinical categories identified by a new prognostic index reflect biological characteristics of patients in early chronic lymphocytic leukemia: The Gruppo Italiano Studio Linfomi (GISL) experience

scientific article published on 31 March 2010

Clinical monoclonal B lymphocytosis versus Rai 0 chronic lymphocytic leukemia: A comparison of cellular, cytogenetic, molecular, and clinical features.

scientific article

Clonal heterogeneity in chronic lymphocytic leukemia cells: superior response to surface IgM cross-linking in CD38, ZAP-70-positive cells

scientific article

Coexpression of Fc gamma receptor IIIA and interleukin-2 receptor beta chain by a subset of human CD3+/CD8+/CD11b+ lymphocytes

scientific article

Corrigendum to “Lack of mutagenicity and clastogenicity of PNAEμ-NLS targeted to a regulatory sequence of the translocated c-myc oncogene in Burkitt's lymphoma” [Mutat. Res. 628 (2007) 129–137]

scholarly article published in Mutation Research

Cytogenetic rearrangement of C-MYC oncogene occurs prior to infection with Epstein-Barr virus in the monoclonal malignant B cells from an AIDS patient

scientific article published in January 1993

Definition of progression risk based on combinations of cellular and molecular markers in patients with Binet stage A chronic lymphocytic leukaemia

scientific article published on 6 May 2009

Distinct patterns of global promoter methylation in early stage chronic lymphocytic leukemia

scientific article published on 18 December 2013

Effects in live cells of a c-myc anti-gene PNA linked to a nuclear localization signal

scientific article published on 01 March 2000

Establishment of Tac-negative, interleukin-2-dependent cytotoxic cell lines from large granular lymphocytes (LGL) of patients with expanded LGL populations

scientific article published on 01 November 1986

Expression of CD10 by human T cells that undergo apoptosis both in vitro and in vivo

scientific article published on 01 April 2001

Expression of CD5 and CD38 by human CD5- B cells: requirement for special stimuli

scientific article published on 01 June 1994

Expression of a receptor for sheep erythrocytes by B lymphocytes from a chronic lymphocytic leukemia patient.

scientific article

Expression of immunoglobulin receptors with distinctive features indicating antigen selection by marginal zone B cells from human spleen.

scientific article published on 17 September 2013

Heterogeneous expression and function of IL-21R and susceptibility to IL-21-mediated apoptosis in follicular lymphoma cells

scientific article

High-throughput sequencing for the identification of NOTCH1 mutations in early stage chronic lymphocytic leukaemia: biological and clinical implications

scientific article

Igs expressed by chronic lymphocytic leukemia B cells show limited binding-site structure variability.

scientific article published in May 2013

Impaired response to influenza vaccine associated with persistent memory B cell depletion in non-Hodgkin's lymphoma patients treated with rituximab-containing regimens.

scientific article

Increased serum BAFF (B-cell activating factor of the TNF family) level is a peculiar feature associated with familial chronic lymphocytic leukemia

scientific article

Inhibition of Burkitt's lymphoma cells growth in SCID mice by a PNA specific for a regulatory sequence of the translocated c-myc

scientific article published on 20 October 2006

Insulin growth factor 1 receptor expression is associated with NOTCH1 mutation, trisomy 12 and aggressive clinical course in chronic lymphocytic leukaemia

scientific article

Integrative genomics analyses reveal molecularly distinct subgroups of B-cell chronic lymphocytic leukemia patients with 13q14 deletion.

scientific article published on 14 October 2010

Interleukin 21 Controls mRNA and MicroRNA Expression in CD40-Activated Chronic Lymphocytic Leukemia Cells

scientific article published on 25 August 2015

Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells

scientific article

Intraclonal cell expansion and selection driven by B cell receptor in chronic lymphocytic leukemia

scientific article

Is ZAP70 still a key prognostic factor in early stage chronic lymphocytic leukaemia? Results of the analysis from a prospective multicentre observational study

scientific article published on 11 September 2014

Lack of mutagenicity and clastogenicity of PNAEmu-NLS targeted to a regulatory sequence of the translocated c-myc oncogene in Burkitt's lymphoma.

scientific article published on 8 January 2007

Low percentage of KRAS mutations revealed by locked nucleic acid polymerase chain reaction: implications for treatment of metastatic colorectal cancer

scientific article published on January 2012

Maintenance of B lymphocyte-related clones in the cerebrospinal fluid of multiple sclerosis patients

scientific article published on December 2003

Markers of increased angiogenesis and their correlation with biological parameters identifying high-risk patients in early B-cell chronic lymphocytic leukemia

scientific article published on 07 May 2007

Maturation of chronic lymphocytic leukemia B cells: correlation between the capacity of responding to T-cell factors in vitro and the stage of maturation reached in vivo.

scientific article

Modulation of neutrophil Fc and C3b receptors. Relationship with the phagocytic process and activation of the respiratory burst

scientific article published on 01 June 1983

Molecular and transcriptional characterization of 17p loss in B-cell chronic lymphocytic leukemia

scientific article published on 01 September 2008

More about NK cells and regulation of B cell activity

scientific article published on 01 October 1985

More on the determination of Ki-67 as a novel potential prognostic marker in B-cell chronic lymphocytic leukemia

scientific article published in December 2010

Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia

scientific article

Multiplex ligation-dependent probe amplification and fluorescence in situ hybridization to detect chromosomal abnormalities in Chronic lymphocytic leukemia: A comparative study

scientific article published on 02 June 2011

Mutation pattern of paired immunoglobulin heavy and light variable domains in chronic lymphocytic leukemia B cells

scientific article (publication date: 2011)

PNAEmu can significantly reduce Burkitt's lymphoma tumor burden in a SCID mice model: cells dissemination similar to the human disease.

scientific article published on 10 April 2009

Phenotypic and functional characterization of human tonsillar subepithelial (SE) B cells.

scientific article published on April 1997

Predictive value of beta2-microglobulin (beta2-m) levels in chronic lymphocytic leukemia since Binet A stages

scientific article published in June 2009

Production of inflammatory cytokines by Epstein-Barr virus (EBV)-infected lymphoblastoid cell lines spontaneously originated from the peripheral blood of patients with human immunodeficiency virus (HIV) infection.

scientific article published on November 1995

Prognostic relevance of serum levels and cellular expression of adiponectin in B-cell chronic lymphocytic leukemia

scientific article published on 27 September 2008

Prognostic relevance ofin vitroresponse to cell stimulation via surface IgD in binet stage a CLL

scientific article published on 08 December 2009

Prospective validation of a risk score based on biological markers for predicting progression free survival in Binet stage A chronic lymphocytic leukemia patients: Results of the multicenter O-CLL1-GISL study

scientific article published on 18 April 2014

Prospective validation of predictive value of abdominal computed tomography scan on time to first treatment in Rai 0 chronic lymphocytic leukemia patients: results of the multicenter O-CLL1-GISL study

scientific article published on 31 March 2015

Recent advances in the molecular biology and immunobiology of chronic lymphocytic leukemia.

scientific article published in July 2004

Receptors for the third complement component on a proportion of large granular lymphocytes from human peripheral blood

scientific article published on 01 June 1982

Relevance of HBV/HBcAb screening in lymphoma patients treated in the Rituximab era

scientific article published on 27 February 2010

Relevance of telomere/telomerase system impairment in early stage chronic lymphocytic leukemia

scientific article

Role of surface IgM and IgD on survival of the cells from B-cell chronic lymphocytic leukemia

scientific article (publication date: 15 March 2002)

Seasonal and pandemic (A/H1N1 2009) MF-59-adjuvanted influenza vaccines in complete remission non-Hodgkin lymphoma patients previously treated with rituximab containing regimens

scientific article published on August 2012

Second-line treatment with intravenous gemcitabine and oral etoposide in platinum-resistant advanced ovarian cancer patients: results of a phase II study.

scientific article published on 5 July 2011

Serum level of CD26 predicts time to first treatment in early B-chronic lymphocytic leukemia

scientific article

Serum thrombopoietin compared with ZAP-70 and immunoglobulin heavy-chain gene mutation status as a predictor of time to first treatment in early chronic lymphocytic leukemia

article

Similarities and differences between the light and heavy chain Ig variable region gene repertoires in chronic lymphocytic leukemia.

scientific article published on November 2006

Small nucleolar RNAs as new biomarkers in chronic lymphocytic leukemia

scientific article

Surrogate molecular markers for IGHV mutational status in chronic lymphocytic leukemia for predicting time to first treatment

scientific article published on 19 May 2015

Synthetic miR-34a mimics as a novel therapeutic agent for multiple myeloma: in vitro and in vivo evidence.

scientific article published on 3 October 2012

Telomere length and telomerase activity delineate distinctive replicative features of the B-CLL subgroups defined by immunoglobulin V gene mutations ⬇️

scientific article published on September 22, 2003

The OECI certification/designation program: the Genoa experience.

scientific article

The cumulative amount of serum-free light chain is a strong prognosticator in chronic lymphocytic leukemia

scientific article published on 13 October 2011

The demonstration of acid α-naphthyl acetate esterase activity in human lymphocytes: Usefulness as a T-cell marker ⬇️

scientific article published on January 1, 1978

The expression pattern of small nucleolar and small Cajal body-specific RNAs characterizes distinct molecular subtypes of multiple myeloma.

scientific article

The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways

scientific article

The peptide nucleic acid targeted to a regulatory sequence of the translocated c-myc oncogene in Burkitt's lymphoma lacks immunogenicity: follow-up characterization of PNAEmu-NLS

scientific article published on 01 January 2007

The propensity to apoptosis of centrocytes and centroblasts correlates with elevated levels of intracellular myc protein

scientific article published on 01 January 1997

The utility of two prognostic models for predicting time to first treatment in early chronic lymphocytic leukemia patients: results of a comparative analysis.

scientific article published on 15 March 2013

Therapeutically promising PNA complementary to a regulatory sequence for c-myc: pharmacokinetics in an animal model of human Burkitt's lymphoma.

scientific article published on January 2005

Total body computed tomography scan in the initial work-up of Binet stage A chronic lymphocytic leukemia patients: Results of the prospective, multicenter O-CLL1-GISL study

scientific article published on 12 June 2013

Ultrastructure and cytochemistry of human peripheral blood lymphocytes. Similarities between the cells of the third population and TG lymphocytes.

scientific article published on July 1980

c-myc proto-oncogene expression by germinal center B cells isolated from human tonsils

scientific article published on 01 April 1997

miR-29b negatively regulates human osteoclastic cell differentiation and function: implications for the treatment of multiple myeloma-related bone disease

scientific article published on July 2013

miR-29b sensitizes multiple myeloma cells to bortezomib-induced apoptosis through the activation of a feedback loop with the transcription factor Sp1

scientific article published on 29 November 2012

microRNAome Expression in Chronic Lymphocytic Leukemia: Comparison with Normal B-cell Subsets and Correlations with Prognostic and Clinical Parameters

scientific article published on 10 June 2014

List of works by Manlio Ferrarini

A lymphoproliferative disorder of the large granular lymphocytes with natural killer activity.

A phase II trial with cisplatin-paclitaxel cytotoxic treatment and concurrent external and endocavitary radiation therapy in locally advanced or recurrent cervical cancer

A prognostic model based on combining estrogen receptor expression and Ki-67 value after neoadjuvant chemotherapy predicts clinical outcome in locally advanced breast cancer: extension and analysis of a previously reported cohort of patients

A progression-risk score to predict treatment-free survival for early stage chronic lymphocytic leukemia patients.

A role for natural killer cells in survival: functions of large granular lymphocytes, including regulation of cell proliferation

A seven-gene expression panel distinguishing clonal expansions of pre-leukemic and chronic lymphocytic leukemia B cells from normal B lymphocytes.

Accelerated chemotherapy with or without GM-CSF for small cell lung cancer: a non-randomised pilot study

Accreditation for excellence of cancer research institutes: recommendations from the Italian Network of Comprehensive Cancer Centers

Alliance Against Cancer, the network of Italian cancer centers bridging research and care

An Increased Number of Individuals with Clinically Recognized Monoclonal B-Cell Lymphocytosis Characterizes a Recent Database of Chronic Lymphocytic Leukemia Rai Stage 0

Analysis of Epstein-Barr virus (EBV) type and variant in spontaneous lymphoblastoid cells and Hu-SCID mouse tumours.

Association between gene and miRNA expression profiles and stereotyped subset #4 B-cell receptor in chronic lymphocytic leukemia

B cell chronic lymphocytic leukaemia/small lymphocytic lymphoma: role of ZAP70 determination on bone marrow biopsy specimens

B cells and their fate in health and disease.

B lymphocytes in humans express ZAP-70 when activated in vivo.

Baff serum level predicts time to first treatment in early chronic lymphocytic leukemia

Biological and clinical relevance of quantitative global methylation of repetitive DNA sequences in chronic lymphocytic leukemia

CASE 1. Complete remission to corticosteroids in an octreotide-refractory thymoma

CD38 and chronic lymphocytic leukemia: a decade later ⬇️

CD5+ B cells with the features of subepithelial B cells found in human tonsils

Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities

Chromosome 2p gain in monoclonal B-cell lymphocytosis and in early stage chronic lymphocytic leukemia.

Chronic lymphocytic leukemia

Chronic lymphocytic leukemia B cells can undergo somatic hypermutation and intraclonal immunoglobulin V(H)DJ(H) gene diversification.

Chronic lymphocytic leukemia nurse-like cells express hepatocyte growth factor receptor (c-MET) and indoleamine 2,3-dioxygenase and display features of immunosuppressive type 2 skewed macrophages

Clinical categories identified by a new prognostic index reflect biological characteristics of patients in early chronic lymphocytic leukemia: The Gruppo Italiano Studio Linfomi (GISL) experience

Clinical monoclonal B lymphocytosis versus Rai 0 chronic lymphocytic leukemia: A comparison of cellular, cytogenetic, molecular, and clinical features.

Clonal heterogeneity in chronic lymphocytic leukemia cells: superior response to surface IgM cross-linking in CD38, ZAP-70-positive cells

Coexpression of Fc gamma receptor IIIA and interleukin-2 receptor beta chain by a subset of human CD3+/CD8+/CD11b+ lymphocytes

Corrigendum to “Lack of mutagenicity and clastogenicity of PNAEμ-NLS targeted to a regulatory sequence of the translocated c-myc oncogene in Burkitt's lymphoma” [Mutat. Res. 628 (2007) 129–137]

Cytogenetic rearrangement of C-MYC oncogene occurs prior to infection with Epstein-Barr virus in the monoclonal malignant B cells from an AIDS patient

Definition of progression risk based on combinations of cellular and molecular markers in patients with Binet stage A chronic lymphocytic leukaemia

Distinct patterns of global promoter methylation in early stage chronic lymphocytic leukemia

Effects in live cells of a c-myc anti-gene PNA linked to a nuclear localization signal

Establishment of Tac-negative, interleukin-2-dependent cytotoxic cell lines from large granular lymphocytes (LGL) of patients with expanded LGL populations

Expression of CD10 by human T cells that undergo apoptosis both in vitro and in vivo

Expression of CD5 and CD38 by human CD5- B cells: requirement for special stimuli

Expression of a receptor for sheep erythrocytes by B lymphocytes from a chronic lymphocytic leukemia patient.

Expression of immunoglobulin receptors with distinctive features indicating antigen selection by marginal zone B cells from human spleen.

Heterogeneous expression and function of IL-21R and susceptibility to IL-21-mediated apoptosis in follicular lymphoma cells

High-throughput sequencing for the identification of NOTCH1 mutations in early stage chronic lymphocytic leukaemia: biological and clinical implications

Igs expressed by chronic lymphocytic leukemia B cells show limited binding-site structure variability.

Impaired response to influenza vaccine associated with persistent memory B cell depletion in non-Hodgkin's lymphoma patients treated with rituximab-containing regimens.

Increased serum BAFF (B-cell activating factor of the TNF family) level is a peculiar feature associated with familial chronic lymphocytic leukemia

Inhibition of Burkitt's lymphoma cells growth in SCID mice by a PNA specific for a regulatory sequence of the translocated c-myc

Insulin growth factor 1 receptor expression is associated with NOTCH1 mutation, trisomy 12 and aggressive clinical course in chronic lymphocytic leukaemia

Integrative genomics analyses reveal molecularly distinct subgroups of B-cell chronic lymphocytic leukemia patients with 13q14 deletion.

Interleukin 21 Controls mRNA and MicroRNA Expression in CD40-Activated Chronic Lymphocytic Leukemia Cells

Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells

Intraclonal cell expansion and selection driven by B cell receptor in chronic lymphocytic leukemia

Is ZAP70 still a key prognostic factor in early stage chronic lymphocytic leukaemia? Results of the analysis from a prospective multicentre observational study

Lack of mutagenicity and clastogenicity of PNAEmu-NLS targeted to a regulatory sequence of the translocated c-myc oncogene in Burkitt's lymphoma.

Low percentage of KRAS mutations revealed by locked nucleic acid polymerase chain reaction: implications for treatment of metastatic colorectal cancer

Maintenance of B lymphocyte-related clones in the cerebrospinal fluid of multiple sclerosis patients

Markers of increased angiogenesis and their correlation with biological parameters identifying high-risk patients in early B-cell chronic lymphocytic leukemia

Maturation of chronic lymphocytic leukemia B cells: correlation between the capacity of responding to T-cell factors in vitro and the stage of maturation reached in vivo.

Modulation of neutrophil Fc and C3b receptors. Relationship with the phagocytic process and activation of the respiratory burst

Molecular and transcriptional characterization of 17p loss in B-cell chronic lymphocytic leukemia

More about NK cells and regulation of B cell activity

More on the determination of Ki-67 as a novel potential prognostic marker in B-cell chronic lymphocytic leukemia

Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia

Multiplex ligation-dependent probe amplification and fluorescence in situ hybridization to detect chromosomal abnormalities in Chronic lymphocytic leukemia: A comparative study

Mutation pattern of paired immunoglobulin heavy and light variable domains in chronic lymphocytic leukemia B cells

PNAEmu can significantly reduce Burkitt's lymphoma tumor burden in a SCID mice model: cells dissemination similar to the human disease.

Phenotypic and functional characterization of human tonsillar subepithelial (SE) B cells.

Predictive value of beta2-microglobulin (beta2-m) levels in chronic lymphocytic leukemia since Binet A stages

Production of inflammatory cytokines by Epstein-Barr virus (EBV)-infected lymphoblastoid cell lines spontaneously originated from the peripheral blood of patients with human immunodeficiency virus (HIV) infection.

Prognostic relevance of serum levels and cellular expression of adiponectin in B-cell chronic lymphocytic leukemia

Prognostic relevance ofin vitroresponse to cell stimulation via surface IgD in binet stage a CLL

Prospective validation of a risk score based on biological markers for predicting progression free survival in Binet stage A chronic lymphocytic leukemia patients: Results of the multicenter O-CLL1-GISL study

Prospective validation of predictive value of abdominal computed tomography scan on time to first treatment in Rai 0 chronic lymphocytic leukemia patients: results of the multicenter O-CLL1-GISL study

Recent advances in the molecular biology and immunobiology of chronic lymphocytic leukemia.

Receptors for the third complement component on a proportion of large granular lymphocytes from human peripheral blood

Relevance of HBV/HBcAb screening in lymphoma patients treated in the Rituximab era

Relevance of telomere/telomerase system impairment in early stage chronic lymphocytic leukemia

Role of surface IgM and IgD on survival of the cells from B-cell chronic lymphocytic leukemia

Seasonal and pandemic (A/H1N1 2009) MF-59-adjuvanted influenza vaccines in complete remission non-Hodgkin lymphoma patients previously treated with rituximab containing regimens

Second-line treatment with intravenous gemcitabine and oral etoposide in platinum-resistant advanced ovarian cancer patients: results of a phase II study.

Serum level of CD26 predicts time to first treatment in early B-chronic lymphocytic leukemia