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List of works by George S Vassiliou

A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia.

scientific article

A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer

scientific article published on 8 December 2014

A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention.

scientific article

A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression

scientific article

A powerful molecular synergy between mutant Nucleophosmin and Flt3-ITD drives acute myeloid leukemia in mice

scientific article published on 12 March 2013

A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes.

scientific article

Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia

scientific article published on 17 January 2013

Acute myeloid leukaemia: a paradigm for the clonal evolution of cancer?

scientific article

Aging as a driver of leukemogenesis

scientific article published on 23 September 2015

An acquired translocation in JAK2 Val617Phe-negative essential thrombocythemia associated with autosomal spread of X-inactivation.

scientific article published in August 2006

Analysis of chimaerism in thalassaemic children undergoing stem cell transplantation

article

Analysis pipelines for cancer genome sequencing in mice

scientific article published on 06 January 2020

Angioimmunoblastic T cell lymphoma: novel molecular insights by mutation profiling

scientific article

Author Correction: The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia

scientific article published on 29 July 2020

British society for haematology slide session, annual scientific meeting, Harrogate, 2001.

scientific article published in February 2003

CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice

scientific article

Calreticulin gene exon 9 frameshift mutations in patients with thrombocytosis.

scientific article published on 24 December 2013

Calreticulin mutations in myeloproliferative neoplasms and new methodology for their detection and monitoring

scientific article

Capturing needles in haystacks: a comparison of B-cell receptor sequencing methods.

scientific article

Characterization of gene mutations and copy number changes in acute myeloid leukemia using a rapid target enrichment protocol

scientific article published on 7 November 2014

Clonal haematopoiesis is not prevalent in survivors of childhood cancer.

scientific article published on 3 April 2017

Clonal heterogeneity of acute myeloid leukemia treated with the IDH2 inhibitor enasidenib

scientific article published on 16 July 2018

Combined Influence of B-Cell Receptor Rearrangement and Somatic Hypermutation on B-Cell Class-Switch Fate in Health and in Chronic Lymphocytic Leukemia

article

Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML

scientific article published on 19 March 2019

Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: a prospective study.

scientific article

Design and Application of Multiplex PCR Seq for the Detection of Somatic Mutations Associated with Myeloid Malignancies

scientific article

Detection of cytoplasmic nucleophosmin expression by imaging flow cytometry.

scientific article published on 11 September 2012

Development and validation of a comprehensive genomic diagnostic tool for myeloid malignancies

scientific article published on 27 April 2016

Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML

scientific article published on 16 March 2020

Dynamic variation of CD5 surface expression levels within individual chronic lymphocytic leukemia clones

scientific article published on 27 September 2016

Effect of mutation order on myeloproliferative neoplasms

scientific article

Enhancing the genome editing toolbox: genome wide CRISPR arrayed libraries

scientific article

Epstein-Barr virus dacryoadenitis as a complication of bone marrow transplant in a child with combined immunodeficiency

scientific article published in December 2001

Evi1 Counteracts Anti-Leukemic and Stem Cell Inhibitory Effects of All-Trans Retinoic Acid on Flt3-ITD/Npm1c-Driven Acute Myeloid Leukemia Cells

scientific article published on 28 September 2020

Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes

scientific article published on 24 January 2018

Eye on the B-ALL: B-cell receptor repertoires reveal persistence of numerous B-lymphoblastic leukemia subclones from diagnosis to relapse.

scientific article published on 23 May 2016

Gene expression changes in HLA mismatched mixed lymphocyte cultures reveal genes associated with allorecognition.

scientific article published on April 2015

Genetic modification of primary human B cells to model high-grade lymphoma

scientific article published on 04 October 2019

Genome-wide transposon screening and quantitative insertion site sequencing for cancer gene discovery in mice.

scientific article

Glutaminolysis is a metabolic dependency in FLT3ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition

scientific article published on 20 February 2018

Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts.

scientific article published on 08 September 2016

Histone deacetylase 1 and 2 are essential for normal T-cell development and genomic stability in mice

scientific article published on 03 January 2013

Identification of a germline F692L drug resistance variant in cis with Flt3-internal tandem duplication in knock-in mice

scientific article published on 12 May 2016

Imatinib improves but may not fully reverse the poor prognosis of patients with CML with derivative chromosome 9 deletions.

scientific article published on 15 May 2003

Immune neutropenia associated with anti-human neutrophil antigen-2a (NB1) antibodies following unrelated donor stem cell transplantation for chronic myeloid leukaemia: perpetuation by granulocyte colony-stimulating factor

scientific article published on 01 May 2001

Imprinting of the human L3MBTL gene, a polycomb family member located in a region of chromosome 20 deleted in human myeloid malignancies

scientific article

Improved outcome of alternative donor bone marrow transplantation in children with severe aplastic anaemia using a conditioning regimen containing low-dose total body irradiation, cyclophosphamide and Campath

scientific article

In situ thrombolysis for cerebral venous thrombosis complicating anti-leukemic therapy

scientific article published on 27 March 2011

JAK2 V617F clonal disorders: fate or chance?

scientific article published on August 2016

KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements

scientific article published on 06 August 2020

KLF2 mutation is the most frequent somatic change in splenic marginal zone lymphoma and identifies a subset with distinct genotype

scientific article published on 27 November 2014

L3mbtl, the mouse orthologue of the imprinted L3MBTL, displays a complex pattern of alternative splicing and escapes genomic imprinting

scientific journal article

Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis

scientific article

Management of the myeloproliferative disorders : distinguishing data from dogma

scientific article

Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia

scientific article published on 23 August 2017

Mouse Models of Myeloid Malignancies

scientific article published on 18 February 2020

Mouse models of NPM1-mutated acute myeloid leukemia: biological and clinical implications.

scientific article published on 02 September 2014

Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice

scientific article

Mutant calreticulin knock-in mice develop thrombocytosis and myelofibrosis without a stem cell self-renewal advantage

scientific article

Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice

scientific article published on 27 March 2011

Network properties derived from deep sequencing of human B-cell receptor repertoires delineate B-cell populations

scientific article published on 06 June 2013

New approaches for modelling sporadic genetic disease in the mouse

scientific article published on September 2009

Novel GPR34 and CCR6 mutation and distinct genetic profiles in MALT lymphomas of different sites

scientific article published on 19 April 2018

Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer

scientific article

PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy

scientific article

PiggyBac transposon mutagenesis: a tool for cancer gene discovery in mice.

scientific article

PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice

scientific article published on 29 March 2019

Prediction of acute myeloid leukaemia risk in healthy individuals

scientific article published in Nature

Preservation of basophils in dapsone-induced agranulocytosis suggests a possible pathogenetic role for leucocyte peroxidases

scientific article published on 01 April 2009

Preventing chemotherapy-induced myelosuppression by repurposing the FLT3 inhibitor quizartinib.

scientific article published in August 2017

Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.

scientific article published on 12 October 2016

Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control.

scientific article published on 27 November 2017

Publisher Correction: The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia

scientific article published on 07 January 2020

Rapid parallel acquisition of somatic mutations afterNPM1in acute myeloid leukaemia evolution

Recurrent histone mutations in T-cell acute lymphoblastic leukaemia

Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia

scientific article published on 13 November 2013

SOCS2 is part of a highly prognostic 4-gene signature in AML and promotes disease aggressiveness

scientific article published on 24 June 2019

SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4

scientific article published in Nature Communications

Stella-Cre mice are highly efficient Cre deleters

scientific article published on 22 July 2011

TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells

scientific article published on 22 February 2019

Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia.

scientific article

The PML-RARA fusion is not detectable in historical blood samples of acute promyelocytic leukaemia patients

publication published on 01 March 2021

The Use of DNA Transposons for Cancer Gene Discovery in Mice

article

The curious incident of TdT-mediated mutations in AML

scientific article published on 01 December 2019

The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia

scientific article published on 25 November 2019

The role of high-throughput technologies in clinical cancer genomics

scientific article published on March 2013

Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia

scientific article

Therapeutics: Click and discover

scientific article published on 01 August 2017

Triple-mutant AML: too clever by HLF?

scientific article published on 01 July 2019

UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs

scientific article published on 07 May 2018

V617F hematopoietic clones are present several years prior to MPN diagnosis and follow different expansion kinetics

scientific article published on 12 June 2017

Vitamin B₁₂-dependent taurine synthesis regulates growth and bone mass

scientific article

rHuEpo TREATMENT IN LOW-RISK MYELODYSPLASTIC SYNDROMES

scientific article published on 01 August 1999

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