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List of works by Melanie Ott

50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond

scientific article published on 30 December 2014

A BAF'ling Approach to Curing HIV.

scientific article published in December 2018

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

scientific article published on 30 April 2020

A combinatorial view of old and new RNA polymerase II modifications

scientific article published on 13 May 2020

A combined proteomics/genomics approach links hepatitis C virus infection with nonsense-mediated mRNA decay

scientific journal article

A genome-wide CRISPR screen identifies UFMylation and TRAMP-like complexes as host factors required for hepatitis A virus infection

scientific article published on 01 March 2021

Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells

scientific article

Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation

scientific article published in July 2003

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

Acetylation of cyclin T1 regulates the equilibrium between active and inactive P-TEFb in cells

scientific article

Acetylation of tau inhibits its degradation and contributes to tauopathy

scientific article

Acetylation of the HIV-1 Tat protein by p300 is important for its transcriptional activity

article

Acetylation of the HIV-1 Tat protein: an in vitro study

scientific article

Acetylphosphate: a novel link between lysine acetylation and intermediary metabolism in bacteria

scientific article published in July 2013

Activating Latent HIV by Inhibiting Bromodomain Proteins

article

Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1).

scientific article

Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy

scientific article published on 04 December 2020

An 'Arms Race' between the Nonsense-mediated mRNA Decay Pathway and Viral Infections

scientific article published on 15 June 2020

An ultra-high affinity synthetic nanobody blocks SARS-CoV-2 infection by locking Spike into an inactive conformation

scientific article published on 10 August 2020

An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike

scientific article published on 05 November 2020

Analysis of p300 acetyltransferase substrate specificity by MALDI TOF mass spectrometry

scientific article published in August 2005

Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men

scientific article published on 17 November 2020

Asna1/TRC40 that mediates membrane insertion of tail-anchored proteins is required for efficient release of Herpes simplex virus 1 virions

scientific article published on 20 October 2016

Author Correction: Senescent cells promote tissue NAD<sup>+</sup> decline during ageing via the activation of CD38<sup>+</sup> macrophages

scientific article published on 10 December 2020

BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism.

scientific article published on February 2012

Bromodomain proteins in HIV infection

scientific article

CRISPR-Cas9 screen of E3 ubiquitin ligases identifies TRAF2 and UHRF1 as regulators of HIV latency in primary human T cells

scientific article published in 2024

CYCLINg through transcription: posttranslational modifications of P-TEFb regulate transcription elongation

scientific article published on 29 May 2010

Characterization of HIV Tat modifications using novel methyl-lysine-specific antibodies

scientific article published on 6 July 2010

Characterization of efflux transport proteins of the human choroid plexus papilloma cell line HIBCPP, a functional in vitro model of the blood-cerebrospinal fluid barrier

scientific article published on 19 May 2015

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

scientific article published on 15 October 2020

Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins

scientific article published on 01 May 2019

Dampened antiviral immunity to intravaginal exposure to RNA viral pathogens allows enhanced viral replication

scientific article (publication date: 16 November 2016)

Decoding Tat: the biology of HIV Tat posttranslational modifications

scientific article

Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core

scientific article

Dual role of HIV Tat in regulation of apoptosis in T cells

article

Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1

scientific article published on 10 October 2010

Emerging role of lipid droplets in host/pathogen interactions.

scientific article published on 16 November 2011

Entangled in a membranous web: ER and lipid droplet reorganization during hepatitis C virus infection

scientific article published on 27 May 2016

Evasion of superinfection exclusion and elimination of primary viral RNA by an adapted strain of hepatitis C virus.

scientific article published on 02 October 2013

Evolution of lysine acetylation in the RNA polymerase II C-terminal domain

scientific article

FOXO1 promotes HIV latency by suppressing ER stress in T cells

scientific article published on 15 June 2020

Faculty of 1000 evaluation for HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP

article

Fibrin drives thromboinflammation and neuropathology in COVID-19

scientific article published on 28 August 2024

Flow Cytometric Analysis of Drug-induced HIV-1 Transcriptional Activity in A2 and A72 J-Lat Cell Lines

scientific article

Flow Cytometric Analysis of HIV-1 Transcriptional Activity in Response to shRNA Knockdown in A2 and A72 J-Lat Cell Lines

scientific article published in June 2017

Functional characterization of the essential tail anchor of the herpes simplex virus type 1 nuclear egress protein pUL34 ⬇️

scientific article published on August 10, 2011

Functional genomic screens identify human host factors for SARS-CoV-2 and common cold coronaviruses

scientific article published on 24 September 2020

Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses

scientific article published on 9 December 2020

HAT trick: p300, small molecule, inhibitor

scientific article published in May 2010

HIV never ceases to surprise: Innovative methods in the quest for a cure

article

HIV-1 Nef mimics an integrin receptor signal that recruits the polycomb group protein Eed to the plasma membrane

scientific article (publication date: 30 January 2004)

Hepatitis C and risk of lymphoma: results of the European multicenter case-control study EPILYMPH.

scientific article

Hepatitis C virus core protein decreases lipid droplet turnover: a mechanism for core-induced steatosis

scientific article published on 7 October 2011

High-Resolution Mass Spectrometry to Identify and Quantify Acetylation Protein Targets

scientific article published on 01 January 2019

Host Methyltransferases and Demethylases: Potential New Epigenetic Targets for HIV Cure Strategies and Beyond.

scientific article

How cells hush a viral invader

scientific article published on 01 December 2018

How the antiviral immune response boosts liver fat.

scientific article published in June 2013

Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation

scientific article

Identification of a therapeutic interfering particle-A single-dose SARS-CoV-2 antiviral intervention with a high barrier to resistance

scientific article published on 10 November 2021

Immune Hyperactivation of HIV-1-Infected T Cells Mediated by Tat and the CD28 Pathway

article

Impact of Race on the Association between Diabetes and HCV

scientific article published on 01 March 2004

Interleukin-2, soluble interleukin-2-receptor, neopterin,l-tryptophan and ?2-microglobulin levels in CSF and serum of patients with relapsing-remitting or chronic-progressive multiple sclerosis

scientific article published on 01 December 1993

International AIDS Society global scientific strategy: towards an HIV cure 2016.

scientific article published on 11 July 2016

Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination

scientific article published in July 2022

Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein

scientific article

Lipid droplets and viral infections.

scientific article published on January 2013

Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract

scientific article published on 25 September 2019

Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics.

scientific article

Manipulation of the host protein acetylation network by human immunodeficiency virus type 1

scientific article (publication date: 2015)

Membrane Flotation Assay

scientific article published on April 2015

Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1.

scientific article published on 30 November 2017

Modeling Multi-organ Infection by SARS-CoV-2 Using Stem Cell Technology

scientific article published on 01 December 2020

Modelling T-cell immunity against hepatitis C virus with liver organoids in a microfluidic coculture system

scientific article published on 02 March 2022

Modification with organometallic compounds improves crossing of the blood-brain barrier of [Leu5]-enkephalin derivatives in an in vitro model system

scientific article

Mutations in thetatGene Are Responsible for Human Immunodeficiency Virus Type 1 Postintegration Latency in the U1 Cell Line ⬇️

scientific article published on February 1, 1998

Nanotoxicity of poly(n-butylcyano-acrylate) nanoparticles at the blood-brain barrier, in human whole blood and in vivo

scientific article published on 10 November 2014

Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants

Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants

scientific article published on 18 March 2022

Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo

scientific article published on 14 August 2020

Nuclear accumulation of host transcripts during Zika Virus Infection

scientific article published in 2023

Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles

preprint article

Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles

scientific article published on 19 July 2022

Optical reporters for the conformation of alpha-synuclein reveal a specific interaction with mitochondria

scientific article published in November 2008

Pregnane X receptor (PXR) regulates P-glycoprotein at the blood-brain barrier: functional similarities between pig and human PXR.

scientific article published on 15 January 2009

Probing lysine acetylation in proteins: strategies, limitations, and pitfalls of in vitro acetyltransferase assays

scientific article

Rapid assessment of SARS-CoV-2 evolved variants using virus-like particles

scientific article published on 5 August 2021

Rapid assessment of SARS-CoV-2–evolved variants using virus-like particles

scientific article

Rapid assessment of p-glycoprotein-drug interactions at the blood-brain barrier

scientific article published on 14 August 2006

Rapid intracellular competition between hepatitis C viral genomes as a result of mitosis.

scientific article

Recruitment and activation of RSK2 by HIV-1 Tat

scientific article published on 17 January 2007

Release and intercellular transfer of cell surface CD81 via microparticles.

scientific article published on November 2002

Retrovirus Integration: Some Assembly Required?

scientific article

Role of chromatin in the transcriptional regulation of HIV-1

article

SARS-CoV-2 infection of human iPSC-derived cardiac cells predicts novel cytopathic features in hearts of COVID-19 patients

scientific article published on 12 September 2020

SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19

scientific article

SIRT1 deacetylates RORγt and enhances Th17 cell generation

scientific article published on 27 April 2015

SIRT1 deacetylates RORγt and enhances Th17 cell generation

scientific article published on 18 May 2015

SIRT1 is downregulated by autophagy in senescence and ageing

scientific article published on 28 September 2020

SIRT1 regulates HIV transcription via Tat deacetylation

scientific article

SMYD2-Mediated Histone Methylation Contributes to HIV-1 Latency

scientific article published on May 2017

Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity

scientific article

Screening a Library of FDA-Approved and Bioactive Compounds for Antiviral Activity against SARS-CoV-2

scientific article

Screening a library of FDA-approved and bioactive compounds for antiviral activity against SARS-CoV-2

Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages

scientific article published on 16 November 2020

Sentinel cells enable genetic detection of SARS-CoV-2 Spike protein

scientific article

Snapshots: chromatin control of viral infection

scientific article

Soluble HLA class I and class II antigens in patients with multiple sclerosis ⬇️

scientific article published on March 1, 1998

St. John's Wort constituents modulate P-glycoprotein transport activity at the blood-brain barrier

scientific article published on 13 March 2010

Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain

scientific article

Subcellular trafficking and functional importance of herpes simplex virus type 1 glycoprotein M domains

scientific article published on 10 August 2015

Superinduction of IL-8 in T cells by HIV-1 Tat protein is mediated through NF-kappaB factors

article

Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif

scientific article published on August 2004

Tat Acetylation: A Regulatory Switch between Early and Late Phases in HIV Transcription Elongation

article

Tat Expression and Function

Tat acetylation: a regulatory switch between early and late phases in HIV transcription elongation

scientific article

The ABC of the Blood-Brain Barrier - Regulation of Drug Efflux Pumps ⬇️

scientific article published on January 1, 2011

The Cellular NMD Pathway Restricts Zika Virus Infection and Is Targeted by the Viral Capsid Protein

scholarly article by Krystal A Fontaine et al published 6 November 2018 in mBio

The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription.

scientific article published in March 2010

The ChemCam Instrument Suite on the Mars Science Laboratory (MSL) Rover: Body Unit and Combined System Tests

article

The Global Phosphorylation Landscape of SARS-CoV-2 Infection

scientific article published on 28 June 2020

The HIV-1 Tat Protein Is Monomethylated at Lysine 71 by the Lysine Methyltransferase KMT7

scientific article

The Herpes Simplex Virus Protein pUL31 Escorts Nucleocapsids to Sites of Nuclear Egress, a Process Coordinated by Its N-Terminal Domain.

scientific article

The Lunar Orbiter Laser Altimeter Investigation on the Lunar Reconnaissance Orbiter Mission

article

The Lunar Reconnaissance Orbiter Laser Ranging Investigation

article by Maria T. Zuber et al published 16 May 2009 in Space Science Reviews

The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter

scientific article

The Short Isoform of BRD4 Promotes HIV-1 Latency by Engaging Repressive SWI/SNF Chromatin-Remodeling Complexes

scientific article published on 17 August 2017

The control of HIV transcription: keeping RNA polymerase II on track

scientific article

The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative gene identification 58 (CGI-58) and lipid droplets

scientific article

The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase

scientific article

The mTOR Complex Controls HIV Latency ⬇️

scientific article

The universal stress protein UspC scaffolds the KdpD/KdpE signaling cascade of Escherichia coli under salt stress

scientific article

The ups and downs of SIRT1.

scientific article published on 18 September 2008

Therapeutics Targeting Protein Acetylation Perturb Latency of Human Viruses

scientific article published on 4 February 2016

Three Rules for HIV Latency: Location, Location, and Location ⬇️

scientific article published on June 12, 2013

Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells

scientific article published on 6 February 2012

Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation.

scientific article published in March 1996

Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain

scientific article

Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19

scientific article published on 10 June 2021

Transmission, infectivity, and antibody neutralization of an emerging SARS-CoV-2 variant in California carrying a L452R spike protein mutation

scientific article

Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant

article by Xianding Deng et al published 24 June 2021 in Cell

Tropism of SARS-CoV-2 for human cortical astrocytes

scientific article published on 12 July 2022

Turning up the heat on HIV-1

scientific article published on 30 June 2020

Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes.

scientific article published on 14 November 2011

Unique ties between hepatitis C virus replication and intracellular lipids.

scientific article published on 15 April 2011

Zika Virus Infection Prevents Host mRNA Nuclear Export by Disrupting UPF1 Function

scientific article

Zinc supplementation induces regulatory T cells by inhibition of Sirt-1 deacetylase in mixed lymphocyte cultures.

scientific article published on 28 November 2015

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