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List of works by Richard F. Keep

3CB2, a marker of radial glia, expression after experimental intracerebral hemorrhage: role of thrombin

scientific article published on 7 June 2008

A balanced view of choroid plexus structure and function: Focus on adult humans

scientific article

A magnetic resonance imaging grading system for subarachnoid hemorrhage severity in a rat model.

scientific article

A morphometric study on the development of the lateral ventricle choroid plexus, choroid plexus capillaries and ventricular ependyma in the rat.

scientific article

A new hippocampal model for examining intracerebral hemorrhage-related neuronal death: effects of deferoxamine on hemoglobin-induced neuronal death

scientific article published on 30 August 2007

A novel role for PHT1 in the disposition of l-histidine in brain: In vitro slice and in vivo pharmacokinetic studies in wildtype and Pht1 null mice

scientific article published on 11 November 2016

Absence of the chemokine receptor CCR2 protects against cerebral ischemia/reperfusion injury in mice

scientific article

Acetazolamide Attenuates Thrombin-Induced Hydrocephalus

scientific article published in January 2016

Activated autophagy pathway in experimental subarachnoid hemorrhage

scientific article published on 16 June 2009

Activation of muscarinic cholinergic receptors on human SH-SY5Y neuroblastoma cells enhances both the influx and efflux of K+ under conditions of hypo-osmolarity

scientific article published on 15 February 2008

Activation of p44/42 mitogen activated protein kinases in thrombin-induced brain tolerance

scientific article

Acute inflammatory reaction following experimental intracerebral hemorrhage in rat.

scientific article

Acute subdural hematoma: new model delineation and effects of coagulation inhibitors.

scientific article

Acute white matter injury after experimental subarachnoid hemorrhage: potential role of lipocalin 2

scientific article

Advances in brain barriers and brain fluid research and news from Fluids and Barriers of the CNS.

scientific article published on 28 January 2016

Ameliorative effects of yokukansan on behavioral deficits in a gerbil model of global cerebral ischemia

scientific article published on 19 November 2013

Analysis of Small Ischemic Lesions in the Examinees of a Brain Dock and Neurological Examination of Animals Subjected to Cortical or Basal Ganglia Photothrombotic Infarction

scientific article published in January 2016

Anti-oxidative effects of d-allose, a rare sugar, on ischemia-reperfusion damage following focal cerebral ischemia in rat.

scientific article published on 16 October 2010

Antioxidative effects of Panax notoginseng saponins in brain cells

scientific article

Autophagy after experimental intracerebral hemorrhage

scientific article

Basal Ganglia Damage in Experimental Subarachnoid Hemorrhage

scientific article published in January 2016

Behavioral tests after intracerebral hemorrhage in the rat.

scientific article published in October 2002

Blood pressure lowering and acute perihematomal brain edema after intracerebral hemorrhage.

scientific article published on April 2014

Blood-brain barrier mechanisms involved in brain calcium and potassium homeostasis

scientific article

Blood-brain barrier models derived from individual patients: a new frontier: An Editorial Highlight on 'An isogenic blood-brain barrier model comprising brain endothelial cells, astrocytes, and neurons derived from human induced pluripotent stem cel

scientific article published on 14 February 2017

Brain CD47 expression in a swine model of intracerebral hemorrhage

scientific article

Brain alpha- and beta-globin expression after intracerebral hemorrhage.

scientific article

Brain barriers and brain fluid research in 2016: advances, challenges and controversies

scientific article published on 2 February 2017

Brain endothelial cell-cell junctions: how to "open" the blood brain barrier

scientific article

Brain fluid calcium concentration and response to acute hypercalcaemia during development in the rat

scientific article published on 01 August 1988

Brain injury after intracerebral hemorrhage in spontaneously hypertensive rats.

scientific article

Brain injury after intracerebral hemorrhage: the role of thrombin and iron.

scientific article published on February 2007

Brain water content. A misunderstood measurement?

scientific article

CD163 Expression in Neurons After Experimental Intracerebral Hemorrhage

scientific article published on 30 March 2017

CD163, a Hemoglobin/Haptoglobin Scavenger Receptor, After Intracerebral Hemorrhage: Functions in Microglia/Macrophages Versus Neurons

scientific article published on 06 April 2017

COA-Cl, a Novel Synthesized Nucleoside Analog, Exerts Neuroprotective Effects in the Acute Phase of Intracerebral Hemorrhage

scientific article

Carnosine uptake in rat choroid plexus primary cell cultures and choroid plexus whole tissue from PEPT2 null mice

scientific article published in April 2004

Characterization of an improved double hemorrhage rat model for the study of delayed cerebral vasospasm

scientific article published on 19 November 2007

Choroid Plexus Ion Transporter Expression and Cerebrospinal Fluid Secretion

scientific article published on 01 January 1997

Choroid plexus histidine transport

scientific article published in February 1998

Choroid plexus structure and function in young rats on a high-potassium diet

scientific article published on 01 June 1987

Choroid plexus taurine transport

scientific article published in April 1996

Choroid plexus transport: gene deletion studies

scientific article published on November 4, 2011

Claudin-1-Dependent Destabilization of the Blood-Brain Barrier in Chronic Stroke

scientific article published on 30 November 2018

Clot formation, vascular repair and hematoma resolution after ICH, a coordinating role for thrombin?

scientific article published on January 2011

Comparison of cerebral blood flow and injury following intracerebral and subdural hematoma in the rat.

scientific article

Comparison of experimental rat models of early brain injury after subarachnoid hemorrhage

scientific article

Cortical microvessels during brain development: a morphometric study in the rat.

scientific article

Critical Role of the Sphingolipid Pathway in Stroke: a Review of Current Utility and Potential Therapeutic Targets.

scientific article published on 24 June 2016

Deferoxamine Attenuated the Upregulation of Lipocalin-2 Induced by Traumatic Brain Injury in Rats

scientific article published in January 2016

Deferoxamine affects heat shock protein expression in heart after intracerebral hemorrhage in aged rats

scientific article published on 01 January 2011

Deferoxamine attenuates acute hydrocephalus after traumatic brain injury in rats

scientific article

Deferoxamine attenuates white matter injury in a piglet intracerebral hemorrhage model

scientific article published on 30 October 2013

Deferoxamine reduces cavity size in the brain after intracerebral hemorrhage in aged rats

scientific article

Deferoxamine reduces early brain injury following subarachnoid hemorrhage

scientific article published in January 2011

Deferoxamine reduces intracerebral hematoma-induced iron accumulation and neuronal death in piglets

scientific article published on 16 April 2009

Deferoxamine reduces intracerebral hemorrhage-induced white matter damage in aged rats

scientific article

Deferoxamine reduces neuronal death and hematoma lysis after intracerebral hemorrhage in aged rats.

scientific article published on October 2013

Delayed argatroban treatment reduces edema in a rat model of intracerebral hemorrhage

scientific article published in December 2002

Development of a rat model of photothrombotic ischemia and infarction within the caudoputamen.

scientific article

Developmental changes in blood-brain barrier potassium permeability in the rat: relation to brain growth

scientific article published in October 1995

Discovery of anthranilamides as a novel class of inhibitors of neurotropic alphavirus replication

scientific article published on 11 February 2015

Divergent developmental expression and function of the proton-coupled oligopeptide transporters PepT2 and PhT1 in regional brain slices of mouse and rat

scientific article

Do brain fluid ion concentrations change in hydrocephalus? A study on potassium and calcium in rats with congenital hydrocephalus

scientific article published on 01 June 1989

Early Erythrolysis in the Hematoma After Experimental Intracerebral Hemorrhage

scientific article

Edaravone attenuates brain edema and neurologic deficits in a rat model of acute intracerebral hemorrhage

scientific article

Edaravone, a free radical scavenger, attenuates behavioral deficits following transient forebrain ischemia by inhibiting oxidative damage in gerbils

scientific article published on 21 October 2011

Effect of Gender on Iron-induced Brain Injury in Low Aerobic Capacity Rats.

scientific article published in January 2016

Effect of electrical stimulation of the cervical spinal cord on blood flow following subarachnoid hemorrhage

scientific article

Effect of sustained-mild and transient-severe hyperglycemia on ischemia-induced blood-brain barrier opening

scientific article published on 7 February 2007

Effect of transporter inhibition on the distribution of cefadroxil in rat brain

scientific article

Effects of Aerobic Capacity on Thrombin-Induced Hydrocephalus and White Matter Injury

scientific article published in January 2016

Effects of Gender and Estrogen Receptors on Iron-Induced Brain Edema Formation

scientific article published in January 2016

Effects of Hyperglycemia on Cerebral Blood Flow and Edema Formation After Carotid Artery Occlusion in Fischer 344 Rats

scientific article published on January 1, 1997

Effects of aging on autophagy after experimental intracerebral hemorrhage

scientific article published in January 2011

Effects of deferoxamine on brain injury after transient focal cerebral ischemia in rats with hyperglycemia.

scientific article published on 23 July 2009

Effects of deferoxamine on intracerebral hemorrhage-induced brain injury in aged rats

scientific article

Effects of gender on heart injury after intracerebral hemorrhage in rats

scientific article

Effects of intraventricular infusion of vascular endothelial growth factor on cerebral blood flow, edema, and infarct volume

scientific article published in January 2003

Effects of progesterone and testosterone on ICH-induced brain injury in rats

scientific article

Effects of the chemokine CCL2 on blood-brain barrier permeability during ischemia-reperfusion injury

scientific article published in June 2006

Effects of thrombin on neurogenesis after intracerebral hemorrhage

scientific article published on 24 April 2008

Endothelium-targeted overexpression of heat shock protein 27 ameliorates blood-brain barrier disruption after ischemic brain injury.

scientific article

Enhanced antinociceptive response to intracerebroventricular kyotorphin in Pept2 null mice

scientific article

Estrogen therapy for experimental intracerebral hemorrhage in rats

scientific article published in July 2005

Evaluation of polymer and self-assembled monolayer-coated silicone surfaces to reduce neural cell growth.

scientific article

Full steam ahead with remote ischemic conditioning for stroke.

scientific article

Glutamine transport at the blood-brain and blood-cerebrospinal fluid barriers

scientific article published in September 2003

Glycyl-L-glutamine disposition in rat choroid plexus epithelial cells in primary culture: role of PEPT2.

scientific article published on 3 August 2005

Hematoma Changes During Clot Resolution After Experimental Intracerebral Hemorrhage.

scientific article published on 28 April 2016

Hemoglobin and iron handling in brain after subarachnoid hemorrhage and the effect of deferoxamine on early brain injury

scientific article published on 25 August 2010

Hemoglobin expression in neurons and glia after intracerebral hemorrhage

scientific article

Hemoglobin-induced neuronal degeneration in the hippocampus after neonatal intraventricular hemorrhage

scientific article

Holo-transferrin and thrombin can interact to cause brain damage

scientific article published on 6 January 2005

Hydrocephalus after intraventricular hemorrhage: the role of thrombin

scientific article published on 11 December 2013

Hyperbaric oxygen-induced attenuation of hemorrhagic transformation after experimental focal transient cerebral ischemia

scientific article published on 22 February 2007

Hyperglycemia and the Vascular Effects of Cerebral Ischemia

scientific article published on January 1, 1997

Impact of genetic knockout of PEPT2 on cefadroxil pharmacokinetics, renal tubular reabsorption, and brain penetration in mice

scientific article

Impact of lipopolysaccharide-induced inflammation on the disposition of the aminocephalosporin cefadroxil.

scientific article published on 30 September 2013

In vitro characterization of a targeted, dye-loaded nanodevice for intraoperative tumor delineation.

scientific article published on May 2009

Inducible cyclooxygenase-2 expression after experimental intracerebral hemorrhage

scientific article

Influence of peptide transporter 2 (PEPT2) on the distribution of cefadroxil in mouse brain: A microdialysis study

scientific article published on 10 February 2017

Inhibition of Carbonic Anhydrase Reduces Brain Injury After Intracerebral Hemorrhage

scientific article published on March 1, 2012

Inhibition of junctional adhesion molecule-A/LFA interaction attenuates leukocyte trafficking and inflammation in brain ischemia/reperfusion injury.

scientific article

Injury mechanisms in acute intracerebral hemorrhage.

scientific article

Intercellular cross-talk in intracerebral hemorrhage

scientific article

Intracerebral haemorrhage: mechanisms of injury and therapeutic targets.

scientific article published on 13 June 2012

Intracerebral hemorrhage: effects of aging on brain edema and neurological deficits

scientific article published on 07 October 2004

Intracerebral hemorrhage: mechanisms and therapies

scientific article published on 11 May 2012

Intraventricular Hemorrhage: the Role of Blood Components in Secondary Injury and Hydrocephalus

scientific article published on 30 June 2016

Intraventricular infusion of vascular endothelial growth factor promotes cerebral angiogenesis with minimal brain edema

scientific article published in March 2002

Iron accumulation and DNA damage in a pig model of intracerebral hemorrhage

scientific article

Iron and iron-handling proteins in the brain after intracerebral hemorrhage.

scientific article published on 13 November 2003

Iron enhances the neurotoxicity of amyloid β.

scientific article

Iron-induced necrotic brain cell death in rats with different aerobic capacity

scientific article published on 5 February 2015

Ischemic preconditioning procedure induces behavioral deficits in the absence of brain injury?

scientific article published in April 2005

Junctional proteins of the blood-brain barrier: New insights into function and dysfunction

scientific article published on January 2016

Lipocalin 2 and Blood-Brain Barrier Disruption in White Matter after Experimental Subarachnoid Hemorrhage

scientific article published in January 2016

Long-term effects of experimental intracerebral hemorrhage: the role of iron

scientific article published in February 2006

MRI Characterization in the Acute Phase of Experimental Subarachnoid Hemorrhage

scientific article published on 28 November 2016

Mechanisms Underlying Astrocyte Endfeet Swelling in Stroke.

scientific article published on January 2016

Mechanisms of 5-aminolevulinic acid uptake at the choroid plexus

scientific article published in July 2000

Mechanisms of brain injury after intracerebral haemorrhage.

scientific article

Mechanisms of cefadroxil uptake in the choroid plexus: studies in wild-type and PEPT2 knockout mice

scientific article published on 4 November 2003

Microglia Activation and Polarization After Intracerebral Hemorrhage in Mice: the Role of Protease-Activated Receptor-1.

scientific article

Microglia/Macrophage Polarization After Experimental Intracerebral Hemorrhage

scientific article

Minocycline Attenuates Iron-Induced Brain Injury

scientific article published in January 2016

Minocycline-induced attenuation of iron overload and brain injury after experimental intracerebral hemorrhage

scientific article published on 13 October 2011

Modifying blood-brain barrier transport to bring hope for patients with lysosomal storage diseases.

scientific article published on 4 November 2015

Monocyte chemoattractant protein-1 regulation of blood-brain barrier permeability

scientific article published in May 2005

Na+ and K+ ion imbalances in Alzheimer's disease.

scientific article

Nestin expression after experimental intracerebral hemorrhage.

scientific article published on August 2003

Neural progenitor cells and blood–brain barrier modeling

scientific article published on November 1, 2011

Neuroprotection of granulocyte colony-stimulating factor during the acute phase of transient forebrain ischemia in gerbils.

scientific article published on 31 December 2013

New grading system based on magnetic resonance imaging in a mouse model of subarachnoid hemorrhage.

scientific article published on 30 December 2014

News from the editors of Fluids and Barriers of the CNS.

scientific article

Nicotine aggravates the brain postischemic inflammatory response.

scientific article

Novel Inhibitors of Neurotropic Alphavirus Replication That Improve Host Survival in a Mouse Model of Acute Viral Encephalitis

scientific article published on April 3, 2012

Novel indole-2-carboxamide compounds are potent broad-spectrum antivirals active against western equine encephalitis virus in vivo.

scientific article

N‐System Amino Acid Transport at the Blood‐CSF Barrier

scientific article published on 01 December 1995

Optimization of novel indole-2-carboxamide inhibitors of neurotropic alphavirus replication

scientific article

Oxidative DNA injury after experimental intracerebral hemorrhage.

scientific article published on March 2005

Oxidative brain injury from extravasated erythrocytes after intracerebral hemorrhage

scientific article published in October 2002

PDCD10 (CCM3) regulates brain endothelial barrier integrity in cerebral cavernous malformation type 3: role of CCM3-ERK1/2-cortactin cross-talk.

scientific article

PEPT2 (Slc15a2)-mediated unidirectional transport of cefadroxil from cerebrospinal fluid into choroid plexus

scientific article published on 17 August 2005

PEPT2-mediated uptake of neuropeptides in rat choroid plexus

scientific article published in June 2001

Peptide and peptide analog transport systems at the blood-CSF barrier.

scientific article published in October 2004

Peptide transporter 2 (PEPT2) expression in brain protects against 5-aminolevulinic acid neurotoxicity

scientific article published on 13 September 2007

Perihematomal brain tissue iron concentration measurement by MRI in patients with intracerebral hemorrhage

scientific article published on 21 May 2020

Potential role of MCP-1 in endothelial cell tight junction 'opening': signaling via Rho and Rho kinase

scientific article published in November 2003

Preliminary investigation into the expression of proton-coupled oligopeptide transporters in neural retina and retinal pigment epithelium (RPE): lack of functional activity in RPE plasma membranes.

scientific article published on September 2003

Progress in translational research on intracerebral hemorrhage: is there an end in sight?

scientific article published on 16 October 2013

Property-based design of a glucosylceramide synthase inhibitor that reduces glucosylceramide in the brain.

scientific article published on 4 November 2011

Protease-activated receptor-1 mediates protection elicited by thrombin preconditioning in a rat 6-hydroxydopamine model of Parkinson's disease.

scientific article published on 28 August 2006

Protective effects of isothiocyanates on blood-CSF barrier disruption induced by oxidative stress

scientific article published on May 9, 2012

Protein kinase Calpha-RhoA cross-talk in CCL2-induced alterations in brain endothelial permeability

scientific article published on 26 January 2006

Rapid endothelial cytoskeletal reorganization enables early blood-brain barrier disruption and long-term ischaemic reperfusion brain injury

scientific article published on 27 January 2016

Recent research on changes in genomic regulation and protein expression in intracerebral haemorrhage.

scientific article

Receptor regulation of osmolyte homeostasis in neural cells.

scientific article published on 24 May 2010

Red blood cell lysis and brain tissue-type transglutaminase upregulation in a hippocampal model of intracerebral hemorrhage

scientific article

Relocalization of junctional adhesion molecule A during inflammatory stimulation of brain endothelial cells.

scientific article

Reply to more on: the role of thrombin in gliomas.

scientific article published in January 2006

Role and relevance of PEPT2 in drug disposition, dynamics, and toxicity

scientific article published on January 2008

Role and relevance of peptide transporter 2 (PEPT2) in the kidney and choroid plexus: in vivo studies with glycylsarcosine in wild-type and PEPT2 knockout mice

scientific article published on 29 June 2005

Role of Erythrocyte CD47 in Intracerebral Hematoma Clearance

scientific article published on 5 January 2016

Role of Human Breast Cancer Related Protein versus P-Glycoprotein as an Efflux Transporter for Benzylpenicillin: Potential Importance at the Blood-Brain Barrier

scientific article

Role of Iron in Brain Injury After Intraventricular Hemorrhage

scientific article published on December 16, 2010

Role of Lipocalin-2 in Thrombin-Induced Brain Injury

scientific article published on 11 February 2016

Role of PEPT2 in glycylsarcosine transport in astrocyte and glioma cultures

scientific article published on 20 December 2005

Role of PEPT2 in peptide/mimetic trafficking at the blood-cerebrospinal fluid barrier: studies in rat choroid plexus epithelial cells in primary culture

scientific article

Role of PEPT2 in the choroid plexus uptake of glycylsarcosine and 5-aminolevulinic acid: studies in wild-type and null mice

scientific article published in September 2004

Role of Protease-Activated Receptor-1 in Glioma Growth.

scientific article

Role of hemoglobin and iron in hydrocephalus after neonatal intraventricular hemorrhage.

scientific article published on December 2014

Role of iron in brain lipocalin 2 upregulation after intracerebral hemorrhage in rats.

scientific article published on 15 February 2013

Role of lipocalin-2 in brain injury after intracerebral hemorrhage.

scientific article

Role of protease-activated receptor-1 in brain injury after experimental global cerebral ischemia

scientific article published on 17 July 2012

Role of red blood cell lysis and iron in hydrocephalus after intraventricular hemorrhage.

scientific article

Ryanodine receptors contribute to the induction of ischemic tolerance

scientific article

STAT3 Inhibition as a Therapeutic Strategy for Chordoma

scientific article

Should the STAIR criteria be modified for preconditioning studies?

scientific article published on February 2013

Susceptibility to intracerebral hemorrhage-induced brain injury segregates with low aerobic capacity in rats.

scientific article published on 24 August 2012

Tamoxifen treatment for intracerebral hemorrhage

scientific article

Targeted disruption of the PEPT2 gene markedly reduces dipeptide uptake in choroid plexus

scientific article published on 6 December 2002

The Effect of Gender on Acute Hydrocephalus after Experimental Subarachnoid Hemorrhage

scientific article published on January 2016

The brain tumor window model: a combined cranial window and implanted glioma model for evaluating intraoperative contrast agents.

scientific article

The choroid plexus as a site of damage in hemorrhagic and ischemic stroke and its role in responding to injury.

scientific article published on 28 March 2017

The control of potassium concentration in the cerebrospinal fluid and brain interstitial fluid of developing rats

scientific article published on 01 February 1987

The development of ion regulation at the blood-brain barrier

scientific article published on January 1, 1992

The effect of thrombin on a 6-hydroxydopamine model of Parkinson's disease depends on timing.

scientific article published on 13 June 2007

The effects of D-allose on transient ischemic neuronal death and analysis of its mechanism

scientific article published on 14 October 2014

The effects of cerebral ischemia on the rat choroid plexus

scientific article published in May 2006

The effects of hypo- and hyperkalemia on choroid plexus potassium transport

scientific article published in May 1997

The effects of thrombin preconditioning on focal cerebral ischemia in rats

The role of complement C3 in intracerebral hemorrhage-induced brain injury

scientific article published on 22 March 2006

The role of the coagulation cascade in brain edema formation after intracerebral hemorrhage

scientific article published on 01 January 1996

The role of thrombin in gliomas.

scientific article published on 24 June 2005

Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models

scientific article published on March 2016

Thrombin preconditioning attenuates iron-induced neuronal death

scientific article

Thrombin preconditioning provides protection in a 6-hydroxydopamine Parkinson's disease model.

scientific article published on 30 November 2004

Thrombin up-regulates vascular endothelial growth factor in experimental gliomas.

scientific article

Thrombin-induced autophagy: a potential role in intracerebral hemorrhage

scientific article published on 8 October 2011

Thrombin-induced cerebral hemorrhage: role of protease-activated receptor-1.

scientific article published on 21 September 2013

Thrombin-induced neuronal protection: role of the mitogen activated protein kinase/ribosomal protein S6 kinase pathway.

scientific article

Tracing the endocytosis of claudin-5 in brain endothelial cells

scientific article published in January 2011

Translational Stroke Research on Blood-Brain Barrier Damage: Challenges, Perspectives, and Goals.

scientific article published on 13 January 2016

Transport of 5-aminolevulinic acid between blood and brain

scientific article

Tumor necrosis factor-alpha increases in the brain after intracerebral hemorrhage and thrombin stimulation

scientific article published in March 2006

Vascular disruption and blood-brain barrier dysfunction in intracerebral hemorrhage

scientific article

Where did the ventricles go?

scientific article published in March 2012

White Matter Injury After Subarachnoid Hemorrhage: Role of Blood-Brain Barrier Disruption and Matrix Metalloproteinase-9.

scientific article published on 15 September 2015

Zinc Protoporphyrin Attenuates White Matter Injury after Intracerebral Hemorrhage

scientific article published in January 2016

d-Allose Attenuates Overexpression of Inflammatory Cytokines after Cerebral Ischemia/Reperfusion Injury in Gerbil

scientific article published on 21 June 2016