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List of works by Salvatore Valitutti

A biased competition theory of cytotoxic T lymphocyte interaction with tumor nodules

scientific article (publication date: 2015)

A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion.

scientific article

A single peptide-major histocompatibility complex ligand triggers digital cytokine secretion in CD4(+) T cells

scientific article published on 10 October 2013

Activation of the ancestral polarity regulator protein kinase C zeta at the immunological synapse drives polarization of Th cell secretory machinery toward APCs

scientific article published on 02 August 2010

Agonist-induced T cell receptor down-regulation: molecular requirements and dissociation from T cell activation

scientific article published on 01 July 1997

Alterations in thymocyte subpopulations in Down's syndrome (trisomy 21).

scientific article published in November 1988

An initial and rapid step of lytic granule secretion precedes microtubule organizing center polarization at the cytotoxic T lymphocyte/target cell synapse.

scientific article

Analysis of peptide/MHC-induced TCR downregulation: deciphering the triggering kinetics.

scientific article published on January 2006

CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation

scientific article

CD160-activating NK cell effector functions depend on the phosphatidylinositol 3-kinase recruitment

scientific article published on 16 February 2007

CD2 and TCR synergize for the activation of phospholipase Cgamma1/calcium pathway at the immunological synapse.

scientific article published on 12 January 2007

CD4+ T cells downregulate Bcl-2 in germinal centers

scientific article published on 01 May 2005

Cell-cell cooperation at the T helper cell/mast cell immunological synapse

scientific article

Clonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8(+) T Lymphocytes

scientific article published on May 2015

Cognate interactions between mast cells and helper T lymphocytes ⬇️

scientific article published on March 17, 2010

Cytotoxic T lymphocytes kill multiple targets simultaneously via spatiotemporal uncoupling of lytic and stimulatory synapses.

scientific article

Degradation of T cell receptor (TCR)-CD3-zeta complexes after antigenic stimulation

scientific article published on May 1997

Different activation signals induce distinct mast cell degranulation strategies

scientific article

Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy.

scientific article published on April 1996

Direct monitoring of basophil degranulation by using avidin-based probes

scientific article published on 20 April 2017

Distinct signaling properties identify functionally different CD4 epitopes.

scientific article

Distribution, function, and prognostic value of cytotoxic T lymphocytes in follicular lymphoma: a 3-D tissue-imaging study

scientific article published on 19 August 2011

Effects of intracellular calcium and actin cytoskeleton on TCR mobility measured by fluorescence recovery

scientific article

Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes

scientific article published on 01 March 2000

Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

scientific article

Frequency encoding of T-cell receptor engagement dynamics in calcium time series.

scientific article

HLA-restricted, processing- and metabolism-independent pathway of drug recognition by human alpha beta T lymphocytes.

scientific article published on October 1998

Human mast cells drive memory CD4+ T cells toward an inflammatory IL-22+ phenotype

scientific article published on 19 March 2013

Human regulatory T cells inhibit polarization of T helper cells toward antigen-presenting cells via a TGF-beta-dependent mechanism

scientific article

Hydroxychloroquine as a novel therapeutic approach in mast cell activation diseases

scientific article published on 10 July 2018

IL-33 fine tunes mast cell degranulation and chemokine production at the single-cell level

scientific article

Identification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes

scientific article published on 24 February 2022

Immunological synapse: center of attention again

scientific article published on 01 September 2008

Immunological synapses are versatile structures enabling selective T cell polarization.

scientific article published on February 2005

Impaired functional responses in follicular lymphoma CD8+TIM-3+ T lymphocytes following TCR engagement.

scientific article published on 24 August 2016

Individual Human Cytotoxic T Lymphocytes Exhibit Intraclonal Heterogeneity during Sustained Killing.

scientific article published on 27 May 2015

Kinetics and extent of protein tyrosine kinase activation in individual T cells upon antigenic stimulation

scientific article

Lymphatic endothelium forms integrin-engaging 3D structures during DC transit across inflamed lymphatic vessels

scientific article published on 25 March 2013

Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: manifestation of a dual activation threshold

scientific article

Mast cells form antibody-dependent degranulatory synapse for dedicated secretion and defence.

scientific article

Measurement of calcium mobilization responses in killer cell/target conjugates by FACS analysis

scientific article

Melanoma cell lysosome secretory burst neutralizes the CTL-mediated cytotoxicity at the lytic synapse

scientific article

Multiparametric analysis of CD8 T cell compartment phenotype in chronic lymphocytic leukemia reveals a signature associated with progression toward therapy

scientific article published on 07 February 2019

New insights to the functional role of the T cell-antigen presenting cell immunological synapse

scientific article

New roles and controls of mast cells.

scientific article published on 13 November 2017

Normal T lymphocytes can express two different T cell receptor beta chains: implications for the mechanism of allelic exclusion

scientific article

Optimal activation of tumor-reactive T cells by selected antigenic peptide analogues.

scientific article

Plasticity of immunological synapses.

scientific article published on January 2010

Platelet-activating factor (PAF) receptor antagonists inhibit mitogen-induced human peripheral blood T-cell proliferation

scientific article published on 01 October 1987

Reciprocal polarization of T and B cells at the immunological synapse

scientific article published on 19 September 2011

Reply: To PMID 23518141.

scientific article published in November 2013

Role of cAMP in regulating cytotoxic T lymphocyte adhesion and motility

scientific article published in April 1993

Sequential adjustment of cytotoxic T lymphocyte densities improves efficacy in controlling tumor growth

scientific article published on 23 August 2019

Signal extinction and T cell repolarization in T helper cell-antigen-presenting cell conjugates

scientific article published on 01 September 1996

Stepwise maturation of lytic granules during differentiation and activation of human CD8+ T lymphocytes

scientific article

Supramolecular attack particles are autonomous killing entities released from cytotoxic T cells

scientific article

Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton

scientific article published on February 1995

T-cell activation is accompanied by an ubiquitination process occurring at the immunological synapse

scientific article published on 20 November 2004

T-cell antagonism by short half-life pMHC ligands can be mediated by an efficient trapping of T-cell polarization toward the APC

scientific article

TCR dynamics on the surface of living T cells

scientific article published on 01 December 2001

The Serial Engagement Model 17 Years After: From TCR Triggering to Immunotherapy ⬇️

scientific article published on August 28, 2012

The Wiskott-Aldrich Syndrome Protein Contributes to the Assembly of the LFA-1 Nanocluster Belt at the Lytic Synapse.

scientific article published on 28 January 2018

The Wiskott-Aldrich syndrome protein permits assembly of a focused immunological synapse enabling sustained T-cell receptor signaling.

scientific article

The Wiskott-Aldrich syndrome protein regulates CTL cytotoxicity and is required for efficient killing of B cell lymphoma targets.

scientific article published on 5 August 2010

The beta1 and beta3 integrins promote T cell receptor-mediated cytotoxic T lymphocyte activation

scientific article published on 10 April 2003

The diversity of immunological synapses.

scientific article

The space and time frames of T cell activation at the immunological synapse ⬇️

scientific article published on October 14, 2010

Theophylline induces differentiation and modulates cytoskeleton dynamics and cytokines secretion in human melanoma-initiating cells

scientific article published on 21 May 2019

Tuning of T cell clone size and activation threshold by control of CD25 expression through mitogen-activated protein kinase pathways

scientific article published in April 2002

Wiskott-Aldrich syndrome protein controls antigen-presenting cell-driven CD4+ T-cell motility by regulating adhesion to intercellular adhesion molecule-1

scientific article

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