Search filters

List of works by Hiroyuki Kagechika

13-cis-retinoic acid alters the cellular morphology of slice-cultured serotonergic neurons in the rat.

scientific article published in May 2008

6-Arylcoumarin as a Scaffold of Photofunctional Molecules with OFF-ON-OFF Type Regulation

scientific article published on 27 December 2020

6-arylcoumarins as novel nonsteroidal type progesterone antagonists: an example with receptor-binding-dependent fluorescence

scientific article published on 5 October 2011

9-cis Retinoic acid modulates myotrophin expression and its miR in physiological and pathophysiological cell models.

scientific article published on 11 March 2017

A Modified Murine Embryonic Stem Cell Test for Evaluating the Teratogenic Effects of Drugs on Early Embryogenesis

scientific article

A Polarity-Sensitive Fluorescent Amino Acid and its Incorporation into Peptides for the Ratiometric Detection of Biomolecular Interactions

scientific article published on 13 October 2019

A cell-based screening for TAZ activators identifies ethacridine, a widely used antiseptic and abortifacient, as a compound that promotes dephosphorylation of TAZ and inhibits adipogenesis in C3H10T1/2 cells

scientific article published on 14 May 2015

A mutation mimicking ligand-induced conformational change yields a constitutive RXR that senses allosteric effects in heterodimers

scientific article published on September 15, 1997

A new RXR agonist, HX630, suppresses intimal hyperplasia in a mouse blood flow cessation model

scientific article published on 11 September 2006

A new cell-based assay to evaluate myogenesis in mouse myoblast C2C12 cells.

scientific article

A novel melatonin derivative modulates sleep-wake cycle in rats.

scientific article

A synthetic retinoid Am80 (tamibarotene) rescues the memory deficit caused by scopolamine in a passive avoidance paradigm.

scientific article published on November 2004

ASKA technology-based pull-down method reveals a suppressive effect of ASK1 on the inflammatory NOD-RIPK2 pathway in brown adipocytes

scientific article published on 10 November 2021

Absolute Helical Arrangement of Sulfonamide in the Crystal

scientific article published on 01 October 2003

Acidic heterocycles as novel hydrophilic pharmacophore of androgen receptor ligands with a carborane core structure

scientific article published on 30 October 2008

Action mechanism of retinoid-synergistic dibenzodiazepines

scientific article published on April 1997

Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-κBp50

scientific article published on 17 September 2013

Affinity gels for purification of retinoid-specific binding protein (RSBP)

scientific article published on 01 August 1988

All trans-retinoic acid analogs promote cancer cell apoptosis through non-genomic Crabp1 mediating ERK1/2 phosphorylation

scientific article published on 03 March 2016

All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells: possible involvement of protein kinase C-delta

scientific article

All-trans retinoic acid induces in vitro angiogenesis via retinoic acid receptor: possible involvement of paracrine effects of endogenous vascular endothelial growth factor signaling

scientific article published on 14 December 2006

Alpha-glucosidase inhibitors with a 4,5,6,7-tetrachlorophthalimide skeleton pendanted with a cycloalkyl or dicarba-closo-dodecaborane group.

scientific article published in June 2001

Alteration in the cellular response to retinoic acid of a human acute promyelocytic leukemia cell line, UF-1, carrying a patient-derived mutant PML-RARalpha chimeric gene

scientific article published on September 2004

Amide Conformational Switching Induced by Protonation of Aromatic Substituent

scientific article published on 01 April 2003

ApoC-III gene expression is sharply increased during adipogenesis and is augmented by retinoid X receptor (RXR) agonists

scientific article published on 31 December 2008

Boron cluster-based development of potent nonsecosteroidal vitamin D receptor ligands: direct observation of hydrophobic interaction between protein surface and carborane

scientific article

Carboxylic Derivatives of Vitamin K2 Inhibit Hepatocellular Carcinoma Cell Growth through Caspase/Transglutaminase-Related Signaling Pathways

scientific article published on 01 January 2015

Cellular retinoic acid binding protein I mediates rapid non-canonical activation of ERK1/2 by all-trans retinoic acid

scientific article

Chemical biology research on nuclear receptors

scientific article published in July 2008

Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy.

scientific article

Chiral spherical molecule constructed from aromatic amides: facile synthesis and highly ordered network structure in the crystal

scientific article published on 10 June 2008

Conformational Properties of Aromatic Oligoamides Bearing Pyrrole Rings

scientific article published on 11 April 2018

Conformational and Chiral Properties of Cyclic-tri(N-methyl-meta-benzamide) Bearing Amidino Groups

scientific article published on 24 June 2015

Contribution of AP-1 interference induced by TAC-101 to tumor growth suppression in a hepatocellular carcinoma model.

scientific article

Copper-mediated C-C cross-coupling reaction of monocarba-closo-dodecaborate anion for the synthesis of functional molecules

scientific article

Correlation of differentiation-inducing activity of retinoids on human leukemia cell lines HL-60 and NB4.

scientific article published in January 1995

Design and Synthesis of 4-(4-Benzoylaminophenoxy)phenol Derivatives As Androgen Receptor Antagonists.

scientific article

Design and synthesis of 4-benzyl-1-(2H)-phthalazinone derivatives as novel androgen receptor antagonists.

scientific article published on 6 August 2015

Design and synthesis of cyclic urea compounds: a pharmacological study for retinoidal activity

scientific article

Design and synthesis of nonsteroidal progesterone receptor antagonists based on C,C'-diphenylcarborane scaffold as a hydrophobic pharmacophore

scientific article published on 10 July 2014

Design and synthesis of tetraol derivatives of 1,12-dicarba- closo -dodecaborane as non-secosteroidal vitamin D analogs

scientific article published on 06 August 2014

Determination of endogenous levels of retinoic acid isomers in type II diabetes mellitus patients. Possible correlation with HbA1c values

scientific article published in October 2002

Development of 1,3-diphenyladamantane derivatives as nonsteroidal progesterone receptor antagonists.

scientific article

Development of 6-arylcoumarins as nonsteroidal progesterone antagonists. Structure-activity relationships and fluorescence properties.

scientific article published on 12 September 2016

Development of Androgen-Antagonistic Coumarinamides with a Unique Aromatic Folded Pharmacophore

scientific article published on 04 August 2020

Development of Helical Aromatic Amide Foldamers with a Diphenylacetylene Backbone

scientific article published on 17 January 2020

Development of N-(4-Phenoxyphenyl)benzenesulfonamide Derivatives as Novel Nonsteroidal Progesterone Receptor Antagonists

scientific article published on 15 September 2016

Development of Novel Inhibitors for Histone Methyltransferase SET7/9 based on Cyproheptadine

scientific article published on 06 July 2018

Development of WNK signaling inhibitors as a new class of antihypertensive drugs.

scientific article

Development of a library of 6-arylcoumarins as candidate fluorescent sensors

scientific article

Development of nonsteroidal glucocorticoid receptor modulators based on N-benzyl-N-(4-phenoxyphenyl)benzenesulfonamide scaffold.

scientific article

Development of novel bisubstrate-type inhibitors of histone methyltransferase SET7/9.

scientific article published on 14 October 2010

Development of p-carborane-based nonsteroidal progesterone receptor antagonists

scientific article published on 7 August 2014

Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis.

scientific article

Differentiation inducers of human promyelocytic leukemia cells HL-60. Phenylcarbamoylbenzoic acids and polyene amides

scientific article

Differentiation-inducing activity of retinoic acid isomers and their oxidized analogs on human promyelocytic leukemia HL-60 cells

scientific article published on 01 December 1992

Diphenylamine-based retinoid antagonists: regulation of RAR and RXR function depending on the N-substituent

scientific article published on 15 March 2011

Discovery of Novel SPAK Inhibitors That Block WNK Kinase Signaling to Cation Chloride Transporters.

scientific article published on 5 November 2014

Docking simulations suggest that all-trans retinoic acid could bind to retinoid X receptors.

scientific article published on 18 September 2015

Docosahexaenoic acid reduces haloperidol-induced dyskinesias in mice: involvement of Nur77 and retinoid receptors.

scientific article published in October 2004

Down-regulation of histone deacetylase 4, -5 and -6 as a mechanism of synergistic enhancement of apoptosis in human lung cancer cells treated with the combination of a synthetic retinoid, Am80 and green tea catechin.

scientific article published on 8 January 2017

Effect of synthetic retinoid, TAC-101, on experimental autoimmune disease.

scientific article published on January 2003

Effects of RXR Agonists on Cell Proliferation/Apoptosis and ACTH Secretion/Pomc Expression.

scientific article published on 29 December 2015

Effects of retinoic acids on the dendritic morphology of cultured hippocampal neurons

scientific article published on 3 May 2008

Efficient induction of CCR9 on T cells requires coactivation of retinoic acid receptors and retinoid X receptors (RXRs): exaggerated T Cell homing to the intestine by RXR activation with organotins

scientific article published on 29 September 2010

Encapsulation of the synthetic retinoids Am80 and LE540 into polymeric micelles and the retinoids' release control

scientific article published on 14 March 2009

Enhancement of imatinib-induced apoptosis of BCR/ABL-expressing cells by nutlin-3 through synergistic activation of the mitochondrial apoptotic pathway

scientific article published in May 2010

Expression of the ligand-binding domain-containing region of retinoic acid receptors alpha, beta and gamma in Escherichia coli and evaluation of ligand-binding selectivity.

scientific article

Fluorescent and photoaffinity labeling probes for retinoic acid receptors

scientific article published on 01 August 1991

Fluorescent probes for retinoic acid receptors: molecular measures for the ligand binding pocket

scientific article published on 01 October 1991

Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes

scientific article

Hmx4 regulates Sonic hedgehog signaling through control of retinoic acid synthesis during forebrain patterning.

scientific article published on 22 April 2011

Hypoxia-inducible factor-3alpha functions as an accelerator of 3T3-L1 adipose differentiation

scientific article published on July 2009

Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription

scientific article

Identification of a novel class of retinoic acid receptor beta-selective retinoid antagonists and their inhibitory effects on AP-1 activity and retinoic acid-induced apoptosis in human breast cancer cells.

scientific article published on May 1999

Identification of absolute helical structures of aromatic multilayered oligo(m-phenylurea)s in solution.

scientific article published in November 2009

Identification of an intermediate in the deboronation of ortho-carborane: an adduct of ortho-carborane with two nucleophiles on one boron atom

scientific article published on 20 February 2008

Identifying the receptor subtype selectivity of retinoid X and retinoic acid receptors via quantum mechanics.

scientific article published on 5 February 2017

In vitro murine spermatogenesis in an organ culture system

scientific article

Increased hydrophobicity and estrogenic activity of simple phenols with silicon and germanium-containing substituents.

scientific article published on 19 December 2012

Inhibition of IL-1-induced IL-6 production by synthetic retinoids

scientific article published on February 1997

Inhibition of mammary carcinoma cell growth by RXR is mediated by the receptor's oligomeric switch.

scientific article

Inhibition of ornithine decarboxylase induction by retinobenzoic acids in relation to their binding affinities to cellular retinoid-binding proteins

scientific article published on 01 January 1988

Lithocholic Acid Derivatives as Potent Vitamin D Receptor Agonists

scientific article published on 28 December 2020

Modulation of intramolecular heterodimer-induced fluorescence quenching of tricarbocyanine dye for the development of fluorescent sensor

scientific article published on 08 October 2010

Molecular chirality and chiral capsule-type dimer formation of cyclic triamidesvia hydrogen-bonding interactions

scientific article published on 05 March 2012

Molecular mechanism by which acyclic retinoid induces nuclear localization of transglutaminase 2 in human hepatocellular carcinoma cells

scientific article

Molecular mechanism of 9-cis-retinoic acid inhibition of adipogenesis in 3T3-L1 cells

scientific article published on 26 February 2013

MyD88 and retinoic acid signaling pathways interact to modulate gastrointestinal activities of dendritic cells

scientific article published on 16 April 2011

NR4A nuclear receptors mediate carnitine palmitoyltransferase 1A gene expression by the rexinoid HX600.

scientific article published on 28 January 2012

Neuritogenic activity of a genipin derivative in retinal ganglion cells is mediated by retinoic acid receptor β expression through nitric oxide/S-nitrosylation signaling

scientific article published on November 9, 2011

New type inducers of differentiation of human HL-60 promyelocytic leukemia cells. Terephthalic anilides

scientific article published on 01 October 1984

Novel Nonsteroidal Progesterone Receptor (PR) Antagonists with a Phenanthridinone Skeleton

scientific article published on 23 June 2018

Novel retinoid X receptor (RXR) antagonists having a dicarba-closo-dodecaborane as a hydrophobic moiety

scientific article published in December 2004

Novel retinoid X receptor antagonists: specific inhibition of retinoid synergism in RXR-RAR heterodimer actions

scientific article

Novel retinoidal tropolone derivatives. Bioisosteric relationship of tropolone ring with benzoic acid moiety in retinoid structure

scientific article published in April 2001

Novel thyroid hormone receptor antagonists with an N-alkylated diphenylamine skeleton.

scientific article published on 3 March 2007

Novel vitamin D receptor ligands bearing a spherical hydrophobic core structure—Comparison of bicyclic hydrocarbon derivatives with boron cluster derivatives

scientific article published on 10 January 2012

Peroxisome proliferator-activated receptor gamma ligands stimulate myeloid differentiation and lipogenensis in human leukemia NB4 cells.

scientific article published on April 2006

Polymethylcarborane as a novel bioactive moiety: derivatives with potent retinoid antagonistic activity

scientific article published on 01 August 2000

Possible involvement of retinoid-like cofactor in serum in hemin/protoporphyrin-IX-induced differentiation of human leukemia K562 cells.

scientific article published on January 1995

RXR agonist enhances the differentiation of cardiomyocytes derived from embryonic stem cells in serum-free conditions.

scientific article published on August 2005

RXR antagonism induces G0/G1 cell cycle arrest and ameliorates obesity by up-regulating the p53-p21$^{\rm{Cip1}}$ pathway in adipocytes

scientific article published on 09 February 2012

Redox-Induced Conformational Alteration ofN,N-Diarylamides

scientific article published on 16 November 2007

Regulation of Retinoidal Actions by Diazepinylbenzoic Acids.1Retinoid Synergists Which Activate the RXR−RAR Heterodimers

scientific article published on 01 December 1997

Retinoic acid imprints gut-homing specificity on T cells

scientific article (publication date: October 2004)

Retinoic acid induces expression of the thyroid hormone transporter, monocarboxylate transporter 8 (Mct8).

scientific article

Retinoic acid receptor agonists regulate expression of ATP-binding cassette transporter G1 in macrophages.

scientific article

Retinoic acid receptor signaling is required to maintain glucose-stimulated insulin secretion and β-cell mass

scientific article

Retinoic acid receptor-α up-regulates proopiomelanocortin gene expression in AtT20 corticotroph cells

scientific article published on 14 August 2014

Retinoic acid via RARalpha inhibits the expression of 24-hydroxylase in human prostate stromal cells

scientific article published on 7 November 2005

Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors

scientific article published in August 2003

Retinoid X receptor agonists modulate Foxp3⁺ regulatory T cell and Th17 cell differentiation with differential dependence on retinoic acid receptor activation

scientific article published on 26 August 2013

Retinoid X receptor gamma signaling accelerates CNS remyelination

scientific article

Retinoid derivative Tp80 exhibits anti-hepatitis C virus activity through restoration of GI-GPx expression.

scientific article

Retinoids induce growth inhibition and apoptosis in mast cell tumor cell lines

scientific article published on August 2006

STAT5a/PPARgamma pathway regulates involucrin expression in keratinocyte differentiation

scientific article published on 01 March 2007

Screening with a novel cell-based assay for TAZ activators identifies a compound that enhances myogenesis in C2C12 cells and facilitates muscle repair in a muscle injury model

scientific article published on 18 February 2014

Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway

scientific article

Specific uptake of retinoids into human promyelocytic leukemia cells HL-60 by retinoid-specific binding protein: possibly the true retinoid receptor.

scientific article published in April 1988

Spontaneous Resolution of Aromatic Sulfonamides:  Effective Screening Method and Discrimination of Absolute Structure

scientific article published on 01 October 2006

Steric structure-activity relationship of cyproheptadine derivatives as inhibitors of histone methyltransferase Set7/9.

scientific article published on 12 July 2016

Structural development of p-carborane-based potent non-secosteroidal vitamin D analogs

scientific article published on 16 September 2014

Structure-Activity study of retinoid agonists bearing substituted dicarba-closo-dodecaborane. Relation between retinoidal activity and conformation of two aromatic nuclei

scientific article

Structure-activity relationship of novel (benzoylaminophenoxy)phenol derivatives as anti-prostate cancer agents

scientific article published on 06 September 2018

Structure-activity relationship study on benzoic acid part of diphenylamine-based retinoids

scientific article

Structures of histone methyltransferase SET7/9 in complexes with adenosylmethionine derivatives

scientific article

Synergistic potentiation of thiazolidinedione-induced ST 13 preadipocyte differentiation by RAR synergists.

scientific article

Synthesis and Biological Activity of Carboxyphenylquinolines and Related Compounds as New Potent Retinoids. Retinobenzoic Acids. VII

scientific article published on December 1, 1994

Synthesis and Conformational Analysis of Alternately N-Alkylated Aromatic Amide Oligomers

scientific article published on 15 November 2018

Synthesis and structure–activity relationship of p-carborane-based non-secosteroidal vitamin D analogs

scientific article published on 21 January 2014

Synthesis of porphyrinylamide and observation of N-methylation-induced trans–cis amide conformational alteration

Synthesis of soluble aromatic multilayered tetra(m-phenylurea) and analysis of its helical conformation in various solvents.

scientific article

Synthetic retinoid Am80 suppresses smooth muscle phenotypic modulation and in-stent neointima formation by inhibiting KLF5.

scientific article published on 13 October 2005

Synthetic retinoids, retinobenzoic acids, Am80, Am580 and Ch55 regulate morphogenesis in chick limb bud.

scientific article published on October 1990

Synthetic retinoids: recent developments concerning structure and clinical utility.

scientific article

Systematic synthesis and anti-inflammatory activity of ω-carboxylated menaquinone derivatives--Investigations on identified and putative vitamin K₂ metabolites

scientific article published on 04 April 2015

The ATRA-dependent overexpression of the glutamate transporter EAAC1 requires RARbeta induction.

scientific article

The endocrine disruptors nonylphenol and octylphenol exert direct effects on T cells to suppress Th1 development and enhance Th2 development

scientific article published in June 2004

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

scientific journal article

The mevalonate pathway regulates primitive streak formation via protein farnesylation

scientific article

The retinoic acid receptor agonist Am80 increases mucosal inflammation in an IL-6 dependent manner during Trichuris muris infection

scientific article published on 15 September 2013

The retinoic acid receptors alpha and beta are expressed in the human promyelocytic leukemia cell line HL-60

scientific article published on 01 July 1989

The transcription factors Nur77 and retinoid X receptors participate in amphetamine-induced locomotor activities.

scientific article

Thyromimetics: a review of recent reports and patents (2004 - 2009).

scientific article published on February 2010

Tributyltin chloride induces ABCA1 expression and apolipoprotein A-I-mediated cellular cholesterol efflux by activating LXRα/RXR.

scientific article published on 8 January 2011

Unusual conformational preference of an aromatic secondary urea: solvent-dependent open-closed conformational switching of N,N'-bis(porphyrinyl)urea

scientific article published in March 2013

Upregulation of nitric oxide production in vascular endothelial cells by all-trans retinoic acid through the phosphoinositide 3-kinase/Akt pathway.

scientific article published on 25 July 2005

Utility of boron clusters for drug design. Relation between estrogen receptor binding affinity and hydrophobicity of phenols bearing various types of carboranyl groups

scientific article published on 01 November 2003

Validation of chemical compound library screening for transcriptional co-activator with PDZ-binding motif inhibitors using GFP-fused transcriptional co-activator with PDZ-binding motif

scientific article

[Retinoid therapy for autoimmune diseases]

scientific article published on 01 June 2006

beta-Cryptoxanthin, a novel natural RAR ligand, induces ATP-binding cassette transporters in macrophages

scientific article published on 22 April 2007

c-Jun N-terminal kinase activation by oxidative stress suppresses retinoid signaling through proteasomal degradation of retinoic acid receptor α protein in hepatic cells

scientific article published on 24 February 2011