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List of works by John E Burke

(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase

scientific article published on 20 June 2019

A phospholipid substrate molecule residing in the membrane surface mediates opening of the lid region in group IVA cytosolic phospholipase A2.

scientific article published on 27 August 2008

A single discrete Rab5-binding site in phosphoinositide 3-kinase β is required for tumor cell invasion

scientific article published on 18 January 2019

Accurate prediction of protein structures and interactions using a three-track neural network

scientific article

Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation

scientific article published on 06 April 2022

Allosteric activation of PI3Kα by oncogenic mutations.

scientific article published in February 2013

An intrinsic lipid-binding interface controls sphingosine kinase 1 function

scientific article published on 11 January 2018

An overview of hydrogen deuterium exchange mass spectrometry (HDX-MS) in drug discovery

scientific article published on 3 August 2017

Calcium binding rigidifies the C2 domain and the intradomain interaction of GIVA phospholipase A2 as revealed by hydrogen/deuterium exchange mass spectrometry

scientific article published on 21 January 2008

Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex

scientific article

Characterization of the c10orf76-PI4KB complex and its necessity for Golgi PI4P levels and enterovirus replication

scientific article published on 12 December 2019

Class I phosphoinositide 3-kinase (PI3K) regulatory subunits and their roles in signaling and disease

scientific article published on 28 September 2019

Conformational disruption of PI3Kδ regulation by immunodeficiency mutations in PIK3CD and PIK3R1.

scientific article published on 6 February 2017

Conformational sampling of membranes by Akt controls its activation and inactivation

scientific article published on 9 April 2018

Connecting with an Old Partner in a New Way ⬇️

scientific article published on May 13, 2013

Crystal structure of a lipin/Pah phosphatidic acid phosphatase

scientific article published on 11 March 2020

Crystal structure of an archaeal CorB magnesium transporter

scientific article published on 29 June 2021

Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention

scientific article

Defining How Oncogenic and Developmental Mutations of PIK3R1 Alter the Regulation of Class IA Phosphoinositide 3-Kinases

scientific article published on 09 December 2019

Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ

scientific article

Discovery and Preclinical Characterization of 5-[4,6-Bis({3-oxa-8-azabicyclo[3.2.1]octan-8-yl})-1,3,5-triazin-2-yl]-4-(difluoromethyl)pyridin-2-amine (PQR620), a Highly Potent and Selective mTORC1/2 Inhibitor for Cancer and Neurological Disorders

scientific article published on 14 November 2018

Dissecting the molecular assembly of the Toxoplasma gondii MyoA motility complex

scientific article published on 25 September 2017

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

scientific article (publication date: 7 September 2016)

Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS) ⬇️

scientific article published on September 13, 2012

Dynamic structural biology at the protein membrane interface

scientific article published in 2019

Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α

scientific article

Endo-fucoidan hydrolases from glycoside hydrolase family 107 (GH107) display structural and mechanistic similarities to α-L-fucosidases from GH29

scientific article published in Journal of Biological Chemistry

Expanding the Scope of Electrophiles Capable of Targeting K-Ras Oncogenes.

scientific article published on 16 June 2017

G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness

scientific article published on 04 December 2012

Group IVA cytosolic phospholipase A2 (cPLA2alpha) and integrin alphaIIbbeta3 reinforce each other's functions during alphaIIbbeta3 signaling in platelets

scientific article published on 07 October 2008

Interaction of group IA phospholipase A2 with metal ions and phospholipid vesicles probed with deuterium exchange mass spectrometry

scientific article published on 24 May 2008

In vitro reconstitution of Sgk3 activation by phosphatidylinositol 3-phosphate

scientific article published on 25 June 2021

Localizing the membrane binding region of Group VIA Ca2+-independent phospholipase A2 using peptide amide hydrogen/deuterium exchange mass spectrometry

scientific article published on 25 June 2009

Location of inhibitors bound to group IVA phospholipase A2 determined by molecular dynamics and deuterium exchange mass spectrometry

scientific article published on June 2009

Methods in the Study of PTEN Structure: X-Ray Crystallography and Hydrogen Deuterium Exchange Mass Spectrometry

scientific article published in January 2016

Molecular Mechanisms of Human Disease Mediated by Oncogenic and Primary Immunodeficiency Mutations in Class IA Phosphoinositide 3-Kinases

scientific article published on 19 March 2018

Molecular basis for recognition of the cancer glycobiomarker LacdiNAc (GalNAc(β1-4)GlcNAc) by Wisteria floribunda agglutinin

scientific article

Molecular basis for the recruitment of the Rab effector protein WDR44 by the GTPase Rab11

scientific article published in 2023

Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne

scientific article

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs)

scientific article

Molecular insight into the autoinhibition of a master regulator of lipid signalling in human disease

scientific article published on 22 January 2020

Molecular mechanism of activation of class IA phosphoinositide 3-kinases (PI3Ks) by membrane-localized HRas

scientific article published on 17 May 2017

Neolymphostin A is a Covalent Phosphoinositide-3-kinase (PI3-K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitor that Employs an Unusual Electrophilic Vinylogous Ester

scientific article published on 28 November 2018

Novel K-Ras G12C Switch-II covalent binders destabilize Ras and accelerate nucleotide exchange

scientific article published on 10 January 2018

Novel PIK3CD mutations affecting N-terminal residues of p110δ cause activated PI3Kδ syndrome (APDS) in humans

scientific article published on 13 April 2017

Novel roles of phosphoinositides in signaling, lipid transport, and disease

scientific article published on 20 January 2020

Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA).

scientific article

PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control

scientific article (publication date: 2013)

Palmitoylation targets the calcineurin phosphatase to the phosphatidylinositol 4-kinase complex at the plasma membrane

scientific article published on 18 October 2021

Phospholipase A2 biochemistry

scientific article

Phospholipase A2 structure/function, mechanism, and signaling

scientific article

Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2.

scientific article

Probing the Architecture, Dynamics, and Inhibition of the PI4KIIIα/TTC7/FAM126 Complex

scientific article published on 18 July 2018

Probing the dynamic regulation of peripheral membrane proteins using hydrogen deuterium exchange-MS (HDX-MS).

scientific article

Publisher Correction: Crystal structure of a lipin/Pah phosphatidic acid phosphatase

scientific article published on 02 April 2020

Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States

scientific article published on 19 September 2017

Recognition of protein-linked glycans as a determinant of peptidase activity

scientific article published on 17 January 2017

Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments

scientific article published on 27 June 2019

Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway

scientific article published on April 2016

Regulation of a Coupled MARCKS-PI3K Lipid Kinase Circuit by Calmodulin: Single-Molecule Analysis of a Membrane-Bound Signaling Module

scientific article published on 10 November 2016

Structural Basis for Regulation of Phosphoinositide Kinases and Their Involvement in Human Disease

scientific article published on 01 September 2018

Structural and mechanistic insights into the function of the unconventional class XIV myosin MyoA from

article published in the Proceedings of the National Academy of Sciences of the United States of America

Structural basis for activation and inhibition of class I phosphoinositide 3-kinases

scientific article published on 18 October 2011

Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5

scientific article published in Nature Communications

Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes

scientific article

Structures of PI4KIII  complexes show simultaneous recruitment of Rab11 and its effectors

scientific article

Synergy in activating class I PI3Ks

scientific article published on 05 January 2015

The Molecular Basis of Aichi Virus 3A Protein Activation of Phosphatidylinositol 4 Kinase IIIβ, PI4KB, through ACBD3.

scientific article published on 7 December 2016

The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site

scientific journal article

The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity

scientific article

The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzyme

scientific article published on 19 March 2019

The middle lipin domain adopts a membrane-binding dimeric protein fold

scientific article published on 05 August 2021

The substrate specificity of the human TRAPPII complex's Rab-guanine nucleotide exchange factor activity

scientific article published on 04 December 2020

Type III phosphatidylinositol 4 kinases: structure, function, regulation, signalling and involvement in disease

scientific article published on February 2016

UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria

scientific article published on 27 August 2018

Using Hydrogen-Deuterium Exchange Mass Spectrometry to Examine Protein-Membrane Interactions

scientific article published on 18 October 2016

Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11

scientific article

Using hydrogen/deuterium exchange mass spectrometry to define the specific interactions of the phospholipase A2 superfamily with lipid substrates, inhibitors, and membranes

scientific article published on 3 December 2012

Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi

scientific article published on 4 August 2013

pH Biosensing by PI4P Regulates Cargo Sorting at the TGN

scientific article published on 09 January 2020

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