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List of works by Ophir D Klein

A DLG1-ARHGAP31-CDC42 axis is essential for the intestinal stem cell response to fluctuating niche Wnt signaling

scientific article published in 2023

A large pool of actively cycling progenitors orchestrates self-renewal and injury repair of an ectodermal appendage

scientific article published on 02 September 2019

Abnormal Ras signaling in Costello syndrome (CS) negatively regulates enamel formation

scientific article published on 20 September 2013

Acute fatal presentation of ornithine transcarbamylase deficiency in a previously healthy male.

scientific article published on 07 May 2008

An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice

scientific article published on 27 April 2017

An integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery

scientific article published on 13 August 2018

Assessment of endometrial volume by three-dimensional ultrasound prior to embryo transfer: clues to endometrial receptivity

scientific article published on 01 November 1999

Atoh1+ secretory progenitors possess renewal capacity independent of Lgr5+ cells during colonic regeneration

scientific article published on 11 January 2019

BCL11B regulates epithelial proliferation and asymmetric development of the mouse mandibular incisor

scientific article published on 22 May 2012

BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor.

scientific article published on 02 June 2013

Brachydactylic multiple delta phalanges plus syndrome

scientific article published on 01 September 2005

Case report: Y;6 translocation with deletion of 6p.

scientific article published on April 2005

Cell fate specification in the lingual epithelium is controlled by antagonistic activities of Sonic hedgehog and retinoic acid.

scientific article

Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia.

scientific article

Characterization of X-linked hypohidrotic ectodermal dysplasia (XL-HED) hair and sweat gland phenotypes using phototrichogram analysis and live confocal imaging.

scientific article published on 17 May 2013

Characterization of dental epithelial stem cells from the mouse incisor with two-dimensional and three-dimensional platforms.

scientific article

Continuously growing rodent molars result from a predictable quantitative evolutionary change over 50 million years

scientific article

Coordinated activity of Spry1 and Spry2 is required for normal development of the external genitalia.

scientific article published on 18 December 2013

Craniofacial and dental development in Costello syndrome.

scientific article

Craniofacial morphometric analysis of individuals with X-linked hypohidrotic ectodermal dysplasia.

scientific article

Crosstalk between miR-34a and Notch Signaling Promotes Differentiation in Apical Papilla Stem Cells (SCAPs).

scientific article published on 7 April 2014

Current trends in stem cell therapy for improvement of bone quality.

scientific article published on 11 December 2013

DLX4 is associated with orofacial clefting and abnormal jaw development.

scientific article published on 7 May 2015

Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth

scientific article published on 23 September 2020

Dental findings in 14q terminal deletion syndrome.

scientific article published in April 2014

Dental, Oral, and Craniofacial Regenerative Medicine: Transforming Biotechnologies for Innovating Patient Care

scientific article published in April 2018

Developing physician-scientists in the fields of neonatology and pediatric critical care medicine: an effort to formulate a departmental policy

scientific article published in September 2013

Developmental disorders of the dentition: an update

scientific article published on 04 October 2013

Downregulation of FGF Signaling by Spry4 Overexpression Leads to Shape Impairment, Enamel Irregularities, and Delayed Signaling Center Formation in the Mouse Molar

scientific article published on 31 July 2019

Dual epithelial and immune cell function of Dvl1 regulates gut microbiota composition and intestinal homeostasis

scientific article published on July 2016

EPHRIN-B1 Mosaicism Drives Cell Segregation in Craniofrontonasal Syndrome hiPSC-Derived Neuroepithelial Cells.

scientific article published on 22 February 2017

EPIREGULIN creates a developmental niche for spatially organized human intestinal enteroids

scientific article published in 2023

Enamel-free teeth: Tbx1 deletion affects amelogenesis in rodent incisors

scientific journal article

Engineering synthetic morphogen systems that can program multicellular patterning

scientific article published on 01 October 2020

Expression of FGFs during early mouse tongue development

scientific article published on 31 December 2015

Expression of microRNAs in the stem cell niche of the adult mouse incisor.

scientific article

FGF signaling refines Wnt gradients to regulate the patterning of taste papillae.

scientific article published on 15 May 2017

FGF signaling regulates the number of posterior taste papillae by controlling progenitor field size.

scientific article

FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells.

scientific article

Fibroblast growth factor signaling in mammalian tooth development

scientific article published on 17 December 2013

From molecules to mastication: the development and evolution of teeth

scientific article (publication date: 2013)

Further supporting evidence for theSATB2-associated syndrome found through whole exome sequencing

scientific article published on 01 May 2015

Genome-Wide Association Study Reveals Multiple Loci Influencing Normal Human Facial Morphology

scientific article

Genomewide Association Study of African Children Identifies Association of SCHIP1 and PDE8A with Facial Size and Shape.

scientific article

Genomic variants of ATF3 in patients with hypospadias.

scientific article published on 19 September 2008

Genotype-phenotype analysis of the branchio-oculo-facial syndrome

scientific article

Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor

scientific article

Human Facial Shape and Size Heritability and Genetic Correlations

scientific article published on 14 December 2016

Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome

scientific article

Hyperplasia of interstitial cells of cajal in sprouty homolog 4 deficient mice

scientific article

Identification of novel Fgf enhancers and their role in dental evolution

scientific article

If a stem cell dies in the crypt, and no one is around to see it….

scientific article published in April 2013

In vitro generation of human pluripotent stem cell derived lung organoids

scientific article (publication date: 24 March 2015)

In vitro patterning of pluripotent stem cell-derived intestine recapitulates in vivo human development.

scientific article published on 07 December 2016

Induction of ectopic taste buds by SHH reveals the competency and plasticity of adult lingual epithelium.

scientific article

Inductive ability of human developing and differentiated dental mesenchyme

scientific article published on 30 July 2013

Inflation-collapse dynamics drive patterning and morphogenesis in intestinal organoids

scientific article published in 2021

Inhibition of Notch Signaling During Mouse Incisor Renewal Leads to Enamel Defects

scientific article published on 14 July 2015

Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning

scientific article published on 19 August 2010

Injectable bone tissue engineering using expanded mesenchymal stem cells

scientific article

Interstitial deletion of chromosome 12q: genotype-phenotype correlation of two patients utilizing array comparative genomic hybridization

scientific article published in November 2005

Interstitial deletions of chromosome 6q: genotype-phenotype correlation utilizing array CGH.

scientific article

Intrinsically disordered proteins drive enamel formation via an evolutionarily conserved self-assembly motif

scientific article published on 14 February 2017

Isl1 Controls Patterning and Mineralization of Enamel in the Continuously Renewing Mouse Incisor

scientific article

Isolation and culture of dental epithelial stem cells from the adult mouse incisor.

scientific article

LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival

scientific article published in Nature Communications

Lgr5+ telocytes are a signaling source at the intestinal villus tip

scientific article published on 22 April 2020

Lineage tracing of epithelial cells in developing teeth reveals two strategies for building signaling centers

scientific article

Migration of Founder Epithelial Cells Drives Proper Molar Tooth Positioning and Morphogenesis

scientific article

Modulation of Fgf3 dosage in mouse and men mirrors evolution of mammalian dentition

scientific article (publication date: 29 December 2009)

Molecular and cellular mechanisms of tooth development, homeostasis and repair

scientific article published on 24 January 2020

Mutational analysis of the catalytic residues lysine 230 and tyrosine 160 in the NADP(+)-dependent isocitrate dehydrogenase from Escherichia coli

scientific article published on 01 January 1995

Mutations of CXorf6 are associated with a range of severities of hypospadias

scientific article

Nuclear to cytoplasmic shuttling of ERK promotes differentiation of muscle stem/progenitor cells.

scientific article

On the cutting edge of organ renewal: Identification, regulation, and evolution of incisor stem cells

scientific article

Opposing activities of Notch and Wnt signaling regulate intestinal stem cells and gut homeostasis.

scientific article

Oral epithelial stem cells in tissue maintenance and disease: the first steps in a long journey.

scientific article published on 26 July 2013

PERP regulates enamel formation via effects on cell-cell adhesion and gene expression

scientific journal article

Phenotypic and evolutionary implications of modulating the ERK-MAPK cascade using the dentition as a model

scientific article

Prenatal β-catenin/Brn2/Tbr2 transcriptional cascade regulates adult social and stereotypic behaviors.

scientific article published on 2 February 2016

Prominin-1 controls stem cell activation by orchestrating ciliary dynamics

scientific article published on 06 December 2018

Publisher Correction: FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells

scientific article published in Nature Communications

Ras Signaling Regulates Stem Cells and Amelogenesis in the Mouse Incisor

scientific article published in June 2017

Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling

scientific article (publication date: September 2011)

Replaying evolutionary transitions from the dental fossil record

scientific article

Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis

scientific article

Role of glutamine 17 of the bovine papillomavirus E5 protein in platelet-derived growth factor beta receptor activation and cell transformation.

scientific article published on November 1998

SOX2 regulation by hedgehog signaling controls adult lingual epithelium homeostasis

scientific article published on 17 July 2018

SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling.

scientific article published on 12 September 2016

Secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor

scientific article published on February 2014

Shh expression in a rudimentary tooth offers new insights into development of the mouse incisor

scientific article

Signaling by FGFR2b controls the regenerative capacity of adult mouse incisors.

scientific article

Sonic Hedgehog Signaling Is Required for Cyp26 Expression during Embryonic Development. ⬇️

scientific article published on 8 May 2019

Sox2 and Lef-1 interact with Pitx2 to regulate incisor development and stem cell renewal.

scientific article published on 22 September 2016

Sox2 marks epithelial competence to generate teeth in mammals and reptiles

scientific article published on 5 March 2013

Spontaneous emergence of overgrown molar teeth in a colony of Prairie voles (Microtus ochrogaster)

scientific article published on 23 March 2015

Sprouty genes regulate proliferation and survival of human embryonic stem cells

scientific article published in January 2013

Sprouty2 regulates endochondral bone formation by modulation of RTK and BMP signaling

scientific article published on 26 April 2016

Spry1 and spry2 are essential for development of the temporomandibular joint

scientific article published on 10 February 2012

Stem Cell and Biomaterials Research in Dental Tissue Engineering and Regeneration ⬇️

scientific article published on July 1, 2012

Structural models of the bovine papillomavirus E5 protein

scientific article published in December 1998

The FaceBase Consortium: a comprehensive program to facilitate craniofacial research

scientific article

The Interaction of Genetic Background and Mutational Effects in Regulation of Mouse Craniofacial Shape.

scientific article

The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation.

scientific article published on 17 July 2013

The WNT10A gene in ectodermal dysplasias and selective tooth agenesis.

scientific article published on 3 April 2014

The dynamics of supernumerary tooth development are differentially regulated by Sprouty genes.

scientific article published on 19 April 2013

Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo

scientific article published on 3 June 2015

Unraveling the molecular mechanisms that lead to supernumerary teeth in mice and men: current concepts and novel approaches

scientific article published on January 2007

microRNA miR-34a regulates cytodifferentiation and targets multi-signaling pathways in human dental papilla cells

scientific article

αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development

scientific article

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