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List of works by James A. McCubrey

A PTEN inhibitor displays preclinical activity against hepatocarcinoma cells

scientific article published on 21 January 2016

A new hope for treatment of glioblastomas.

scientific article published in July 2003

A novel ring-substituted diindolylmethane,1,1-bis[3'-(5-methoxyindolyl)]-1-(p-t-butylphenyl) methane, inhibits extracellular signal-regulated kinase activation and induces apoptosis in acute myelogenous leukemia

scientific article

AMP-dependent kinase/mammalian target of rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications.

scientific article published on 4 October 2011

Abilities of berberine and chemically modified berberines to interact with metformin and inhibit proliferation of pancreatic cancer cells

scientific article published on 21 April 2019

Abilities of β-Estradiol to interact with chemotherapeutic drugs, signal transduction inhibitors and nutraceuticals and alter the proliferation of pancreatic cancer cells

scientific article published on 18 October 2019

Activation of the calcium/calmodulin-dependent protein kinases as a consequence of oxidative stress.

scientific article published on September 2006

Activity of the novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 against T-cell acute lymphoblastic leukemia.

scientific article published on 28 September 2010

Activity of the pan-class I phosphoinositide 3-kinase inhibitor NVP-BKM120 in T-cell acute lymphoblastic leukemia.

scientific article published on 6 November 2013

Activity of the selective IκB kinase inhibitor BMS-345541 against T-cell acute lymphoblastic leukemia: involvement of FOXO3a

scientific article

Advances in targeting signal transduction pathways

scientific article

Advances in understanding the acute lymphoblastic leukemia bone marrow microenvironment: From biology to therapeutic targeting

scientific article published on September 2015

Akt as a therapeutic target in cancer

scientific article published on 01 September 2008

Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy

scientific article published on 21 February 2008

Analysis of TIMP-1 gene polymorphisms in Italian sclerodermic patients.

scientific article published in January 2006

Analysis of the B-RafV600E mutation in cutaneous melanoma patients with occupational sun exposure

scientific article published on 14 January 2014

Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics

scientific article

Aurora-A mitotic kinase induces endocrine resistance through down-regulation of ERα expression in initially ERα+ breast cancer cells

scientific article

Autophagy in acute leukemias: a double-edged sword with important therapeutic implications

scientific article

B-Raf-dependent expression of vascular endothelial growth factor-A in Kaposi sarcoma-associated herpesvirus-infected human B cells.

scientific article published on 10 February 2005

Biology of Kaposi's sarcoma-associated herpesvirus

scientific article published on 01 September 2005

COX-2-dependent and COX-2-independent mode of action of celecoxib in human liver cancer cells.

scientific article published on 16 March 2011

Calcium-induced ERK activation in human T lymphocytes occurs via p56(Lck) and CaM-kinase.

scientific article

Calcium/calmodulin-dependent kinase I and calcium/calmodulin-dependent kinase kinase participate in the control of cell cycle progression in MCF-7 human breast cancer cells.

scientific article published on June 2005

Calcium/calmodulin-dependent protein kinases as potential targets in cancer therapy.

scientific article

Characterization of proteins binding the 3' regulatory region of the IL-3 gene in IL-3-dependent and autocrine-transformed hematopoietic cells.

scientific article published on April 1998

Cigarette smoke concentrate inhibits Kaposi's sarcoma-associated herpesvirus infection

scientific article published on 18 August 2005

Co-targeting of Bcl-2 and mTOR pathway triggers synergistic apoptosis in BH3 mimetics resistant acute lymphoblastic leukemia

scientific article published on 16 September 2015

Combining chemo-, hormonal and targeted therapies to treat breast cancer (Review).

scientific article published on March 2008

Comparative study of rapamycin and temsirolimus demonstrates superimposable anti-tumour potency on prostate cancer cells.

scientific article

Computational Modeling of PI3K/AKT and MAPK Signaling Pathways in Melanoma Cancer

scientific article

Conditional EGFR promotes cell cycle progression and prevention of apoptosis in the absence of autocrine cytokines

scientific article

Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia.

scientific article published on 13 March 2008

Cooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells

scientific article published on August 2011

Critical Roles of EGFR Family Members in Breast Cancer and Breast Cancer Stem Cells: Targets for Therapy

scientific article published on 4 March 2016

Current treatment strategies for inhibiting mTOR in cancer

scientific article

Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: targeting the unfolded protein response signaling

scientific article published on 20 November 2013

Cytotoxic activity of the novel Akt inhibitor, MK-2206, in T-cell acute lymphoblastic leukemia.

scientific article published on 22 May 2012

Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention

scientific article

Development of a conditional in vivo model to evaluate the efficacy of small molecule inhibitors for the treatment of Raf-transformed hematopoietic cells

scientific article published on November 2005

Diagnostic value of neutrophil gelatinase-associated lipocalin/matrix metalloproteinase-9 pathway in transitional cell carcinoma of the bladder.

scientific article published on 26 January 2016

Diphtheria toxin-interleukin-3 fusion protein (DT(388)IL3) prolongs disease-free survival of leukemic immunocompromised mice

scientific article published in January 2003

Diverse roles of GSK-3: tumor promoter-tumor suppressor, target in cancer therapy

scientific article published on 08 October 2013

Dominant roles of the Raf/MEK/ERK pathway in cell cycle progression, prevention of apoptosis and sensitivity to chemotherapeutic drugs

scientific article published on 15 April 2010

Dual Inhibition of Phosphatidylinositol 3-Kinase and Mammalian Target of Rapamycin: a Therapeutic Strategy for Acute Leukemias.

scientific article published on 21 November 2012

Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia

scientific article published on 07 April 2009

EGFR family signaling and its association with breast cancer development and resistance to chemotherapy (Review).

scientific article

Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine

scientific article published on 16 November 2012

Effects of Ectopic Expression of NGAL on Doxorubicin Sensitivity ⬇️

scientific article published on October 1, 2012

Effects of deregulated RAF and MEK1 expression on the cytokine-dependency of hematopoietic cells.

scientific article

Effects of endogenous epidermal growth factor receptor signaling on DNA synthesis and ERK activation in a cytokine-dependent hematopoietic cell line

scientific article

Effects of mutations in Wnt/β-catenin, hedgehog, Notch and PI3K pathways on GSK-3 activity-Diverse effects on cell growth, metabolism and cancer

scientific article published on 06 September 2016

Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs

scientific article published on 12 June 2017

Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells.

scientific article published in April 2003

Emerging MEK inhibitors.

scientific article published on June 2010

Emerging Raf inhibitors.

scientific article published on December 2009

Emerging targeted therapies for melanoma treatment (review)

scientific article

Enhanced ability of daniplestim and myelopoietin-1 to suppress apoptosis in human hematopoietic cells

scientific article published on 01 August 2001

Enhancing the effectiveness of nucleoside analogs with mTORC1 blockers to treat acute myeloid leukemia patients

scientific article published on 24 May 2013

Enhancing therapeutic efficacy by targeting non-oncogene addicted cells with combinations of signal transduction inhibitors and chemotherapy

scientific article published on 15 May 2010

Erucylphosphohomocholine, the first intravenously applicable alkylphosphocholine, is cytotoxic to acute myelogenous leukemia cells through JNK- and PP2A-dependent mechanisms

scientific article published on 4 March 2010

Exploiting p53 status to enhance effectiveness of chemotherapy by lowering associated toxicity

scientific article published on March 2011

Expression of multidrug resistance proteins in prostate cancer is related with cell sensitivity to chemotherapeutic drugs.

scientific article published in September 2009

Fibroblastic, hematopoietic, and hormone responsive epithelial cell lines and culture conditions for elucidation of signal transduction and drug resistance pathways by gene transfer.

scientific article

Foreword: "Targeting signaling pathways in stem cells"

scientific article published on 19 July 2014

GSK-3 as potential target for therapeutic intervention in cancer

scientific article

Gene alterations in the PI3K/PTEN/AKT pathway as a mechanism of drug-resistance (review).

scientific article published on 20 December 2011

Genetic interactions in induction of endogenous murine leukemia virus from low leukemic mice

scientific article published in April 1982

Healthy CD4+ T lymphocytes are not affected by targeted therapies against the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia.

scientific article published on August 2016

Identification of a functional nuclear export sequence in diacylglycerol kinase-zeta.

scientific article published on 29 January 2010

In vitro and in vivo anticancer action of Saquinavir-NO, a novel nitric oxide-derivative of the protease inhibitor saquinavir, on hormone resistant prostate cancer cells.

scientific article published on February 2011

Increased Akt Signaling Resulting from the Loss of Androgen Responsiveness in Prostate Cancer ⬇️

scientific article published on January 1, 2013

Increased NGAL (Lnc2) expression after chemotherapeutic drug treatment.

scientific article

Increased protein expression of the PTEN tumor suppressor in the presence of constitutively active Notch-1.

scientific article published on 13 October 2005

Induction of caspase-independent apoptotic-like cell death of mouse mammary tumor TA3Ha cells in vitro and reduction of their lethality in vivo by the novel chemotherapeutic agent GIT-27NO.

scientific article

Inhibition of CREB transcriptional activity in human T lymphocytes by oxidative stress.

scientific article published in April 2005

Inhibition of Cdk2 activity decreases Aurora-A kinase centrosomal localization and prevents centrosome amplification in breast cancer cells.

scientific article published on 27 February 2013

Inhibition of Cdk2 kinase activity selectively targets the CD44⁺/CD24⁻/Low stem-like subpopulation and restores chemosensitivity of SUM149PT triple-negative breast cancer cells.

scientific article

Inhibition of GSK-3β activity can result in drug and hormonal resistance and alter sensitivity to targeted therapy in MCF-7 breast cancer cells

scientific article published on 09 January 2014

Inhibition of PI3K, mTOR and MEK signaling pathways promotes rapid apoptosis in B-lineage ALL in the presence of stromal cell support.

scientific article

Inositide-dependent signaling pathways as new therapeutic targets in myelodysplastic syndromes

scientific article

Insulin receptor substrate is a mediator of phosphoinositide 3-kinase activation in quiescent pancreatic cancer cells

scientific article

Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells

scientific article published on September 2011

Involvement of Akt-1 and mTOR in sensitivity of breast cancer to targeted therapy

scientific article published on July 2011

Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.

scientific article

Involvement of p53 and Raf/MEK/ERK pathways in hematopoietic drug resistance

scientific article published on 7 August 2008

K562 cell proliferation is modulated by PLCβ1 through a PKCα-mediated pathway

scientific article published on 6 May 2013

Kinases: positive and negative regulators of apoptosis.

scientific article

Malignant melanoma in elderly patients: biological, surgical and medical issues.

scientific article published on 24 September 2014

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

scientific article

Modulation of nuclear PI-PLCbeta1 during cell differentiation

scientific article

Molecular mechanisms of sorafenib action in liver cancer cells.

scientific article

Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention.

scientific article published on 19 June 2013

Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response

scientific article published on September 2012

Mutations in the catalytic subunit of class IA PI3K confer leukemogenic potential to hematopoietic cells.

scientific article

NOTCH and PTEN in prostate cancer

scientific article

Neosis and its potential role in cancer development and chemoresistance

scientific article

New landscapes and horizons in hepatocellular carcinoma therapy

scientific article published on 04 February 2020

New perspectives in HCV therapy: entry inhibitors.

scientific article

No-Modified Saquinavir is Equally Efficient Against Doxorubicin Sensitive and Resistant Non-Small Cell Lung Carcinoma Cells / MODIFIKOVANA KOVANA FORMA SAKVINAVIRA EFIKASNO SU PRIMI RA RAST ĆELIJA NESITNOĆELIJSKOG KARCINOMA PLUĆA RAZLIČITE OSETUI

scientific article published in 2013

Novel approaches to target cancer initiating cells-eliminating the root of the cancer

scientific article published on January 2012

Novel combination of sorafenib and celecoxib provides synergistic anti-proliferative and pro-apoptotic effects in human liver cancer cells.

scientific article

Novel roles of androgen receptor, epidermal growth factor receptor, TP53, regulatory RNAs, NF-kappa-B, chromosomal translocations, neutrophil associated gelatinase, and matrix metalloproteinase-9 in prostate cancer and prostate cancer stem cells

scientific article

Nuclear PI-PLCβ1 and myelodysplastic syndromes: genetics and epigenetics

scientific article published on January 2012

Nuclear PI-PLCβ1: an appraisal on targets and pathology

scientific article

Nuclear Phosphatidylinositol Signaling: Focus on Phosphatidylinositol Phosphate Kinases and Phospholipases C.

scientific article

Nuclear Phospholipase C isoenzyme imbalance leads to pathologies in brain, hematologic, neuromuscular and fertility disorders

scientific article published on 04 October 2018

Nuclear phosphoinositides and their roles in cell biology and disease

scientific article published on 14 September 2011

Nuclear phospholipase C β1 signaling, epigenetics and treatments in MDS.

scientific article published on 21 September 2012

OSU-03012 in the treatment of glioblastoma.

scientific article published on 4 May 2006

P21(Cip1) induced by Raf is associated with increased Cdk4 activity in hematopoietic cells.

scientific article

PI3K activation is associated with intracellular sodium/iodide symporter protein expression in breast cancer

scientific article

PI3K/AKT/mTORC1 and MEK/ERK signaling in T-cell acute lymphoblastic leukemia: new options for targeted therapy

scientific article published on 01 January 2012

PIK3CA mutations in human solid tumors: role in sensitivity to various therapeutic approaches

scientific article published on 23 May 2009

PKR regulates B56(alpha)-mediated BCL2 phosphatase activity in acute lymphoblastic leukemia-derived REH cells

scientific article published on 28 October 2008

PLC and PI3K/Akt/mTOR signalling in disease and cancer

scientific article

PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer

scientific article published on 21 February 2017

Pancreatic cancer stem cells: association with cell surface markers, prognosis, resistance, metastasis and treatment.

scientific article

Participation of the calcium/calmodulin-dependent kinases in hydrogen peroxide-induced Ikappa B phosphorylation in human T lymphocytes

scientific article

Phosphatidylinositol 3'-kinase activation leads to multidrug resistance protein-1 expression and subsequent chemoresistance in advanced prostate cancer cells.

scientific article published in November 2004

Potential use of rapamycin in HIV infection

scientific article

Preclinical testing of the Akt inhibitor triciribine in T-cell acute lymphoblastic leukemia.

scientific article published on March 2011

Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-cell acute lymphoblastic leukemia

scientific article published on 24 June 2008

Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells

scientific article published on 11 October 2007

RAS/RAF/MEK/ERK, PI3K/PTEN/AKT/mTORC1 and TP53 pathways and regulatory miRs as therapeutic targets in hepatocellular carcinoma

scientific article published on 04 November 2019

RETRACTED ARTICLE: MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complex ⬇️

scientific article published on November 8, 2011

Raf promotes human herpesvirus-8 (HHV-8/KSHV) infection.

scientific article published on July 2004

Raf-1 oncogenic signaling is linked to activation of mesenchymal to epithelial transition pathway in metastatic breast cancer cells ⬇️

scientific article published on March 19, 2012

Raf-induced vascular endothelial growth factor augments Kaposi's sarcoma-associated herpesvirus infection

scientific article published on December 2004

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance

scientific article

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health

scientific article published on March 2011

Reactive oxygen intermediates and signaling through kinase pathways

scientific article published on 01 September 2006

Redox regulation of the calcium/calmodulin-dependent protein kinases.

scientific article

Regulation and targeting of antiapoptotic XIAP in acute myeloid leukemia

scientific article

Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review).

scientific article

Regulation of the mitogen-activated protein kinase kinase (MEK)-1 by NAD(+)-dependent deacetylases

scientific article

Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia.

scientific article published in June 2003

Revisiting nuclear phospholipase C signalling in MDS.

scientific article published on January 2012

Role for Raf in the entry of viruses associated with AIDS (review).

scientific article published in August 2004

Roles of EGFR and KRAS and their downstream signaling pathways in pancreatic cancer and pancreatic cancer stem cells

scientific article published on 17 July 2015

Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells

scientific article

Roles of NGAL and MMP-9 in the tumor microenvironment and sensitivity to targeted therapy

scientific article published on 13 August 2015

Roles of signaling pathways in drug resistance, cancer initiating cells and cancer progression and metastasis

scientific article

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

scientific article

Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance

scientific article

Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.

scientific article published on 15 April 2011

STAT transcription factors in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention ⬇️

scientific article published on June 25, 2013

Saquinavir-NO-targeted S6 protein mediates sensitivity of androgen-dependent prostate cancer cells to TRAIL.

scientific article

Selective killing of adriamycin-resistant (G2 checkpoint-deficient and MRP1-expressing) cancer cells by docetaxel

scientific article published in May 2005

Senescence-associated exosome release from human prostate cancer cells.

scientific article published on October 2008

Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.

scientific article

Signaling intermediates (MAPK and PI3K) as therapeutic targets in NSCLC.

scientific article published on January 2014

Signaling through 3',5'-cyclic adenosine monophosphate and phosphoinositide-3 kinase induces sodium/iodide symporter expression in breast cancer

scientific article published on 01 October 2004

Sorafenib induces apoptosis of AML cells via Bim-mediated activation of the intrinsic apoptotic pathway.

scientific article published on 17 January 2008

Subcellular Localization Relevance and Cancer-Associated Mechanisms of Diacylglycerol Kinases

scientific article published on 26 July 2020

Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors.

scientific article published on 10 March 2008

Synergistic cytotoxic effects of bortezomib and CK2 inhibitor CX-4945 in acute lymphoblastic leukemia: turning off the prosurvival ER chaperone BIP/Grp78 and turning on the pro-apoptotic NF-κB.

scientific article published on 22 November 2015

Synergistic effects of pi3k/akt on abrogation of cytokine-dependency induced by oncogenic raf.

scientific article published in January 2001

Synergistic proapoptotic activity of recombinant TRAIL plus the Akt inhibitor Perifosine in acute myelogenous leukemia cells

scientific article

Synergy between an IGF-1R antibody and Raf/MEK/ERK and PI3K/Akt/mTOR pathway inhibitors in suppressing IGF-1R-mediated growth in hematopoietic cells.

scientific article published on 27 April 2006

Targeted inhibition of mTORC1 and mTORC2 by active-site mTOR inhibitors has cytotoxic effects in T-cell acute lymphoblastic leukemia.

scientific article published on 18 February 2011

Targeting GSK3 and Associated Signaling Pathways Involved in Cancer

scientific article published on 30 April 2020

Targeting breast cancer initiating cells: advances in breast cancer research and therapy

scientific article

Targeting phosphatidylinositol 3-kinase signaling in acute myelogenous leukemia

scientific article published on 11 June 2013

Targeting prostate cancer based on signal transduction and cell cycle pathways.

scientific article published on 16 June 2008

Targeting signal transduction pathways to eliminate chemotherapeutic drug resistance and cancer stem cells.

scientific article

Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy.

scientific article published on 13 March 2008

Targeting the PI3K and MAPK pathways to treat Kaposi's-sarcoma-associated herpes virus infection and pathogenesis

scientific article published on May 2007

Targeting the PI3K/AKT/mTOR signaling network in acute myelogenous leukemia

scientific article published in September 2009

Targeting the PI3K/Akt/mTOR signaling pathway in B-precursor acute lymphoblastic leukemia and its therapeutic potential.

scientific article published on 29 July 2013

Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance.

scientific article published on 26 March 2007

Targeting the Raf kinase cascade in cancer therapy--novel molecular targets and therapeutic strategies

scientific article

Targeting the Raf/MEK/ERK pathway with small-molecule inhibitors.

scientific article

Targeting the cancer initiating cell: The Achilles’ heel of cancer ⬇️

scientific article published on October 28, 2010

Targeting the cancer initiating cell: the ultimate target for cancer therapy.

scientific article published on January 2012

Targeting the leukemic stem cell: the Holy Grail of leukemia therapy

scientific article published on 18 September 2008

Targeting the liver kinase B1/AMP-activated protein kinase pathway as a therapeutic strategy for hematological malignancies

scientific article published on 12 June 2012

The NO-modified HIV protease inhibitor as a valuable drug for hematological malignancies: Role of p70S6K.

scientific article published on 28 June 2015

The Raf/MEK/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy

scientific article published on 10 May 2010

The Role of GSK-3 in Cancer Immunotherapy: GSK-3 Inhibitors as a New Frontier in Cancer Treatment

scientific article published on 09 June 2020

The antitumor properties of a nontoxic, nitric oxide-modified version of saquinavir are independent of Akt.

scientific article

The complexity of PTEN: mutation, marker and potential target for therapeutic intervention

scientific article

The emerging role of the phosphatidylinositol 3-kinase/ akt/mammalian target of rapamycin signaling network in cancer stem cell biology

scientific article published on 18 August 2010

The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in normal myelopoiesis and leukemogenesis.

scientific article published on 23 April 2010

The epidermal growth factor receptor gene family as a target for therapeutic intervention in numerous cancers: what's genetics got to do with it?

scientific article

The insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 induces apoptosis in acute myeloid leukemia cells exhibiting autocrine insulin-like growth factor-I secretion

scientific article published on 15 March 2007

The mechanism of contribution of integrin linked kinase (ILK) to epithelial-mesenchymal transition (EMT).

scientific article published on 28 October 2010

The mitogen-activated protein kinase (MAPK) cascade controls phosphatase and tensin homolog (PTEN) expression through multiple mechanisms

scientific article

The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism

scientific article published on 3 April 2008

The novel NF-κB inhibitor DHMEQ synergizes with celecoxib to exert antitumor effects on human liver cancer cells by a ROS-dependent mechanism.

scientific article

The role of downstream signaling pathways of the epidermal growth factor receptor for Artesunate's activity in cancer cells.

scientific article

The therapeutic potential of mTOR inhibitors in breast cancer

scientific article published on 5 April 2016

Therapeutic potential of MEK inhibition in acute myelogenous leukemia: rationale for "vertical" and "lateral" combination strategies

scientific article

Therapeutic potential of nitric oxide-modified drugs in colon cancer cells

scientific article

Therapeutic potential of targeting mTOR in T-cell acute lymphoblastic leukemia (review).

scientific article published on 26 June 2014

Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways.

scientific article

Therapeutic targeting of Polo-like kinase-1 and Aurora kinases in T-cell acute lymphoblastic leukemia

scientific article

Transfer of specificity by murine alpha and beta T-cell receptor genes

scientific article published in March 1986

Treatment by design in leukemia, a meeting report, Philadelphia, Pennsylvania, December 2002.

scientific article published in December 2003

Tumor microenvironment in diffuse large B-cell lymphoma: Matrixmetalloproteinases activation is mediated by osteopontin overexpression

scientific article published on 14 September 2015

Vascular endothelial growth factor augments human herpesvirus-8 (HHV-8/KSHV) infection

scientific article published on 21 September 2004

mTOR as a multifunctional therapeutic target in HIV infection.

scientific article

p53 expression controls prostate cancer sensitivity to chemotherapy and the MDM2 inhibitor Nutlin-3.

scientific article published on 27 November 2012

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