List of works by Rory J. McCrimmon

5'AMP-activated protein kinase alpha deficiency enhances stress-induced apoptosis in BHK and PC12 cells

scientific article published on March 2007

A randomised controlled study of high intensity exercise as a dishabituating stimulus to improve hypoglycaemia awareness in people with type 1 diabetes: a proof-of-concept study

scientific article published on 15 January 2020

AICAR and phlorizin reverse the hypoglycemia-specific defect in glucagon secretion in the diabetic BB rat.

scientific article published in November 2002

AMP-activated protein kinase (AMPK) activator A-769662 increases intracellular calcium and ATP release from astrocytes in an AMPK-independent manner

scientific article

AMPK modulates glucose-sensing in insulin-secreting cells by altered phosphotransfer to KATP channels

scientific article published on 11 April 2013

Activation of AMP-activated protein kinase within the ventromedial hypothalamus amplifies counterregulatory hormone responses in rats with defective counterregulation

scientific article published on June 2006

Activation of ATP-sensitive K+ channels in the ventromedial hypothalamus amplifies counterregulatory hormone responses to hypoglycemia in normal and recurrently hypoglycemic rats

scientific article published on November 2005

Amplified hormonal counterregulatory responses to hypoglycemia in rats after systemic delivery of a SUR-1-selective K(+) channel opener?

scientific article published on 05 September 2008

Amputation-free survival in 17,353 people at high risk for foot ulceration in diabetes: a national observational study

scientific article published on 31 August 2018

An estimate of lifetime cognitive change and its relationship with diabetes health in older adults with type 1 diabetes: preliminary results

scientific article

Anger state during acute insulin-induced hypoglycaemia

scientific article published in August 1999

Antecedent hypercortisolemia is not primarily responsible for generating hypoglycemia-associated autonomic failure

scientific article published on 01 April 2006

Appraisal of mood and personality during hypoglycaemia in human subjects

scientific article published in August 1999

Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice. ⬇️

scientific article

Blockade of GABA(A) receptors in the ventromedial hypothalamus further stimulates glucagon and sympathoadrenal but not the hypothalamo-pituitary-adrenal response to hypoglycemia

scientific article published in April 2006

CD44 contributes to hyaluronan-mediated insulin resistance in skeletal muscle of high-fat-fed C57BL/6 mice

scientific article published on 24 September 2019

Cardiovascular Disease, Cancer, and Mortality Among People With Type 2 Diabetes and Alcoholic or Nonalcoholic Fatty Liver Disease Hospital Admission

scientific article published on 22 November 2017

Cardiovascular disease prevalence and risk factor prevalence in Type 2 diabetes: a contemporary analysis.

scientific article published on 10 October 2018

Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function

scientific article published on 26 April 2016

Chronic exposure to KATP channel openers results in attenuated glucose sensing in hypothalamic GT1-7 neurons.

scientific article published on 09 September 2016

Cognitive ability and brain structure in type 1 diabetes: relation to microangiopathy and preceding severe hypoglycemia

scientific article published in January 2003

Continuous hypothalamic K(ATP) activation blunts glucose counter-regulation in vivo in rats and suppresses K(ATP) conductance in vitro

scientific article published on 22 June 2013

Corticotrophin-releasing factor receptors within the ventromedial hypothalamus regulate hypoglycemia-induced hormonal counterregulation

scientific article published on June 2006

Diabetes and cognitive dysfunction

scientific article published on 09 June 2012

Diazoxide improves hormonal counterregulatory responses to acute hypoglycemia in long-standing type 1 diabetes.

scientific article

Does dapagliflozin regress left ventricular hypertrophy in patients with type 2 diabetes? A prospective, double-blind, randomised, placebo-controlled study

scientific article published on 23 August 2017

Dominantly inherited syndrome comprising partially absent eye muscles, hydrocephaly, skeletal abnormalities, and a distinctive facial phenotype

scientific article published in September 1991

Effect of Hypoglycemia on Inflammatory Responses and the Response to Low-Dose Endotoxemia in Humans

scientific article published in April 2019

Effect of acute hypoglycemia on visual information processing in adults with type 1 diabetes mellitus.

scientific article published in July 1998

Effects of acute hypoglycaemia on auditory information processing in adults with Type I diabetes

scientific article published on 23 November 2002

Effects of once-weekly semaglutide vs once-daily canagliflozin on body composition in type 2 diabetes: a substudy of the SUSTAIN 8 randomised controlled clinical trial

scientific article published on 02 January 2020

Effects of recurrent antecedent hypoglycaemia and chronic hyperglycaemia on brainstem extra-cellular glucose concentrations during acute hypoglycaemia in conscious diabetic BB rats

scientific article published on 5 November 2003

Efficacy and safety of once-weekly semaglutide versus daily canagliflozin as add-on to metformin in patients with type 2 diabetes (SUSTAIN 8): a double-blind, phase 3b, randomised controlled trial

scientific article published on 17 September 2019

Erratum to: Trends in type 2 diabetes incidence and mortality in Scotland between 2004 and 2013.

scientific article published on 5 September 2016

Estimated life expectancy in a Scottish cohort with type 1 diabetes, 2008-2010

scientific article

Ethnicity and risk of cardiovascular disease (CVD): 4.8 year follow-up of patients with type 2 diabetes living in Scotland

scientific article published on 12 February 2015

Exercise management in type 1 diabetes: a consensus statement

scientific article published on 23 January 2017

Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2).

scientific article published on 13 December 2017

Frequency of thyroid dysfunction in diabetic patients: value of annual screening

scientific article published in July 1995

Glucose sensing during hypoglycemia: lessons from the lab.

scientific article published on August 2009

Glycaemic benefit of iGlarLixi in insulin-naive type 2 diabetes patients with high HbA1c or those with inadequate glycaemic control on two oral antihyperglycaemic drugs in the LixiLan-O randomized trial

scientific article published on 18 June 2019

Glycaemic control trends in people with type 1 diabetes in Scotland 2004-2016

scientific article published on 18 May 2019

High-Intensity Exercise as a Dishabituating Stimulus Restores Counterregulatory Responses in Recurrently Hypoglycemic Rodents

scientific article

Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance

scientific article

Hypoglycaemia, the most feared complication of insulin therapy.

scientific article

Hypoglycaemia: exercise for the brain?

scientific article published in October 2012

Hypoglycaemic symptoms reported by children with type 1 diabetes mellitus and by their parents

scientific article published on 01 October 1998

Hypoglycemia in type 1 diabetes

scientific article published on October 2010

Hypothalamic AMP-activated protein kinase activation with AICAR amplifies counterregulatory responses to hypoglycemia in a rodent model of type 1 diabetes.

scientific article

Hypothalamic ATP-sensitive K + channels play a key role in sensing hypoglycemia and triggering counterregulatory epinephrine and glucagon responses

scientific article published in October 2004

Hypothalamic Fkbp51 is induced by fasting, and elevated hypothalamic expression promotes obese phenotypes

scientific article published on 7 February 2012

Impaired hypoglycaemia awareness in type 1 diabetes: lessons from the lab.

scientific article published on 7 February 2018

In-vivo correlations between skin metabolic oscillations and vasomotion in wild-type mice and in a model of oxidative stress

scientific article published in Scientific Reports

Incident ischaemic stroke and Type 2 diabetes: trends in incidence and case fatality in Scotland 2004-2013.

scientific article published on 17 October 2017

Increased GABAergic tone in the ventromedial hypothalamus contributes to suppression of counterregulatory responses after antecedent hypoglycemia

scientific article

Influence of an early-onset age of type 1 diabetes on cerebral structure and cognitive function.

scientific article

Influence of insulin in the ventromedial hypothalamus on pancreatic glucagon secretion in vivo

scientific article

Inhibition of NFAT Signaling Restores Microvascular Endothelial Function in Diabetic Mice

scientific article published on 05 December 2019

Investigating the Relationship Between Type 2 Diabetes and Dementia Using Electronic Medical Records in the GoDARTS Bioresource

scientific article published on 07 August 2019

Key role for AMP-activated protein kinase in the ventromedial hypothalamus in regulating counterregulatory hormone responses to acute hypoglycemia

scientific article

Long-term, intermittent, insulin-induced hypoglycemia produces marked obesity without hyperphagia or insulin resistance: a model for weight gain with intensive insulin therapy

scientific article published on 20 November 2012

Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice

scientific article published on 27 November 2019

Medium-chain fatty acids improve cognitive function in intensively treated type 1 diabetic patients and support in vitro synaptic transmission during acute hypoglycemia

scientific article published on 17 February 2009

Microvascular disease and heart failure with reduced and preserved ejection fraction in type 2 diabetes

scientific article published on 02 April 2020

Mouse hypothalamic GT1-7 cells demonstrate AMPK-dependent intrinsic glucose-sensing behaviour.

scientific article

Nrf2-Mediated Neuroprotection Against Recurrent Hypoglycemia Is Insufficient to Prevent Cognitive Impairment in a Rodent Model of Type 1 Diabetes

scientific article published on 13 July 2016

Oleate induces KATP channel-dependent hyperpolarization in mouse hypothalamic glucose-excited neurons without altering cellular energy charge

scientific article published on 9 January 2017

Perceived symptoms of hypoglycaemia in elderly type 2 diabetic patients treated with insulin

scientific article published on 01 May 1998

Potential role of non-insulin adjunct therapy in Type 1 diabetes.

scientific article published on February 2013

Prescribing Paradigm Shift? Applying the 2019 European Society of Cardiology-Led Guidelines on Diabetes, Prediabetes, and Cardiovascular Disease to Assess Eligibility for Sodium-Glucose Cotransporter 2 Inhibitors or Glucagon-Like Peptide 1 Receptor

scientific article published on 24 June 2020

Probability of Achieving Glycemic Control with Basal Insulin in Patients with Type 2 Diabetes in Real-World Practice in the USA.

scientific article

RD Lawrence Lecture 2015 Old habits are hard to break: lessons from the study of hypoglycaemia.

scientific article published on 22 October 2016

Radix astragali (huangqi) as a treatment for defective hypoglycemia counterregulation in diabetes

scientific article

Real-time Continuous Glucose Monitoring During a Hyperinsulinemic Hypoglycemic Clamp Significantly Underestimates the Degree of Hypoglycemia

scientific article published on 20 August 2020

Reducing the burden of hypoglycaemia in people with diabetes through increased understanding: design of the Hypoglycaemia REdefining SOLutions for better liVEs (Hypo-RESOLVE) project

scientific article published on 22 January 2020

Renal and Cardiovascular Effects of sodium-glucose cotransporter 2 (SGLT2) inhibition in combination with loop Diuretics in diabetic patients with Chronic Heart Failure (RECEDE-CHF): protocol for a randomised controlled double-blind cross-over trial

scientific article

Risk of acute kidney injury and survival in patients treated with Metformin: an observational cohort study.

scientific article

SGLT inhibitor adjunct therapy in type 1 diabetes

Saxagliptin co-therapy in C-peptide negative Type 1 diabetes does not improve counter-regulatory responses to hypoglycaemia

article

Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathways

scientific article

Socio-economic status and mortality in people with type 1 diabetes in Scotland 2006-2015: a retrospective cohort study

scientific article published on 22 January 2020

Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes but not w ⬇️

scholarly article by Paul Meakin published in September 2014

Symptomatic and physiological responses to hypoglycaemia induced by human soluble insulin and the analogue Lispro human insulin

scientific article published on 01 November 1997

Symptoms reported during experimental hypoglycaemia: effect of method of induction of hypoglycaemia and of diabetes per se

scientific article published on 01 June 2003

Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia

scientific article published in May 2007

Testing the accelerator hypothesis: a new approach to type 1 diabetes prevention (adAPT 1)

scientific article published on 01 January 2016

The Scylla and Charybdis of glucose control in childhood type 1 diabetes?

scientific article

The effect of dapagliflozin on glycaemic control and other cardiovascular disease risk factors in type 2 diabetes mellitus: a real-world observational study

scientific article published on 10 January 2019

The mechanisms that underlie glucose sensing during hypoglycaemia in diabetes.

scientific article published on 27 February 2008

The medial amygdalar nucleus: a novel glucose-sensing region that modulates the counterregulatory response to hypoglycemia

scientific article published on 13 July 2010

The physiology and pathophysiology of the neural control of the counterregulatory response

scientific article

The response to hypoglycemia: a role for the opioid system?

scientific article published in November 2011

Trends in type 2 diabetes incidence and mortality in Scotland between 2004 and 2013.

scientific article published on 28 July 2016

Type 1 corticotropin-releasing factor receptors in the ventromedial hypothalamus promote hypoglycemia-induced hormonal counterregulation

scientific article published on 19 June 2007

Type 2 diabetes, socioeconomic status and life expectancy in Scotland (2012-2014): a population-based observational study.

scientific article published on 26 October 2017

Update in the CNS response to hypoglycemia

scientific article published on January 2012

Ventromedial hypothalamic nitric oxide production is necessary for hypoglycemia detection and counterregulation

scientific article

Visual information processing during controlled hypoglycaemia in humans.

scientific article

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