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List of works by Jeff S McDermott

ABT-089: pharmacological properties of a neuronal nicotinic acetylcholine receptor agonist for the potential treatment of cognitive disorders

scientific article

Bioisosteres of ethyl 8-ethynyl-6-(pyridin-2-yl)-4 H -benzo[ f ]imidazo [1,5- a ][1,4]diazepine-3-carboxylate (HZ-166) as novel alpha 2,3 selective potentiators of GABA A receptors: Improved bioavailability enhances anticonvulsant efficacy

scientific article published on 03 May 2018

Block of hERG channel by ziprasidone: biophysical properties and molecular determinants.

scientific article published on December 2005

Cardiac ion channels

scientific article published on 20 August 2015

Control of Neurotransmission by NaV1.7 in Human, Guinea Pig, and Mouse Airway Parasympathetic Nerves

scientific article

Correction to "Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement".

scientific article published on 28 February 2017

Discovery and hit-to-lead optimization of pyrrolopyrimidines as potent, state-dependent Nav1.7 antagonists ⬇️

scientific article published on January 18, 2012

Discovery and optimization of aminopyrimidinones as potent and state-dependent Nav1.7 antagonists

scientific article published on 6 December 2011

Discovery and optimization of substituted piperidines as potent, selective, CNS-penetrant alpha4beta2 nicotinic acetylcholine receptor potentiators.

scientific article

Extracellular signal-regulated kinases mediate the enhancing effects of inflammatory mediators on resurgent currents in dorsal root ganglion neurons

scientific article published on 01 January 2019

Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain.

scientific article published on 2 June 2011

Importance of species selection in arrythmogenic models of Q-T interval prolongation

scientific article published on March 2002

Inhibition of Inactive States of Tetrodotoxin-Sensitive Sodium Channels Reduces Spontaneous Firing of C-Fiber Nociceptors and Produces Analgesia in Formalin and Complete Freund's Adjuvant Models of Pain

scientific article

Pharmacological effects of nonselective and subtype-selective nicotinic acetylcholine receptor agonists in animal models of persistent pain

scientific article published on 18 February 2010

Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement

scientific article published on 21 September 2016

Synthesis and activity of substituted carbamates as potentiators of the alpha4beta2 nicotinic acetylcholine receptor.

scientific article

Targeting the Nerve Growth Factor (NGF) Pathway in Drug Discovery. Potential Applications to New Therapies for Chronic Pain

scientific article published on 25 October 2016

Tetrodotoxin-resistant sodium channels in sensory neurons generate slow resurgent currents that are enhanced by inflammatory mediators

scientific article

The canine Purkinje fiber: an in vitro model system for acquired long QT syndrome and drug-induced arrhythmogenesis

scientific article

The discovery of aminopyrazines as novel, potent Nav1.7 antagonists: Hit-to-lead identification and SAR

scientific article published on 18 January 2012

The discovery of benzoxazine sulfonamide inhibitors of NaV1.7: Tools that bridge efficacy and target engagement.

scientific article

The effects of plasma proteins on delayed repolarization in vitro with cisapride, risperidone, and D, L-sotalol

scientific article published on 12 February 2007

The utility of hERG and repolarization assays in evaluating delayed cardiac repolarization: influence of multi-channel block

scientific article published in March 2004

[125I]A-312110, a novel high-affinity 1,4-dihydropyridine ATP-sensitive K+ channel opener: characterization and pharmacology of binding

scientific article

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