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List of works by Nick R. Leslie

3D Printing in Suspension Baths: Keeping the Promises of Bioprinting Afloat

scientific article published on 16 January 2020

A screen for novel phosphoinositide 3-kinase effector proteins.

scientific article

A simple and robust real-time qPCR method for the detection of PIK3CA mutations

scientific article published on 9 March 2018

A unified nomenclature and amino acid numbering for human PTEN.

scientific article

Antagonism of PI 3-kinase-dependent signalling pathways by the tumour suppressor protein, PTEN.

scientific article

Assaying PTEN catalysis in vitro

scientific article published on 13 November 2014

Beta1-integrin and PTEN control the phosphorylation of protein kinase C.

scientific article

C1-Ten is a protein tyrosine phosphatase of insulin receptor substrate 1 (IRS-1), regulating IRS-1 stability and muscle atrophy

scientific article published on 11 February 2013

Cell biology. Where is PTEN?

scientific article published in July 2013

Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase

scientific article

Class I PI 3-kinases: Function and evolution

scientific article published on 20 June 2015

Controlling PTEN (Phosphatase and Tensin Homolog) Stability: A DOMINANT ROLE FOR LYSINE 66.

scientific article published on 12 July 2016

Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling

scientific article published on 26 August 2013

Differential redox regulation within the PTP superfamily

scientific article

Disruption of epithelial architecture caused by loss of PTEN or by oncogenic mutant p110α/PIK3CA but not by HER2 or mutant AKT1 ⬇️

scientific article published on October 22, 2012

Distinct inactivation of PI3K signalling by PTEN and 5-phosphatases.

scientific article published on January 2012

Functionally distinct groups of inherited PTEN mutations in autism and tumour syndromes

scientific article

GSK3 and its interactions with the PI3K/AKT/mTOR signalling network

scientific article

Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice

scientific article published in October 2005

IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold

scientific article

Importin-11 keeps PTEN safe from harm

scientific article published on 13 February 2017

In Cell and In Vitro Assays to Measure PTEN Ubiquitination

scientific article published on January 2016

Indirect mechanisms of carcinogenesis via downregulation of PTEN function.

scientific article

Inherited PTEN mutations and the prediction of phenotype

scientific article

Leptin regulates AMPA receptor trafficking via PTEN inhibition

scientific journal article

Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression.

scientific article published on December 2006

Loss of PTEN selectively desensitizes upstream IGF1 and insulin signaling.

scientific article published on 7 May 2007

Mechanism of activation of PKB/Akt by the protein phosphatase inhibitor Calyculin A.

scientific article published on December 2010

Mechanisms of PTEN loss in cancer: It's all about diversity

scientific article published on 07 February 2019

Metabolic switching of PI3K-dependent lipid signals

scientific article

Migration Stimulating Factor (MSF) promotes fibroblast migration by inhibiting AKT.

scientific article published in July 2010

Mutant PTEN in Cancer: Worse Than Nothing

scientific article published in April 2014

MyosinV controls PTEN function and neuronal cell size.

scientific article published on 20 September 2009

Non-genomic loss of PTEN function in cancer: not in my genes.

scientific article published on 13 January 2011

P-REX2a driving tumorigenesis by PTEN inhibition

scientific article

PDK1 controls upstream PI3K expression and PIP3 generation.

scientific article published on 29 July 2013

PTEN function: how normal cells control it and tumour cells lose it

scientific article

PTEN inhibitors: an evaluation of current compounds.

scientific article

PTEN is destabilized by phosphorylation on Thr366.

scientific article published on August 2007

PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

scientific article published on October 2008

PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity

scientific article

PTEN regulates IGF-1R-mediated therapy resistance in melanoma.

scientific article

PTEN: The down side of PI 3-kinase signalling.

scientific article

PTEN: an intercellular peacekeeper?

scientific article

Phosphoinositide-regulated kinases and phosphoinositide phosphatases.

scientific article

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells.

scientific article published on April 2014

Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN

scientific article

Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity

scientific article

PtdIns5P protects Akt from dephosphorylation through PP2A inhibition.

scientific article published in July 2009

Redox regulation of PI 3-kinase signalling via inactivation of PTEN

scientific article

Redox regulation of phosphatase function.

scientific article

Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo

scientific article published on July 2004

Stimulation of PI 3-kinase signaling via inhibition of the tumor suppressor phosphatase, PTEN.

scientific article published on 30 December 2006

Substrate specificity and acute regulation of the tumour suppressor phosphatase, PTEN.

scientific article published on January 2007

Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors.

scientific article published on 10 March 2008

TPIP: a novel phosphoinositide 3-phosphatase ⬇️

scientific article published on December 1, 2001

Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions

scientific article

The PTEN protein: cellular localization and post-translational regulation

scientific article published on February 2016

The regulation of cell migration by PTEN.

scientific article

Three-dimensional bioprinting of complex cell laden alginate hydrogel structures

scientific article published on 21 December 2015

Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress.

scientific article

Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake

scientific article

Yeast-based methods to assess PTEN phosphoinositide phosphatase activity in vivo.

scientific article

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