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List of works by Jiafu Wang

A dileucine in the protease of botulinum toxin A underlies its long-lived neuroparalysis: transfer of longevity to a novel potential therapeutic

scientific article

A novel therapeutic with two SNAP-25 inactivating proteases shows long-lasting anti-hyperalgesic activity in a rat model of neuropathic pain.

scientific article published on 24 March 2017

Activation of TRPV1 mediates calcitonin gene-related peptide release, which excites trigeminal sensory neurons and is attenuated by a retargeted botulinum toxin with anti-nociceptive potential

scientific article published on April 2009

Conjugate of an IgG Binding Domain with Botulinum Neurotoxin A Lacking the Acceptor Moiety Targets Its SNARE Protease into TrkA-Expressing Cells When Coupled to Anti-TrkA IgG or Fc-βNGF.

scientific article

Extravesicular intraneuronal migration of internalized botulinum neurotoxins without detectable inhibition of distal neurotransmission

scientific article published on 01 January 2012

Fusion of Golgi-derived vesicles mediated by SNAP-25 is essential for sympathetic neuron outgrowth but relatively insensitive to botulinum neurotoxins in vitro

scientific article published on 13 June 2014

Longer-acting and highly potent chimaeric inhibitors of excessive exocytosis created with domains from botulinum neurotoxin A and B

scientific article published on 01 May 2012

Molecular components required for resting and stimulated endocytosis of botulinum neurotoxins by glutamatergic and peptidergic neurons

scientific journal article

Neuronal entry and high neurotoxicity of botulinum neurotoxin A require its N-terminal binding sub-domain

scientific article published on 15 March 2017

New Engineered-Botulinum Toxins Inhibit the Release of Pain-Related Mediators

scientific article published on 30 December 2019

Novel chimeras of botulinum and tetanus neurotoxins yield insights into their distinct sites of neuroparalysis

scientific article published on 31 August 2012

Novel chimeras of botulinum neurotoxins A and E unveil contributions from the binding, translocation, and protease domains to their functional characteristics

scientific article published on 8 April 2008

Novel therapeutics based on recombinant botulinum neurotoxins to normalize the release of transmitters and pain mediators

scientific article

Pharmacological characteristics of Kv1.1- and Kv1.2-containing channels are influenced by the stoichiometry and positioning of their α subunits

scientific article published in August 2013

Position-dependent attenuation by Kv1.6 of N-type inactivation of Kv1.4-containing channels

scientific article published in September 2011

Role of SNARE proteins in tumourigenesis and their potential as targets for novel anti-cancer therapeutics.

scientific article published on 05 May 2015

Role of SNAREs in Atopic Dermatitis-Related Cytokine Secretion and Skin-Nerve Communication

scientific article published on 23 May 2019

SNAP-23 and VAMP-3 contribute to the release of IL-6 and TNFα from a human synovial sarcoma cell line

scientific article

Selective cleavage of SNAREs in sensory neurons unveils protein complexes mediating peptide exocytosis triggered by different stimuli

scientific article published on 08 March 2014

Synaptobrevin I mediates exocytosis of CGRP from sensory neurons and inhibition by botulinum toxins reflects their anti-nociceptive potential

scientific article published on 31 July 2007

TNFα induces co-trafficking of TRPV1/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18-1/syntaxin1/SNAP-25 mediated fusion

scientific article

Targeted delivery into motor nerve terminals of inhibitors for SNARE-cleaving proteases via liposomes coupled to an atoxic botulinum neurotoxin.

scientific article published on 14 June 2012

Targeted delivery of a SNARE protease to sensory neurons using a single chain antibody (scFv) against the extracellular domain of P2X(3) inhibits the release of a pain mediator.

scientific article

Therapeutic effectiveness of botulinum neurotoxin A: potent blockade of autonomic transmission by targeted cleavage of only the pertinent SNAP-25.

scientific article

Two protein trafficking processes at motor nerve endings unveiled by botulinum neurotoxin E.

scientific article published on 18 October 2006

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