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List of works by Joanne Edwards

A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth

scientific journal article

Aberrant expression of extracellular signal-regulated kinase 5 in human prostate cancer

scientific article published on 10 December 2007

Activation of the IL-6R/Jak/stat pathway is associated with a poor outcome in resected pancreatic ductal adenocarcinoma.

scientific article published on 23 February 2013

Activation of β-Catenin Cooperates with Loss of Pten to Drive AR-Independent Castration-Resistant Prostate Cancer

scientific article published on 12 November 2019

Amplification of the androgen receptor gene in bone metastases from hormone-refractory prostate cancer

article

Amplification of the androgen receptor may not explain the development of androgen-independent prostate cancer

scientific article

Androgen receptor gene amplification and protein expression in hormone refractory prostate cancer.

scientific article published on August 2003

Androgen receptor phosphorylation at serine 515 by Cdk1 predicts biochemical relapse in prostate cancer patients.

scientific article published on 4 December 2012

Androgen receptor phosphorylation at serine 81 and serine 213 in castrate-resistant prostate cancer

scientific article published on 01 May 2020

Androgen receptor phosphorylation status at serine 578 predicts poor outcome in prostate cancer patients.

scientific article published on 25 November 2016

BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration

scientific article published on 18 November 2019

Bad expression influences time to androgen escape in prostate cancer.

scientific article published on 2 June 2007

Body Mass Index Predicts Failure of Surgical Management in Benign Prostatic Hyperplasia

scientific article published on 15 December 2012

Breast cancer outcomes by steroid hormone receptor status assessed visually and by computer image analysis

scientific article published on 09 May 2012

Breast cancer patients' clinical outcome measures are associated with Src kinase family member expression.

scientific article

CLIC3 controls recycling of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancer

scientific article

Colorectal cancer subtypes: Translation to routine clinical pathology

scientific article

Comparison of Visual and automated assessment of Ki-67 proliferative activity and their impact on outcome in primary operable invasive ductal breast cancer ⬇️

scientific article published on January 3, 2012

Comparison of visual and automated assessment of HER2 status and their impact on outcome in primary operable invasive ductal breast cancer

scientific article

Comparison of visual and automated assessment of microvessel density and their impact on outcome in primary operable invasive ductal breast cancer

scientific article

Correction: BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration

scientific article published on 01 March 2020

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer

scientific article published on October 2013

Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer.

scientific article

Drug screening of biopsy-derived spheroids using a self-generated microfluidic concentration gradient

scientific article published in Scientific Reports

ERK and p38MAPK combine to improve survival in patients with BRAF mutant colorectal cancer

scientific article published on 10 July 2018

Elevated LIM kinase 1 in nonmetastatic prostate cancer reflects its role in facilitating androgen receptor nuclear translocation

scientific article

Evaluation of a tumor microenvironment-based prognostic score in primary operable colorectal cancer

scientific article published on 3 December 2014

Expression levels of the JAK/STAT pathway in the transition from hormone-sensitive to hormone-refractory prostate cancer.

scientific article

Expression of RUNX1 correlates with poor patient prognosis in triple negative breast cancer

scientific article

Expression of hypoxia inducible factor-1 alpha in matched hormone naive and castrate resistant prostate cancer specimens

scientific article published on 01 January 2010

Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor-negative breast cancer ⬇️

scientific article published on March 29, 2012

Expression of tumor necrosis factor alpha converting enzyme in endocrine cancers

scientific article published in May 2008

Gut γδ T cells as guardians, disruptors, and instigators of cancer

scientific article published on 24 August 2020

HER2 and COX2 expression in human prostate cancer

scientific article published on 01 January 2004

HER2 overcomes PTEN (loss)-induced senescence to cause aggressive prostate cancer

scientific article

Heregulin Expression and Prognosis in Prostate Adenocarcinoma

scientific article published on 24 August 2011

High Expression of Sphingosine 1-Phosphate Receptors, S1P1 and S1P3, Sphingosine Kinase 1, and Extracellular Signal-Regulated Kinase-1/2 Is Associated with Development of Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer Patients ⬇️

scientific article published on October 1, 2010

High IKKα expression is associated with reduced time to recurrence and cancer specific survival in oestrogen receptor (ER)-positive breast cancer.

scientific article published on 22 December 2016

High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In Vitro

scientific article published on 25 September 2020

Histological phenotypic subtypes predict recurrence risk and response to adjuvant chemotherapy in patients with stage III colorectal cancer

scientific article published on 13 May 2020

IGFBP-5 enhances epithelial cell adhesion and protects epithelial cells from TGFβ1-induced mesenchymal invasion ⬇️

scientific article published on 11 October 2013

Identification of loci associated with putative recurrence genes in transitional cell carcinoma of the urinary bladder.

scientific article published on April 2002

Identification of novel functional and spatial associations between sphingosine kinase 1, sphingosine 1-phosphate receptors and other signaling proteins that affect prognostic outcome in estrogen receptor-positive breast cancer

scientific article published on 11 July 2012

Immunohistochemical detection improves the prognostic value of lymphatic and blood vessel invasion in primary ductal breast cancer.

scientific article

Immunotherapy: enhancing the efficacy of this promising therapeutic in multiple cancers

scientific article published on 18 January 2019

In reply to 'Hynes et al. Back to the future: routine morphological assessment of the tumour microenvironment is prognostic in stage II/III colon cancer in a large population-based study'.

scientific article published on 22 February 2017

Inhibitory Kappa B Kinase α (IKKα) Inhibitors That Recapitulate Their Selectivity in Cells against Isoform-Related Biomarkers

scientific article published on 24 July 2017

Interactions between MAP kinase and oestrogen receptor in human breast cancer

scientific article

Interrelationships between Tumor Proliferative Activity, Leucocyte and Macrophage Infiltration, Systemic Inflammatory Response, and Survival in Patients Selected for Potentially Curative Resection for Gastroesophageal Cancer

scientific article published on 16 March 2011

Is PTEN loss associated with clinical outcome measures in human prostate cancer?

scientific article published in October 2008

Is expression or activation of Src kinase associated with cancer-specific survival in ER-, PR- and HER2-negative breast cancer patients?

scientific article published on 17 September 2009

Is the Presence or Absence of Tumour Necrosis a Significant Predictor of Survival in Renal Cell Cancer?

scientific article published on 27 October 2011

Is the biology of breast cancer changing? A study of hormone receptor status 1984-1986 and 1996-1997.

scientific article published on 17 February 2009

Is there an association with phosphorylation and dephosphorylation of Src kinase at tyrosine 530 and breast cancer patient disease-specific survival ⬇️

scientific article published on November 9, 2010

Loss of heterozygosity on chromosomes 11 and 17 are markers of recurrence in TCC of the bladder ⬇️

scientific article published on December 14, 2001

Loss of signal transducer and activator of transcription 1 is associated with prostate cancer recurrence

scientific article published on 23 October 2015

MIR21-induced loss of junctional adhesion molecule A promotes activation of oncogenic pathways, progression and metastasis in colorectal cancer

scientific article published on 05 July 2021

MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression

scientific article published on 16 December 2020

Mismatch repair status in patients with primary operable colorectal cancer: associations with the local and systemic tumour environment

scientific article published on 9 February 2016

Molecular alterations in AKT1, AKT2 and AKT3 detected in breast and prostatic cancer by FISH.

scientific article published in January 2010

Molecular mechanism of the TP53-MDM2-AR-AKT signalling network regulation by USP12

scientific article published on 14 May 2018

NFκB signalling is upregulated in a subset of castrate-resistant prostate cancer patients and correlates with disease progression

scientific article

Next-generation sequencing of advanced prostate cancer treated with androgen-deprivation therapy

scientific article published on 14 August 2013

Nuclear factor κB predicts poor outcome in patients with hormone-naive prostate cancer with high nuclear androgen receptor.

scientific article published on 9 March 2012

Observer variation in immunohistochemical analysis of protein expression, time for a change?

scientific article

Phosphorylated c-Src in the nucleus is associated with improved patient outcome in ER-positive breast cancer.

scientific article

Phosphorylation of androgen receptors at serine 515 is a potential prognostic marker for triple negative breast cancer

scientific article

Phosphorylation of the androgen receptor is associated with reduced survival in hormone-refractory prostate cancer patients.

scientific article

Poor survival outcomes in HER2-positive breast cancer patients with low-grade, node-negative tumours.

scientific article published on 17 February 2009

Preoperative, biopsy-based assessment of the tumour microenvironment in patients with primary operable colorectal cancer

scientific article published on 14 October 2019

Presence of tumoural C-reactive protein correlates with progressive prostate cancer

scientific article published on 01 March 2011

Prospective Study of the Role of Inflammation in Renal Cancer

scientific article published on 23 February 2012

RUNX1 is a driver of renal cell carcinoma correlating with clinical outcome

scientific article published on 10 March 2020

RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland

scientific article

Raf-1 expression may influence progression to androgen insensitive prostate cancer

scientific article published on 01 June 2005

Ras/Raf-1/MAPK pathway mediates response to tamoxifen but not chemotherapy in breast cancer patients

scientific article published in February 2009

Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1.

scientific article published on 21 November 2013

Relationship between immune checkpoint proteins, tumour microenvironment characteristics, and prognosis in primary operable colorectal cancer

scientific article published on 18 December 2020

Relationship between tumour PTEN/Akt/COX-2 expression, inflammatory response and survival in patients with colorectal cancer.

scientific article published on 20 September 2016

Routine Acid Decalcification of Bone Marrow Samples Can Preserve DNA for FISH and CGH Studies in Metastatic Prostate Cancer ⬇️

scientific article published on January 1, 2002

SIRT2: tumour suppressor or tumour promoter in operable breast cancer?

scientific article

SPRY2 loss enhances ErbB trafficking and PI3K/AKT signalling to drive human and mouse prostate carcinogenesis

scientific article published on 31 May 2012

SRC family kinase activity is up-regulated in hormone-refractory prostate cancer.

scientific article

Senescent cells harbour features of the cancer epigenome.

scientific article published on 24 November 2013

Shorter disease-specific survival of ER-positive breast cancer patients with high cytoplasmic Src kinase expression after tamoxifen treatment

scientific article published on 02 December 2011

Signal Transduction and Activator of Transcription-3 (STAT3) in Patients with Colorectal Cancer: Associations with the Phenotypic Features of the Tumor and Host

scientific article published on 27 September 2016

Sphingosine 1-Phosphate Receptor 4 Uses HER2 (ERBB2) to Regulate Extracellular Signal Regulated Kinase-1/2 in MDA-MB-453 Breast Cancer Cells ⬇️

scientific article published on September 13, 2010

Sphingosine 1-phosphate signalling in cancer ⬇️

scientific article published on February 1, 2012

Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression

scientific article published on 22 February 2013

THEM6-mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer

scientific article published on 11 January 2022

Tamoxifen resistance in early breast cancer: statistical modelling of tissue markers to improve risk prediction

scientific article

Targeting sphingosine kinase 1 in cancer ⬇️

scientific article published on January 1, 2012

The Glasgow Microenvironment Score associates with prognosis and adjuvant chemotherapy response in colorectal cancer

scientific article published on 23 November 2020

The Pretreatment Systemic Inflammatory Response is an Important Determinant of Poor Pathologic Response for Patients Undergoing Neoadjuvant Therapy for Rectal Cancer

scientific article

The Prognostic Use of Inflammation and Tissue Necrosis in Benign Prostatic Hyperplasia

scientific article published on 10 January 2013

The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 1: Modifications to the androgen receptor.

scientific article

The bodies fight against cancer: is human leucocyte antigen (HLA) class 1 the key? ⬇️

scientific article published on March 18, 2012

The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism

scientific article

The in situ local immune response, tumour senescence and proliferation in colorectal cancer.

scientific article published on 10 September 2013

The interrelationships between Src, Cav-1 and RhoGD12 in transitional cell carcinoma of the bladder.

scientific article published on 21 February 2012

The relationship between angiogenesis and cyclooxygenase-2 expression in prostate cancer

scientific article published on 01 July 2005

The relationship between components of tumour inflammatory cell infiltrate and clinicopathological factors and survival in patients with primary operable invasive ductal breast cancer ⬇️

scientific article published on August 9, 2012

The relationship between genetic profiling, clinicopathological factors and survival in patients undergoing surgery for node-negative colorectal cancer: 10-year follow-up

scientific article published on 26 September 2013

The relationship between members of the canonical NF-κB pathway, components of tumour microenvironment and survival in patients with invasive ductal breast cancer

scientific article

The relationship between oestrogen receptor-alpha phosphorylation and the tumour microenvironment in patients with primary operable ductal breast cancer.

scientific article published on 28 November 2016

The relationship between the local and systemic inflammatory responses and survival in patients undergoing resection for localized renal cancer

article

The relationship between the tumour stroma percentage, clinicopathological characteristics and outcome in patients with operable ductal breast cancer

scientific article

The relationship between tumour budding, the tumour microenvironment and survival in patients with invasive ductal breast cancer

scientific article

The relationship between tumour necrosis, tumour proliferation, local and systemic inflammation, microvessel density and survival in patients undergoing potentially curative resection of oesophageal adenocarcinoma

scientific article published on 12 January 2012

The relationship between tumour site, clinicopathological characteristics and cancer-specific survival in patients undergoing surgery for colorectal cancer

scientific article published in December 2012

The role of HER1-HER4 and EGFRvIII in hormone-refractory prostate cancer

scientific article published in January 2006

The role of c-Jun and c-Fos expression in androgen-independent prostate cancer.

scientific article

The role of lymphatic and blood vessel invasion in predicting survival and methods of detection in patients with primary operable breast cancer.

scientific article published on 12 September 2013

The stress-responsive kinase DYRK2 activates heat shock factor 1 promoting resistance to proteotoxic stress

scientific article published on 02 December 2020

Tumoral C-reactive protein and nuclear factor kappa-B expression are associated with clinical outcome in patients with prostate cancer

scientific article published in January 2011

Tumour invasiveness, the local and systemic environment and the basis of staging systems in colorectal cancer

scientific article published on 20 April 2017

Type I receptor tyrosine kinases are associated with hormone escape in prostate cancer

scientific article

Upregulated FGFR1 expression is associated with the transition of hormone-naive to castrate-resistant prostate cancer.

scientific article published on 27 September 2011

Upregulation of MAPK pathway is associated with survival in castrate-resistant prostate cancer.

scientific article published on 10 May 2011

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