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List of works by Jonathan D Licht

A Mutation in Histone H2B Represents a New Class of Oncogenic Driver

scientific article published on 23 July 2019

An activating mutation of the NSD2 histone methyltransferase drives oncogenic reprogramming in acute lymphocytic leukemia.

scientific article published on 31 August 2018

BRCA1 Augments Transcription by the NF-κB Transcription Factor by Binding to the Rel Domain of the p65/RelA Subunit ⬇️

scientific article (publication date: 18 July 2003)

Chromatin modulation by oncogenic transcription factors: new complexity, new therapeutic targets.

scientific article published on June 2007

Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors.

scientific article

DNA Methylation Inhibitors in Cancer Therapy: The Immunity Dimension

scientific article published in August 2015

DNMT3A mutations in acute myeloid leukemia

scientific article published on 29 March 2011

Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding

scientific article published on 27 June 2019

Deregulation of H3K27 methylation in cancer

scientific article published in February 2010

Deregulation of NPM and PLZF in a variant t(5;17) case of acute promyelocytic leukemia

scientific article published in January 1999

Drosophila Krüppel protein is a transcriptional repressor

scientific article published in July 1990

ETO protein of t(8;21) AML is a corepressor for Bcl-6 B-cell lymphoma oncoprotein.

scientific article published on 9 October 2003

EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis

scientific journal article

Emerging Epigenetic Targets and Therapies in Cancer Medicine ⬇️

scientific article published on April 23, 2012

Epigenetic regulatory mutations and epigenetic therapy for multiple myeloma

scientific article published in July 2017

Epigenetic therapy of hematological malignancies: where are we now? ⬇️

scientific article published on April 1, 2013

Essential Role for the Mnk Pathway in the Inhibitory Effects of Type I Interferons on Myeloproliferative Neoplasm (MPN) Precursors ⬇️

scientific article published on June 28, 2013

Expression of Leukemia-Associated Fusion Proteins Increases Sensitivity to Histone Deacetylase Inhibitor–Induced DNA Damage and Apoptosis ⬇️

scientific article published on March 27, 2013

FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML

scientific article published on 17 February 2020

FQI1: a transcription-methylation switch for cancer

scientific article published on 4 February 2017

Functional characterization of Wilms tumor-suppressor WTX and tumor-associated mutants ⬇️

scientific article published on October 18, 2010

G Protein-regulated Inducer of Neurite Outgrowth (GRIN) Modulates Sprouty Protein Repression of Mitogen-activated Protein Kinase (MAPK) Activation by Growth Factor Stimulation ⬇️

scientific article published on April 20, 2012

HDAC Inhibition Enhances the In Vivo Efficacy of MEK Inhibitor Therapy in Uveal Melanoma

scientific article published on 21 June 2019

HDAC8 Regulates a Stress Response Pathway in Melanoma to Mediate Escape from BRAF Inhibitor Therapy

scientific article published on 15 April 2019

HOX deregulation in acute myeloid leukemia

scientific article

Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture ⬇️

scientific article published on 9 December 2020

Histone H3 G34 Tail Mutations in Cancer: Actions in <i>Cis</i> and <i>Trans</i> to Alter Chromatin and Gene Expression

scientific article published on 01 December 2020

Histone deacetylase inhibitors in cancer therapy: is transcription the primary target?

scientific article

Loss of Mll3 Catalytic Function Promotes Aberrant Myelopoiesis

scientific article

MEK and MAF in myeloma therapy ⬇️

scientific article published on February 24, 2011

Molecular pathogenesis of acute promyelocytic leukaemia and APL variants

scientific article (publication date: September 2003)

Partners in crime: Genes within an amplicon collude to globally deregulate chromatin in lymphoma

scientific article published on December 2010

Phase II trial of trimetrexate in patients with advanced soft-tissue sarcoma ⬇️

scientific article published on January 1, 1991

Ponatinib—A Step Forward in Overcoming Resistance in Chronic Myeloid Leukemia ⬇️

scientific article published on 09 August 2013

Reconstructing a disease: What essential features of the retinoic acid receptor fusion oncoproteins generate acute promyelocytic leukemia?

scientific article published in February 2006

Regulation of CD4⁺ and CD8⁺ effector responses by Sprouty-1

scientific article

SETD2: a complex role in blood malignancy

scientific article published in December 2017

Sequence-specific DNA Binding and Transcriptional Regulation by the Promyelocytic Leukemia Zinc Finger Protein ⬇️

scientific article published on September 5, 1997

Sprouty Proteins Are Negative Regulators of Interferon (IFN) Signaling and IFN-inducible Biological Responses ⬇️

scientific article published on October 16, 2012

Spry1 and Spry2 are necessary for eyelid closure

scientific article published on 17 September 2013

Spry1 as a novel regulator of erythropoiesis, EPO/EPOR target, and suppressor of JAK2 ⬇️

scientific article published on April 16, 2012

Spry1andSpry2Are Necessary for Lens Vesicle Separation and Corneal Differentiation ⬇️

scientific article published on August 29, 2011

Targeting aberrant transcriptional repression in leukemia: a therapeutic reality?

scientific article

The 12th international conference on differentiation therapy: targeting the aberrant growth, differentiation and cell death programs of cancer cells ⬇️

scientific article published on January 7, 2011

The Promyelocytic Leukemia Zinc Finger Protein Affects Myeloid Cell Growth, Differentiation, and Apoptosis ⬇️

scientific article published on September 1, 1998

The U.S. EPA Conference on Preventable Causes of Cancer in Children: a research agenda ⬇️

scientific article published on June 1, 1998

The acute promyelocytic leukemia–associated protein, promyelocytic leukemia zinc finger, regulates 1,25-dihydroxyvitamin D3–induced monocytic differentiation of U937 cells through a physical interaction with vitamin D3receptor ⬇️

scientific article (publication date: December 2001)

The mevalonate pathway is an actionable vulnerability of t(4;14)-positive multiple myeloma

scientific article published on 14 July 2020

The theoretical basis of transcriptional therapy of cancer: can it be put into practice?

scientific article

Therapeutic intervention in leukemias that express the activated fms-like tyrosine kinase 3 (FLT3): opportunities and challenges

scientific article

Treatment of low-grade and intermediate-grade lymphoma with intensive combination chemotherapy results in long-term, disease-free survival ⬇️

scientific article published on August 15, 1990

Two Evolutionarily Conserved Repression Domains in the Drosophila Krüppel Protein Differ in Activator Specificity ⬇️

scientific article published on August 1, 1997

miR-433 is aberrantly expressed in myeloproliferative neoplasms and suppresses hematopoietic cell growth and differentiation ⬇️

scientific article published on August 6, 2012

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