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List of works by Karl Gruber

A biocatalytic Henry reaction--the hydroxynitrile lyase from Hevea brasiliensis also catalyzes nitroaldol reactions

scientific article published on 01 May 2006

A blue corrinoid from partial degradation of vitamin B12 in aqueous bicarbonate: spectra, structure, and interaction with proteins of B12 transport

scientific article published on 24 August 2011

A conserved inter-domain communication mechanism regulates the ATPase activity of the AAA-protein Drg1

scientific article published on 17 March 2017

A crystalline B12 dimer from beta-cyano-neocobyrate

scientific article published on 01 January 2008

A novel Porphyromonas gingivalis enzyme: An atypical dipeptidyl peptidase III with an ARM repeat domain.

scientific article published on 30 November 2017

A small molecule chaperone rescues the stability and activity of a cancer-associated variant of NAD(P)H:quinone oxidoreductase 1 in vitro

scientific article published on 30 October 2019

Access to organometallic arylcobaltcorrins through radical synthesis: 4-ethylphenylcobalamin, a potential "antivitamin B(12)".

scientific article published on 13 February 2013

An Esterase from Anaerobic Clostridium hathewayi Can Hydrolyze Aliphatic-Aromatic Polyesters

scientific article

Anthranoyl-CoA monooxygenase/reductase from Azoarcus evansii possesses both FMN and FAD in two distinct and independent active sites

scientific article published on 02 April 2015

Asymmetric Bioreduction of CC Bonds using Enoate Reductases OPR1, OPR3 and YqjM: Enzyme-Based Stereocontrol

scholarly article by Mélanie Hall et al published 22 February 2008 in Advanced Synthesis & Catalysis

Asymmetric Reductive Carbocyclization Using Engineered Ene Reductases.

scientific article published on 24 April 2018

Asymmetric enzymatic hydration of hydroxystyrene derivatives

scientific article published on 17 January 2013

Atomic resolution crystal structure of hydroxynitrile lyase from Hevea brasiliensis

scientific article

Atomic resolution crystal structures and quantum chemistry meet to reveal subtleties of hydroxynitrile lyase catalysis

scientific article

B12-retro-riboswitches: constitutional switching of B12 coenzymes induced by nucleotides

scientific article published on 01 April 2005

Berberine bridge enzyme catalyzes the six electron oxidation of (S)-reticuline to dehydroscoulerine

scientific article

Biocatalytic Enantioselective Oxidative CC Coupling by Aerobic CH Activation

scientific article published on 18 January 2011

Biocatalytic Friedel-Crafts Acylation and Fries Reaction

scientific article published on 23 May 2017

Biocatalytic access to alpha,alpha-dialkyl-alpha-amino acids by a mechanism-based approach

scientific article published on 01 January 2010

Biochemical and structural characterization of a novel bacterial manganese-dependent hydroxynitrile lyase

scientific article

Bioreduction of alpha-methylcinnamaldehyde derivatives: chemo-enzymatic asymmetric synthesis of Lilial and Helional.

scientific article published on 11 May 2010

C-terminal truncation of a metagenome-derived detergent protease for effective expression in E. coli

scientific article

Can electromagnetic fields influence the structure and enzymatic digest of proteins? A critical evaluation of microwave-assisted proteomics protocols.

scientific article

Carving the active site of almond R-HNL for increased enantioselectivity

scientific article published in July 2005

Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H:quinone oxidoreductase 1 (NQO1).

scientific article published on 25 February 2017

Characterization of a poly(butylene adipate-co-terephthalate)- hydrolyzing lipase from Pelosinus fermentans

scientific article

Characterization of the PLP-dependent aminotransferase NikK from Streptomyces tendae and its putative role in nikkomycin biosynthesis

article

Chemoenzymatic Total Synthesis of Deoxy-, epi -, and Podophyllotoxin and a Biocatalytic Kinetic Resolution of Dibenzylbutyrolactones

scientific article published on 08 May 2019

Chemoenzymatische Totalsynthese von Deoxy‐, epi ‐ und Podophyllotoxin sowie biokatalytische kinetische Racematspaltung von Dibenzylbutyrolactonen

Chlorophyll-Derived Yellow Phyllobilins of Higher Plants as Medium-Responsive Chiral Photoswitches

scientific article (publication date: 19 December 2016)

Coenzyme B(12) dependent glutamate mutase.

scientific article

Coenzyme B12 Repurposed for Photoregulation of Gene Expression

scientific article published on 24 March 2016

Cofactor Specificity Engineering of Streptococcus mutans NADH Oxidase 2 for NAD(P)(+) Regeneration in Biocatalytic Oxidations

scientific article

Collapse of the native structure caused by a single amino acid exchange in human NAD(P)H:quinone oxidoreductase(1.)

scientific article

Complete switch from α-2,3- to α-2,6-regioselectivity in Pasteurella dagmatis β-D-galactoside sialyltransferase by active-site redesign

scientific article

Comprehensive step-by-step engineering of an (R)-hydroxynitrile lyase for large-scale asymmetric synthesis.

scientific article published in October 2003

Conformational Plasticity and Ligand Binding of Bacterial Monoacylglycerol Lipase

scientific article

Crystal Structure and Catalytic Mechanism of CouO, a Versatile C-Methyltransferase from Streptomyces rishiriensis ⬇️

scientific article

Crystal structure of Dioclea violacea lectin and a comparative study of vasorelaxant properties with Dioclea rostrata lectin

scientific article

Crystal structure of a pro-inflammatory lectin from the seeds of Dioclea wilsonii Standl

scientific article

Crystal structure of dipeptidyl peptidase III from the human gut symbiont Bacteroides thetaiotaomicron.

scientific article published on 2 November 2017

Crystal structure of the Saccharomyces cerevisiae monoglyceride lipase Yju3p

scientific article

Crystallization and preliminary X-ray diffraction analysis of human dipeptidyl peptidase 10 (DPPY), a component of voltage-gated potassium channels ⬇️

scientific article published on January 26, 2012

Crystallization and preliminary X-ray diffraction of the surfactant protein Lv-ranaspumin from the frog Leptodactylus vastus

scientific article published on 23 February 2012

Crystallization of the novel S-adenosyl-L-methionine-dependent C-methyltransferase CouO from Streptomyces rishiriensis and preliminary diffraction data analysis

scientific article

Cutting Long Syntheses Short: Access to Non-Natural Tyrosine Derivatives Employing an Engineered Tyrosine Phenol Lyase

Discovery and structural characterisation of new fold type IV-transaminases exemplify the diversity of this enzyme fold

scientific article published on December 2016

Disruption of the methyltransferase-like 23 gene METTL23 causes mild autosomal recessive intellectual disability

scientific article

Elucidation of the mode of substrate binding to hydroxynitrile lyase from Hevea brasiliensis.

scientific article published on July 2001

Engineering of choline oxidase from Arthrobacter nicotianae for potential use as biological bleach in detergents

scientific article

Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III

scientific article

Enzymatic Surface Hydrolysis of PET: Effect of Structural Diversity on Kinetic Properties of Cutinases from Thermobifida

Enzymatic aerobic alkene cleavage catalyzed by a Mn(3+) -dependent proteinase a homologue

scientific article published on 4 November 2013

Enzyme discovery beyond homology: a unique hydroxynitrile lyase in the Bet v1 superfamily.

scientific article

Epoxide-hydrolase-initiated hydrolysis/rearrangement cascade of a methylene-interrupted bis-epoxide yields chiral THF moieties without involvement of a "cyclase".

scientific article published in July 2009

Erratum: Enzyme discovery beyond homology: a unique hydroxynitrile lyase in the Bet v1 superfamily

scientific article published on 26 May 2017

Evolving the Promiscuity of Elizabethkingia meningoseptica Oleate Hydratase for the Regio- and Stereoselective Hydration of Oleic Acid Derivatives.

scientific article published on 17 April 2019

Extracellular serine proteases from Stenotrophomonas maltophilia: Screening, isolation and heterologous expression in E. coli

scientific article

Heterologous expression and characterization of choline oxidase from the soil bacterium Arthrobacter nicotianae

scientific article published on 12 September 2008

High-resolution structure of a new Tn antigen-binding lectin from Vatairea macrocarpa and a comparative analysis of Tn-binding legume lectins

scientific article

Homocoenzyme B12 and bishomocoenzyme B12: covalent structural mimics for homolyzed, enzyme-bound coenzyme B12.

scientific article published in December 2004

Hydrolysis of synthetic polyesters by Clostridium botulinum esterases

scientific article

Hydroxynitrile Lyases with α/β-Hydrolase Fold: Two Enzymes with Almost Identical 3D Structures but Opposite Enantioselectivities and Different Reaction Mechanisms

scientific article

Identification of Key Residues for Enzymatic Carboxylate Reduction.

scientific article published on 19 February 2018

Identification of promiscuous ene-reductase activity by mining structural databases using active site constellations

scientific article

Inverting enantioselectivity of Burkholderia gladioli esterase EstB by directed and designed evolution

scientific article published on 20 October 2006

Inverting the regioselectivity of the berberine bridge enzyme by employing customized fluorine-containing substrates

scientific article published on 7 September 2012

Isovitamin B12: a vitamin B12 derivative that flips its tail

scientific article published on 01 September 2010

Laboratory evolved biocatalysts for stereoselective syntheses of substituted benzaldehyde cyanohydrins

scientific article published in January 2008

Metal complexes of a biconcave porphyrin with D4-structure--versatile chiral shift agents

scientific article published on 01 June 2001

Molecular recognition determinants for type IV secretion of diverse families of conjugative relaxases

scientific article published on 15 October 2010

Observation of a short, strong hydrogen bond in the active site of hydroxynitrile lyase from Hevea brasiliensis explains a large pKa shift of the catalytic base induced by the reaction intermediate

scientific article published on 3 November 2003

Old Yellow Enzyme-Catalyzed Dehydrogenation of Saturated Ketones

article by Matthias Schittmayer et al published 9 February 2011 in Advanced Synthesis & Catalysis

Oxidation of Monolignols by Members of the Berberine Bridge Enzyme Family Suggests a Role in Plant Cell Wall Metabolism

scientific article published on 2 June 2015

Oxidative cyclization of -methyl-dopa by a fungal flavoenzyme of the amine oxidase family

scientific article published in Journal of Biological Chemistry

Polyester hydrolysis is enhanced by a truncated esterase: Less is more.

scientific article

PpEst is a novel PBAT degrading polyesterase identified by proteomic screening of Pseudomonas pseudoalcaligenes

scientific article published on 21 November 2016

Rational Engineered C-Acyltransferase Transforms Sterically Demanding Acyl Donors

scientific article published on 27 December 2019

Regioselective Enzymatic β-Carboxylation of para-Hydroxy- styrene Derivatives Catalyzed by Phenolic Acid Decarboxylases.

scientific article published on 2 April 2015

Regioselective para-Carboxylation of Catechols by a Prenylated Flavin Dependent Decarboxylase.

scientific article published on 30 August 2017

Role of the general base Glu-268 in nitroglycerin bioactivation and superoxide formation by aldehyde dehydrogenase-2.

scientific article published on 8 June 2009

Serine scanning: a tool to prove the consequences of N-glycosylation of proteins

scientific article published on 09 December 2006

Small cause, large effect: Structural characterization of cutinases from Thermobifida cellulosilytica.

scientific article

Stereoselective biocatalytic synthesis of (S)-2-hydroxy-2-methylbutyric acid via substrate engineering by using "thio-disguised" precursors and oxynitrilase catalysis

scientific article published in January 2007

Structural and Functional Characterization of NikO, an Enolpyruvyl Transferase Essential in Nikkomycin Biosynthesis

scientific article

Structural and biochemical properties of LuxF from Photobacterium leiognathi

scientific article published on 21 July 2015

Structural and kinetic studies on RosA, the enzyme catalysing the methylation of 8-demethyl-8-amino-d-riboflavin to the antibiotic roseoflavin.

scientific article

Structural and mechanistic studies reveal the functional role of bicovalent flavinylation in berberine bridge enzyme

scientific article published on 19 May 2009

Structural characterization of a Vatairea macrocarpa lectin in complex with a tumor-associated antigen: A new tool for cancer research

scientific article

Structural insights into substrate specificity and solvent tolerance in alcohol dehydrogenase ADH-'A' from Rhodococcus ruber DSM 44541

scientific article

Structural studies of an anti-inflammatory lectin from Canavalia boliviana seeds in complex with dimannosides

scientific article (publication date: 2014)

Structure and biochemical properties of recombinant human dimethylglycine dehydrogenase and comparison to the disease-related H109R variant

scientific article

Structure and catalytic mechanism of a bacterial Friedel-Crafts acylase

scholarly article by Tea Pavkov‐Keller published in October 2018

Structure and function of YcnD from Bacillus subtilis, a flavin-containing oxidoreductase.

scientific article

Structure and stability of an unusual zinc-binding protein from Bacteroides thetaiotaomicron

scientific article

Structure of a Berberine Bridge Enzyme-Like Enzyme with an Active Site Specific to the Plant Family Brassicaceae

scientific article

Structure of human dipeptidyl peptidase 10 (DPPY): a modulator of neuronal Kv4 channels.

scientific article published on 05 March 2015

Structure, biochemical and kinetic properties of recombinant Pst2p from Saccharomyces cerevisiae, a FMN-dependent NAD(P)H:quinone oxidoreductase.

scientific article published on 9 May 2017

Structure-Based Mechanism of Oleate Hydratase from Elizabethkingia meningoseptica.

scientific article

Structures of Human DPP7 Reveal the Molecular Basis of Specific Inhibition and the Architectural Diversity of Proline-Specific Peptidases

scientific article

Structures of almond hydroxynitrile lyase isoenzyme 5 provide a rationale for the lack of oxidoreductase activity in flavin dependent HNLs

scientific article

Substituting the catalytic proline of 4-oxalocrotonate tautomerase with non-canonical analogues reveals a finely tuned catalytic system

scientific article published on 25 February 2019

Substrate Binding in the FAD-Dependent Hydroxynitrile Lyase from Almond Provides Insight into the Mechanism of Cyanohydrin Formation and Explains the Absence of Dehydrogenation Activity † , ‡

scientific article

Substrate complexes of human dipeptidyl peptidase III reveal the mechanism of enzyme inhibition.

scientific article published on 30 March 2016

Surface engineering of a cutinase from Thermobifida cellulosilytica for improved polyester hydrolysis

scientific article published on 29 April 2013

Tailoring a Stabilized Variant of Hydroxynitrile Lyase from Arabidopsis thaliana

scientific article published on 29 February 2012

Targeting the substrate binding site of E. coli nitrile reductase QueF by modeling, substrate and enzyme engineering

scientific article published on 17 April 2013

The 2.5 A Structure of the Enterococcus Conjugation Protein TraM resembles VirB8 Type IV Secretion Proteins

scientific article

The Hydrogenobyric Acid Structure Reveals the Corrin Ligand as an Entatic State Module Empowering B12 Cofactors for Catalysis

scientific article published on 26 June 2019

The Structure of Glycerol Trinitrate Reductase NerA from Agrobacterium radiobacter Reveals the Molecular Reason for Nitro- and Ene-Reductase Activity in OYE Homologues

scientific article

The active site of hydroxynitrile lyase from Prunus amygdalus: modeling studies provide new insights into the mechanism of cyanogenesis

scientific article

The crystal structure and characterization of a copper(II) complex with a guanosine-5′-monophosphate analog (acyclovir monophosphate)

The crystal structure of D-threonine aldolase from Alcaligenes xylosoxidans provides insight into a metal ion assisted PLP-dependent mechanism

scientific article published on 17 April 2015

The first structure of dipeptidyl-peptidase III provides insight into the catalytic mechanism and mode of substrate binding

scientific article

The hydroxynitrile lyase from almond: a lyase that looks like an oxidoreductase

scientific article

The structure of monoacylglycerol lipase from Bacillus sp. H257 reveals unexpected conservation of the cap architecture between bacterial and human enzymes

scientific article

Thermophilic Xylanase fromThermomyceslanuginosus: High-Resolution X-ray Structure and Modeling Studies, ⬇️

scientific article published on September 29, 1998

Total Synthesis, Structure, and Biological Activity of Adenosylrhodibalamin, the Non-Natural Rhodium Homologue of Coenzyme B12

scientific article (publication date: 5 September 2016)

Uneven twins: comparison of two enantiocomplementary hydroxynitrile lyases with alpha/beta-hydrolase fold.

scientific article published on 27 March 2009

Unique crystal structure of a novel surfactant protein from the foam nest of the frog Leptodactylus vastus

scientific article

VASCo: computation and visualization of annotated protein surface contacts.

scientific article

Vascular Bioactivation of Nitroglycerin by Aldehyde Dehydrogenase-2: REACTION INTERMEDIATES REVEALED BY CRYSTALLOGRAPHY AND MASS SPECTROMETRY

scientific article

Vitamin B12-derivatives-enzyme cofactors and ligands of proteins and nucleic acids

scientific article published on 20 June 2011

Vitamin B12: a methyl group without a job?

scientific article published on 01 January 2006

X-ray structural characterization of imidazolylcobalamin and histidinylcobalamin: cobalamin models for aquacobalamin bound to the B12 transporter protein transcobalamin.

scientific article published on 04 April 2007

XAS spectroscopy reveals X-ray-induced photoreduction of free and protein-bound B12 cofactors

scientific article published on 01 July 2000

Zinc Substitution of Cobalt in Vitamin B12 : Zincobyric acid and Zincobalamin as Luminescent Structural B12 -Mimics

scientific article published on 04 September 2019

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