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List of works by Jörg Rademann

2-Cyanoisonicotinamide Conjugation: A Facile Approach to Generate Potent Peptide Inhibitors of the Zika Virus Protease

scientific article

A phosphorane as supported acylanion equivalent: linker reagents for smooth and versatile C-C coupling reactions

scientific article published on 01 June 2003

Acylated cholesteryl galactosides are ubiquitous glycolipid antigens among Borrelia burgdorferi sensu lato

scientific article published on 27 June 2011

Advanced polymer reagents based on activated reactants and reactive intermediates: powerful novel tools in diversity-oriented synthesis

scientific article published on 01 January 2003

Alkylating Polymers: Resin-Released Carbenium Ions as Versatile Reactive Intermediates in Polymer-Assisted Solution-Phase Synthesis

article published in 2001

Alkylating Polymers: Resin-Released Carbenium Ions as Versatile Reactive Intermediates in Polymer-Assisted Solution-Phase Synthesis J.R. gratefully acknowledges support from Prof. M. E. Maier, Tübingen, the Strukturfonds of the University of Tübinge

scientific article published on 01 January 2001

Alzheimer's disease: identification and development of β-secretase (BACE-1) binding fragments and inhibitors by dynamic ligation screening (DLS).

scientific article

An Intrinsic Hydrophobicity Scale for Amino Acids and Its Application to Fluorinated Compounds

scientific article published on 10 May 2019

An efficient method for the synthesis of peptide aldehyde libraries employed in the discovery of reversible SARS coronavirus main protease (SARS-CoV Mpro) inhibitors

scientific article published in July 2006

Benzoylphosphonate-based photoactive phosphopeptide mimetics for modulation of protein tyrosine phosphatases and highly specific labeling of SH2 domains

scientific article published on 21 August 2012

Benzyl Mono-P-Fluorophosphonate and Benzyl Penta-P-Fluorophosphate Anions Are Physiologically Stable Phosphotyrosine Mimetics and Inhibitors of Protein Tyrosine Phosphatases

scientific article

Biological characterization, mechanistic investigation and structure-activity relationship of chemically stable TLR2 antagonists

scientific article published on 25 April 2020

Biophysical characterization of synthetic rhamnolipids

scientific article published on 24 October 2006

Biotransformation of 2,4-toluenediamine in human skin and reconstructed tissues

scientific article published on 23 March 2017

C-acylations of polymeric phosphoranylidene acetates for C-terminal variation of peptide carboxylic acids

scientific article published on 17 February 2007

C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells

scientific article published on 09 January 2017

Catalytic activation of pre-substrates via dynamic fragment assembly on protein templates

scientific article published on 18 November 2014

Catching a Moving Target: Comparative Modeling of Flaviviral NS2B-NS3 Reveals Small Molecule Zika Protease Inhibitors

scientific article published on 03 March 2020

Characterization of defined sulfated heparin-like oligosaccharides by electrospray ionization ion trap mass spectrometry

scientific article published on 01 February 2021

Chemical synthesis of a glycolipid library by a solid-phase strategy allows elucidation of the structural specificity of immunostimulation by rhamnolipids

scientific article published in September 2006

Chemoenzymatic Synthesis of Nonasulfated Tetrahyaluronan with a Paramagnetic Tag for Studying Its Complex with Interleukin-10.

scientific article published on 25 February 2016

Chemoenzymatic synthesis of a glycolipid library and elucidation of the antigenic epitope for construction of a vaccine against Lyme disease

scientific article

Chemoselective Wittig and Michael ligations of unprotected peptidyl phosphoranes in water furnish potent inhibitors of caspase-3

scientific article published on 20 August 2014

Chemoselective and Bioorthogonal Ligation Reactions. Concepts and Applications. 2 Bände Herausgegeben von W. Russ Algar, Philip Dawson und Igor L. Medintz.

scientific article published in 2017

Chemoselective and Bioorthogonal Ligation Reactions. Concepts and Applications. 2 Volumes Edited by W. Russ Algar, Philip Dawson, and Igor L. Medintz.

scientific article published in 2017

Cholesteryl esters stabilize human CD1c conformations for recognition by self-reactive T cells.

scientific article published on 16 February 2016

Combinatorial Chemistry in the Commercial Jungle

scientific article published on 01 July 2001

Corrigendum to: Off-target inhibition by active site-targeting SHP2 inhibitors

scientific article published on 01 December 2019

Coupling to polymeric scaffolds stabilizes biofunctional peptides for intracellular applications

scientific article published on 19 January 2011

Cyclative cleavage through dipolar cycloaddition: polymer-bound azidopeptidylphosphoranes deliver locked cis-triazolylcyclopeptides as privileged protein binders

scientific article published in July 2010

Design of chemical libraries with potentially bioactive molecules applying a maximum common substructure concept

scientific article published on 15 August 2009

Discovery of Mycobacterium tuberculosis protein tyrosine phosphatase A (MptpA) inhibitors based on natural products and a fragment-based approach

scientific article

Discovery, structure-activity relationship studies, and crystal structure of nonpeptide inhibitors bound to the Shank3 PDZ domain

scientific article

Dual Action of Sulfated Hyaluronan on Angiogenic Processes in Relation to Vascular Endothelial Growth Factor-A

scientific article published on 02 December 2019

Dynamic substrate enhancement for the identification of specific, second-site-binding fragments targeting a set of protein tyrosine phosphatases

scientific article published on 3 November 2011

Dynamic template-assisted strategies in fragment-based drug discovery.

scientific article published on 11 August 2009

Effects of charge and charge distribution on the cellular uptake of multivalent arginine-containing peptide-polymer conjugates

scientific article published on 24 September 2013

Efficient access to peptidyl ketones and peptidyl diketones via C-alkylations and C-acylations of polymer-supported phosphorus ylides followed by hydrolytic and/or oxidative cleavage

scientific article published in January 2010

Endotoxin-like properties of a rhamnolipid exotoxin from Burkholderia (Pseudomonas) plantarii: immune cell stimulation and biophysical characterization

scientific article published on 01 March 2006

Epitope-mapping of transglutaminase with parallel label-free optical detection

scientific article published on 01 December 2002

Extra- and intracellular imaging of human matrix metalloprotease 11 (hMMP-11) with a cell-penetrating FRET substrate.

scientific article

Flexible, polymer-supported synthesis of sphingosine derivatives provides ceramides with enhanced biological activity.

scientific article published on 24 July 2014

Fluorescent mimetics of CMP-Neu5Ac are highly potent, cell-permeable polarization probes of eukaryotic and bacterial sialyltransferases and inhibit cellular sialylation

scientific article published on 15 April 2014

Fmoc-based synthesis of peptide thioacids for azide ligations via 2-cyanoethyl thioesters

scientific article published on 19 September 2012

Fmoc-based synthesis of peptide thioesters for native chemical ligation employing a tert-butyl thiol linker

scientific article published on 28 February 2011

HPMA as a scaffold for the modular assembly of functional peptide polymers by native chemical ligation

scientific article

High yield expression of catalytically active USP18 (UBP43) using a Trigger Factor fusion system.

scientific article

Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions

scientific article published on 23 September 2013

Hydrophobically assisted switching phase synthesis: the flexible combination of solid-phase and solution-phase reactions employed for oligosaccharide preparation.

scientific article published in May 2005

IR action spectroscopy of glycosaminoglycan oligosaccharides

scientific article published on 18 December 2019

Identification and Validation of Larixyl Acetate as a Potent TRPC6 Inhibitor.

scientific article published on 23 October 2015

Identification and validation of a novel dual small-molecule TLR2/8 antagonist

scientific article published on 05 April 2020

Identification of a pyrrogallol derivative as a potent and selective human TLR2 antagonist by structure-based virtual screening.

scientific article published on 20 April 2018

Identification of the Glycosaminoglycan Binding Site of Interleukin-10 by NMR Spectroscopy

scientific article published on 16 December 2015

Incorporation of Amino Acids with Long-Chain Terminal Olefins into Proteins.

scientific article published on 29 February 2016

Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments

scientific article published on 28 September 2016

Light-switched inhibitors of protein tyrosine phosphatase PTP1B based on phosphonocarbonyl phenylalanine as photoactive phosphotyrosine mimetic

scientific article published on 4 April 2015

Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl- accumulation

scientific article

Mapping Protein-Protein Interactions of the Resistance-Related Bacterial Zeta Toxin-Epsilon Antitoxin Complex (ε₂ζ₂) with High Affinity Peptide Ligands Using Fluorescence Polarization

scientific article published on 16 July 2016

Metal-free, regioselective triazole ligations that deliver locked cis peptide mimetics.

scientific article published in January 2009

Modulation of Human CXCL12 Binding Properties to Glycosaminoglycans To Enhance Chemotactic Gradients

scientific article from 2019

Multivalent design of apoptosis-inducing bid-BH3 peptide-oligosaccharides boosts the intracellular activity at identical overall peptide concentrations

scientific article published on 4 November 2012

Multivalent presentation of the cell-penetrating peptide nona-arginine on a linear scaffold strongly increases its membrane-perturbing capacity

scientific article published on 07 August 2014

Nanoparticular Inhibitors of Flavivirus Proteases from Zika, West Nile and Dengue Virus Are Cell-Permeable Antivirals

scientific article

New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, and β-amyloid-reducing properties

scientific article

One-Pot Synthesis of Unprotected Anomeric Glycosyl Thiols in Water for Glycan Ligation Reactions with Highly Functionalized Sugars

scientific article published on 11 November 2016

Organic protein chemistry: drug discovery through the chemical modification of proteins

scientific article published in September 2004

Oxidizing Polymers: A Polymer-Supported, Recyclable Hypervalent Iodine(V) Reagent for the Efficient Conversion of Alcohols, Carbonyl Compounds, and Unsaturated Carbamates in Solution J.R. gratefully acknowledges generous support from Prof. M. E. Mai

scientific article published in December 2001

Oxoammonium Resins as Metal-Free, Highly Reactive, Versatile Polymeric Oxidation Reagents

scientific article published in April 2001

Oxoammonium Resins as Metal-Free, Highly Reactive, Versatile Polymeric Oxidation Reagents J.R. gratefully acknowledges generous support from Prof. M. E. Maier, Tübingen, the Strukturfonds of the Universität Tübingen, and Merck KGaA, Darmstadt, Germa

scientific article published on 01 April 2001

Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease

scientific article

Peptide-mediated surface coatings for the release of wound-healing cytokines

scientific article published on 06 September 2020

Peptide-polymer ligands for a tandem WW-domain, an adaptive multivalent protein-protein interaction: lessons on the thermodynamic fitness of flexible ligands

scientific article published on 18 May 2015

Pharmacological inhibition of FSGS-related TRPC6 gain of function mutants by semisynthetic larixol-derived compounds.

scientific article

Phenylthiomethyl Ketone-Based Fragments Show Selective and Irreversible Inhibition of Enteroviral 3C Proteases

scientific article published on 12 January 2018

Phosphoinositol 3-kinase-gamma mediates antineutrophil cytoplasmic autoantibody-induced glomerulonephritis

scientific article published on 11 November 2009

Physical properties of poly(ethylene glycol) (PEG)-based resins for combinatorial solid phase organic chemistry: a comparison of PEG-cross-linked and PEG-grafted resins

scientific article published on 01 March 2000

Polymer-bound alkyltriazenes for mild racemization-free esterification of amino acid and peptide derivatives

scientific article published in October 2004

Progress in the preparation of peptide aldehydes via polymer supported IBX oxidation and scavenging by threonyl resin

scientific article published in March 2005

Propargyl amides as irreversible inhibitors of cysteine proteases--a lesson on the biological reactivity of alkynes

scientific article published on 21 June 2013

Protein-Templated Formation of an Inhibitor of the Blood Coagulation Factor Xa through a Background-Free Amidation Reaction

scientific article published on 15 February 2017

Protein-Templated Fragment Ligations-From Molecular Recognition to Drug Discovery.

scientific article

Proteintemplat-gesteuerte Fragmentligationen - von der molekularen Erkennung zur Wirkstofffindung

scientific article published on 31 May 2017

Resin-bound aminofluorescein for C-terminal labeling of peptides: high-affinity polarization probes binding to polyproline-specific GYF domains

scientific article

Reversible cross-linking of hyperbranched polymers: a strategy for the combinatorial decoration of multivalent scaffolds

scientific article published on 01 February 2005

Rhamnolipids form drug-loaded nanoparticles for dermal drug delivery.

scientific article published on 21 December 2016

SPOCC-194, a new high functional group density PEG-based resin for solid-phase organic synthesis

scientific article published in September 2002

Selective identification of cooperatively binding fragments in a high-throughput ligation assay enables development of a picomolar caspase-3 inhibitor.

scientific article published in January 2009

Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in vitro and in vivo

scientific article

Sensitized detection of inhibitory fragments and iterative development of non-peptidic protease inhibitors by dynamic ligation screening

scientific article published on 01 January 2008

Shp2 signaling suppresses senescence in PyMT-induced mammary gland cancer in mice.

scientific article published on 3 March 2015

Side-Chain Modification of Peptides Using a Phosphoranylidene Amino Acid

scientific article published on 30 March 2020

Small-Molecule Scaffolds for CYP51 Inhibitors Identified by High-Throughput Screening and Defined by X-Ray Crystallography

scientific article

Solid-Phase Supported Synthesis of the Branched Pentasaccharide Moiety That Occurs in Most Complex Type N-Glycan Chains.

scientific article published in May 1998

Solid-phase synthesis of a glycosylated hexapeptide of human sialophorin, using the trichloroacetimidate method

scientific article published on 01 April 1995

Soluble peptidyl phosphoranes for metal-free, stereoselective ligations in organic and aqueous solution.

scientific article published on 2 December 2011

Spatially resolved single bead analysis: homogeneity, diffusion, and adsorption in cross-linked polystyrene

scientific article published on 01 September 2001

Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking.

scholarly article

Stereospecific synthesis of chiral 2,3-dihydro-1,4-benzodithiine and methyl-2,3-dihydro-1,4-benzodithiine derivatives and their toxic effects on Trypanosoma brucei

scientific article published in August 2005

Structural Basis for Binding of Fluorescent CMP-Neu5Ac Mimetics to Enzymes of the Human ST8Sia Family

scientific article published on 26 July 2018

Structural and functional insights into the interaction of sulfated glycosaminoglycans with tissue inhibitor of metalloproteinase-3 - A possible regulatory role on extracellular matrix homeostasis

scientific article published on 18 August 2016

Sulfated Hyaluronan Alters Endothelial Cell Activation in Vitro by Controlling the Biological Activity of the Angiogenic Factors Vascular Endothelial Growth Factor-A and Tissue Inhibitor of Metalloproteinase-3.

scientific article

Sulfated Hyaluronan Alters the Interaction Profile of TIMP-3 with the Endocytic Receptor LRP-1 Clusters II and IV and Increases the Extracellular TIMP-3 Level of Human Bone Marrow Stromal Cells

scientific article published on 9 September 2016

Sulfated Hyaluronan Derivatives Modulate TGF-β1:Receptor Complex Formation: Possible Consequences for TGF-β1 Signaling

scientific article published on 26 April 2017

Sulfation Patterns of Saccharides and Heavy Metal Ion Binding

scientific article published on 28 July 2019

Syntheses of defined sulfated oligohyaluronans reveal structural effects, diversity and thermodynamics of GAG-protein binding

scientific article published on 01 November 2018

Tailoring ultraresins based on the cross-linking of polyethylene imines. Comparative investigation of the chemical composition, the swelling, the mobility, the chemical accessibility, and the performance in solid-phase synthesis of very high loaded

scientific article published on 01 May 2004

The potential of P1 site alterations in peptidomimetic protease inhibitors as suggested by virtual screening and explored by the use of C-C-coupling reagents

scientific article published in April 2006

The structural investigation of glycosaminoglycan binding to CXCL12 displays distinct interaction sites

scientific article published on 24 June 2016

The transcription factor STAT5 catalyzes Mannich ligation reactions yielding inhibitors of leukemic cell proliferation

scientific article published in Nature Communications

ULTRA loaded resins based on the cross-linking of linear poly(ethylene imine). Improving the atom economy of polymer-supported chemistry

scientific article published on 01 August 2002

Understanding supported reactions in spherical compartments: a general algorithm to model and determine rate constants, diffusion coefficients, and spatial product distributions

scientific article published in November 2005

alpha-Ketocarbonyl peptides: a general approach to reactive resin-bound intermediates in the synthesis of peptide isosteres for protease inhibitor screening on solid support

scientific article published in March 2001

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